CZ2004457A3 - Použití inhibitorů fotodiesterasy IV - Google Patents

Info

Publication number

CZ2004457A3

CZ2004457A3 CZ2004457A CZ2004457A CZ2004457A3 CZ 2004457 A3 CZ2004457 A3 CZ 2004457A3 CZ 2004457 A CZ2004457 A CZ 2004457A CZ 2004457 A CZ2004457 A CZ 2004457A CZ 2004457 A3 CZ2004457 A3 CZ 2004457A3

Authority

CZ

Czechia

Prior art keywords

ethyl

dihydro

tetrahydropyridazin

dimethoxyphenyl

methoxyphenyl

Prior art date

2001-10-12

Links

• Espacenet
• Global Dossier
• Discuss

• 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title abstract description 5
• 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title abstract 2
• 239000003814 drug Substances 0.000 claims abstract description 23
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 22
• 238000011282 treatment Methods 0.000 claims abstract description 21
• 150000003839 salts Chemical class 0.000 claims abstract description 16
• 208000030507 AIDS Diseases 0.000 claims abstract description 9
• 206010027476 Metastases Diseases 0.000 claims abstract description 9
• 201000006417 multiple sclerosis Diseases 0.000 claims abstract description 9
• 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 9
• 208000001132 Osteoporosis Diseases 0.000 claims abstract description 8
• 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 8
• 201000001320 Atherosclerosis Diseases 0.000 claims abstract description 7
• -1 methylenedioxy Chemical group 0.000 claims description 528
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 186
• 150000001875 compounds Chemical class 0.000 claims description 56
• 150000001715 carbamic acids Chemical class 0.000 claims description 55
• 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 50
• 150000002148 esters Chemical class 0.000 claims description 35
• 229910052731 fluorine Inorganic materials 0.000 claims description 26
• 239000011737 fluorine Substances 0.000 claims description 26
• 239000001257 hydrogen Substances 0.000 claims description 24
• 229910052739 hydrogen Inorganic materials 0.000 claims description 24
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 23
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 20
• DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 20
• 238000002360 preparation method Methods 0.000 claims description 16
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 14
• 239000000460 chlorine Substances 0.000 claims description 14
• 229910052801 chlorine Inorganic materials 0.000 claims description 14
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 11
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 11
• 229910052794 bromium Inorganic materials 0.000 claims description 11
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 11
• 229910052760 oxygen Inorganic materials 0.000 claims description 10
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 9
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
• 229910052757 nitrogen Inorganic materials 0.000 claims description 8
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
• 230000003902 lesion Effects 0.000 claims description 7
• 239000001301 oxygen Substances 0.000 claims description 7
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 6
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 6
• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
• LEURGHMXWSUXTF-UHFFFAOYSA-N 5-[4-(difluoromethoxy)-3-methoxyphenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(F)F)C(OC)=CC(C=2CSC(=O)NN=2)=C1 LEURGHMXWSUXTF-UHFFFAOYSA-N 0.000 claims description 4
• KQUGNOYYBNPZBP-UHFFFAOYSA-N 5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC(F)F)C(OC)=C1 KQUGNOYYBNPZBP-UHFFFAOYSA-N 0.000 claims description 4
• CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 4
• 125000002252 acyl group Chemical group 0.000 claims description 4
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
• 150000002431 hydrogen Chemical class 0.000 claims description 4
• 229910052717 sulfur Inorganic materials 0.000 claims description 4
• 125000000217 alkyl group Chemical group 0.000 claims description 3
• 230000006907 apoptotic process Effects 0.000 claims description 3
• 125000000000 cycloalkoxy group Chemical group 0.000 claims description 3
• RQPOEGOXCVKURG-UHFFFAOYSA-N ethyl n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 RQPOEGOXCVKURG-UHFFFAOYSA-N 0.000 claims description 3
• 125000001153 fluoro group Chemical group F* 0.000 claims description 3
• VZVHHKYHUMMCRW-UHFFFAOYSA-N methyl n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 VZVHHKYHUMMCRW-UHFFFAOYSA-N 0.000 claims description 3
• XDGXAZPROPKMKW-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 XDGXAZPROPKMKW-UHFFFAOYSA-N 0.000 claims description 3
• YMAJLELSVNAWDQ-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 YMAJLELSVNAWDQ-UHFFFAOYSA-N 0.000 claims description 3
• ZUIQPDPVTCODLP-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 ZUIQPDPVTCODLP-UHFFFAOYSA-N 0.000 claims description 3
• NZUBMTQQNISIDZ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 NZUBMTQQNISIDZ-UHFFFAOYSA-N 0.000 claims description 3
• UZFKGQZERPKMQX-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 UZFKGQZERPKMQX-UHFFFAOYSA-N 0.000 claims description 3
• BCINSFUJSPEZRI-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 BCINSFUJSPEZRI-UHFFFAOYSA-N 0.000 claims description 3
• JEHXGPPOGAKEIP-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=NC=C1 JEHXGPPOGAKEIP-UHFFFAOYSA-N 0.000 claims description 3
• MWJLPJRBACIIEQ-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 MWJLPJRBACIIEQ-UHFFFAOYSA-N 0.000 claims description 3
• 230000001613 neoplastic effect Effects 0.000 claims description 3
• 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims description 2
• FGQYYCHKYIREFI-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methyl]-5-(3,4-dimethoxyphenyl)-6-ethyl-6h-1,3,4-thiadiazin-2-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=C(Cl)C=CC=C1Cl FGQYYCHKYIREFI-UHFFFAOYSA-N 0.000 claims description 2
• RCWFQIICHNGYHS-UHFFFAOYSA-N 3-[(4-aminophenyl)methyl]-5-(3,4-dimethoxyphenyl)-6-ethyl-6h-1,3,4-thiadiazin-2-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=C(N)C=C1 RCWFQIICHNGYHS-UHFFFAOYSA-N 0.000 claims description 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 2
• 125000002947 alkylene group Chemical group 0.000 claims description 2
• NIHJXZMNNAHEEV-UHFFFAOYSA-N ethyl n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 NIHJXZMNNAHEEV-UHFFFAOYSA-N 0.000 claims description 2
• 210000005260 human cell Anatomy 0.000 claims description 2
• FCEFLSGAPFCWGS-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NS(C)(=O)=O)=C1 FCEFLSGAPFCWGS-UHFFFAOYSA-N 0.000 claims description 2
• VULAEEDZQSJNRT-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=C(NC(C)=O)C=C1 VULAEEDZQSJNRT-UHFFFAOYSA-N 0.000 claims description 2
• HTZVRAPOLYURTG-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 HTZVRAPOLYURTG-UHFFFAOYSA-N 0.000 claims description 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
• 229920006395 saturated elastomer Polymers 0.000 claims description 2
• 125000004434 sulfur atom Chemical group 0.000 claims description 2
• JPJFJTANAMGIFE-UHFFFAOYSA-N 5-(3,4-dimethoxyphenyl)-6-ethyl-3-[(4-methoxyphenyl)methyl]-6h-1,3,4-thiadiazin-2-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=C(OC)C=C1 JPJFJTANAMGIFE-UHFFFAOYSA-N 0.000 claims 1
• GWVPBGLOGIVWER-UHFFFAOYSA-N 5-(3,4-dimethoxyphenyl)-6-ethyl-3-[(4-nitrophenyl)methyl]-6h-1,3,4-thiadiazin-2-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 GWVPBGLOGIVWER-UHFFFAOYSA-N 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 abstract description 4
• 206010009887 colitis Diseases 0.000 abstract 1
• KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 23
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 23
• KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 description 23
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 10
• 125000004494 ethyl ester group Chemical group 0.000 description 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 6
• QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 6
• 229940080818 propionamide Drugs 0.000 description 6
• 239000012453 solvate Substances 0.000 description 5
• MLGXDYNVEUDWHZ-UHFFFAOYSA-N 5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC)C(OC)=C1 MLGXDYNVEUDWHZ-UHFFFAOYSA-N 0.000 description 4
• 201000010099 disease Diseases 0.000 description 4
• 208000023275 Autoimmune disease Diseases 0.000 description 3
• 206010012438 Dermatitis atopic Diseases 0.000 description 3
• 208000006673 asthma Diseases 0.000 description 3
• 201000008937 atopic dermatitis Diseases 0.000 description 3
• 210000000988 bone and bone Anatomy 0.000 description 3
• 201000011510 cancer Diseases 0.000 description 3
• 210000004027 cell Anatomy 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 238000000034 method Methods 0.000 description 3
• 239000000203 mixture Substances 0.000 description 3
• GUTBSANSYUYRAN-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C([N+]([O-])=O)C=C1 GUTBSANSYUYRAN-UHFFFAOYSA-N 0.000 description 2
• 201000004681 Psoriasis Diseases 0.000 description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 208000027866 inflammatory disease Diseases 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• YYLMPPQOOUHPPJ-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(C)=O)=C1 YYLMPPQOOUHPPJ-UHFFFAOYSA-N 0.000 description 2
• YCHIWCIRMQIQIQ-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(C)(C)C)=C1 YCHIWCIRMQIQIQ-UHFFFAOYSA-N 0.000 description 2
• MHQLCHXVPJLEKO-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CNC=2)=C1 MHQLCHXVPJLEKO-UHFFFAOYSA-N 0.000 description 2
• OJCARHSRJBWXPK-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 OJCARHSRJBWXPK-UHFFFAOYSA-N 0.000 description 2
• DJFNEVLEQCTYRC-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 DJFNEVLEQCTYRC-UHFFFAOYSA-N 0.000 description 2
• NGBGHDLHCVJZGA-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 NGBGHDLHCVJZGA-UHFFFAOYSA-N 0.000 description 2
• JSINYLALQWCWRZ-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(C)(C)C)=CC=3)N=2)C=C1OC1CCCC1 JSINYLALQWCWRZ-UHFFFAOYSA-N 0.000 description 2
• NEXRJPBVDDLSLY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 NEXRJPBVDDLSLY-UHFFFAOYSA-N 0.000 description 2
• 210000005170 neoplastic cell Anatomy 0.000 description 2
• 238000007911 parenteral administration Methods 0.000 description 2
• 238000011321 prophylaxis Methods 0.000 description 2
• 230000025915 regulation of apoptotic process Effects 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• 238000011200 topical administration Methods 0.000 description 2
• URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
• 102000003390 tumor necrosis factor Human genes 0.000 description 2
• IFBWEQCVAZUXNI-UHFFFAOYSA-N (1-methylpiperidin-4-yl) carbamate Chemical compound CN1CCC(OC(N)=O)CC1 IFBWEQCVAZUXNI-UHFFFAOYSA-N 0.000 description 1
• BCNRPIZGMQNEOI-UHFFFAOYSA-N (1-methylpiperidin-4-yl) n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)OC1CCN(C)CC1 BCNRPIZGMQNEOI-UHFFFAOYSA-N 0.000 description 1
• LJDHNCWSXDXYLI-UHFFFAOYSA-N (1-methylpiperidin-4-yl) n-[4-[[3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=C(OCF)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)OC1CCN(C)CC1 LJDHNCWSXDXYLI-UHFFFAOYSA-N 0.000 description 1
• LKKLDKBWCWESPV-UHFFFAOYSA-N (2-phenylphenyl) hydrogen carbonate Chemical class OC(=O)OC1=CC=CC=C1C1=CC=CC=C1 LKKLDKBWCWESPV-UHFFFAOYSA-N 0.000 description 1
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
• 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 description 1
• HHUMWUTXEBWPRM-UHFFFAOYSA-N 2-[(2,3-diaminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(N)=C1N HHUMWUTXEBWPRM-UHFFFAOYSA-N 0.000 description 1
• GEAFHPLNBQGKFB-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methyl]-6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=C(Cl)C=CC=C1Cl GEAFHPLNBQGKFB-UHFFFAOYSA-N 0.000 description 1
• TUEUZWWJKXNVQR-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methyl]-6-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=C(Cl)C=CC=C1Cl TUEUZWWJKXNVQR-UHFFFAOYSA-N 0.000 description 1
• PGOYHKFWHCPMGL-UHFFFAOYSA-N 2-[(2-aminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1N PGOYHKFWHCPMGL-UHFFFAOYSA-N 0.000 description 1
• FOUFYAPVLCPYDL-UHFFFAOYSA-N 2-[(2-aminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1N FOUFYAPVLCPYDL-UHFFFAOYSA-N 0.000 description 1
• RYWBHVSCSVILSQ-UHFFFAOYSA-N 2-[(2-chlorophenyl)methyl]-6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1Cl RYWBHVSCSVILSQ-UHFFFAOYSA-N 0.000 description 1
• JTWIJAOMHFNHHV-UHFFFAOYSA-N 2-[(2-chlorophenyl)methyl]-6-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1Cl JTWIJAOMHFNHHV-UHFFFAOYSA-N 0.000 description 1
• HMZVEJHYLSVILI-UHFFFAOYSA-N 2-[(3-aminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(N)=C1 HMZVEJHYLSVILI-UHFFFAOYSA-N 0.000 description 1
• NVICXHQJKAMFAP-UHFFFAOYSA-N 2-[(3-aminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(N)=C1 NVICXHQJKAMFAP-UHFFFAOYSA-N 0.000 description 1
• PZNRFDHGWUVLFY-UHFFFAOYSA-N 2-[(3-aminophenyl)methyl]-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(N)=C1 PZNRFDHGWUVLFY-UHFFFAOYSA-N 0.000 description 1
• QKSFCXULPYSRAK-UHFFFAOYSA-N 2-[(3-aminophenyl)methyl]-6-(3-ethoxy-4-methoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=C(N)C=CC=3)N=2)=C1 QKSFCXULPYSRAK-UHFFFAOYSA-N 0.000 description 1
• MMDTVKQAMAVCEF-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-5-ethyl-6-(3-hydroxy-4-methoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 MMDTVKQAMAVCEF-UHFFFAOYSA-N 0.000 description 1
• BTSDVDRHRRQDJL-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-5-ethyl-6-(4-methylsulfonylphenyl)-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 BTSDVDRHRRQDJL-UHFFFAOYSA-N 0.000 description 1
• ATKOFBILLWFQKT-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-5-ethyl-6-[3-(fluoromethoxy)-4-methoxyphenyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 ATKOFBILLWFQKT-UHFFFAOYSA-N 0.000 description 1
• ULQICEDTKQRPCW-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-5-ethyl-6-[3-methoxy-4-(trifluoromethoxy)phenyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 ULQICEDTKQRPCW-UHFFFAOYSA-N 0.000 description 1
• QOSJAGUNKWUMFH-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-5-ethyl-6-[4-(fluoromethoxy)-3-methoxyphenyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 QOSJAGUNKWUMFH-UHFFFAOYSA-N 0.000 description 1
• ZZUOFAAYBYUNCP-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-5-ethyl-6-[4-methoxy-3-(trifluoromethoxy)phenyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 ZZUOFAAYBYUNCP-UHFFFAOYSA-N 0.000 description 1
• HNIYMECRMVGTPJ-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(N)C=C1 HNIYMECRMVGTPJ-UHFFFAOYSA-N 0.000 description 1
• OZPDNWIBHLGDMW-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 OZPDNWIBHLGDMW-UHFFFAOYSA-N 0.000 description 1
• AEZSPTCLHOMXBT-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 AEZSPTCLHOMXBT-UHFFFAOYSA-N 0.000 description 1
• GWGUERLHLNJMGM-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(N)=CC=3)N=2)CC)=C1 GWGUERLHLNJMGM-UHFFFAOYSA-N 0.000 description 1
• KTWPIJIZEUKFFP-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-(4-ethoxy-3-methoxyphenyl)-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC1=CC=C(N)C=C1 KTWPIJIZEUKFFP-UHFFFAOYSA-N 0.000 description 1
• WRRCFXRTAMXOMM-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-[3-(difluoromethoxy)-4-methoxyphenyl]-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 WRRCFXRTAMXOMM-UHFFFAOYSA-N 0.000 description 1
• ATDGQBXNRBFZTR-UHFFFAOYSA-N 2-[(4-aminophenyl)methyl]-6-[4-(difluoromethoxy)-3-methoxyphenyl]-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(N)C=C1 ATDGQBXNRBFZTR-UHFFFAOYSA-N 0.000 description 1
• OCYHTAYXTAKBFJ-UHFFFAOYSA-N 2-[2-(4-aminophenyl)ethyl]-6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC1=CC=C(N)C=C1 OCYHTAYXTAKBFJ-UHFFFAOYSA-N 0.000 description 1
• ISIYZRIJJAIJFN-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-6-ethyl-6H-1,3,4-oxadiazin-2-one Chemical compound COC=1C=C(C=CC=1OC)N1C(OC(C=N1)CC)=O ISIYZRIJJAIJFN-UHFFFAOYSA-N 0.000 description 1
• BMGFMYTZEXBTEJ-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-6-ethyl-6H-1,3,4-thiadiazin-2-one Chemical compound COC=1C=C(C=CC=1OC)N1C(SC(C=N1)CC)=O BMGFMYTZEXBTEJ-UHFFFAOYSA-N 0.000 description 1
• UNXMPWAFEWXQEH-UHFFFAOYSA-N 4-[[3-(3,4-dihydroxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzoic acid Chemical compound N1=C(C=2C=C(O)C(O)=CC=2)C(CC)CC(=O)N1CC1=CC=C(C(O)=O)C=C1 UNXMPWAFEWXQEH-UHFFFAOYSA-N 0.000 description 1
