DD128594A5 - PROCESS FOR THE PREPARATION OF NEW OXIM DERIVATIVES OF 7-AMINOTHIAZOLYLAZETAMIDO-ZEPHALOSPORANSAURE - Google Patents

PROCESS FOR THE PREPARATION OF NEW OXIM DERIVATIVES OF 7-AMINOTHIAZOLYLAZETAMIDO-ZEPHALOSPORANSAURE

Info

Publication number
DD128594A5
DD128594A5 DD7700197036A DD19703677A DD128594A5 DD 128594 A5 DD128594 A5 DD 128594A5 DD 7700197036 A DD7700197036 A DD 7700197036A DD 19703677 A DD19703677 A DD 19703677A DD 128594 A5 DD128594 A5 DD 128594A5
Authority
DD
German Democratic Republic
Prior art keywords
zephalosporansaure
aminothiazolylazetamido
preparation
new
oxim
Prior art date
Application number
DD7700197036A
Other languages
German (de)
Inventor
Rene Heymes
Andre Lutz
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27250574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD128594(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR7601834A external-priority patent/FR2346014A1/en
Priority claimed from FR7617743A external-priority patent/FR2361893A2/en
Priority claimed from FR7625051A external-priority patent/FR2361894A2/en
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DD128594A5 publication Critical patent/DD128594A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD7700197036A 1976-01-23 1977-01-21 PROCESS FOR THE PREPARATION OF NEW OXIM DERIVATIVES OF 7-AMINOTHIAZOLYLAZETAMIDO-ZEPHALOSPORANSAURE DD128594A5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7601834A FR2346014A1 (en) 1976-01-23 1976-01-23 Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity
FR7617743A FR2361893A2 (en) 1976-01-23 1976-06-11 Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity
FR7625051A FR2361894A2 (en) 1976-01-23 1976-08-18 Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity

Publications (1)

Publication Number Publication Date
DD128594A5 true DD128594A5 (en) 1977-11-30

Family

ID=27250574

Family Applications (2)

Application Number Title Priority Date Filing Date
DD7700200629A DD132869A5 (en) 1976-01-23 1977-01-21 PROCESS FOR THE PREPARATION OF NEW AMINOTHIAZOLYLAZETAMIDO DERIVATIVES
DD7700197036A DD128594A5 (en) 1976-01-23 1977-01-21 PROCESS FOR THE PREPARATION OF NEW OXIM DERIVATIVES OF 7-AMINOTHIAZOLYLAZETAMIDO-ZEPHALOSPORANSAURE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DD7700200629A DD132869A5 (en) 1976-01-23 1977-01-21 PROCESS FOR THE PREPARATION OF NEW AMINOTHIAZOLYLAZETAMIDO DERIVATIVES

Country Status (31)

