CZ300499B6 - Použití bunecných linií lidské prostaty k lécbe zhoubného bujení prostaty - Google Patents
Použití bunecných linií lidské prostaty k lécbe zhoubného bujení prostaty Download PDFInfo
- Publication number
- CZ300499B6 CZ300499B6 CZ20012032A CZ20012032A CZ300499B6 CZ 300499 B6 CZ300499 B6 CZ 300499B6 CZ 20012032 A CZ20012032 A CZ 20012032A CZ 20012032 A CZ20012032 A CZ 20012032A CZ 300499 B6 CZ300499 B6 CZ 300499B6
- Authority
- CZ
- Czechia
- Prior art keywords
- cell lines
- immunotherapeutic agent
- treatment
- prostate cancer
- prostate
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title claims abstract description 15
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims abstract description 15
- 210000005267 prostate cell Anatomy 0.000 title claims abstract description 9
- 238000011282 treatment Methods 0.000 title claims description 19
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 42
- 201000011510 cancer Diseases 0.000 claims abstract description 20
- 210000001519 tissue Anatomy 0.000 claims abstract description 19
- 230000000735 allogeneic effect Effects 0.000 claims abstract description 9
- 210000002307 prostate Anatomy 0.000 claims abstract description 6
- 230000036210 malignancy Effects 0.000 claims abstract description 5
- 210000004027 cell Anatomy 0.000 claims description 98
- 239000002955 immunomodulating agent Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 9
- 210000002966 serum Anatomy 0.000 claims description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 210000004881 tumor cell Anatomy 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 4
- 102000000588 Interleukin-2 Human genes 0.000 claims description 4
- 108010002350 Interleukin-2 Proteins 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 241000187644 Mycobacterium vaccae Species 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000002163 immunogen Effects 0.000 claims description 3
- 239000012646 vaccine adjuvant Substances 0.000 claims description 3
- 229940124931 vaccine adjuvant Drugs 0.000 claims description 3
- 241000588832 Bordetella pertussis Species 0.000 claims description 2
- 102000013462 Interleukin-12 Human genes 0.000 claims description 2
- 108010065805 Interleukin-12 Proteins 0.000 claims description 2
- 102000004388 Interleukin-4 Human genes 0.000 claims description 2
- 108090000978 Interleukin-4 Proteins 0.000 claims description 2
- 102000000704 Interleukin-7 Human genes 0.000 claims description 2
- 108010002586 Interleukin-7 Proteins 0.000 claims description 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 2
- 229940117681 interleukin-12 Drugs 0.000 claims description 2
- 229940028885 interleukin-4 Drugs 0.000 claims description 2
- 229940100994 interleukin-7 Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 229960000814 tetanus toxoid Drugs 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940021747 therapeutic vaccine Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 abstract description 13
- 229940030156 cell vaccine Drugs 0.000 abstract description 8
- 241000124008 Mammalia Species 0.000 abstract description 4
- 230000003211 malignant effect Effects 0.000 abstract description 3
- 230000010076 replication Effects 0.000 abstract description 3
- 239000012528 membrane Substances 0.000 description 18
- 239000006166 lysate Substances 0.000 description 16
- 238000013459 approach Methods 0.000 description 13
- 239000000427 antigen Substances 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 210000000987 immune system Anatomy 0.000 description 11
- 238000002255 vaccination Methods 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 10
- 239000012894 fetal calf serum Substances 0.000 description 10
- 238000009169 immunotherapy Methods 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 238000010790 dilution Methods 0.000 description 8
- 239000012895 dilution Substances 0.000 description 8
- 230000001900 immune effect Effects 0.000 description 8
- 230000003902 lesion Effects 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 201000001441 melanoma Diseases 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 229930182816 L-glutamine Natural products 0.000 description 4
- 238000001574 biopsy Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000003828 downregulation Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000002752 melanocyte Anatomy 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000003068 static effect Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000013592 cell lysate Substances 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000009987 spinning Methods 0.000 description 3
- 229940031626 subunit vaccine Drugs 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 206010011968 Decreased immune responsiveness Diseases 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 230000006052 T cell proliferation Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000013475 authorization Methods 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000002619 cancer immunotherapy Methods 0.000 description 2