• QTGGTDXYRVNELR-UHFFFAOYSA-N 4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzonitrile Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(C#N)C=C1 QTGGTDXYRVNELR-UHFFFAOYSA-N 0.000 description 1
• UEPOMMYKILGXQO-UHFFFAOYSA-N 4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(C(O)=O)C=C1 UEPOMMYKILGXQO-UHFFFAOYSA-N 0.000 description 1
• WTCHLMPHJHTRAT-UHFFFAOYSA-N 4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(C#N)C=C1 WTCHLMPHJHTRAT-UHFFFAOYSA-N 0.000 description 1
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
• XWOPDEFLUBYEPX-UHFFFAOYSA-N 5-(3-cyclopentyloxy-4-methoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1(CCCC1)OC=1C=C(C=CC1OC)C1=NNC(SC1)=O XWOPDEFLUBYEPX-UHFFFAOYSA-N 0.000 description 1
• XMOWZYWYSQJSIH-UHFFFAOYSA-N 5-(4-methoxy-3-propan-2-yloxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C(C)(C)OC=1C=C(C=CC1OC)C1=NNC(SC1)=O XMOWZYWYSQJSIH-UHFFFAOYSA-N 0.000 description 1
• SZVAYBVWGFNCCJ-UHFFFAOYSA-N 5-(4-methoxy-3-propoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C(CC)OC=1C=C(C=CC1OC)C1=NNC(SC1)=O SZVAYBVWGFNCCJ-UHFFFAOYSA-N 0.000 description 1
• KYTOLIPSUUEDHP-UHFFFAOYSA-N 5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC)C(OC(F)F)=C1 KYTOLIPSUUEDHP-UHFFFAOYSA-N 0.000 description 1
• NFVDPBJLIVZORM-UHFFFAOYSA-N 5-[3-ethoxy-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(F)(F)C(F)F)C(OCC)=CC(C=2CSC(=O)NN=2)=C1 NFVDPBJLIVZORM-UHFFFAOYSA-N 0.000 description 1
• WAQOVEOJJOTSGJ-UHFFFAOYSA-N 5-[3-methoxy-4-(1,1,2,2,2-pentachloroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(Cl)(Cl)C(Cl)(Cl)Cl)C(OC)=CC(C=2CSC(=O)NN=2)=C1 WAQOVEOJJOTSGJ-UHFFFAOYSA-N 0.000 description 1
• UMQOGRJHCTTXAB-UHFFFAOYSA-N 5-[3-methoxy-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(F)(F)C(F)F)C(OC)=CC(C=2CSC(=O)NN=2)=C1 UMQOGRJHCTTXAB-UHFFFAOYSA-N 0.000 description 1
• GEALBRGGYDWVHZ-UHFFFAOYSA-N 5-[3-methoxy-4-(1,2,2-trichloroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(Cl)C(Cl)Cl)C(OC)=CC(C=2CSC(=O)NN=2)=C1 GEALBRGGYDWVHZ-UHFFFAOYSA-N 0.000 description 1
• IHAQINXMFIKGQG-UHFFFAOYSA-N 5-[3-methoxy-4-(2,2,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OCC(F)(F)F)C(OC)=CC(C=2CSC(=O)NN=2)=C1 IHAQINXMFIKGQG-UHFFFAOYSA-N 0.000 description 1
• NYBSXLCWFCOWBR-UHFFFAOYSA-N 5-[3-methoxy-4-(trichloromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(Cl)(Cl)Cl)C(OC)=CC(C=2CSC(=O)NN=2)=C1 NYBSXLCWFCOWBR-UHFFFAOYSA-N 0.000 description 1
• QNQFBUTZXCQEEV-UHFFFAOYSA-N 5-[3-methoxy-4-(trifluoromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(F)(F)F)C(OC)=CC(C=2CSC(=O)NN=2)=C1 QNQFBUTZXCQEEV-UHFFFAOYSA-N 0.000 description 1
• MPWNTFSFOAEVJC-UHFFFAOYSA-N 5-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(F)(F)F)C(OC)=CC(C=2C(SC(=O)NN=2)C)=C1 MPWNTFSFOAEVJC-UHFFFAOYSA-N 0.000 description 1
• QWGCLACWWKVLAA-UHFFFAOYSA-N 5-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-propyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCCC1SC(=O)NN=C1C1=CC=C(OC(F)(F)F)C(OC)=C1 QWGCLACWWKVLAA-UHFFFAOYSA-N 0.000 description 1
• VBQPTMOQZFDEKT-UHFFFAOYSA-N 5-[4-(chloromethoxy)-3-methoxyphenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OCCl)C(OC)=CC(C=2CSC(=O)NN=2)=C1 VBQPTMOQZFDEKT-UHFFFAOYSA-N 0.000 description 1
• DQNMXCGXNCMEMS-UHFFFAOYSA-N 5-[4-(chloromethoxy)-3-methoxyphenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OCCl)C(OC)=C1 DQNMXCGXNCMEMS-UHFFFAOYSA-N 0.000 description 1
• OQOUABBWARVTEW-UHFFFAOYSA-N 5-[4-(chloromethoxy)-3-methoxyphenyl]-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OCCl)C(OC)=CC(C=2C(SC(=O)NN=2)C)=C1 OQOUABBWARVTEW-UHFFFAOYSA-N 0.000 description 1
• NILSXFOPMXZRSS-UHFFFAOYSA-N 5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=C(OC(F)F)C(OC)=CC(C=2C(SC(=O)NN=2)C)=C1 NILSXFOPMXZRSS-UHFFFAOYSA-N 0.000 description 1
• DOBVAOCMYMLRBG-UHFFFAOYSA-N 5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-propyl-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCCC1SC(=O)NN=C1C1=CC=C(OC(F)F)C(OC)=C1 DOBVAOCMYMLRBG-UHFFFAOYSA-N 0.000 description 1
• GBAYZDAPBUUPIJ-UHFFFAOYSA-N 5-[4-(difluoromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=CC(OC(F)F)=CC=C1C1=NNC(=O)SC1 GBAYZDAPBUUPIJ-UHFFFAOYSA-N 0.000 description 1
• DTAXWQHIEHNKFR-UHFFFAOYSA-N 5-[4-(trifluoromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1C1=NNC(=O)SC1 DTAXWQHIEHNKFR-UHFFFAOYSA-N 0.000 description 1
• IJYJSJINMZHKMW-UHFFFAOYSA-N 5-ethyl-6-(3-hydroxy-4-methoxyphenyl)-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 IJYJSJINMZHKMW-UHFFFAOYSA-N 0.000 description 1
• CZRXGUVPFIUBMI-UHFFFAOYSA-N 5-ethyl-6-(4-methylsulfonylphenyl)-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 CZRXGUVPFIUBMI-UHFFFAOYSA-N 0.000 description 1
• HXXLXXVCOSMAQA-UHFFFAOYSA-N 5-ethyl-6-[3-(fluoromethoxy)-4-methoxyphenyl]-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 HXXLXXVCOSMAQA-UHFFFAOYSA-N 0.000 description 1
• CGJDKNHODAKJDN-UHFFFAOYSA-N 5-ethyl-6-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 CGJDKNHODAKJDN-UHFFFAOYSA-N 0.000 description 1
• NEPMDFYUQKVKFQ-UHFFFAOYSA-N 5-ethyl-6-[4-(fluoromethoxy)-3-methoxyphenyl]-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 NEPMDFYUQKVKFQ-UHFFFAOYSA-N 0.000 description 1
• VQRHKEPXDFXYRY-UHFFFAOYSA-N 5-ethyl-6-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 VQRHKEPXDFXYRY-UHFFFAOYSA-N 0.000 description 1
• AYFMNTFHSFEMKH-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-(4-nitrophenyl)-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=NN(C=2C=CC(=CC=2)[N+]([O-])=O)C(=O)CC1 AYFMNTFHSFEMKH-UHFFFAOYSA-N 0.000 description 1
• OSRJCUUNYDFWFO-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(2,3-dinitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC([N+]([O-])=O)=C1[N+]([O-])=O OSRJCUUNYDFWFO-UHFFFAOYSA-N 0.000 description 1
• CYSSWZNZTHTWOQ-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(2,3-dinitrophenyl)methyl]-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC([N+]([O-])=O)=C1[N+]([O-])=O CYSSWZNZTHTWOQ-UHFFFAOYSA-N 0.000 description 1
• GPBJNOMVTMERMC-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(2,4-dinitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O GPBJNOMVTMERMC-UHFFFAOYSA-N 0.000 description 1
• RPPVJVZJARMXOT-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(2,4-dinitrophenyl)methyl]-5-ethyl-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O RPPVJVZJARMXOT-UHFFFAOYSA-N 0.000 description 1
• IMJVKDSLSCEDOT-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(2-methoxyphenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound COC1=CC=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 IMJVKDSLSCEDOT-UHFFFAOYSA-N 0.000 description 1
• YRQRRDSSBTURMR-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(2-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1[N+]([O-])=O YRQRRDSSBTURMR-UHFFFAOYSA-N 0.000 description 1
• FPEQYMNBLYIKNN-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(3-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC([N+]([O-])=O)=C1 FPEQYMNBLYIKNN-UHFFFAOYSA-N 0.000 description 1
• CSUZAZCIGPDIFG-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-2-[(4-methoxyphenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=CC(OC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 CSUZAZCIGPDIFG-UHFFFAOYSA-N 0.000 description 1
• ZXTYELHQOWKBKO-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-5-ethyl-2-[(2-methoxyphenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1OC ZXTYELHQOWKBKO-UHFFFAOYSA-N 0.000 description 1
• AGJJTGCXNNJRID-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-5-ethyl-2-[(4-methoxyphenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(OC)C=C1 AGJJTGCXNNJRID-UHFFFAOYSA-N 0.000 description 1
• LRZJDTGLQBWDEM-UHFFFAOYSA-N 6-(3,4-dimethoxyphenyl)-5-ethyl-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 LRZJDTGLQBWDEM-UHFFFAOYSA-N 0.000 description 1
• ROVIJKPEOVMZTG-UHFFFAOYSA-N 6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 ROVIJKPEOVMZTG-UHFFFAOYSA-N 0.000 description 1
• CJHCCGRZGMPIPK-UHFFFAOYSA-N 6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(=CC=3)[N+]([O-])=O)N=2)CC)=C1 CJHCCGRZGMPIPK-UHFFFAOYSA-N 0.000 description 1
• MVJOYEZFHWRBRQ-UHFFFAOYSA-N 6-[3-(difluoromethoxy)-4-methoxyphenyl]-5-ethyl-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 MVJOYEZFHWRBRQ-UHFFFAOYSA-N 0.000 description 1
• CBPUXPWGNXWJEO-UHFFFAOYSA-N 6-[4-(difluoromethoxy)-3-methoxyphenyl]-5-ethyl-2-[(4-nitrophenyl)methyl]-4,5-dihydropyridazin-3-one Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C([N+]([O-])=O)C=C1 CBPUXPWGNXWJEO-UHFFFAOYSA-N 0.000 description 1
• YBLOYMBRZAVUGN-UHFFFAOYSA-N 6-chloro-n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=C(Cl)N=N1 YBLOYMBRZAVUGN-UHFFFAOYSA-N 0.000 description 1
• NIGUZTXWVQOZLR-UHFFFAOYSA-N 6-chloro-n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=C(Cl)N=N1 NIGUZTXWVQOZLR-UHFFFAOYSA-N 0.000 description 1
• FQSXPHPQPYMHFQ-UHFFFAOYSA-N 6-chloro-n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=C(Cl)N=N1 FQSXPHPQPYMHFQ-UHFFFAOYSA-N 0.000 description 1
• IAKORKXIHSRPAU-UHFFFAOYSA-N 6-chloro-n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=C(Cl)N=N1 IAKORKXIHSRPAU-UHFFFAOYSA-N 0.000 description 1
• URMYVEIRRDPEPD-UHFFFAOYSA-N 6-chloro-n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=C(Cl)N=N1 URMYVEIRRDPEPD-UHFFFAOYSA-N 0.000 description 1
• HBFLFHUXEQFRHL-UHFFFAOYSA-N 6-chloro-n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=C(Cl)N=N1 HBFLFHUXEQFRHL-UHFFFAOYSA-N 0.000 description 1
• VUBGCFBAYVTASP-UHFFFAOYSA-N 6-chloro-n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=NC(Cl)=CC=2)=C1 VUBGCFBAYVTASP-UHFFFAOYSA-N 0.000 description 1
• JHOOEEXXPJSMLC-UHFFFAOYSA-N 6-chloro-n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=C(Cl)N=N1 JHOOEEXXPJSMLC-UHFFFAOYSA-N 0.000 description 1
• IKQNNHBLTXIGFY-UHFFFAOYSA-N 6-chloro-n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=NC(Cl)=CC=2)=C1 IKQNNHBLTXIGFY-UHFFFAOYSA-N 0.000 description 1
• CYZQLZXCGQSAAI-UHFFFAOYSA-N 6-chloro-n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=NC(Cl)=CC=2)=C1 CYZQLZXCGQSAAI-UHFFFAOYSA-N 0.000 description 1
• DBUZECDCCHZLMY-UHFFFAOYSA-N 6-chloro-n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=C(Cl)N=N1 DBUZECDCCHZLMY-UHFFFAOYSA-N 0.000 description 1
• KQFYSERYVVZWTE-UHFFFAOYSA-N 6-chloro-n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=C(Cl)N=N1 KQFYSERYVVZWTE-UHFFFAOYSA-N 0.000 description 1
• QPUJWJUQHJAJKR-UHFFFAOYSA-N 6-chloro-n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=C(Cl)N=N1 QPUJWJUQHJAJKR-UHFFFAOYSA-N 0.000 description 1
• PQJBVXSTNVOLPW-UHFFFAOYSA-N 6-chloro-n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=C(Cl)N=N1 PQJBVXSTNVOLPW-UHFFFAOYSA-N 0.000 description 1
• XMIJMMGMQCHZLA-UHFFFAOYSA-N 6-chloro-n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 XMIJMMGMQCHZLA-UHFFFAOYSA-N 0.000 description 1
• RQNHWEKMSPOVFI-UHFFFAOYSA-N 6-chloro-n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 RQNHWEKMSPOVFI-UHFFFAOYSA-N 0.000 description 1
• GCEAOOZEUMYZRO-UHFFFAOYSA-N 6-chloro-n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 GCEAOOZEUMYZRO-UHFFFAOYSA-N 0.000 description 1
• YGLCMGGGZKHUKR-UHFFFAOYSA-N 6-chloro-n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 YGLCMGGGZKHUKR-UHFFFAOYSA-N 0.000 description 1
• QSRFKZVUNXOLDD-UHFFFAOYSA-N 6-chloro-n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 QSRFKZVUNXOLDD-UHFFFAOYSA-N 0.000 description 1
• FPUXPPDINOIMNZ-UHFFFAOYSA-N 6-chloro-n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 FPUXPPDINOIMNZ-UHFFFAOYSA-N 0.000 description 1
• XZXNFMJVHSSTLG-UHFFFAOYSA-N 6-chloro-n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 XZXNFMJVHSSTLG-UHFFFAOYSA-N 0.000 description 1
• AGDXUZVLTPLOPM-UHFFFAOYSA-N 6-chloro-n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 AGDXUZVLTPLOPM-UHFFFAOYSA-N 0.000 description 1
• DHMBUCFZMQLFQH-UHFFFAOYSA-N 6-chloro-n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4N=NC(Cl)=CC=4)=CC=3)N=2)CC)=C1 DHMBUCFZMQLFQH-UHFFFAOYSA-N 0.000 description 1
• JXXJGUXWYMRBJH-UHFFFAOYSA-N 6-chloro-n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 JXXJGUXWYMRBJH-UHFFFAOYSA-N 0.000 description 1
• HYZJVXSQRAQINS-UHFFFAOYSA-N 6-chloro-n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 HYZJVXSQRAQINS-UHFFFAOYSA-N 0.000 description 1
• PGDQINSMCFWJSA-UHFFFAOYSA-N 6-chloro-n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 PGDQINSMCFWJSA-UHFFFAOYSA-N 0.000 description 1
• JFEXYRLZGPOCGL-UHFFFAOYSA-N 6-chloro-n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 JFEXYRLZGPOCGL-UHFFFAOYSA-N 0.000 description 1
• IJCZSUITYOEBAE-UHFFFAOYSA-N 6-chloro-n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 IJCZSUITYOEBAE-UHFFFAOYSA-N 0.000 description 1
• LELSOVSERFWDCE-UHFFFAOYSA-N 6-chloro-n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 LELSOVSERFWDCE-UHFFFAOYSA-N 0.000 description 1
• MCPGSRLAILEQSP-UHFFFAOYSA-N 6-chloro-n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 MCPGSRLAILEQSP-UHFFFAOYSA-N 0.000 description 1
• LGWGTHUKJUUJCC-UHFFFAOYSA-N 6-chloro-n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 LGWGTHUKJUUJCC-UHFFFAOYSA-N 0.000 description 1
• WGZVRLCFNOWBKK-UHFFFAOYSA-N 6-chloro-n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 WGZVRLCFNOWBKK-UHFFFAOYSA-N 0.000 description 1
• SVVMFPAOZJKTOT-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 SVVMFPAOZJKTOT-UHFFFAOYSA-N 0.000 description 1
• SAMPJMNQIAFGQA-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 SAMPJMNQIAFGQA-UHFFFAOYSA-N 0.000 description 1
• OCGDVVIGUSBQIE-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 OCGDVVIGUSBQIE-UHFFFAOYSA-N 0.000 description 1
• BZLDUJCEAWFFEV-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 BZLDUJCEAWFFEV-UHFFFAOYSA-N 0.000 description 1
• BSSHPMVQSSZEBH-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 BSSHPMVQSSZEBH-UHFFFAOYSA-N 0.000 description 1
• FIIRAJXSJXVVNT-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 FIIRAJXSJXVVNT-UHFFFAOYSA-N 0.000 description 1
• VNJQPHPMMBZABF-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4N=NC(Cl)=CC=4)=CC=3)N=2)CC)=C1 VNJQPHPMMBZABF-UHFFFAOYSA-N 0.000 description 1
• NZKSCSACLASAQQ-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4N=NC(Cl)=CC=4)=CC=3)N=2)CC)=C1 NZKSCSACLASAQQ-UHFFFAOYSA-N 0.000 description 1
• RCUQNADLJAERLR-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 RCUQNADLJAERLR-UHFFFAOYSA-N 0.000 description 1
• KGOWTUBGCAJBLN-UHFFFAOYSA-N 6-chloro-n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 KGOWTUBGCAJBLN-UHFFFAOYSA-N 0.000 description 1
• SAHVOGROSKEGCS-UHFFFAOYSA-N 6-chloro-n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 SAHVOGROSKEGCS-UHFFFAOYSA-N 0.000 description 1
• DMGFDIQNVLEOEO-UHFFFAOYSA-N 6-chloro-n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 DMGFDIQNVLEOEO-UHFFFAOYSA-N 0.000 description 1
• QDSYBUCMKIICKR-UHFFFAOYSA-N 6-chloro-n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 QDSYBUCMKIICKR-UHFFFAOYSA-N 0.000 description 1
• PTXHSSWLYMGVIM-UHFFFAOYSA-N 6-chloro-n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 PTXHSSWLYMGVIM-UHFFFAOYSA-N 0.000 description 1
• ZVZDCAVWEFMSKD-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 ZVZDCAVWEFMSKD-UHFFFAOYSA-N 0.000 description 1
• AMWJYEHZUXVQFN-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 AMWJYEHZUXVQFN-UHFFFAOYSA-N 0.000 description 1
• ZZUNYADKGXXCNZ-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 ZZUNYADKGXXCNZ-UHFFFAOYSA-N 0.000 description 1
• LGQKQIRTZRBJTM-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 LGQKQIRTZRBJTM-UHFFFAOYSA-N 0.000 description 1
• MHQSIMPCYZCNKQ-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 MHQSIMPCYZCNKQ-UHFFFAOYSA-N 0.000 description 1
• YGVGNBOSJHGQIF-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 YGVGNBOSJHGQIF-UHFFFAOYSA-N 0.000 description 1
• DUBBTNDSISQZLA-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 DUBBTNDSISQZLA-UHFFFAOYSA-N 0.000 description 1
• NMGMBYCIZXKMHE-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 NMGMBYCIZXKMHE-UHFFFAOYSA-N 0.000 description 1
• UEGLFKXWADVRML-UHFFFAOYSA-N 6-chloro-n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridazine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)N=N1 UEGLFKXWADVRML-UHFFFAOYSA-N 0.000 description 1
• BRIUWIKMOWPTQD-UHFFFAOYSA-N 6-ethyl-5-[3-methoxy-4-(1,1,2,2,2-pentachloroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC(Cl)(Cl)C(Cl)(Cl)Cl)C(OC)=C1 BRIUWIKMOWPTQD-UHFFFAOYSA-N 0.000 description 1
• OVMKCQLJYSGCNV-UHFFFAOYSA-N 6-ethyl-5-[3-methoxy-4-(1,1,2,2,3-pentafluoropropoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC(F)(F)C(F)(F)CF)C(OC)=C1 OVMKCQLJYSGCNV-UHFFFAOYSA-N 0.000 description 1