Country Link
JP (3) JPS52102293A (en)
AR (1) AR231985A1 (en)
AT (2) AT355205B (en)
AU (1) AU511680B2 (en)
BE (1) BE850662A (en)
CA (1) CA1319682C (en)
CH (1) CH622264A5 (en)
CY (1) CY1123A (en)
DD (2) DD132869A5 (en)
DE (3) DE2760287C2 (en)
DK (1) DK161082C (en)
ES (2) ES455089A1 (en)
GB (2) GB1580621A (en)
GE (1) GEP19970783B (en)
GR (1) GR70302B (en)
HK (1) HK50381A (en)
HU (1) HU173110B (en)
IE (1) IE45015B1 (en)
IL (2) IL51192A (en)
IT (1) IT1104601B (en)
KE (1) KE3365A (en)
LU (1) LU76624A1 (en)
MX (1) MX4407E (en)
MY (1) MY8500417A (en)
NL (1) NL7700706A (en)
NZ (1) NZ183150A (en)
PL (1) PL122698B1 (en)
PT (1) PT66099B (en)
SE (2) SE440655B (en)
SU (1) SU822754A3 (en)
YU (3) YU41060B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408613A2 (en) * 1977-07-19 1979-06-08 Roussel Uclaf NEW OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
DK162391C (en) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
DE2715385A1 (en) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
ZA781502B (en) * 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
FR2400519A1 (en) * 1977-08-17 1979-03-16 Roussel Uclaf CRYSTALLINE FORM OF SODIUM SALT OF AN OXIMIN DERIVATIVE OF 7-AMINO-THIAZOLYL ACETAMIDO CEPHALOSPORANIC, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
FR2410655A1 (en) * 1977-12-05 1979-06-29 Roussel Uclaf NEW OXIMES DERIVED FROM 3-SUBSTITUTE 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
FR2387235A1 (en) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3,7-DISUBSTITUE-3-CEPHEM-4-CARBOXYLIC ACID AND NEW PRODUCTS THUS OBTAINED, HAVING A STRONG ANTIBACTERIAL ACTIVITY
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
SE445350B (en) * 1978-04-14 1986-06-16 Roussel Uclaf OXIMO DERIVATIVES OF 3-AZIDOMETHYL-7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID AND ITS USE AS ANTIBIOTICS
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
FR2448543A1 (en) * 1979-02-09 1980-09-05 Roussel Uclaf NOVEL OXIMES O-SUBSTITUTED BY A RADICAL COMPRISING A QUATERNARY AMMONIUM AND DERIVATIVES OF 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2461713A1 (en) * 1979-07-19 1981-02-06 Roussel Uclaf SUBSTITUTED ALKYLOXIMIC NEWS DERIVED FROM 7- (2-AMINO 4-THIAZOLYL) ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
FR2461712A1 (en) * 1979-07-23 1981-02-06 Hoechst Ag 2-Oximino-acylamino cephem cpds. prodn. - by acylating 7-amino-cephem cpds. with complexes of 2-syn-oximino-acyl halide(s) and N,N-di:substd. amide(s)
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
FR2506307A1 (en) * 1981-05-22 1982-11-26 Roussel Uclaf 7-thiazolyl-acetamido-cephalosporin oxime derivs. - useful as broad spectrum antibacterials and disinfectants (BE 1.10.79)
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
HUT53892A (en) * 1989-04-07 1990-12-28 Technologishen Kom Za Promy Mi Process for producing synaminothiazolyl and synaminooxazolyl derivatives
CN112457271A (en) * 2020-11-18 2021-03-09 河北合佳医药科技集团股份有限公司 Continuous flow synthesis method of aminothiazoly loximate intermediate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DK154939C (en) 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DE2760123C2 (en) 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them
JPS6011713B2 (en) 1976-09-08 1985-03-27 武田薬品工業株式会社 Cephalosporin derivatives and their production method

Also Published As

Publication number Publication date
SE8204893L (en) 1982-08-26
AT373592B (en) 1984-02-10
DE2760287C2 (en) 1988-04-14
KE3365A (en) 1984-02-03
DE2759895C2 (en) 1986-01-16
JPS52102293A (en) 1977-08-27
JPS6228152B2 (en) 1987-06-18
DK161082B (en) 1991-05-27
ATA209479A (en) 1983-06-15
IT1104601B (en) 1985-10-21
IL51192A0 (en) 1977-02-28
YU43143B (en) 1989-04-30
MY8500417A (en) 1985-12-31
DD132869A5 (en) 1978-11-15
DK23677A (en) 1977-07-24
HU173110B (en) 1979-02-28
SE440655B (en) 1985-08-12
NL7700706A (en) 1977-07-26
AU511680B2 (en) 1980-08-28
PT66099A (en) 1977-02-01
YU41060B (en) 1986-10-31
AU2157977A (en) 1978-08-03
BE850662A (en) 1977-07-22
DK161082C (en) 1991-11-04
SE7614678L (en) 1977-07-24
JPH03204868A (en) 1991-09-06
GEP19970783B (en) 1997-01-28
CA1319682C (en) 1993-06-29
PL195504A1 (en) 1978-03-13
GB1580623A (en) 1980-12-03
GB1580621A (en) 1980-12-03
IE45015L (en) 1977-07-23
AR231985A1 (en) 1985-04-30
NZ183150A (en) 1979-12-11
JPH05247013A (en) 1993-09-24
YU13777A (en) 1983-04-30
SU822754A3 (en) 1981-04-15
HK50381A (en) 1981-10-30
SE455307B (en) 1988-07-04
LU76624A1 (en) 1977-08-12
IE45015B1 (en) 1982-06-02
MX4407E (en) 1982-04-27
CH622264A5 (en) 1981-03-31
ATA41277A (en) 1979-07-15
CY1123A (en) 1982-02-19
PL122698B1 (en) 1982-08-31
DE2702501C2 (en) 1982-11-18
IL57445A0 (en) 1979-09-30
GR70302B (en) 1982-09-06
DE2702501A1 (en) 1977-07-28
SE8204893D0 (en) 1982-08-26
ES455089A1 (en) 1978-04-16
PT66099B (en) 1979-03-09
AT355205B (en) 1980-02-25
ES466539A1 (en) 1978-10-01
IL51192A (en) 1980-11-30
YU1283A (en) 1984-02-29
YU1183A (en) 1984-02-29

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