- 229940022399 cancer vaccine Drugs 0.000 description 2
- 238000009566 cancer vaccine Methods 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 238000001516 cell proliferation assay Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000009260 cross reactivity Effects 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 102000054766 genetic haplotypes Human genes 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 208000037819 metastatic cancer Diseases 0.000 description 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000009696 proliferative response Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 101710164309 56 kDa type-specific antigen Proteins 0.000 description 1
- 101100082447 Arabidopsis thaliana PBL1 gene Proteins 0.000 description 1
- 101100082457 Arabidopsis thaliana PBL2 gene Proteins 0.000 description 1
- 101100407148 Arabidopsis thaliana PBL3 gene Proteins 0.000 description 1
- 101100407149 Arabidopsis thaliana PBL4 gene Proteins 0.000 description 1
- 101100407150 Arabidopsis thaliana PBL5 gene Proteins 0.000 description 1
- 101100407151 Arabidopsis thaliana PBL6 gene Proteins 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102400001368 Epidermal growth factor Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102100034763 Peroxiredoxin-2 Human genes 0.000 description 1
- 238000003559 RNA-seq method Methods 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000007660 Residual Neoplasm Diseases 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 229960005521 allovectin-7 Drugs 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 229940037642 autologous vaccine Drugs 0.000 description 1
- 238000007630 basic procedure Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 229940038872 cell-based cancer vaccine Drugs 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 108010032337 diaminobenzidine peroxidase Proteins 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- HBNYJWAFDZLWRS-UHFFFAOYSA-N ethyl isothiocyanate Chemical compound CCN=C=S HBNYJWAFDZLWRS-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 229940022353 herceptin Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000037451 immune surveillance Effects 0.000 description 1
- 230000000899 immune system response Effects 0.000 description 1
- 238000011293 immunotherapeutic strategy Methods 0.000 description 1
- 229940032219 immunotherapy vaccine Drugs 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 238000012007 large scale cell culture Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 231100001223 noncarcinogenic Toxicity 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000008823 permeabilization Effects 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000001709 templated self-assembly Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/884—Vaccine for a specifically defined cancer prostate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9827104.2A GB9827104D0 (en) | 1998-12-10 | 1998-12-10 | New cancer treatments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20012032A3 CZ20012032A3 (cs) | 2001-10-17 |
| CZ300499B6 true CZ300499B6 (cs) | 2009-06-03 |
Family
ID=10843926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20012032A CZ300499B6 (cs) | 1998-12-10 | 1999-12-09 | Použití bunecných linií lidské prostaty k lécbe zhoubného bujení prostaty |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6972128B1 (enExample) |
| EP (1) | EP1137422B1 (enExample) |
| JP (2) | JP4949554B2 (enExample) |
| KR (1) | KR20010090874A (enExample) |
| AT (1) | ATE304365T1 (enExample) |
| AU (1) | AU763485B2 (enExample) |
| CA (1) | CA2354045C (enExample) |
| CZ (1) | CZ300499B6 (enExample) |
| DE (1) | DE69927286T2 (enExample) |
| ES (1) | ES2249046T3 (enExample) |
| GB (1) | GB9827104D0 (enExample) |
| HU (1) | HUP0104568A3 (enExample) |
| IL (2) | IL143296A0 (enExample) |
| MX (1) | MXPA01005816A (enExample) |
| NO (1) | NO327044B1 (enExample) |
| NZ (1) | NZ512004A (enExample) |
| PL (1) | PL201016B1 (enExample) |
| WO (1) | WO2000033869A2 (enExample) |
| ZA (1) | ZA200104164B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9827104D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
| GB9827103D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
| AU4935700A (en) * | 1999-05-21 | 2000-12-12 | Onyvax Limited | New vaccine formulations-3 |
| CA2404388C (en) * | 2000-04-01 | 2010-06-15 | Onyvax Limited | New prostate cell lines |
| US6667479B2 (en) * | 2001-06-01 | 2003-12-23 | Raytheon Company | Advanced high speed, multi-level uncooled bolometer and method for fabricating same |
| US20050019336A1 (en) | 2003-07-23 | 2005-01-27 | Dalgleish Angus George | Human prostate cell lines in cancer treatment |
| WO2005023328A2 (en) * | 2003-08-26 | 2005-03-17 | Becton Dickinson And Company | Methods for intradermal delivery of therapeutics agents |