• VNTKYXWOYNMRKP-UHFFFAOYSA-N 6-ethyl-5-[3-methoxy-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC(F)(F)C(F)F)C(OC)=C1 VNTKYXWOYNMRKP-UHFFFAOYSA-N 0.000 description 1
• RXMMEOLLNAJJSC-UHFFFAOYSA-N 6-ethyl-5-[3-methoxy-4-(1,1,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC(F)(F)CF)C(OC)=C1 RXMMEOLLNAJJSC-UHFFFAOYSA-N 0.000 description 1
• PBASBDNSZQRBKR-UHFFFAOYSA-N 6-ethyl-5-[3-methoxy-4-(2,2,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OCC(F)(F)F)C(OC)=C1 PBASBDNSZQRBKR-UHFFFAOYSA-N 0.000 description 1
• CRVAECICDQAMRA-UHFFFAOYSA-N 6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC(F)(F)F)C(OC)=C1 CRVAECICDQAMRA-UHFFFAOYSA-N 0.000 description 1
• ICOHPJVJSUNRKJ-UHFFFAOYSA-N 6-ethyl-5-[4-(2,2,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OCC(F)(F)F)C=C1 ICOHPJVJSUNRKJ-UHFFFAOYSA-N 0.000 description 1
• UVQWYEWSXFPRMW-UHFFFAOYSA-N 6-ethyl-5-[4-methoxy-3-(2,2,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one Chemical compound CCC1SC(=O)NN=C1C1=CC=C(OC)C(OCC(F)(F)F)=C1 UVQWYEWSXFPRMW-UHFFFAOYSA-N 0.000 description 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
• 206010006458 Bronchitis chronic Diseases 0.000 description 1
• DRQGQWJFYBUIMP-UHFFFAOYSA-N CCC1(CC(=O)N(Cc2ccc(NC(=O)OC3CCN(C)CC3)cc2)N=C1)c1ccc(OC)c(OC)c1 Chemical compound CCC1(CC(=O)N(Cc2ccc(NC(=O)OC3CCN(C)CC3)cc2)N=C1)c1ccc(OC)c(OC)c1 DRQGQWJFYBUIMP-UHFFFAOYSA-N 0.000 description 1
• HYSUGYIVGLNXQE-UHFFFAOYSA-N COc1ccc(cc1OC1CCCC1)C1=NN(Cc2ccc(NC(=O)OC3CCN(C)CC3)cc2)C(=O)CC1 Chemical compound COc1ccc(cc1OC1CCCC1)C1=NN(Cc2ccc(NC(=O)OC3CCN(C)CC3)cc2)C(=O)CC1 HYSUGYIVGLNXQE-UHFFFAOYSA-N 0.000 description 1
• PJMGRXXDPFGROQ-UHFFFAOYSA-N Cl.C(C1=CC=NC=C1)(=O)NC1=CC=C(CN2N=C(CCC2=O)C2=CC(=C(C=C2)OC)OCC)C=C1 Chemical compound Cl.C(C1=CC=NC=C1)(=O)NC1=CC=C(CN2N=C(CCC2=O)C2=CC(=C(C=C2)OC)OCC)C=C1 PJMGRXXDPFGROQ-UHFFFAOYSA-N 0.000 description 1
• BNVNYYBKCBPEHA-UHFFFAOYSA-N Cl.C(C1=CN=CC=C1)(=O)NC1=CC=C(CN2N=C(CCC2=O)C2=CC(=C(C=C2)OC)OC)C=C1 Chemical compound Cl.C(C1=CN=CC=C1)(=O)NC1=CC=C(CN2N=C(CCC2=O)C2=CC(=C(C=C2)OC)OC)C=C1 BNVNYYBKCBPEHA-UHFFFAOYSA-N 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• BOSLWYTUGKROGR-UHFFFAOYSA-N FCOC=1C=C(C=CC1OC)C1=NNC(SC1)=O Chemical compound FCOC=1C=C(C=CC1OC)C1=NNC(SC1)=O BOSLWYTUGKROGR-UHFFFAOYSA-N 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
• 206010021118 Hypotonia Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 208000026139 Memory disease Diseases 0.000 description 1
• UPONSWWGJIQETN-UHFFFAOYSA-N N-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-1-phenylethyl]pyridine-4-carboxamide Chemical compound N1=CC=C(C=C1)C(=O)NC(CN1N=C(C(CC1=O)CC)C1=CC(=C(C=C1)OC)OC)C1=CC=CC=C1 UPONSWWGJIQETN-UHFFFAOYSA-N 0.000 description 1
• CAPZMVQDVHFKQR-UHFFFAOYSA-N N-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]-1-phenylethyl]pyridine-4-carboxamide Chemical compound N1=CC=C(C=C1)C(=O)NC(CN1N=C(CCC1=O)C1=CC(=C(C=C1)OC)OC)C1=CC=CC=C1 CAPZMVQDVHFKQR-UHFFFAOYSA-N 0.000 description 1
• DSUXQHVKDZKDHU-UHFFFAOYSA-N N-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6H-1,3,4-oxadiazin-3-yl]-1-phenylethyl]pyridine-4-carboxamide Chemical compound N1=CC=C(C=C1)C(=O)NC(CN1C(OCC(=N1)C1=CC(=C(C=C1)OC)OC)=O)C1=CC=CC=C1 DSUXQHVKDZKDHU-UHFFFAOYSA-N 0.000 description 1
• IGKJMKBRPRNHAD-UHFFFAOYSA-N N-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6H-1,3,4-thiadiazin-3-yl]-1-phenylethyl]pyridine-4-carboxamide Chemical compound N1=CC=C(C=C1)C(=O)NC(CN1C(SCC(=N1)C1=CC(=C(C=C1)OC)OC)=O)C1=CC=CC=C1 IGKJMKBRPRNHAD-UHFFFAOYSA-N 0.000 description 1
• WNXUCXGYNKQLGG-UHFFFAOYSA-N N-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6H-1,3,4-oxadiazin-3-yl]-1-phenylethyl]pyridine-4-carboxamide Chemical compound N1=CC=C(C=C1)C(=O)NC(CN1C(OC(C(=N1)C1=CC(=C(C=C1)OC)OC)CC)=O)C1=CC=CC=C1 WNXUCXGYNKQLGG-UHFFFAOYSA-N 0.000 description 1
• AVDLOGNKKXRZOM-UHFFFAOYSA-N N-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6H-1,3,4-thiadiazin-3-yl]-1-phenylethyl]pyridine-4-carboxamide Chemical compound N1=CC=C(C=C1)C(=O)NC(CN1C(SC(C(=N1)C1=CC(=C(C=C1)OC)OC)CC)=O)C1=CC=CC=C1 AVDLOGNKKXRZOM-UHFFFAOYSA-N 0.000 description 1
• WJJYCHJXHAJUAM-UHFFFAOYSA-N N-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound C(C)OC=1C=C(C=CC=1OC)C=1CCC(N(N=1)CC1=CC=C(C=C1)NC(CCN1CCSCC1)=O)=O WJJYCHJXHAJUAM-UHFFFAOYSA-N 0.000 description 1
• XELXSLDSHSGTRQ-UHFFFAOYSA-N NC1=C(CC2N=C(CCC2=O)C2=CC(=C(C=C2)OC)OC)C=CC(=C1)N Chemical compound NC1=C(CC2N=C(CCC2=O)C2=CC(=C(C=C2)OC)OC)C=CC(=C1)N XELXSLDSHSGTRQ-UHFFFAOYSA-N 0.000 description 1
• 208000018737 Parkinson disease Diseases 0.000 description 1
• 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
• JJFXIWKHUFPDJW-UHFFFAOYSA-N S1CCN(CC1)CCCOC(N)=O Chemical compound S1CCN(CC1)CCCOC(N)=O JJFXIWKHUFPDJW-UHFFFAOYSA-N 0.000 description 1
• 208000012658 Skin autoimmune disease Diseases 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 206010052779 Transplant rejections Diseases 0.000 description 1
• 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 description 1
• 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 description 1
• VYIARBHOXCULJF-UHFFFAOYSA-N [3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(N)=O)=C1 VYIARBHOXCULJF-UHFFFAOYSA-N 0.000 description 1
• PTBCOXINDSJHGG-UHFFFAOYSA-N [4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(N)=O)C=C1 PTBCOXINDSJHGG-UHFFFAOYSA-N 0.000 description 1
• CCWSHRIZBHBETG-UHFFFAOYSA-N [4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]urea Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC1=CC=C(NC(N)=O)C=C1 CCWSHRIZBHBETG-UHFFFAOYSA-N 0.000 description 1
• COUWRZYTHLZNQC-UHFFFAOYSA-N [4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 COUWRZYTHLZNQC-UHFFFAOYSA-N 0.000 description 1
• CIZREEGOCQWNPD-UHFFFAOYSA-N [4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(NC(N)=O)C=C1 CIZREEGOCQWNPD-UHFFFAOYSA-N 0.000 description 1
• BVBMAKLIRDSMBS-UHFFFAOYSA-N [4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 BVBMAKLIRDSMBS-UHFFFAOYSA-N 0.000 description 1
• YOLXFGYYSSUXTQ-UHFFFAOYSA-N [4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(N)=O)=CC=3)N=2)C=C1OC1CCCC1 YOLXFGYYSSUXTQ-UHFFFAOYSA-N 0.000 description 1
• ONFVLRWCUFULEW-UHFFFAOYSA-N [4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(N)=O)=CC=3)N=2)CC)=C1 ONFVLRWCUFULEW-UHFFFAOYSA-N 0.000 description 1
• YMFFBPIOIXNHKJ-UHFFFAOYSA-N [4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(N)=O)=CC=3)N=2)=C1 YMFFBPIOIXNHKJ-UHFFFAOYSA-N 0.000 description 1
• QXANBNXHRANVRZ-UHFFFAOYSA-N [4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamic acid Chemical compound C(C)(C)OC=1C=C(C=CC=1OC)C=1CCC(N(N=1)CC1=CC=C(C=C1)NC(O)=O)=O QXANBNXHRANVRZ-UHFFFAOYSA-N 0.000 description 1
• GXIJWQYTEMJDJB-UHFFFAOYSA-N [4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 GXIJWQYTEMJDJB-UHFFFAOYSA-N 0.000 description 1
• MUYYUWXZOICQLT-UHFFFAOYSA-N [4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 MUYYUWXZOICQLT-UHFFFAOYSA-N 0.000 description 1
• COJHOKXVQOBJIF-UHFFFAOYSA-N [4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 COJHOKXVQOBJIF-UHFFFAOYSA-N 0.000 description 1
• LPLQYKYLYGJNAL-UHFFFAOYSA-N [4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 LPLQYKYLYGJNAL-UHFFFAOYSA-N 0.000 description 1
• CDVLZUINIYBNKE-UHFFFAOYSA-N [4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 CDVLZUINIYBNKE-UHFFFAOYSA-N 0.000 description 1
• ZCDJAPCKHRMEMK-UHFFFAOYSA-N [4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]urea Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(N)=O)C=C1 ZCDJAPCKHRMEMK-UHFFFAOYSA-N 0.000 description 1
• WLEPOOXSYIBFLK-UHFFFAOYSA-N [N+](=O)([O-])C1=C(CC2N=C(C(CC2=O)CC)C2=CC(=C(C=C2)OC)OC)C=CC=C1 Chemical compound [N+](=O)([O-])C1=C(CC2N=C(C(CC2=O)CC)C2=CC(=C(C=C2)OC)OC)C=CC=C1 WLEPOOXSYIBFLK-UHFFFAOYSA-N 0.000 description 1
• FGUNPOMYLVZSHS-UHFFFAOYSA-N [N+](=O)([O-])C1=CC=C(CC2N=C(C(CC2=O)CC)C2=CC(=C(C=C2)OCC)OC)C=C1 Chemical compound [N+](=O)([O-])C1=CC=C(CC2N=C(C(CC2=O)CC)C2=CC(=C(C=C2)OCC)OC)C=C1 FGUNPOMYLVZSHS-UHFFFAOYSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 230000001088 anti-asthma Effects 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• 150000003938 benzyl alcohols Chemical class 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 210000000038 chest Anatomy 0.000 description 1
• 125000004651 chloromethoxy group Chemical group ClCO* 0.000 description 1
• 208000007451 chronic bronchitis Diseases 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 230000000593 degrading effect Effects 0.000 description 1
• 125000004783 dichloromethoxy group Chemical group ClC(O*)Cl 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
• 239000000890 drug combination Substances 0.000 description 1
• 238000010410 dusting Methods 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• URBLGKZUXYOKEX-UHFFFAOYSA-N ethyl n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound CCOC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 URBLGKZUXYOKEX-UHFFFAOYSA-N 0.000 description 1
• SFZRRCZVQQMRJY-UHFFFAOYSA-N ethyl n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound CCOC(=O)NC1=CC=CC(CN2C(CCC(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 SFZRRCZVQQMRJY-UHFFFAOYSA-N 0.000 description 1
• XVAVKPRGWLAJPM-UHFFFAOYSA-N ethyl n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound CCOC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC3CCCC3)C(OC)=CC=2)=O)=C1 XVAVKPRGWLAJPM-UHFFFAOYSA-N 0.000 description 1
• GCTGMPXZEYVMKM-UHFFFAOYSA-N ethyl n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CCN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 GCTGMPXZEYVMKM-UHFFFAOYSA-N 0.000 description 1
• ARSIANLVWYUQBF-UHFFFAOYSA-N ethyl n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CCN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 ARSIANLVWYUQBF-UHFFFAOYSA-N 0.000 description 1
• SSIBZUDDTFSNAO-UHFFFAOYSA-N ethyl n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 SSIBZUDDTFSNAO-UHFFFAOYSA-N 0.000 description 1
• ZQIUHVHFDUIYQD-UHFFFAOYSA-N ethyl n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 ZQIUHVHFDUIYQD-UHFFFAOYSA-N 0.000 description 1
• QVWKBVPRCSKSIE-UHFFFAOYSA-N ethyl n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCC)C(OC)=CC=2)=N1 QVWKBVPRCSKSIE-UHFFFAOYSA-N 0.000 description 1
• SDKPDXHJQJYWBK-UHFFFAOYSA-N ethyl n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CCC(C=2C=C(OCC)C(OC)=CC=2)=N1 SDKPDXHJQJYWBK-UHFFFAOYSA-N 0.000 description 1
• BDMQCZIGYDYBBE-UHFFFAOYSA-N ethyl n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)F)C(OC)=CC=2)=N1 BDMQCZIGYDYBBE-UHFFFAOYSA-N 0.000 description 1
• LIUJINWHPPBRJU-UHFFFAOYSA-N ethyl n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)F)=CC=2)=N1 LIUJINWHPPBRJU-UHFFFAOYSA-N 0.000 description 1
• WABGJDMYOUPEKJ-UHFFFAOYSA-N ethyl n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCF)C(OC)=CC=2)=N1 WABGJDMYOUPEKJ-UHFFFAOYSA-N 0.000 description 1
• DOKWENINAQJBTQ-UHFFFAOYSA-N ethyl n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)=N1 DOKWENINAQJBTQ-UHFFFAOYSA-N 0.000 description 1
• QHAWILCTEYTIAR-UHFFFAOYSA-N ethyl n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OCF)=CC=2)=N1 QHAWILCTEYTIAR-UHFFFAOYSA-N 0.000 description 1
• RDQXPJUVTBTRER-UHFFFAOYSA-N ethyl n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)=N1 RDQXPJUVTBTRER-UHFFFAOYSA-N 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 235000013773 glyceryl triacetate Nutrition 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 239000000543 intermediate Substances 0.000 description 1
• 201000002313 intestinal cancer Diseases 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• YWPDKNOLKSLTLB-UHFFFAOYSA-N methyl 2-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(=O)OC)=C1 YWPDKNOLKSLTLB-UHFFFAOYSA-N 0.000 description 1
• KXSOQZRWQCSFJG-UHFFFAOYSA-N methyl 2-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound COC(=O)C(=O)NC1=CC=CC(CN2C(CCC(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 KXSOQZRWQCSFJG-UHFFFAOYSA-N 0.000 description 1
• QXMPDRNZOKHCDA-UHFFFAOYSA-N methyl 2-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(=O)OC)=C1 QXMPDRNZOKHCDA-UHFFFAOYSA-N 0.000 description 1
• OUPGIHQDRGFOQM-UHFFFAOYSA-N methyl 2-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)C(=O)OC)C=C1 OUPGIHQDRGFOQM-UHFFFAOYSA-N 0.000 description 1
• WNXOKRJNHQBTDQ-UHFFFAOYSA-N methyl 2-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 WNXOKRJNHQBTDQ-UHFFFAOYSA-N 0.000 description 1
• HVQLONHFPXVKGM-UHFFFAOYSA-N methyl 2-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound C1=CC(NC(=O)C(=O)OC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 HVQLONHFPXVKGM-UHFFFAOYSA-N 0.000 description 1
• PZZOMTVBAIJTSM-UHFFFAOYSA-N methyl 2-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 PZZOMTVBAIJTSM-UHFFFAOYSA-N 0.000 description 1
• PNAAXTXDAXPPCR-UHFFFAOYSA-N methyl 2-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound C1=CC(NC(=O)C(=O)OC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 PNAAXTXDAXPPCR-UHFFFAOYSA-N 0.000 description 1
• ZUTDQPMRVIUTPA-UHFFFAOYSA-N methyl 2-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C(=O)OC)=CC=3)N=2)CC)=C1 ZUTDQPMRVIUTPA-UHFFFAOYSA-N 0.000 description 1
• MTACDBARDPRQMY-UHFFFAOYSA-N methyl 2-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(=O)OC)=CC=3)N=2)=C1 MTACDBARDPRQMY-UHFFFAOYSA-N 0.000 description 1
• DRNAKASZNADFQV-UHFFFAOYSA-N methyl 2-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 DRNAKASZNADFQV-UHFFFAOYSA-N 0.000 description 1
• UQHNVTCKSFRTDI-UHFFFAOYSA-N methyl 2-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 UQHNVTCKSFRTDI-UHFFFAOYSA-N 0.000 description 1
• ZUIHGOLCNVKKKR-UHFFFAOYSA-N methyl 2-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 ZUIHGOLCNVKKKR-UHFFFAOYSA-N 0.000 description 1
• POAZMKKVOWSGND-UHFFFAOYSA-N methyl 2-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 POAZMKKVOWSGND-UHFFFAOYSA-N 0.000 description 1
• IWVUUKXMZFMIRB-UHFFFAOYSA-N methyl 2-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 IWVUUKXMZFMIRB-UHFFFAOYSA-N 0.000 description 1
• ZKWVJXUKPDWNJJ-UHFFFAOYSA-N methyl 2-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]anilino]-2-oxoacetate Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(=O)OC)C=C1 ZKWVJXUKPDWNJJ-UHFFFAOYSA-N 0.000 description 1
• AAVSBRVGOGNZDK-UHFFFAOYSA-N methyl n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)OC)=C1 AAVSBRVGOGNZDK-UHFFFAOYSA-N 0.000 description 1
• QVGFXSAKMWSHSR-UHFFFAOYSA-N methyl n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound COC(=O)NC1=CC=CC(CN2C(CCC(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 QVGFXSAKMWSHSR-UHFFFAOYSA-N 0.000 description 1
• WOHSIJFDZKWNRL-UHFFFAOYSA-N methyl n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)OC)=C1 WOHSIJFDZKWNRL-UHFFFAOYSA-N 0.000 description 1
• IGVUZYDRMGFKFD-UHFFFAOYSA-N methyl n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)OC)C=C1 IGVUZYDRMGFKFD-UHFFFAOYSA-N 0.000 description 1
• FONCJTUPQGDYCT-UHFFFAOYSA-N methyl n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1CCN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 FONCJTUPQGDYCT-UHFFFAOYSA-N 0.000 description 1
• HSEWOFPHGBRPMD-UHFFFAOYSA-N methyl n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 HSEWOFPHGBRPMD-UHFFFAOYSA-N 0.000 description 1
• QOMQZZYHFYONCG-UHFFFAOYSA-N methyl n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 QOMQZZYHFYONCG-UHFFFAOYSA-N 0.000 description 1
• JCNUKBBYWVDZTM-UHFFFAOYSA-N methyl n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 JCNUKBBYWVDZTM-UHFFFAOYSA-N 0.000 description 1
• GNIQXHKTYKZEEI-UHFFFAOYSA-N methyl n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)OC)=CC=3)N=2)CC)=C1 GNIQXHKTYKZEEI-UHFFFAOYSA-N 0.000 description 1
• NDOUMDUYIWPXOX-UHFFFAOYSA-N methyl n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)OC)=CC=3)N=2)=C1 NDOUMDUYIWPXOX-UHFFFAOYSA-N 0.000 description 1
• FNFJFNYSSGZYGV-UHFFFAOYSA-N methyl n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 FNFJFNYSSGZYGV-UHFFFAOYSA-N 0.000 description 1
• OCCVKBRWWJHYBW-UHFFFAOYSA-N methyl n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 OCCVKBRWWJHYBW-UHFFFAOYSA-N 0.000 description 1
• WGCOJCYYPSQGGN-UHFFFAOYSA-N methyl n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 WGCOJCYYPSQGGN-UHFFFAOYSA-N 0.000 description 1
• UXPKUOTZZJNOBG-UHFFFAOYSA-N methyl n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 UXPKUOTZZJNOBG-UHFFFAOYSA-N 0.000 description 1
• SVKHSLUYEANZCF-UHFFFAOYSA-N methyl n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 SVKHSLUYEANZCF-UHFFFAOYSA-N 0.000 description 1
• WSWIJVFPBWPGLH-UHFFFAOYSA-N methyl n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)OC)C=C1 WSWIJVFPBWPGLH-UHFFFAOYSA-N 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 230000036640 muscle relaxation Effects 0.000 description 1
• PKWYHHBCGBVQQT-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=NO1 PKWYHHBCGBVQQT-UHFFFAOYSA-N 0.000 description 1
• KFMYVLMJISCKNM-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CN=CO1 KFMYVLMJISCKNM-UHFFFAOYSA-N 0.000 description 1
• UIIGGQCDCOFTMC-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CNC=N1 UIIGGQCDCOFTMC-UHFFFAOYSA-N 0.000 description 1
• OTIXJVDUVJCHIM-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C=1C=CNN=1 OTIXJVDUVJCHIM-UHFFFAOYSA-N 0.000 description 1
• KPEZGGNLLNZMQM-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CN1 KPEZGGNLLNZMQM-UHFFFAOYSA-N 0.000 description 1
• DPDQGSZMEJXVGV-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C=1SC(C)=NC=1C DPDQGSZMEJXVGV-UHFFFAOYSA-N 0.000 description 1
• CGVROIUYQJFQFB-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CO1 CGVROIUYQJFQFB-UHFFFAOYSA-N 0.000 description 1
• WXBXENDYUZBAQF-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CN=CC=N1 WXBXENDYUZBAQF-UHFFFAOYSA-N 0.000 description 1
• BNSCCCSCMKTSTI-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CN=C1 BNSCCCSCMKTSTI-UHFFFAOYSA-N 0.000 description 1
• ZNHBGFZBALEVPZ-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=NC=C1 ZNHBGFZBALEVPZ-UHFFFAOYSA-N 0.000 description 1
• UKHYXPBUHKEBTE-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=NC=CC=N1 UKHYXPBUHKEBTE-UHFFFAOYSA-N 0.000 description 1
• MIEGLCFHJCHDEO-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CS1 MIEGLCFHJCHDEO-UHFFFAOYSA-N 0.000 description 1
• JNEVLEUKNUVSGY-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=NO1 JNEVLEUKNUVSGY-UHFFFAOYSA-N 0.000 description 1
• ZHLSDPJNUPVQSH-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CN=CO1 ZHLSDPJNUPVQSH-UHFFFAOYSA-N 0.000 description 1
• LXPLZSNSOHWPEJ-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CNC=N1 LXPLZSNSOHWPEJ-UHFFFAOYSA-N 0.000 description 1
• RWMSJJZJJWTXQO-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=NNC=C1 RWMSJJZJJWTXQO-UHFFFAOYSA-N 0.000 description 1
• IEGMIKIJXYKRMK-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CN1 IEGMIKIJXYKRMK-UHFFFAOYSA-N 0.000 description 1
• RAVOWHFURQATIO-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=C(C)N=C(C)S1 RAVOWHFURQATIO-UHFFFAOYSA-N 0.000 description 1
• GRUSYVHPIRGGJY-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CO1 GRUSYVHPIRGGJY-UHFFFAOYSA-N 0.000 description 1
• KNUWNCARQUDUSF-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CN=CC=N1 KNUWNCARQUDUSF-UHFFFAOYSA-N 0.000 description 1
• CELNHASYKXCXKP-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CN=C1 CELNHASYKXCXKP-UHFFFAOYSA-N 0.000 description 1
• JQHWYZJURZMSOU-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=NC=C1 JQHWYZJURZMSOU-UHFFFAOYSA-N 0.000 description 1
• DQDNKBXVHLYWLV-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=NC=CC=N1 DQDNKBXVHLYWLV-UHFFFAOYSA-N 0.000 description 1
• NUPLGGQAVYINCT-UHFFFAOYSA-N n-[2-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CS1 NUPLGGQAVYINCT-UHFFFAOYSA-N 0.000 description 1
• XQMIZNNNMJMDAA-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=NO1 XQMIZNNNMJMDAA-UHFFFAOYSA-N 0.000 description 1
• YOOXXZHJWDELIH-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CN=CO1 YOOXXZHJWDELIH-UHFFFAOYSA-N 0.000 description 1
• WQMIGCSMOIEWDT-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CNC=N1 WQMIGCSMOIEWDT-UHFFFAOYSA-N 0.000 description 1
• GXQMBBGDPAFHKI-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=NNC=C1 GXQMBBGDPAFHKI-UHFFFAOYSA-N 0.000 description 1
• BNPJBDCOGRBFIK-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CN1 BNPJBDCOGRBFIK-UHFFFAOYSA-N 0.000 description 1
• VLZUNGZBTVRMFF-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=C(C)N=C(C)S1 VLZUNGZBTVRMFF-UHFFFAOYSA-N 0.000 description 1
• FYVOGAWSQZDUOF-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CO1 FYVOGAWSQZDUOF-UHFFFAOYSA-N 0.000 description 1
• ODVFUBRBUJKWIR-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CN=CC=N1 ODVFUBRBUJKWIR-UHFFFAOYSA-N 0.000 description 1
• DXMISARGCHGSGA-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CN=C1 DXMISARGCHGSGA-UHFFFAOYSA-N 0.000 description 1
• WCYBOQPXIPPKBR-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=NC=C1 WCYBOQPXIPPKBR-UHFFFAOYSA-N 0.000 description 1
• QBBXRMFWQOYQPL-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=NC=CC=N1 QBBXRMFWQOYQPL-UHFFFAOYSA-N 0.000 description 1
• RZGBLNMMHKOPMF-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CS1 RZGBLNMMHKOPMF-UHFFFAOYSA-N 0.000 description 1
• MAGMCYQGBISBIH-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=NO1 MAGMCYQGBISBIH-UHFFFAOYSA-N 0.000 description 1
• YDMZUQAYNNFPCY-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CN=CO1 YDMZUQAYNNFPCY-UHFFFAOYSA-N 0.000 description 1
• CTQIVWZACHOFOH-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CNC=N1 CTQIVWZACHOFOH-UHFFFAOYSA-N 0.000 description 1
• JUZWSKOCRMKYIV-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=NNC=C1 JUZWSKOCRMKYIV-UHFFFAOYSA-N 0.000 description 1
• YUNBPAIKCYBBLS-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CN1 YUNBPAIKCYBBLS-UHFFFAOYSA-N 0.000 description 1
• NAQTUAIBAHFIKL-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=C(C)N=C(C)S1 NAQTUAIBAHFIKL-UHFFFAOYSA-N 0.000 description 1
• KQLJNTWTQHAONW-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CO1 KQLJNTWTQHAONW-UHFFFAOYSA-N 0.000 description 1
• LTKXLGCUTSGOAK-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CN=CC=N1 LTKXLGCUTSGOAK-UHFFFAOYSA-N 0.000 description 1
• HRBUMZZJKSXPMX-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CN=C1 HRBUMZZJKSXPMX-UHFFFAOYSA-N 0.000 description 1
• FHYPNCUMAKSVIO-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=NC=C1 FHYPNCUMAKSVIO-UHFFFAOYSA-N 0.000 description 1
• VKCIDCPYSCWKRU-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=NC=CC=N1 VKCIDCPYSCWKRU-UHFFFAOYSA-N 0.000 description 1
• GLRQUESLXFTFTI-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC=C1NC(=O)C1=CC=CS1 GLRQUESLXFTFTI-UHFFFAOYSA-N 0.000 description 1
• WLFIDKOKLZEGSD-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=NO1 WLFIDKOKLZEGSD-UHFFFAOYSA-N 0.000 description 1
• XHIQZEYUVYWSIT-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CN=CO1 XHIQZEYUVYWSIT-UHFFFAOYSA-N 0.000 description 1
• ISGVKEOWPRRHMO-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CNC=N1 ISGVKEOWPRRHMO-UHFFFAOYSA-N 0.000 description 1
• XKSDWBINBFQIQD-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C=1C=CNN=1 XKSDWBINBFQIQD-UHFFFAOYSA-N 0.000 description 1
• AIGBLAONWAJLFL-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CN1 AIGBLAONWAJLFL-UHFFFAOYSA-N 0.000 description 1
• IIDKCQVGVFYGKJ-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C=1SC(C)=NC=1C IIDKCQVGVFYGKJ-UHFFFAOYSA-N 0.000 description 1
• JSGJPCQEDVBXQU-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CO1 JSGJPCQEDVBXQU-UHFFFAOYSA-N 0.000 description 1
• LKJCHLDTHJYQAV-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CN=CC=N1 LKJCHLDTHJYQAV-UHFFFAOYSA-N 0.000 description 1
• DNRNRRLFMRTVAS-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CN=C1 DNRNRRLFMRTVAS-UHFFFAOYSA-N 0.000 description 1
• ZKPFQVMCAMWWOW-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=NC=C1 ZKPFQVMCAMWWOW-UHFFFAOYSA-N 0.000 description 1
• MZWUTSRFKXCDHX-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=NC=CC=N1 MZWUTSRFKXCDHX-UHFFFAOYSA-N 0.000 description 1
• XNVIQNZTQMLAHP-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CS1 XNVIQNZTQMLAHP-UHFFFAOYSA-N 0.000 description 1
• JFYGMWMHLDXTPS-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=NO1 JFYGMWMHLDXTPS-UHFFFAOYSA-N 0.000 description 1
• IEWLPYHNFUJDNP-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CN=CO1 IEWLPYHNFUJDNP-UHFFFAOYSA-N 0.000 description 1
• MDDQQRMRNLBATF-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CNC=N1 MDDQQRMRNLBATF-UHFFFAOYSA-N 0.000 description 1
• QPIKLUWYZFSIMQ-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C=1C=CNN=1 QPIKLUWYZFSIMQ-UHFFFAOYSA-N 0.000 description 1
• KIELDBZEVBMQBD-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CN1 KIELDBZEVBMQBD-UHFFFAOYSA-N 0.000 description 1
• DXQDWPBPCBRHMZ-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C=1SC(C)=NC=1C DXQDWPBPCBRHMZ-UHFFFAOYSA-N 0.000 description 1
• GRDOFMOMGVTSAX-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CO1 GRDOFMOMGVTSAX-UHFFFAOYSA-N 0.000 description 1
• FHMBYRBADRVXHH-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CN=CC=N1 FHMBYRBADRVXHH-UHFFFAOYSA-N 0.000 description 1
• ZCAZUWGATZTCCC-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CN=C1 ZCAZUWGATZTCCC-UHFFFAOYSA-N 0.000 description 1
• TXTJHIKUXPLJMY-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=NC=C1 TXTJHIKUXPLJMY-UHFFFAOYSA-N 0.000 description 1
• FCMJUQZHDZZWQP-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=NC=CC=N1 FCMJUQZHDZZWQP-UHFFFAOYSA-N 0.000 description 1
• OATMQNOLPPIOJV-UHFFFAOYSA-N n-[2-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC1=CC=CC=C1NC(=O)C1=CC=CS1 OATMQNOLPPIOJV-UHFFFAOYSA-N 0.000 description 1
• RMZNJHUNOPLACG-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NO1 RMZNJHUNOPLACG-UHFFFAOYSA-N 0.000 description 1
• UKVDXAAPZOMMPA-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CO1 UKVDXAAPZOMMPA-UHFFFAOYSA-N 0.000 description 1
• NTLOEOJMFWWCEC-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CNC=N1 NTLOEOJMFWWCEC-UHFFFAOYSA-N 0.000 description 1
• SYCZLKCDJMJDDH-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1C=CNN=1 SYCZLKCDJMJDDH-UHFFFAOYSA-N 0.000 description 1
• LRVZIQVUWOAJBL-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN1 LRVZIQVUWOAJBL-UHFFFAOYSA-N 0.000 description 1
• PMTXSMYNLKOLQA-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(F)(F)F)=C1 PMTXSMYNLKOLQA-UHFFFAOYSA-N 0.000 description 1
• ZFEWBPXBLZYTMO-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(F)(F)C(F)(F)F)=C1 ZFEWBPXBLZYTMO-UHFFFAOYSA-N 0.000 description 1
• QTODLXDNAYCFCM-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(C)(C)C)=C1 QTODLXDNAYCFCM-UHFFFAOYSA-N 0.000 description 1
• INPXCQONEKYXOO-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1SC(C)=NC=1C INPXCQONEKYXOO-UHFFFAOYSA-N 0.000 description 1
• XRXMIOANOHBDMR-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(C)C)=C1 XRXMIOANOHBDMR-UHFFFAOYSA-N 0.000 description 1
• CKRQUCVYBCJQIM-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound CCCC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 CKRQUCVYBCJQIM-UHFFFAOYSA-N 0.000 description 1
• HDZXMQRQNKUUBE-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CO1 HDZXMQRQNKUUBE-UHFFFAOYSA-N 0.000 description 1
• SDXVJGBDDHCWOX-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound CCCCCC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 SDXVJGBDDHCWOX-UHFFFAOYSA-N 0.000 description 1
• IMPMWTVLKWWAOE-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NS(C)(=O)=O)=C1 IMPMWTVLKWWAOE-UHFFFAOYSA-N 0.000 description 1
• ASYAHCZPAVKUPK-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound CCCCC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 ASYAHCZPAVKUPK-UHFFFAOYSA-N 0.000 description 1
• PUVPXUCVSHAYCI-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)CC)=C1 PUVPXUCVSHAYCI-UHFFFAOYSA-N 0.000 description 1
• XLVNUISCFNUPAS-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CC=N1 XLVNUISCFNUPAS-UHFFFAOYSA-N 0.000 description 1
• LKILMCVXFMVZAL-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN=C1 LKILMCVXFMVZAL-UHFFFAOYSA-N 0.000 description 1
• KTGGSXXRUKKDDV-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NC=C1 KTGGSXXRUKKDDV-UHFFFAOYSA-N 0.000 description 1
• MVUJZEDZTXZORP-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=NC=CC=N1 MVUJZEDZTXZORP-UHFFFAOYSA-N 0.000 description 1
• JWUIAPPPPJPRDC-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CS1 JWUIAPPPPJPRDC-UHFFFAOYSA-N 0.000 description 1
• HZVXLKDOLXRWPX-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2ON=CC=2)=C1 HZVXLKDOLXRWPX-UHFFFAOYSA-N 0.000 description 1
• DDQJWDCFGMPHOK-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2OC=NC=2)=C1 DDQJWDCFGMPHOK-UHFFFAOYSA-N 0.000 description 1
• JSHANPPBXGGEGL-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CNC=2)=C1 JSHANPPBXGGEGL-UHFFFAOYSA-N 0.000 description 1
• DBIYLMNJGPJYQZ-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C2=NNC=C2)=C1 DBIYLMNJGPJYQZ-UHFFFAOYSA-N 0.000 description 1
• DOJCDJGMLQSWEU-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2NC=CC=2)=C1 DOJCDJGMLQSWEU-UHFFFAOYSA-N 0.000 description 1
• CPJYMIDKXHPDCA-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C(F)(F)F)=C1 CPJYMIDKXHPDCA-UHFFFAOYSA-N 0.000 description 1
• LZVWGYYGKBSWLJ-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C(F)(F)C(F)(F)F)=C1 LZVWGYYGKBSWLJ-UHFFFAOYSA-N 0.000 description 1
• DSZXEXAFDZVTGT-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C(C)(C)C)=C1 DSZXEXAFDZVTGT-UHFFFAOYSA-N 0.000 description 1
• PBEAZHKCLCRHFI-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C2=C(N=C(C)S2)C)=C1 PBEAZHKCLCRHFI-UHFFFAOYSA-N 0.000 description 1
• PJBKPKPHIJTYRX-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C(C)C)=C1 PJBKPKPHIJTYRX-UHFFFAOYSA-N 0.000 description 1
• GYPYIOOZSNHLFN-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound CCCC(=O)NC1=CC=CC(CN2C(CCC(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 GYPYIOOZSNHLFN-UHFFFAOYSA-N 0.000 description 1
• HYRAGOPNVUXTDX-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2OC=CC=2)=C1 HYRAGOPNVUXTDX-UHFFFAOYSA-N 0.000 description 1
• BEGAKRBHEWQDIK-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound CCC(=O)NC1=CC=CC(CN2C(CCC(=N2)C=2C=C(OC)C(OC)=CC=2)=O)=C1 BEGAKRBHEWQDIK-UHFFFAOYSA-N 0.000 description 1
• COZTUOUJSFZAJV-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CC=NC=2)=C1 COZTUOUJSFZAJV-UHFFFAOYSA-N 0.000 description 1
• WYNZOQNHYQIRIA-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CC=CN=2)=C1 WYNZOQNHYQIRIA-UHFFFAOYSA-N 0.000 description 1
• VWHMREFIMQNOKV-UHFFFAOYSA-N n-[3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(NC(=O)C=2SC=CC=2)=C1 VWHMREFIMQNOKV-UHFFFAOYSA-N 0.000 description 1
• IMGGEZHPWVUWSL-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NO1 IMGGEZHPWVUWSL-UHFFFAOYSA-N 0.000 description 1
• NQSGVQJWHMLDKT-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CNC=N1 NQSGVQJWHMLDKT-UHFFFAOYSA-N 0.000 description 1
• HXDGLGLOZPTTQU-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1C=CNN=1 HXDGLGLOZPTTQU-UHFFFAOYSA-N 0.000 description 1
• PENMGOPZBHFNGR-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN1 PENMGOPZBHFNGR-UHFFFAOYSA-N 0.000 description 1
• IMBKPELBPLNDSA-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(F)(F)F)=C1 IMBKPELBPLNDSA-UHFFFAOYSA-N 0.000 description 1
• VVLOKKHSWWZACU-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(F)(F)C(F)(F)F)=C1 VVLOKKHSWWZACU-UHFFFAOYSA-N 0.000 description 1
• UPMVWYYUDGBIMZ-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1SC(C)=NC=1C UPMVWYYUDGBIMZ-UHFFFAOYSA-N 0.000 description 1
• FMRWLEUAQBXMGW-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)C(C)C)=C1 FMRWLEUAQBXMGW-UHFFFAOYSA-N 0.000 description 1
• SIYPPBBKXUGDEL-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(C)=O)=C1 SIYPPBBKXUGDEL-UHFFFAOYSA-N 0.000 description 1
• SQUFNPSBUUOTDY-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound CCCC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC3CCCC3)C(OC)=CC=2)=O)=C1 SQUFNPSBUUOTDY-UHFFFAOYSA-N 0.000 description 1
• ZVIZFWNPDYUZPR-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CO1 ZVIZFWNPDYUZPR-UHFFFAOYSA-N 0.000 description 1
• ZBRXBNZAJZZPHT-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound CCCCCC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC3CCCC3)C(OC)=CC=2)=O)=C1 ZBRXBNZAJZZPHT-UHFFFAOYSA-N 0.000 description 1
• MBUIEYNWMZFMFJ-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NS(C)(=O)=O)=C1 MBUIEYNWMZFMFJ-UHFFFAOYSA-N 0.000 description 1
• NFHFQAYYRMKLJT-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound CCCCC(=O)NC1=CC=CC(CN2C(CC(CC)C(=N2)C=2C=C(OC3CCCC3)C(OC)=CC=2)=O)=C1 NFHFQAYYRMKLJT-UHFFFAOYSA-N 0.000 description 1
• JUOSDCWQVHSOII-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=CC(NC(=O)CC)=C1 JUOSDCWQVHSOII-UHFFFAOYSA-N 0.000 description 1
• FCJIVJHRSYULLW-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CC=N1 FCJIVJHRSYULLW-UHFFFAOYSA-N 0.000 description 1
• CJRVQBFOGHWOAT-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN=C1 CJRVQBFOGHWOAT-UHFFFAOYSA-N 0.000 description 1