| CN105664147A (zh) * | 2007-02-07 | 2016-06-15 | 日本电气株式会社 | 用于癌症的治疗剂 |
| US20100255020A1 (en) * | 2007-11-20 | 2010-10-07 | Nec Corporation | Method for inducing cytotoxic t-cells, cytotoxic t-cell inducers, and pharmaceutical compositions and vaccines employing them |
| AU2009200767A1 (en) * | 2008-03-10 | 2009-09-24 | Aristocrat Technologies Australia Pty Limited | A gaming system and a method of gaming |
| CA2743904A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997004802A1 (en) * | 1995-07-31 | 1997-02-13 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| WO1997028255A1 (en) * | 1996-02-02 | 1997-08-07 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Immortal human prostate epithelial cell lines and clones and their applications in the research and therapy of prostate cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE230615T1 (de) * | 1991-10-04 | 2003-01-15 | Whitehead Biomedical Inst | Regulierung der systemischen immunantworten mittels zytokinen und antigenen |
| JPH05246889A (ja) * | 1992-03-05 | 1993-09-24 | Seitai Chiyousetsu Kenkyusho:Kk | 制癌方法および制癌剤 |
| WO1995029704A1 (en) * | 1994-04-28 | 1995-11-09 | Scott Freeman | Cell lines obtained by in vivo migration and by fusion with autoimmune cells |
| JP3201610B2 (ja) * | 1995-03-17 | 2001-08-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 腫瘍を処置する方法 |
| ES2191784T3 (es) * | 1995-12-28 | 2003-09-16 | Univ Johns Hopkins Med | Vacunas de tumores de citocinas paracrinas alogenicas. |
| GB9620350D0 (en) * | 1996-09-30 | 1996-11-13 | Maudsley David J | Cancer vaccine |
| US6207805B1 (en) * | 1997-07-18 | 2001-03-27 | University Of Iowa Research Foundation | Prostate cell surface antigen-specific antibodies |
| GB9827104D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
-
1998
- 1998-12-10 GB GBGB9827104.2A patent/GB9827104D0/en not_active Ceased
-
1999
- 1999-12-09 ES ES99959542T patent/ES2249046T3/es not_active Expired - Lifetime
- 1999-12-09 CZ CZ20012032A patent/CZ300499B6/cs not_active IP Right Cessation
- 1999-12-09 NZ NZ512004A patent/NZ512004A/en unknown
- 1999-12-09 IL IL14329699A patent/IL143296A0/xx active IP Right Grant
- 1999-12-09 AT AT99959542T patent/ATE304365T1/de not_active IP Right Cessation
- 1999-12-09 HU HU0104568A patent/HUP0104568A3/hu unknown
- 1999-12-09 KR KR1020017007096A patent/KR20010090874A/ko not_active Ceased
- 1999-12-09 PL PL348828A patent/PL201016B1/pl not_active IP Right Cessation
- 1999-12-09 US US09/857,691 patent/US6972128B1/en not_active Expired - Lifetime
- 1999-12-09 CA CA2354045A patent/CA2354045C/en not_active Expired - Fee Related
- 1999-12-09 JP JP2000586359A patent/JP4949554B2/ja not_active Expired - Fee Related
- 1999-12-09 WO PCT/GB1999/004129 patent/WO2000033869A2/en not_active Ceased
- 1999-12-09 EP EP99959542A patent/EP1137422B1/en not_active Expired - Lifetime
- 1999-12-09 MX MXPA01005816A patent/MXPA01005816A/es active IP Right Grant
- 1999-12-09 DE DE69927286T patent/DE69927286T2/de not_active Expired - Lifetime
- 1999-12-09 AU AU16683/00A patent/AU763485B2/en not_active Ceased
-
2001
- 2001-05-22 ZA ZA200104164A patent/ZA200104164B/en unknown
- 2001-05-22 IL IL143296A patent/IL143296A/en not_active IP Right Cessation
- 2001-05-29 NO NO20012634A patent/NO327044B1/no not_active IP Right Cessation
-
2005
- 2005-07-12 US US11/178,415 patent/US8034360B2/en not_active Expired - Fee Related
-
2011
- 2011-10-07 JP JP2011223318A patent/JP2012021028A/ja active Pending
- 2011-10-11 US US13/270,820 patent/US20120164099A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997004802A1 (en) * | 1995-07-31 | 1997-02-13 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| WO1997028255A1 (en) * | 1996-02-02 | 1997-08-07 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Immortal human prostate epithelial cell lines and clones and their applications in the research and therapy of prostate cancer |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Banchereau et al. | Immune and clinical responses in patients with metastatic melanoma to CD34+ progenitor-derived dendritic cell vaccine | |
| US6699483B1 (en) | Cancer treatments | |
| US20120164099A1 (en) | Use of human prostate cell lines in cancer treatment | |
| US8545835B2 (en) | Human prostate cell lines in cancer treatment | |
| AU2002252268B2 (en) | Method of treating malignancies through induction of blood immune responses | |
| WO2000033871A2 (en) | Use of human prostate tumour cell lines in cancer treatment | |
| Mizote et al. | Three novel NY-ESO-1 epitopes bound to DRB1* 0803, DQB1* 0401 and DRB1* 0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients | |
| NZ527763A (en) | Allogeneic immunotherapeutic agent comprising three human prostate tumour cell lines derived from three different primary tumours useful in treating prostate cancer | |
| HK1134787A (en) | Method of treating malignancies through induction of blood immune responses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 19991209 |