• FGKLBXWODCDFDR-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NC=C1 FGKLBXWODCDFDR-UHFFFAOYSA-N 0.000 description 1
• NMIOGVWONPQQAF-UHFFFAOYSA-N n-[3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CS1 NMIOGVWONPQQAF-UHFFFAOYSA-N 0.000 description 1
• MQZDKLBSXVEHCR-UHFFFAOYSA-N n-[3-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=C(NC(=O)C=4C=NC=CC=4)C=CC=3)N=2)=C1 MQZDKLBSXVEHCR-UHFFFAOYSA-N 0.000 description 1
• FHSMPMVEMKDAIE-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2ON=CC=2)=C1 FHSMPMVEMKDAIE-UHFFFAOYSA-N 0.000 description 1
• WCITUUMHRHJZLY-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2OC=NC=2)=C1 WCITUUMHRHJZLY-UHFFFAOYSA-N 0.000 description 1
• XMMOBJRCTZLKCL-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C2=NNC=C2)=C1 XMMOBJRCTZLKCL-UHFFFAOYSA-N 0.000 description 1
• IGPCMGGYEWJRQX-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2NC=CC=2)=C1 IGPCMGGYEWJRQX-UHFFFAOYSA-N 0.000 description 1
• JHKWBFHDXJJQQZ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2OC=CC=2)=C1 JHKWBFHDXJJQQZ-UHFFFAOYSA-N 0.000 description 1
• KJJDOLAVBGBUDS-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CC=NC=2)=C1 KJJDOLAVBGBUDS-UHFFFAOYSA-N 0.000 description 1
• WXRGPBAWABJVCY-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2C=NC=CC=2)=C1 WXRGPBAWABJVCY-UHFFFAOYSA-N 0.000 description 1
• HKAKHPZHTDMSID-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2C=CN=CC=2)=C1 HKAKHPZHTDMSID-UHFFFAOYSA-N 0.000 description 1
• LQEPBYSCVOILIL-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CC=CN=2)=C1 LQEPBYSCVOILIL-UHFFFAOYSA-N 0.000 description 1
• GGJCRQGKMHLYDZ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC1=CC=CC(NC(=O)C=2SC=CC=2)=C1 GGJCRQGKMHLYDZ-UHFFFAOYSA-N 0.000 description 1
• ZWQPZUQRKZQRHN-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2ON=CC=2)=C1 ZWQPZUQRKZQRHN-UHFFFAOYSA-N 0.000 description 1
• JLOCRXHUNGZZHK-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2OC=NC=2)=C1 JLOCRXHUNGZZHK-UHFFFAOYSA-N 0.000 description 1
• BHKNLEZCNCEXGS-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CNC=2)=C1 BHKNLEZCNCEXGS-UHFFFAOYSA-N 0.000 description 1
• KMFVWGQQLSCIIM-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C2=NNC=C2)=C1 KMFVWGQQLSCIIM-UHFFFAOYSA-N 0.000 description 1
• WJFPPDGRXYASAR-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2NC=CC=2)=C1 WJFPPDGRXYASAR-UHFFFAOYSA-N 0.000 description 1
• WLXRPCNHYDSROB-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C2=C(N=C(C)S2)C)=C1 WLXRPCNHYDSROB-UHFFFAOYSA-N 0.000 description 1
• BDAYAXDNEBSCHC-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperazin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)CN2CCNCC2)=C1 BDAYAXDNEBSCHC-UHFFFAOYSA-N 0.000 description 1
• OGYNWZKQFBMAJV-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)CN2CCCCC2)=C1 OGYNWZKQFBMAJV-UHFFFAOYSA-N 0.000 description 1
• HRKBUCQAZSELJY-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)CN2CCCC2)=C1 HRKBUCQAZSELJY-UHFFFAOYSA-N 0.000 description 1
• XXXURFZSBYRDOT-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)CN2CCSCC2)=C1 XXXURFZSBYRDOT-UHFFFAOYSA-N 0.000 description 1
• USVBIHHFWGKJNH-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2OC=CC=2)=C1 USVBIHHFWGKJNH-UHFFFAOYSA-N 0.000 description 1
• HMSKGTSPKWLWBJ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CC=NC=2)=C1 HMSKGTSPKWLWBJ-UHFFFAOYSA-N 0.000 description 1
• BKHRYNHPODKZKM-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2C=NC=CC=2)=C1 BKHRYNHPODKZKM-UHFFFAOYSA-N 0.000 description 1
• SLRPTPDYGCFUMU-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2C=CN=CC=2)=C1 SLRPTPDYGCFUMU-UHFFFAOYSA-N 0.000 description 1
• GSMQYHHXSRZQAM-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2N=CC=CN=2)=C1 GSMQYHHXSRZQAM-UHFFFAOYSA-N 0.000 description 1
• UAYNQIPAQIWFSV-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC1=CC=CC(NC(=O)C=2SC=CC=2)=C1 UAYNQIPAQIWFSV-UHFFFAOYSA-N 0.000 description 1
• MGHVVOPUXAHXLU-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NO1 MGHVVOPUXAHXLU-UHFFFAOYSA-N 0.000 description 1
• RYXUITQIYRAQDW-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CO1 RYXUITQIYRAQDW-UHFFFAOYSA-N 0.000 description 1
• RWPADIIDOYBSLJ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CNC=N1 RWPADIIDOYBSLJ-UHFFFAOYSA-N 0.000 description 1
• VHRHZPKOCRFCJJ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN1 VHRHZPKOCRFCJJ-UHFFFAOYSA-N 0.000 description 1
• KBJDVJSKLYPOAY-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1SC(C)=NC=1C KBJDVJSKLYPOAY-UHFFFAOYSA-N 0.000 description 1
• FUIYUYKRDHZPAQ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CO1 FUIYUYKRDHZPAQ-UHFFFAOYSA-N 0.000 description 1
• ARCJMTGOALPZRA-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CC=N1 ARCJMTGOALPZRA-UHFFFAOYSA-N 0.000 description 1
• JKLFWRXIZWXORX-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN=C1 JKLFWRXIZWXORX-UHFFFAOYSA-N 0.000 description 1
• PPRHADFRVKLEGN-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NC=C1 PPRHADFRVKLEGN-UHFFFAOYSA-N 0.000 description 1
• MVIFQDUADPJSKB-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=NC=CC=N1 MVIFQDUADPJSKB-UHFFFAOYSA-N 0.000 description 1
• FUVDUEICLJFMOQ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CS1 FUVDUEICLJFMOQ-UHFFFAOYSA-N 0.000 description 1
• DWWILRMDNXCAKT-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NO1 DWWILRMDNXCAKT-UHFFFAOYSA-N 0.000 description 1
• PFLMYUQOFKHYOX-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CO1 PFLMYUQOFKHYOX-UHFFFAOYSA-N 0.000 description 1
• FSGMLGBEGFNFLD-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CNC=N1 FSGMLGBEGFNFLD-UHFFFAOYSA-N 0.000 description 1
• BMCGDLVIQIEBLC-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1C=CNN=1 BMCGDLVIQIEBLC-UHFFFAOYSA-N 0.000 description 1
• RZLYNHATXCUJPK-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN1 RZLYNHATXCUJPK-UHFFFAOYSA-N 0.000 description 1
• FZLRKJZOSSHPGX-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1SC(C)=NC=1C FZLRKJZOSSHPGX-UHFFFAOYSA-N 0.000 description 1
• UETKQJXPJBCZQF-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CO1 UETKQJXPJBCZQF-UHFFFAOYSA-N 0.000 description 1
• VEDJPALOJLTYDE-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CC=N1 VEDJPALOJLTYDE-UHFFFAOYSA-N 0.000 description 1
• VEXHOKWJQPKVMT-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN=C1 VEXHOKWJQPKVMT-UHFFFAOYSA-N 0.000 description 1
• SOAKKXRGLXRHOQ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NC=C1 SOAKKXRGLXRHOQ-UHFFFAOYSA-N 0.000 description 1
• NERVBJLUHXAJTK-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=NC=CC=N1 NERVBJLUHXAJTK-UHFFFAOYSA-N 0.000 description 1
• UFITXYDZZCAPTJ-UHFFFAOYSA-N n-[3-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CS1 UFITXYDZZCAPTJ-UHFFFAOYSA-N 0.000 description 1
• OXRBXHDLNXBKDA-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NO1 OXRBXHDLNXBKDA-UHFFFAOYSA-N 0.000 description 1
• YGMVNSGMAMRRFB-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CO1 YGMVNSGMAMRRFB-UHFFFAOYSA-N 0.000 description 1
• CTDDSDPMLXSXRP-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CNC=N1 CTDDSDPMLXSXRP-UHFFFAOYSA-N 0.000 description 1
• ZLHSWGORNLFZRZ-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1C=CNN=1 ZLHSWGORNLFZRZ-UHFFFAOYSA-N 0.000 description 1
• LWFDNFNDAMCGEE-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN1 LWFDNFNDAMCGEE-UHFFFAOYSA-N 0.000 description 1
• JPXKTBRLOJTEGB-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1SC(C)=NC=1C JPXKTBRLOJTEGB-UHFFFAOYSA-N 0.000 description 1
• DVMWOKDGYCGOHZ-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CO1 DVMWOKDGYCGOHZ-UHFFFAOYSA-N 0.000 description 1
• RKORZNXABCVDIP-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CC=N1 RKORZNXABCVDIP-UHFFFAOYSA-N 0.000 description 1
• OZVDXIOWZXEPJZ-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN=C1 OZVDXIOWZXEPJZ-UHFFFAOYSA-N 0.000 description 1
• LCULFOYZBYPYDV-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NC=C1 LCULFOYZBYPYDV-UHFFFAOYSA-N 0.000 description 1
• SVFLQIPIZHLVKS-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=NC=CC=N1 SVFLQIPIZHLVKS-UHFFFAOYSA-N 0.000 description 1
• ONHWJADRRZYODM-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CS1 ONHWJADRRZYODM-UHFFFAOYSA-N 0.000 description 1
• FMVUQGMRGIJYBP-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NO1 FMVUQGMRGIJYBP-UHFFFAOYSA-N 0.000 description 1
• AXMMUHUTVHMQKE-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CO1 AXMMUHUTVHMQKE-UHFFFAOYSA-N 0.000 description 1
• NKSCSXCVDHCGPC-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CNC=N1 NKSCSXCVDHCGPC-UHFFFAOYSA-N 0.000 description 1
• KFGASXPWEKHPJN-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C=1C=CNN=1 KFGASXPWEKHPJN-UHFFFAOYSA-N 0.000 description 1
• PRKILGOALIYPFN-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN1 PRKILGOALIYPFN-UHFFFAOYSA-N 0.000 description 1
• DHMGNQSVOMDHRO-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CO1 DHMGNQSVOMDHRO-UHFFFAOYSA-N 0.000 description 1
• TZOMHNIREPHHIN-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CN=CC=N1 TZOMHNIREPHHIN-UHFFFAOYSA-N 0.000 description 1
• IIRCKDGOQRLYJV-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CN=C1 IIRCKDGOQRLYJV-UHFFFAOYSA-N 0.000 description 1
• HIQIJHYVHUJGQJ-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=NC=C1 HIQIJHYVHUJGQJ-UHFFFAOYSA-N 0.000 description 1
• QINALPOGVRVWGK-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=NC=CC=N1 QINALPOGVRVWGK-UHFFFAOYSA-N 0.000 description 1
• WIUIWVYDZYNMJM-UHFFFAOYSA-N n-[3-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=1)=CC=CC=1NC(=O)C1=CC=CS1 WIUIWVYDZYNMJM-UHFFFAOYSA-N 0.000 description 1
• IWFYXOZJPAMBSY-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=NO1 IWFYXOZJPAMBSY-UHFFFAOYSA-N 0.000 description 1
• TUZHGEPNEBVBOI-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CN=CO1 TUZHGEPNEBVBOI-UHFFFAOYSA-N 0.000 description 1
• FHMNCYCNWHAFIN-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CNC=N1 FHMNCYCNWHAFIN-UHFFFAOYSA-N 0.000 description 1
• JSTSFHJEYAESSF-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 JSTSFHJEYAESSF-UHFFFAOYSA-N 0.000 description 1
• UTBDUIVLKVKBGJ-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN1 UTBDUIVLKVKBGJ-UHFFFAOYSA-N 0.000 description 1
• OYUPFCMSNHIYFX-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)C(F)(F)F)C=C1 OYUPFCMSNHIYFX-UHFFFAOYSA-N 0.000 description 1
• YIFNXTKNYSTOQN-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 YIFNXTKNYSTOQN-UHFFFAOYSA-N 0.000 description 1
• KSAIUXQNNNBRGZ-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)C(C)(C)C)C=C1 KSAIUXQNNNBRGZ-UHFFFAOYSA-N 0.000 description 1
• OXYPWZDEFBASNR-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C OXYPWZDEFBASNR-UHFFFAOYSA-N 0.000 description 1
• SPPGJJQBAMKCOQ-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)C(C)C)C=C1 SPPGJJQBAMKCOQ-UHFFFAOYSA-N 0.000 description 1
• MTWIMUKUUHUEPF-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(C)=O)C=C1 MTWIMUKUUHUEPF-UHFFFAOYSA-N 0.000 description 1
• FNMKAUKQMSMLOP-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CCN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 FNMKAUKQMSMLOP-UHFFFAOYSA-N 0.000 description 1
• DCEPHPPAAOOHJK-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CO1 DCEPHPPAAOOHJK-UHFFFAOYSA-N 0.000 description 1
• IAUFKBXKHDXICM-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CCN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 IAUFKBXKHDXICM-UHFFFAOYSA-N 0.000 description 1
• AQFHUUKMWSDXTA-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NS(C)(=O)=O)C=C1 AQFHUUKMWSDXTA-UHFFFAOYSA-N 0.000 description 1
• VDBQZFJZSMBGFM-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CCN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 VDBQZFJZSMBGFM-UHFFFAOYSA-N 0.000 description 1
• UPHNXXXOUDCDLH-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC1=CC=C(NC(=O)CC)C=C1 UPHNXXXOUDCDLH-UHFFFAOYSA-N 0.000 description 1
• SCXQIVZRDUIILU-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 SCXQIVZRDUIILU-UHFFFAOYSA-N 0.000 description 1
• YTIYPPZQLHGQPC-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 YTIYPPZQLHGQPC-UHFFFAOYSA-N 0.000 description 1
• WVBRMHARSQKHPG-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 WVBRMHARSQKHPG-UHFFFAOYSA-N 0.000 description 1
• SMROTMCDOVLHED-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 SMROTMCDOVLHED-UHFFFAOYSA-N 0.000 description 1
• HXQNZPZSWSHSFJ-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CS1 HXQNZPZSWSHSFJ-UHFFFAOYSA-N 0.000 description 1
• QGYBCFIFZSASME-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=NO1 QGYBCFIFZSASME-UHFFFAOYSA-N 0.000 description 1
• CYKAGOZDZHOAHN-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CN=CO1 CYKAGOZDZHOAHN-UHFFFAOYSA-N 0.000 description 1
• LCDHDUQNYMTZEH-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CNC=N1 LCDHDUQNYMTZEH-UHFFFAOYSA-N 0.000 description 1
• RYYCAZCEXIGUKU-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=NNC=C1 RYYCAZCEXIGUKU-UHFFFAOYSA-N 0.000 description 1
• BIBWUEJLIBQZMH-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN1 BIBWUEJLIBQZMH-UHFFFAOYSA-N 0.000 description 1
• DPYXATRTEDSCIB-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC1=CC=C(NC(=O)C(F)(F)F)C=C1 DPYXATRTEDSCIB-UHFFFAOYSA-N 0.000 description 1
• ZWKRPCIADJBEHX-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 ZWKRPCIADJBEHX-UHFFFAOYSA-N 0.000 description 1
• OZBWDEPEJSIECI-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 OZBWDEPEJSIECI-UHFFFAOYSA-N 0.000 description 1
• ZPPDDYLMPYSMHI-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CO1 ZPPDDYLMPYSMHI-UHFFFAOYSA-N 0.000 description 1
• RJKZOBONKSQAKP-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]methanesulfonamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC1=CC=C(NS(C)(=O)=O)C=C1 RJKZOBONKSQAKP-UHFFFAOYSA-N 0.000 description 1
• WXSCEKPQXROWDR-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]propanamide Chemical compound C1=CC(NC(=O)CC)=CC=C1CCN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 WXSCEKPQXROWDR-UHFFFAOYSA-N 0.000 description 1
• GIIRMKFFPDJRKT-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 GIIRMKFFPDJRKT-UHFFFAOYSA-N 0.000 description 1
• BBJMZXHBKBTFGH-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 BBJMZXHBKBTFGH-UHFFFAOYSA-N 0.000 description 1
• YGQAAIKYSQHWDE-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 YGQAAIKYSQHWDE-UHFFFAOYSA-N 0.000 description 1
• JPIHCLQYSARLEP-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 JPIHCLQYSARLEP-UHFFFAOYSA-N 0.000 description 1
• IPZIYUPAOUYVNE-UHFFFAOYSA-N n-[4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CS1 IPZIYUPAOUYVNE-UHFFFAOYSA-N 0.000 description 1
• RTASDSQGAXKGOQ-UHFFFAOYSA-N n-[4-[2-[5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C2(C=CC=C(OC)C2)OC)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CNC=N1 RTASDSQGAXKGOQ-UHFFFAOYSA-N 0.000 description 1
• IZNUVJFSBZYMBU-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=NO1 IZNUVJFSBZYMBU-UHFFFAOYSA-N 0.000 description 1
• NLUAUKZRORAQNN-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CN=CO1 NLUAUKZRORAQNN-UHFFFAOYSA-N 0.000 description 1
• XAKQPDPOESIPPX-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CNC=N1 XAKQPDPOESIPPX-UHFFFAOYSA-N 0.000 description 1
• FPOMHKLQEXXPJE-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=NNC=C1 FPOMHKLQEXXPJE-UHFFFAOYSA-N 0.000 description 1
• SHGIWOBGFMBJRL-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN1 SHGIWOBGFMBJRL-UHFFFAOYSA-N 0.000 description 1
• NIXLYWIFCYFNKN-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 NIXLYWIFCYFNKN-UHFFFAOYSA-N 0.000 description 1
• MZKNOFSUXOYVAS-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CO1 MZKNOFSUXOYVAS-UHFFFAOYSA-N 0.000 description 1
• HRBRCOHGZGRWTD-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 HRBRCOHGZGRWTD-UHFFFAOYSA-N 0.000 description 1
• AGMSXFZQXYNUMM-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 AGMSXFZQXYNUMM-UHFFFAOYSA-N 0.000 description 1
• VMGCFFFRCRNSHY-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 VMGCFFFRCRNSHY-UHFFFAOYSA-N 0.000 description 1
• DYYHUFHYHJFPMS-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 DYYHUFHYHJFPMS-UHFFFAOYSA-N 0.000 description 1
• CRQRDQVMLISODL-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CS1 CRQRDQVMLISODL-UHFFFAOYSA-N 0.000 description 1
• XEBDPCFKQRTTQA-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=NO1 XEBDPCFKQRTTQA-UHFFFAOYSA-N 0.000 description 1
• PTIKTSADWKTVPB-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CN=CO1 PTIKTSADWKTVPB-UHFFFAOYSA-N 0.000 description 1
• IIVWCNYLHPMQGA-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CNC=N1 IIVWCNYLHPMQGA-UHFFFAOYSA-N 0.000 description 1
• KGUDCXCJZOOVAQ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=NNC=C1 KGUDCXCJZOOVAQ-UHFFFAOYSA-N 0.000 description 1
• LJRZQFFMYPQIHM-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN1 LJRZQFFMYPQIHM-UHFFFAOYSA-N 0.000 description 1
• LBIXRKGYFQHSQI-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 LBIXRKGYFQHSQI-UHFFFAOYSA-N 0.000 description 1
• ZUTKTKWEZHSAOM-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CO1 ZUTKTKWEZHSAOM-UHFFFAOYSA-N 0.000 description 1
• XIXNPSMJUQQIQP-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 XIXNPSMJUQQIQP-UHFFFAOYSA-N 0.000 description 1
• CBPZXGXRUCWMIR-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 CBPZXGXRUCWMIR-UHFFFAOYSA-N 0.000 description 1
• JUSWZUDWNNRPHT-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 JUSWZUDWNNRPHT-UHFFFAOYSA-N 0.000 description 1
• NNIUIJBZFHMMGG-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 NNIUIJBZFHMMGG-UHFFFAOYSA-N 0.000 description 1
• ZHVHFVLOXRRBQW-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CS1 ZHVHFVLOXRRBQW-UHFFFAOYSA-N 0.000 description 1
• BWLGAMAWFRRIPP-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=NO1 BWLGAMAWFRRIPP-UHFFFAOYSA-N 0.000 description 1
• GCNQJWJDBFBAQE-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CN=CO1 GCNQJWJDBFBAQE-UHFFFAOYSA-N 0.000 description 1
• LGOCOXSAHBDVMI-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 LGOCOXSAHBDVMI-UHFFFAOYSA-N 0.000 description 1
• MGPIAFZJLXZMLL-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN1 MGPIAFZJLXZMLL-UHFFFAOYSA-N 0.000 description 1
• PPWIPAGTAOPUHU-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C PPWIPAGTAOPUHU-UHFFFAOYSA-N 0.000 description 1
• XUVMSPAQRRAOKJ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CO1 XUVMSPAQRRAOKJ-UHFFFAOYSA-N 0.000 description 1
• UIZWUNAUXKYDCI-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 UIZWUNAUXKYDCI-UHFFFAOYSA-N 0.000 description 1
• CGEMOJROLAKCQJ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 CGEMOJROLAKCQJ-UHFFFAOYSA-N 0.000 description 1
• GXOYIWGTZNBUSJ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 GXOYIWGTZNBUSJ-UHFFFAOYSA-N 0.000 description 1
• DMMZJFKEYVEBSA-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 DMMZJFKEYVEBSA-UHFFFAOYSA-N 0.000 description 1
• IRGRHOYYJULIMC-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]ethyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CS1 IRGRHOYYJULIMC-UHFFFAOYSA-N 0.000 description 1
• AEMQDYZVKHJMQE-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=NO1 AEMQDYZVKHJMQE-UHFFFAOYSA-N 0.000 description 1
• KRLHCPXYHQFZEO-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CN=CO1 KRLHCPXYHQFZEO-UHFFFAOYSA-N 0.000 description 1
• HFJABNMXIVQBBO-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CNC=N1 HFJABNMXIVQBBO-UHFFFAOYSA-N 0.000 description 1
• VJHLADRYVHCFLW-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 VJHLADRYVHCFLW-UHFFFAOYSA-N 0.000 description 1
• KNSNXPZIQWWKNO-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN1 KNSNXPZIQWWKNO-UHFFFAOYSA-N 0.000 description 1
• PRDHRXPNINEGCQ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C PRDHRXPNINEGCQ-UHFFFAOYSA-N 0.000 description 1
• VANZRBCPYBRKBJ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CO1 VANZRBCPYBRKBJ-UHFFFAOYSA-N 0.000 description 1
• SBZRRFVUIRKDCC-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 SBZRRFVUIRKDCC-UHFFFAOYSA-N 0.000 description 1
• RESWNVMYCWUOTK-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 RESWNVMYCWUOTK-UHFFFAOYSA-N 0.000 description 1
• YKHNVQVLVXQRBI-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 YKHNVQVLVXQRBI-UHFFFAOYSA-N 0.000 description 1
• JVEKGXZQOCILCT-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 JVEKGXZQOCILCT-UHFFFAOYSA-N 0.000 description 1
• BENZCPJSOQESQZ-UHFFFAOYSA-N n-[4-[2-[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]ethyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CCC(C=C1)=CC=C1NC(=O)C1=CC=CS1 BENZCPJSOQESQZ-UHFFFAOYSA-N 0.000 description 1
• MBHPUMMXXROVCO-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 MBHPUMMXXROVCO-UHFFFAOYSA-N 0.000 description 1
• IPNQYRCSOBCLEK-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 IPNQYRCSOBCLEK-UHFFFAOYSA-N 0.000 description 1
• LTWQOOIKLJMWLV-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 LTWQOOIKLJMWLV-UHFFFAOYSA-N 0.000 description 1
• QRKDVEJCYZUCCZ-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 QRKDVEJCYZUCCZ-UHFFFAOYSA-N 0.000 description 1
• VSHAMVOINWKBNY-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 VSHAMVOINWKBNY-UHFFFAOYSA-N 0.000 description 1
• LSFVJFOCSYCHAI-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 LSFVJFOCSYCHAI-UHFFFAOYSA-N 0.000 description 1
• FBUHCJPUQGHCQP-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C FBUHCJPUQGHCQP-UHFFFAOYSA-N 0.000 description 1
• PRNJBLLHHKZGEK-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 PRNJBLLHHKZGEK-UHFFFAOYSA-N 0.000 description 1
• WKTCAVZKUCNILW-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 WKTCAVZKUCNILW-UHFFFAOYSA-N 0.000 description 1
• BGOWBMHUFXVWEU-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 BGOWBMHUFXVWEU-UHFFFAOYSA-N 0.000 description 1
• KWBZKPARMAXPHP-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 KWBZKPARMAXPHP-UHFFFAOYSA-N 0.000 description 1
• RULAZHPFDSCPQW-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 RULAZHPFDSCPQW-UHFFFAOYSA-N 0.000 description 1
• PKXMAPSZMRMFSS-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC)=CC=2)=N1 PKXMAPSZMRMFSS-UHFFFAOYSA-N 0.000 description 1
• PTYRBJQQCCESNG-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 PTYRBJQQCCESNG-UHFFFAOYSA-N 0.000 description 1
• SHUUQVVWLZEKGT-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 SHUUQVVWLZEKGT-UHFFFAOYSA-N 0.000 description 1
• CSWXHGBPTZTYGR-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 CSWXHGBPTZTYGR-UHFFFAOYSA-N 0.000 description 1
• BGVKUPJIIQZFSV-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 BGVKUPJIIQZFSV-UHFFFAOYSA-N 0.000 description 1
• MHSYGHCWYPWZHF-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 MHSYGHCWYPWZHF-UHFFFAOYSA-N 0.000 description 1
• ZYQNZHAOXKCSQR-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 ZYQNZHAOXKCSQR-UHFFFAOYSA-N 0.000 description 1
• LDARLIAUQDIQHK-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 LDARLIAUQDIQHK-UHFFFAOYSA-N 0.000 description 1
• WKXGPSOMVHQYNP-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 WKXGPSOMVHQYNP-UHFFFAOYSA-N 0.000 description 1
• NFPVJCMZMRJSDC-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=NNC=C1 NFPVJCMZMRJSDC-UHFFFAOYSA-N 0.000 description 1
• DWBOLKDQWCIYTI-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 DWBOLKDQWCIYTI-UHFFFAOYSA-N 0.000 description 1
• YAQARPAYPJFFAV-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 YAQARPAYPJFFAV-UHFFFAOYSA-N 0.000 description 1
• JNUJNRBXGMMBJK-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 JNUJNRBXGMMBJK-UHFFFAOYSA-N 0.000 description 1
• OLRMAKQDIIWJJO-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 OLRMAKQDIIWJJO-UHFFFAOYSA-N 0.000 description 1
• HLNLAZJQLNOYKY-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperazin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCNCC1 HLNLAZJQLNOYKY-UHFFFAOYSA-N 0.000 description 1
• HAAWTNQVPFNWLN-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCCC1 HAAWTNQVPFNWLN-UHFFFAOYSA-N 0.000 description 1
• SBEAHBVTSNKPAT-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCC1 SBEAHBVTSNKPAT-UHFFFAOYSA-N 0.000 description 1
• ZVEPYXXYRFAWFJ-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCSCC1 ZVEPYXXYRFAWFJ-UHFFFAOYSA-N 0.000 description 1
• ZFQZWPZVVVPQDM-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCNCC1 ZFQZWPZVVVPQDM-UHFFFAOYSA-N 0.000 description 1
• KOZRQTSMVZWPAB-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCC1 KOZRQTSMVZWPAB-UHFFFAOYSA-N 0.000 description 1
• AWLOEJYMXAWOGI-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(NC(C)=O)C=C1 AWLOEJYMXAWOGI-UHFFFAOYSA-N 0.000 description 1
• AECIDAYTQNOEET-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 AECIDAYTQNOEET-UHFFFAOYSA-N 0.000 description 1
• RLHKDZXDIOQPQP-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 RLHKDZXDIOQPQP-UHFFFAOYSA-N 0.000 description 1
• ZXQVNJNCZWCWGF-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(NS(C)(=O)=O)C=C1 ZXQVNJNCZWCWGF-UHFFFAOYSA-N 0.000 description 1
• CYQBZXRICWGEDT-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 CYQBZXRICWGEDT-UHFFFAOYSA-N 0.000 description 1
• RVRIMMYYXWINPA-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound C1=CC(NC(=O)CC)=CC=C1CN1C(=O)CCC(C=2C=C(OC)C(OC)=CC=2)=N1 RVRIMMYYXWINPA-UHFFFAOYSA-N 0.000 description 1
• BTUUBDYJMHFGGV-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 BTUUBDYJMHFGGV-UHFFFAOYSA-N 0.000 description 1
• HNKIVFWNYCJMMO-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 HNKIVFWNYCJMMO-UHFFFAOYSA-N 0.000 description 1
• UKVNJWQPLOHQOA-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 UKVNJWQPLOHQOA-UHFFFAOYSA-N 0.000 description 1
• HIVDKVAVQJTLRW-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 HIVDKVAVQJTLRW-UHFFFAOYSA-N 0.000 description 1
• SJFPWFQMGFXJCJ-UHFFFAOYSA-N n-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 SJFPWFQMGFXJCJ-UHFFFAOYSA-N 0.000 description 1
• VOBCNTVBQRWBEE-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 VOBCNTVBQRWBEE-UHFFFAOYSA-N 0.000 description 1
• SQKGYPJMGBEAES-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 SQKGYPJMGBEAES-UHFFFAOYSA-N 0.000 description 1
• ZZLPOMCWVPJZJM-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 ZZLPOMCWVPJZJM-UHFFFAOYSA-N 0.000 description 1
• ALBVLVFUQAEHSZ-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 ALBVLVFUQAEHSZ-UHFFFAOYSA-N 0.000 description 1
• AVMITOPIIUCYTG-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 AVMITOPIIUCYTG-UHFFFAOYSA-N 0.000 description 1
• PUQVDLZHRJKYEE-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 PUQVDLZHRJKYEE-UHFFFAOYSA-N 0.000 description 1
• IFVURQPKIBABJK-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 IFVURQPKIBABJK-UHFFFAOYSA-N 0.000 description 1
• XUFQWDWAQVZSPG-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C XUFQWDWAQVZSPG-UHFFFAOYSA-N 0.000 description 1
• OCONMAIEXHJGSP-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 OCONMAIEXHJGSP-UHFFFAOYSA-N 0.000 description 1
• CUTIOIUGZCUMQC-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 CUTIOIUGZCUMQC-UHFFFAOYSA-N 0.000 description 1
• UTSNJDJNGJGUQO-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 UTSNJDJNGJGUQO-UHFFFAOYSA-N 0.000 description 1
• DKNWRJSSKAVEJC-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 DKNWRJSSKAVEJC-UHFFFAOYSA-N 0.000 description 1
• IUZCFXXYSNPJLV-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 IUZCFXXYSNPJLV-UHFFFAOYSA-N 0.000 description 1
• MKNQYAVCUIOWFU-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 MKNQYAVCUIOWFU-UHFFFAOYSA-N 0.000 description 1
• WJQATSQKYADHBS-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 WJQATSQKYADHBS-UHFFFAOYSA-N 0.000 description 1
• OBJGSJYNUIIBSW-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 OBJGSJYNUIIBSW-UHFFFAOYSA-N 0.000 description 1
• JCVRBAQBXJQLKS-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 JCVRBAQBXJQLKS-UHFFFAOYSA-N 0.000 description 1
• QCPGMQADJZUNSA-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 QCPGMQADJZUNSA-UHFFFAOYSA-N 0.000 description 1
• BNCSZZZDIKCRMH-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 BNCSZZZDIKCRMH-UHFFFAOYSA-N 0.000 description 1
• LSEMFCQGPRBWOJ-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 LSEMFCQGPRBWOJ-UHFFFAOYSA-N 0.000 description 1
• BBXYTIFELMUEAC-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 BBXYTIFELMUEAC-UHFFFAOYSA-N 0.000 description 1
• SYFLPVBOKGKOKR-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(F)(F)F)=CC=3)N=2)C=C1OC1CCCC1 SYFLPVBOKGKOKR-UHFFFAOYSA-N 0.000 description 1
• WSNNHTBNKKUSHM-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(F)(F)C(F)(F)F)=CC=3)N=2)C=C1OC1CCCC1 WSNNHTBNKKUSHM-UHFFFAOYSA-N 0.000 description 1
• REALZWXLYIBYKE-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(C)C)=CC=3)N=2)C=C1OC1CCCC1 REALZWXLYIBYKE-UHFFFAOYSA-N 0.000 description 1
• FJSMNFXWAQBRNM-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-morpholin-4-ylacetamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCOCC4)=CC=3)N=2)C=C1OC1CCCC1 FJSMNFXWAQBRNM-UHFFFAOYSA-N 0.000 description 1
• WIZHJALLHGDAHF-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCCCC4)=CC=3)N=2)C=C1OC1CCCC1 WIZHJALLHGDAHF-UHFFFAOYSA-N 0.000 description 1
• TVKAMNQBMPAOEX-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCCC4)=CC=3)N=2)C=C1OC1CCCC1 TVKAMNQBMPAOEX-UHFFFAOYSA-N 0.000 description 1
• QLVIAQGIOKNCBR-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCSCC4)=CC=3)N=2)C=C1OC1CCCC1 QLVIAQGIOKNCBR-UHFFFAOYSA-N 0.000 description 1
• BNOQNSXAFYGPFU-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCNCC4)=CC=3)N=2)C=C1OC1CCCC1 BNOQNSXAFYGPFU-UHFFFAOYSA-N 0.000 description 1
• UKYGRTHETUBPPM-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCCCC4)=CC=3)N=2)C=C1OC1CCCC1 UKYGRTHETUBPPM-UHFFFAOYSA-N 0.000 description 1
• WYJJWADQSFEHMD-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCSCC4)=CC=3)N=2)C=C1OC1CCCC1 WYJJWADQSFEHMD-UHFFFAOYSA-N 0.000 description 1
• IBXQKJVVUSVAIR-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(C)=O)=CC=3)N=2)C=C1OC1CCCC1 IBXQKJVVUSVAIR-UHFFFAOYSA-N 0.000 description 1
• BBORXPQCZISKOE-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 BBORXPQCZISKOE-UHFFFAOYSA-N 0.000 description 1
• SANNOJVJYJBWIU-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 SANNOJVJYJBWIU-UHFFFAOYSA-N 0.000 description 1
• RWHXIXAHQDVKLN-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NS(C)(=O)=O)=CC=3)N=2)C=C1OC1CCCC1 RWHXIXAHQDVKLN-UHFFFAOYSA-N 0.000 description 1
• HXSNJHGXUZJLCU-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 HXSNJHGXUZJLCU-UHFFFAOYSA-N 0.000 description 1
• BMHVXNYLFKEJMJ-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound C1=CC(NC(=O)CC)=CC=C1CN1C(=O)CCC(C=2C=C(OC3CCCC3)C(OC)=CC=2)=N1 BMHVXNYLFKEJMJ-UHFFFAOYSA-N 0.000 description 1
• GVNSPPGQBCFJIX-UHFFFAOYSA-N n-[4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(NC(=O)C=4C=NC=CC=4)=CC=3)N=2)C=C1OC1CCCC1 GVNSPPGQBCFJIX-UHFFFAOYSA-N 0.000 description 1
• WLNXZJHGUJNZRN-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4ON=CC=4)=CC=3)N=2)CC)=C1 WLNXZJHGUJNZRN-UHFFFAOYSA-N 0.000 description 1
• XINNVXXNRTZJCM-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4OC=NC=4)=CC=3)N=2)CC)=C1 XINNVXXNRTZJCM-UHFFFAOYSA-N 0.000 description 1
• JLGVUAXSTZHWFP-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4N=CNC=4)=CC=3)N=2)CC)=C1 JLGVUAXSTZHWFP-UHFFFAOYSA-N 0.000 description 1
• PYNUQPZHMRYALR-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C4=NNC=C4)=CC=3)N=2)CC)=C1 PYNUQPZHMRYALR-UHFFFAOYSA-N 0.000 description 1
• MGRHBPLLERCIFZ-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4NC=CC=4)=CC=3)N=2)CC)=C1 MGRHBPLLERCIFZ-UHFFFAOYSA-N 0.000 description 1
• BFXUMFUKHBKVIC-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C(F)(F)F)=CC=3)N=2)CC)=C1 BFXUMFUKHBKVIC-UHFFFAOYSA-N 0.000 description 1
• DHURZQUZNBYUSO-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C(F)(F)C(F)(F)F)=CC=3)N=2)CC)=C1 DHURZQUZNBYUSO-UHFFFAOYSA-N 0.000 description 1
• LACQSLSXBQMUFN-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C(C)(C)C)=CC=3)N=2)CC)=C1 LACQSLSXBQMUFN-UHFFFAOYSA-N 0.000 description 1
• ARWQIOOMNFJDHS-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C4=C(N=C(C)S4)C)=CC=3)N=2)CC)=C1 ARWQIOOMNFJDHS-UHFFFAOYSA-N 0.000 description 1
• YUAXUZSFVYZZEB-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C(C)C)=CC=3)N=2)CC)=C1 YUAXUZSFVYZZEB-UHFFFAOYSA-N 0.000 description 1
• RMRQPQJNYZCTEJ-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(C)=O)=CC=3)N=2)CC)=C1 RMRQPQJNYZCTEJ-UHFFFAOYSA-N 0.000 description 1
• XASGVCNLRXHAJR-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCC)C(OC)=CC=2)=N1 XASGVCNLRXHAJR-UHFFFAOYSA-N 0.000 description 1
• UXBNRRSFSQZZQC-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4OC=CC=4)=CC=3)N=2)CC)=C1 UXBNRRSFSQZZQC-UHFFFAOYSA-N 0.000 description 1
• QOSCEQNBCIBURY-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCC)C(OC)=CC=2)=N1 QOSCEQNBCIBURY-UHFFFAOYSA-N 0.000 description 1
• OUUQCVWXABMTMH-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NS(C)(=O)=O)=CC=3)N=2)CC)=C1 OUUQCVWXABMTMH-UHFFFAOYSA-N 0.000 description 1
• HYFFZJTTXOPJKZ-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCC)C(OC)=CC=2)=N1 HYFFZJTTXOPJKZ-UHFFFAOYSA-N 0.000 description 1
• LBJQHGPEOJULDC-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)CC)=CC=3)N=2)CC)=C1 LBJQHGPEOJULDC-UHFFFAOYSA-N 0.000 description 1
• HHHWSEYYWLVHNN-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4N=CC=NC=4)=CC=3)N=2)CC)=C1 HHHWSEYYWLVHNN-UHFFFAOYSA-N 0.000 description 1
• FEQJEKBWGYQLMR-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4C=NC=CC=4)=CC=3)N=2)CC)=C1 FEQJEKBWGYQLMR-UHFFFAOYSA-N 0.000 description 1
• MMUIYLYVAKIMDS-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4C=CN=CC=4)=CC=3)N=2)CC)=C1 MMUIYLYVAKIMDS-UHFFFAOYSA-N 0.000 description 1
• JODUTSBYCKGLSC-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4N=CC=CN=4)=CC=3)N=2)CC)=C1 JODUTSBYCKGLSC-UHFFFAOYSA-N 0.000 description 1
• RYYLIDGBAQVDFN-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(NC(=O)C=4SC=CC=4)=CC=3)N=2)CC)=C1 RYYLIDGBAQVDFN-UHFFFAOYSA-N 0.000 description 1
• ZOYFOSSAHQFOOR-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C=4ON=CC=4)=CC=3)N=2)=C1 ZOYFOSSAHQFOOR-UHFFFAOYSA-N 0.000 description 1
• JLQUJLQUKSYJEQ-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(F)(F)F)=CC=3)N=2)=C1 JLQUJLQUKSYJEQ-UHFFFAOYSA-N 0.000 description 1
• DNBUBKXHWQHGFC-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(F)(F)C(F)(F)F)=CC=3)N=2)=C1 DNBUBKXHWQHGFC-UHFFFAOYSA-N 0.000 description 1
• KRVZISUMWLQUDQ-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(C)(C)C)=CC=3)N=2)=C1 KRVZISUMWLQUDQ-UHFFFAOYSA-N 0.000 description 1
• GWHXPTVJUUAPNH-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C(C)C)=CC=3)N=2)=C1 GWHXPTVJUUAPNH-UHFFFAOYSA-N 0.000 description 1
• UKBOLVXCNPJLHD-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperazin-1-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCNCC4)=CC=3)N=2)=C1 UKBOLVXCNPJLHD-UHFFFAOYSA-N 0.000 description 1
• ZHUBXVRUKABNCU-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCCCC4)=CC=3)N=2)=C1 ZHUBXVRUKABNCU-UHFFFAOYSA-N 0.000 description 1
• MDUOPEGENPYDJZ-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCCC4)=CC=3)N=2)=C1 MDUOPEGENPYDJZ-UHFFFAOYSA-N 0.000 description 1
• WJSRAXULYOWFSX-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCSCC4)=CC=3)N=2)=C1 WJSRAXULYOWFSX-UHFFFAOYSA-N 0.000 description 1
• KGFCQLSISMEIKX-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCNCC4)=CC=3)N=2)=C1 KGFCQLSISMEIKX-UHFFFAOYSA-N 0.000 description 1
• WSBSPQZFGLNQLA-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCCCC4)=CC=3)N=2)=C1 WSBSPQZFGLNQLA-UHFFFAOYSA-N 0.000 description 1
• KDBBMZBWBVUJNV-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCCC4)=CC=3)N=2)=C1 KDBBMZBWBVUJNV-UHFFFAOYSA-N 0.000 description 1
• JQFDTKJVMJNMBH-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(C)=O)=CC=3)N=2)=C1 JQFDTKJVMJNMBH-UHFFFAOYSA-N 0.000 description 1
• YAIONCUIWZHWIT-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NS(C)(=O)=O)=CC=3)N=2)=C1 YAIONCUIWZHWIT-UHFFFAOYSA-N 0.000 description 1
• KLYCBRRGMSPFAR-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CCC(C=2C=C(OCC)C(OC)=CC=2)=N1 KLYCBRRGMSPFAR-UHFFFAOYSA-N 0.000 description 1
• FMLLPRFROXWDGX-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CC)=CC=3)N=2)=C1 FMLLPRFROXWDGX-UHFFFAOYSA-N 0.000 description 1
• RYAZKYJTMOBZAY-UHFFFAOYSA-N n-[4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)C=4N=CC=NC=4)=CC=3)N=2)=C1 RYAZKYJTMOBZAY-UHFFFAOYSA-N 0.000 description 1
• BJMMXXDQVHURCE-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 BJMMXXDQVHURCE-UHFFFAOYSA-N 0.000 description 1
• PISLJLPWUAJECG-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 PISLJLPWUAJECG-UHFFFAOYSA-N 0.000 description 1
• BCISJKYRXHAMGY-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 BCISJKYRXHAMGY-UHFFFAOYSA-N 0.000 description 1
• CJHVARVRYNVJJV-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=NNC=C1 CJHVARVRYNVJJV-UHFFFAOYSA-N 0.000 description 1
• UBPYWNXZBLBOJC-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 UBPYWNXZBLBOJC-UHFFFAOYSA-N 0.000 description 1
• ZHQZKFNFDHFZSI-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 ZHQZKFNFDHFZSI-UHFFFAOYSA-N 0.000 description 1
• QHHTYWSEVMSGGP-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 QHHTYWSEVMSGGP-UHFFFAOYSA-N 0.000 description 1
• FLCYGAFSJFQXCN-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 FLCYGAFSJFQXCN-UHFFFAOYSA-N 0.000 description 1
• KOESPSISQDYAQB-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 KOESPSISQDYAQB-UHFFFAOYSA-N 0.000 description 1
• MUCYJVZYUXETJR-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 MUCYJVZYUXETJR-UHFFFAOYSA-N 0.000 description 1
• UUEKRVUGLITNEP-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 UUEKRVUGLITNEP-UHFFFAOYSA-N 0.000 description 1
• KBBLZRXBDNIOTO-UHFFFAOYSA-N n-[4-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 KBBLZRXBDNIOTO-UHFFFAOYSA-N 0.000 description 1
• QMHOFQBGFJUMNV-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCCC1 QMHOFQBGFJUMNV-UHFFFAOYSA-N 0.000 description 1
• YTHSMQJICPJLQI-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCC1 YTHSMQJICPJLQI-UHFFFAOYSA-N 0.000 description 1
• RKWHFSQHSINRRE-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCSCC1 RKWHFSQHSINRRE-UHFFFAOYSA-N 0.000 description 1
• YUVGHOZKMXWGLB-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCNCC1 YUVGHOZKMXWGLB-UHFFFAOYSA-N 0.000 description 1
• FXLPZQJOFFEUES-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCCC1 FXLPZQJOFFEUES-UHFFFAOYSA-N 0.000 description 1
• TVUSLENZBVKRTN-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCC1 TVUSLENZBVKRTN-UHFFFAOYSA-N 0.000 description 1
• ZZLQXZNKOJBHFL-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propan-2-yloxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CCC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCSCC1 ZZLQXZNKOJBHFL-UHFFFAOYSA-N 0.000 description 1
• IJKWZVSXSRQBSS-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCCCC4)=CC=3)N=2)=C1 IJKWZVSXSRQBSS-UHFFFAOYSA-N 0.000 description 1
• OBVJNFXQWVCJAA-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCCC4)=CC=3)N=2)=C1 OBVJNFXQWVCJAA-UHFFFAOYSA-N 0.000 description 1
• BYMIZIMEYOCPCF-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CN4CCSCC4)=CC=3)N=2)=C1 BYMIZIMEYOCPCF-UHFFFAOYSA-N 0.000 description 1
• IGCYDCXJJQXDMO-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCNCC4)=CC=3)N=2)=C1 IGCYDCXJJQXDMO-UHFFFAOYSA-N 0.000 description 1
• MVAGKSZLQAWSDL-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCCCC4)=CC=3)N=2)=C1 MVAGKSZLQAWSDL-UHFFFAOYSA-N 0.000 description 1
• PVRNCOSNMUOFEW-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCCC4)=CC=3)N=2)=C1 PVRNCOSNMUOFEW-UHFFFAOYSA-N 0.000 description 1
• UKDPNLDMETVFLC-UHFFFAOYSA-N n-[4-[[3-(4-methoxy-3-propoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CCC(=O)N(CC=3C=CC(NC(=O)CCN4CCSCC4)=CC=3)N=2)=C1 UKDPNLDMETVFLC-UHFFFAOYSA-N 0.000 description 1
• JEQQGCHKXGNWIC-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 JEQQGCHKXGNWIC-UHFFFAOYSA-N 0.000 description 1
• OLPMYXMPBHUJGD-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 OLPMYXMPBHUJGD-UHFFFAOYSA-N 0.000 description 1
• JJLHYDCMSUUSNY-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 JJLHYDCMSUUSNY-UHFFFAOYSA-N 0.000 description 1
• FKYUQBJSAZJOBR-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 FKYUQBJSAZJOBR-UHFFFAOYSA-N 0.000 description 1
• YFNAQNDMZKYXKU-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 YFNAQNDMZKYXKU-UHFFFAOYSA-N 0.000 description 1
• DDDMBWGBYSUDMS-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 DDDMBWGBYSUDMS-UHFFFAOYSA-N 0.000 description 1
• LDSJRRUDEKIZDM-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 LDSJRRUDEKIZDM-UHFFFAOYSA-N 0.000 description 1
• VMAWCHLKNPYXMY-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C VMAWCHLKNPYXMY-UHFFFAOYSA-N 0.000 description 1
• PIIHCEDSBYGBFO-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 PIIHCEDSBYGBFO-UHFFFAOYSA-N 0.000 description 1
• MWFQAZPZZBYGJW-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 MWFQAZPZZBYGJW-UHFFFAOYSA-N 0.000 description 1
• ZUHWGUYDZOSNNJ-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)F)C(OC)=CC=2)=N1 ZUHWGUYDZOSNNJ-UHFFFAOYSA-N 0.000 description 1
• YSFJQJDCEMKVOE-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 YSFJQJDCEMKVOE-UHFFFAOYSA-N 0.000 description 1
• SILTUOASIBVKSO-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)F)C(OC)=CC=2)=N1 SILTUOASIBVKSO-UHFFFAOYSA-N 0.000 description 1
• JXCGXFLJXNOVRF-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 JXCGXFLJXNOVRF-UHFFFAOYSA-N 0.000 description 1
• ZTPWIWUMDSNZBM-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)F)C(OC)=CC=2)=N1 ZTPWIWUMDSNZBM-UHFFFAOYSA-N 0.000 description 1
• UUFLWYHRTHRVJZ-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 UUFLWYHRTHRVJZ-UHFFFAOYSA-N 0.000 description 1
• CBBNKIIPZKDKEW-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 CBBNKIIPZKDKEW-UHFFFAOYSA-N 0.000 description 1
• DIKZVNCRPUTSRH-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 DIKZVNCRPUTSRH-UHFFFAOYSA-N 0.000 description 1
• WXPHWCORPDPDQA-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 WXPHWCORPDPDQA-UHFFFAOYSA-N 0.000 description 1
• IBMCLTFTGABOJD-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 IBMCLTFTGABOJD-UHFFFAOYSA-N 0.000 description 1
• FZOOJIXNSQZYEK-UHFFFAOYSA-N n-[4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 FZOOJIXNSQZYEK-UHFFFAOYSA-N 0.000 description 1
• SHFBBLCHRRMBTF-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 SHFBBLCHRRMBTF-UHFFFAOYSA-N 0.000 description 1
• UBYYJNQLVFSYNF-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 UBYYJNQLVFSYNF-UHFFFAOYSA-N 0.000 description 1
• OOTVKVYVTRJRSB-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 OOTVKVYVTRJRSB-UHFFFAOYSA-N 0.000 description 1
• IEKGLSSYZYAZKI-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 IEKGLSSYZYAZKI-UHFFFAOYSA-N 0.000 description 1
• NTVSVXPWOQOMBE-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 NTVSVXPWOQOMBE-UHFFFAOYSA-N 0.000 description 1
• FYYSLMHQILXIFU-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 FYYSLMHQILXIFU-UHFFFAOYSA-N 0.000 description 1
• ZBVPUKXCQJRLSM-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 ZBVPUKXCQJRLSM-UHFFFAOYSA-N 0.000 description 1
• SPRWJXJQAGTLFT-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 SPRWJXJQAGTLFT-UHFFFAOYSA-N 0.000 description 1
• UHBXXXHIBHDQSV-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C UHBXXXHIBHDQSV-UHFFFAOYSA-N 0.000 description 1
• CQJYATXWKYHDDQ-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 CQJYATXWKYHDDQ-UHFFFAOYSA-N 0.000 description 1
• DQTUNCRUEGQJFY-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 DQTUNCRUEGQJFY-UHFFFAOYSA-N 0.000 description 1
• LJVHZLMYINIMGH-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)F)=CC=2)=N1 LJVHZLMYINIMGH-UHFFFAOYSA-N 0.000 description 1
• QEKMHKSERSEZKF-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 QEKMHKSERSEZKF-UHFFFAOYSA-N 0.000 description 1
• CFPFPGKZDDXKSJ-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)F)=CC=2)=N1 CFPFPGKZDDXKSJ-UHFFFAOYSA-N 0.000 description 1
• SGHZTKREHZSOIV-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 SGHZTKREHZSOIV-UHFFFAOYSA-N 0.000 description 1
• CHMPNJNMGSHZLL-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)F)=CC=2)=N1 CHMPNJNMGSHZLL-UHFFFAOYSA-N 0.000 description 1
• WMHMDERCUYXSOH-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 WMHMDERCUYXSOH-UHFFFAOYSA-N 0.000 description 1
• BWRJRWGVCDLKRZ-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 BWRJRWGVCDLKRZ-UHFFFAOYSA-N 0.000 description 1
• HNIFXTDOMHUYKX-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 HNIFXTDOMHUYKX-UHFFFAOYSA-N 0.000 description 1
• MOSAFUDEUCNXRN-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 MOSAFUDEUCNXRN-UHFFFAOYSA-N 0.000 description 1
• PVIVPXVBAADOLZ-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 PVIVPXVBAADOLZ-UHFFFAOYSA-N 0.000 description 1
• BZLWTTPAXCUADJ-UHFFFAOYSA-N n-[4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 BZLWTTPAXCUADJ-UHFFFAOYSA-N 0.000 description 1
• ZWOSZZFOVIETJY-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 ZWOSZZFOVIETJY-UHFFFAOYSA-N 0.000 description 1
• YJXNUUHGJLSEKQ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 YJXNUUHGJLSEKQ-UHFFFAOYSA-N 0.000 description 1
• LUCNKNZILSEHAI-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 LUCNKNZILSEHAI-UHFFFAOYSA-N 0.000 description 1
• YXSWJQLMTMKAKY-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 YXSWJQLMTMKAKY-UHFFFAOYSA-N 0.000 description 1
• RXGLUKINSAIOII-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 RXGLUKINSAIOII-UHFFFAOYSA-N 0.000 description 1
• WLYZJPNXHWDQIB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C WLYZJPNXHWDQIB-UHFFFAOYSA-N 0.000 description 1
• UCDQOMDPZRIUBO-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 UCDQOMDPZRIUBO-UHFFFAOYSA-N 0.000 description 1
• MDBYYOONFNIWNF-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 MDBYYOONFNIWNF-UHFFFAOYSA-N 0.000 description 1
• LRSVVNCTCXUSCD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 LRSVVNCTCXUSCD-UHFFFAOYSA-N 0.000 description 1
• MJRLLLYRDRGGQE-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 MJRLLLYRDRGGQE-UHFFFAOYSA-N 0.000 description 1
• YMUIUPFPWHOAAM-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 YMUIUPFPWHOAAM-UHFFFAOYSA-N 0.000 description 1
• MEKDRKAJONTVED-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 MEKDRKAJONTVED-UHFFFAOYSA-N 0.000 description 1
• TWOMFFJHECQDIK-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 TWOMFFJHECQDIK-UHFFFAOYSA-N 0.000 description 1
• NEAULNZBTHBWFR-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 NEAULNZBTHBWFR-UHFFFAOYSA-N 0.000 description 1
• BCACEEZPMUYRNH-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 BCACEEZPMUYRNH-UHFFFAOYSA-N 0.000 description 1
• DOOUPITZKWIRKU-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 DOOUPITZKWIRKU-UHFFFAOYSA-N 0.000 description 1
• CYBGRGZRVWLNOT-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C CYBGRGZRVWLNOT-UHFFFAOYSA-N 0.000 description 1
• KVCZSKRHHKCVGF-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 KVCZSKRHHKCVGF-UHFFFAOYSA-N 0.000 description 1
• ALTSTELFKHAWHR-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 ALTSTELFKHAWHR-UHFFFAOYSA-N 0.000 description 1
• HRFLPEFRIGSTSZ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 HRFLPEFRIGSTSZ-UHFFFAOYSA-N 0.000 description 1
• RVIWCXRRPLYSEB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 RVIWCXRRPLYSEB-UHFFFAOYSA-N 0.000 description 1
• ZYEHTPJNYXFSJB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 ZYEHTPJNYXFSJB-UHFFFAOYSA-N 0.000 description 1
• HRMPYTXZTZQHDC-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 HRMPYTXZTZQHDC-UHFFFAOYSA-N 0.000 description 1
• UCJCZNVRFLMMHN-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 UCJCZNVRFLMMHN-UHFFFAOYSA-N 0.000 description 1
• JOPQNYOJVHHEPY-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 JOPQNYOJVHHEPY-UHFFFAOYSA-N 0.000 description 1
• NCCPKCVRZNOZCP-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 NCCPKCVRZNOZCP-UHFFFAOYSA-N 0.000 description 1
• KKPOYFNFGVFGEY-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 KKPOYFNFGVFGEY-UHFFFAOYSA-N 0.000 description 1
• WGJGDKSUGNLHHO-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 WGJGDKSUGNLHHO-UHFFFAOYSA-N 0.000 description 1
• ANMXUQSCQSFLCL-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 ANMXUQSCQSFLCL-UHFFFAOYSA-N 0.000 description 1
• BXCUWZXHKFQMAI-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 BXCUWZXHKFQMAI-UHFFFAOYSA-N 0.000 description 1
• BODCHTXFYNUURR-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 BODCHTXFYNUURR-UHFFFAOYSA-N 0.000 description 1
• MNBQEFSLFSWPEY-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCF)C(OC)=CC=2)=N1 MNBQEFSLFSWPEY-UHFFFAOYSA-N 0.000 description 1
• VYYXVPVBHHKRTP-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCF)C(OC)=CC=2)=N1 VYYXVPVBHHKRTP-UHFFFAOYSA-N 0.000 description 1
• AQWCCKWIQGHHHL-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 AQWCCKWIQGHHHL-UHFFFAOYSA-N 0.000 description 1
• JTODFCKXJFWTSW-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OCF)C(OC)=CC=2)=N1 JTODFCKXJFWTSW-UHFFFAOYSA-N 0.000 description 1
• GROSGNBOPNAJBA-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 GROSGNBOPNAJBA-UHFFFAOYSA-N 0.000 description 1
• IJKBFBQKDSQTDG-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 IJKBFBQKDSQTDG-UHFFFAOYSA-N 0.000 description 1
• HXGPXXNYXFUWBJ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 HXGPXXNYXFUWBJ-UHFFFAOYSA-N 0.000 description 1
• ZMRCRFCRVPCTSH-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 ZMRCRFCRVPCTSH-UHFFFAOYSA-N 0.000 description 1
• SDQHWBIVQOSZCD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 SDQHWBIVQOSZCD-UHFFFAOYSA-N 0.000 description 1
• JPEYKQALFNUEAC-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 JPEYKQALFNUEAC-UHFFFAOYSA-N 0.000 description 1
• VPDBCMOJHVUUED-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 VPDBCMOJHVUUED-UHFFFAOYSA-N 0.000 description 1
• NHVIXOZNEBDYGS-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 NHVIXOZNEBDYGS-UHFFFAOYSA-N 0.000 description 1
• DBDCFORLVZTMOH-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 DBDCFORLVZTMOH-UHFFFAOYSA-N 0.000 description 1
• SHLIZWWWLDOLKT-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 SHLIZWWWLDOLKT-UHFFFAOYSA-N 0.000 description 1
• WWMWDNPBSIMYAM-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 WWMWDNPBSIMYAM-UHFFFAOYSA-N 0.000 description 1
• IAQKLLCPLVZEQV-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 IAQKLLCPLVZEQV-UHFFFAOYSA-N 0.000 description 1
• HWMDAPCDEBMYLW-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 HWMDAPCDEBMYLW-UHFFFAOYSA-N 0.000 description 1
• JBELZRCOOWTIOC-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 JBELZRCOOWTIOC-UHFFFAOYSA-N 0.000 description 1
• HXNXFFPDLMBFDW-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 HXNXFFPDLMBFDW-UHFFFAOYSA-N 0.000 description 1
• KISPJCCFBQXDKZ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)=N1 KISPJCCFBQXDKZ-UHFFFAOYSA-N 0.000 description 1
• LUNXXCKNBZMDNE-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 LUNXXCKNBZMDNE-UHFFFAOYSA-N 0.000 description 1
• TUWIIWDUZCLSAL-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)=N1 TUWIIWDUZCLSAL-UHFFFAOYSA-N 0.000 description 1
• SDYWTBYQQHCVPO-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 SDYWTBYQQHCVPO-UHFFFAOYSA-N 0.000 description 1
• GLPLTCNNYLYEHD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)=N1 GLPLTCNNYLYEHD-UHFFFAOYSA-N 0.000 description 1
• DISNSKXNWZRFIK-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 DISNSKXNWZRFIK-UHFFFAOYSA-N 0.000 description 1
• CZDCSZWNCPMBBT-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 CZDCSZWNCPMBBT-UHFFFAOYSA-N 0.000 description 1
• NFGVAKFHTDTQSJ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 NFGVAKFHTDTQSJ-UHFFFAOYSA-N 0.000 description 1
• BJDCMAOQROTXFU-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 BJDCMAOQROTXFU-UHFFFAOYSA-N 0.000 description 1
• SCMGXRCRJDXVQE-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 SCMGXRCRJDXVQE-UHFFFAOYSA-N 0.000 description 1
• IMZROJYIQAFJNX-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 IMZROJYIQAFJNX-UHFFFAOYSA-N 0.000 description 1
• XKZPGCJBPDDGLS-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 XKZPGCJBPDDGLS-UHFFFAOYSA-N 0.000 description 1
• DUPQXNVUYLTCFU-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 DUPQXNVUYLTCFU-UHFFFAOYSA-N 0.000 description 1
• XSWBTUWHICEIDB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 XSWBTUWHICEIDB-UHFFFAOYSA-N 0.000 description 1
• UBJNBFDMQHNCSX-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 UBJNBFDMQHNCSX-UHFFFAOYSA-N 0.000 description 1
• SQIXKJIZPUAXRD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 SQIXKJIZPUAXRD-UHFFFAOYSA-N 0.000 description 1
• GHBHAAAXALPJCF-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 GHBHAAAXALPJCF-UHFFFAOYSA-N 0.000 description 1
• GZBHKVTYJMEKFQ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 GZBHKVTYJMEKFQ-UHFFFAOYSA-N 0.000 description 1
• OWJJCUGISXOQLV-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C OWJJCUGISXOQLV-UHFFFAOYSA-N 0.000 description 1
• FAMHIMFNIIDZBL-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 FAMHIMFNIIDZBL-UHFFFAOYSA-N 0.000 description 1
• SEYVXBRUSHJRRO-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 SEYVXBRUSHJRRO-UHFFFAOYSA-N 0.000 description 1
• JZQVRDPLZSMHED-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OCF)=CC=2)=N1 JZQVRDPLZSMHED-UHFFFAOYSA-N 0.000 description 1
• KQHFZPSTDPEDGE-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 KQHFZPSTDPEDGE-UHFFFAOYSA-N 0.000 description 1
• MXXZODOHGPQQMK-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OCF)=CC=2)=N1 MXXZODOHGPQQMK-UHFFFAOYSA-N 0.000 description 1
• MNEDWOXTEZAZFU-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 MNEDWOXTEZAZFU-UHFFFAOYSA-N 0.000 description 1
• ATQQEIMIJRRPOD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC)C(OCF)=CC=2)=N1 ATQQEIMIJRRPOD-UHFFFAOYSA-N 0.000 description 1
• WAAIEGWRDLGKMQ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 WAAIEGWRDLGKMQ-UHFFFAOYSA-N 0.000 description 1
• YTWSTHGPHQLBRX-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 YTWSTHGPHQLBRX-UHFFFAOYSA-N 0.000 description 1
• TYPALWWZDSFIEE-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 TYPALWWZDSFIEE-UHFFFAOYSA-N 0.000 description 1
• VEYSUIGVCKNLJL-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 VEYSUIGVCKNLJL-UHFFFAOYSA-N 0.000 description 1
• XHFXDEQLYVUGGA-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 XHFXDEQLYVUGGA-UHFFFAOYSA-N 0.000 description 1
• ZPOQLRQNCOGFNH-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 ZPOQLRQNCOGFNH-UHFFFAOYSA-N 0.000 description 1
• VQRHZSOHOQGDJS-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 VQRHZSOHOQGDJS-UHFFFAOYSA-N 0.000 description 1
• POWXYGMTPOTJSN-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 POWXYGMTPOTJSN-UHFFFAOYSA-N 0.000 description 1
• XLICPTCXINABAK-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 XLICPTCXINABAK-UHFFFAOYSA-N 0.000 description 1
• WOPLTMYZMVWKLN-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 WOPLTMYZMVWKLN-UHFFFAOYSA-N 0.000 description 1
• HCIIILHARBGSCT-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,2-trifluoroacetamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)F)C=C1 HCIIILHARBGSCT-UHFFFAOYSA-N 0.000 description 1
• GXPGROZYCUDOBK-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2,3,3,3-pentafluoropropanamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(F)(F)C(F)(F)F)C=C1 GXPGROZYCUDOBK-UHFFFAOYSA-N 0.000 description 1
• QAZRTIJVQWHSKD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,2-dimethylpropanamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)(C)C)C=C1 QAZRTIJVQWHSKD-UHFFFAOYSA-N 0.000 description 1
• ORYKNGJNMQHWNM-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C ORYKNGJNMQHWNM-UHFFFAOYSA-N 0.000 description 1
• XOKWHBMCZIUZAW-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-2-methylpropanamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)C(C)C)C=C1 XOKWHBMCZIUZAW-UHFFFAOYSA-N 0.000 description 1
• QRQUWADTBAWCGB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]acetamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(C)=O)C=C1 QRQUWADTBAWCGB-UHFFFAOYSA-N 0.000 description 1
• UIENXVAOQOTTLB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)=N1 UIENXVAOQOTTLB-UHFFFAOYSA-N 0.000 description 1
• BHHFMDLXTCGSSR-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 BHHFMDLXTCGSSR-UHFFFAOYSA-N 0.000 description 1
• DKPLPSVBMQQUHZ-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]hexanamide Chemical compound C1=CC(NC(=O)CCCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)=N1 DKPLPSVBMQQUHZ-UHFFFAOYSA-N 0.000 description 1
• PAJCFNJDVPWEOB-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]methanesulfonamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NS(C)(=O)=O)C=C1 PAJCFNJDVPWEOB-UHFFFAOYSA-N 0.000 description 1
• VTFROQVQLSWIEV-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pentanamide Chemical compound C1=CC(NC(=O)CCCC)=CC=C1CN1C(=O)CC(CC)C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)=N1 VTFROQVQLSWIEV-UHFFFAOYSA-N 0.000 description 1
• GEACBONKLUCJMN-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]propanamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC1=CC=C(NC(=O)CC)C=C1 GEACBONKLUCJMN-UHFFFAOYSA-N 0.000 description 1
• WUGMRCBCMOHSJH-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 WUGMRCBCMOHSJH-UHFFFAOYSA-N 0.000 description 1
• BDBOSKHOAIIHBX-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 BDBOSKHOAIIHBX-UHFFFAOYSA-N 0.000 description 1
• ISAQKGUTQBDYOP-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 ISAQKGUTQBDYOP-UHFFFAOYSA-N 0.000 description 1
• DVBVXMKYALVMDD-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 DVBVXMKYALVMDD-UHFFFAOYSA-N 0.000 description 1
• ZOGBDKUXEUDRFC-UHFFFAOYSA-N n-[4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 ZOGBDKUXEUDRFC-UHFFFAOYSA-N 0.000 description 1
• BCFVORTVKPDPNB-UHFFFAOYSA-N n-[4-[[4-methyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(C)CC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 BCFVORTVKPDPNB-UHFFFAOYSA-N 0.000 description 1
• IOLSESOVHZEQKP-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 IOLSESOVHZEQKP-UHFFFAOYSA-N 0.000 description 1
• LELDDMBRHWJUFI-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 LELDDMBRHWJUFI-UHFFFAOYSA-N 0.000 description 1
• QAFAXERRJIIAPI-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 QAFAXERRJIIAPI-UHFFFAOYSA-N 0.000 description 1
• OALCJQAVICKLIV-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=NNC=C1 OALCJQAVICKLIV-UHFFFAOYSA-N 0.000 description 1
• JNHMERIFYJEXDQ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 JNHMERIFYJEXDQ-UHFFFAOYSA-N 0.000 description 1
• CHSMGFIZPNHFSM-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 CHSMGFIZPNHFSM-UHFFFAOYSA-N 0.000 description 1
• BJUQKHWKXGZEPC-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 BJUQKHWKXGZEPC-UHFFFAOYSA-N 0.000 description 1
• OPYBOFRCQOFDIO-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 OPYBOFRCQOFDIO-UHFFFAOYSA-N 0.000 description 1
• CBXNPRYLAJVECO-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 CBXNPRYLAJVECO-UHFFFAOYSA-N 0.000 description 1
• VEKZVJIUCNXQJH-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 VEKZVJIUCNXQJH-UHFFFAOYSA-N 0.000 description 1
• GLQMXVDTFJOOQD-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 GLQMXVDTFJOOQD-UHFFFAOYSA-N 0.000 description 1
• VTELPFYSHGZYDQ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 VTELPFYSHGZYDQ-UHFFFAOYSA-N 0.000 description 1
• ZHHHFJJAZZOXIF-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 ZHHHFJJAZZOXIF-UHFFFAOYSA-N 0.000 description 1
• JLGFQXIMTPECGI-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 JLGFQXIMTPECGI-UHFFFAOYSA-N 0.000 description 1
• LNHCZIHFKDECBY-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 LNHCZIHFKDECBY-UHFFFAOYSA-N 0.000 description 1
• HAPBDQYJPUGJIE-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=NNC=C1 HAPBDQYJPUGJIE-UHFFFAOYSA-N 0.000 description 1
• KRPACDCMAXXTPN-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 KRPACDCMAXXTPN-UHFFFAOYSA-N 0.000 description 1
• VNXHFPZNXCJJNL-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 VNXHFPZNXCJJNL-UHFFFAOYSA-N 0.000 description 1
• KDMCONGNZRYUTF-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-morpholin-4-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCOCC1 KDMCONGNZRYUTF-UHFFFAOYSA-N 0.000 description 1
• DEEICJVLZLSBPI-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperazin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCNCC1 DEEICJVLZLSBPI-UHFFFAOYSA-N 0.000 description 1
• XVCOINPKMWPZDA-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCCC1 XVCOINPKMWPZDA-UHFFFAOYSA-N 0.000 description 1
• HSJUIOZTOPSKRJ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCC1 HSJUIOZTOPSKRJ-UHFFFAOYSA-N 0.000 description 1
• OXLCDOSNKWZQHT-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCSCC1 OXLCDOSNKWZQHT-UHFFFAOYSA-N 0.000 description 1
• GVILQNDAHCIHBK-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCNCC1 GVILQNDAHCIHBK-UHFFFAOYSA-N 0.000 description 1
• CYJFWSNWHZGUJR-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCCC1 CYJFWSNWHZGUJR-UHFFFAOYSA-N 0.000 description 1
• SYKPSNZDQNYOHW-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCC1 SYKPSNZDQNYOHW-UHFFFAOYSA-N 0.000 description 1
• PIVGVZGKMSLOKS-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCSCC1 PIVGVZGKMSLOKS-UHFFFAOYSA-N 0.000 description 1
• KKXOXXRBJZYKDQ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 KKXOXXRBJZYKDQ-UHFFFAOYSA-N 0.000 description 1
• OYVOVVFQUKLKKO-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 OYVOVVFQUKLKKO-UHFFFAOYSA-N 0.000 description 1
• KVEXVMFPWHVCIZ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 KVEXVMFPWHVCIZ-UHFFFAOYSA-N 0.000 description 1
• KGTFSEAAKSGHPC-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 KGTFSEAAKSGHPC-UHFFFAOYSA-N 0.000 description 1
• QHMMKLZOFSHUKX-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-4h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound O=C1OC(CC)=C(C=2C=C(OC)C(OC)=CC=2)NN1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C QHMMKLZOFSHUKX-UHFFFAOYSA-N 0.000 description 1
• BRLBAARKMPFAIT-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 BRLBAARKMPFAIT-UHFFFAOYSA-N 0.000 description 1
• LGCBHICIAZMOMD-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 LGCBHICIAZMOMD-UHFFFAOYSA-N 0.000 description 1
• JOTOSAHJZMYHRS-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 JOTOSAHJZMYHRS-UHFFFAOYSA-N 0.000 description 1
• INPYWHFYLQXRAT-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 INPYWHFYLQXRAT-UHFFFAOYSA-N 0.000 description 1
• ISIVFLDXEWNWPD-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 ISIVFLDXEWNWPD-UHFFFAOYSA-N 0.000 description 1
• GGOGAVHBDFNROY-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 GGOGAVHBDFNROY-UHFFFAOYSA-N 0.000 description 1
• SKLCAMKFALXCBZ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 SKLCAMKFALXCBZ-UHFFFAOYSA-N 0.000 description 1
• WAHPMNNMFKLROQ-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 WAHPMNNMFKLROQ-UHFFFAOYSA-N 0.000 description 1
• VNIBWOLYJZOXFP-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 VNIBWOLYJZOXFP-UHFFFAOYSA-N 0.000 description 1
• RGZGQVAJXPRDJW-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 RGZGQVAJXPRDJW-UHFFFAOYSA-N 0.000 description 1
• UJJGMQJQOPMRDU-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 UJJGMQJQOPMRDU-UHFFFAOYSA-N 0.000 description 1
• ZGMKQLRMSACPAS-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 ZGMKQLRMSACPAS-UHFFFAOYSA-N 0.000 description 1
• WBTYPXXLGNOCAD-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 WBTYPXXLGNOCAD-UHFFFAOYSA-N 0.000 description 1
• ABXNZKJYYLBAFY-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C ABXNZKJYYLBAFY-UHFFFAOYSA-N 0.000 description 1
• WJZJVYKMQLTJPD-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 WJZJVYKMQLTJPD-UHFFFAOYSA-N 0.000 description 1
• BCFRQBRKRLWAER-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 BCFRQBRKRLWAER-UHFFFAOYSA-N 0.000 description 1
• KZJCPUXRBFEXHS-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 KZJCPUXRBFEXHS-UHFFFAOYSA-N 0.000 description 1
• GZVFOLIKLJQMMP-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 GZVFOLIKLJQMMP-UHFFFAOYSA-N 0.000 description 1
• VIYCWGHQCPZMRI-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 VIYCWGHQCPZMRI-UHFFFAOYSA-N 0.000 description 1
• PXVSOJPJIWCGRA-UHFFFAOYSA-N n-[4-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 PXVSOJPJIWCGRA-UHFFFAOYSA-N 0.000 description 1
• NGNAGCADQFRKOD-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCCCC4)=CC=3)N=2)C=C1OC1CCCC1 NGNAGCADQFRKOD-UHFFFAOYSA-N 0.000 description 1
• SWZJRKXIJPRANN-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCCC4)=CC=3)N=2)C=C1OC1CCCC1 SWZJRKXIJPRANN-UHFFFAOYSA-N 0.000 description 1
• DYMHHWXJQZJDKY-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCSCC4)=CC=3)N=2)C=C1OC1CCCC1 DYMHHWXJQZJDKY-UHFFFAOYSA-N 0.000 description 1
• OPSGOVPFOYSBKN-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCNCC4)=CC=3)N=2)C=C1OC1CCCC1 OPSGOVPFOYSBKN-UHFFFAOYSA-N 0.000 description 1
• LFBOKBPPHMYQCQ-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCCCC4)=CC=3)N=2)C=C1OC1CCCC1 LFBOKBPPHMYQCQ-UHFFFAOYSA-N 0.000 description 1
• WLXFNBVLYNPLMC-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCCC4)=CC=3)N=2)C=C1OC1CCCC1 WLXFNBVLYNPLMC-UHFFFAOYSA-N 0.000 description 1
• SYXGBBQKICMPPU-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound COC1=CC=C(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCSCC4)=CC=3)N=2)C=C1OC1CCCC1 SYXGBBQKICMPPU-UHFFFAOYSA-N 0.000 description 1
• XRSLKUHVVMNMGO-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 XRSLKUHVVMNMGO-UHFFFAOYSA-N 0.000 description 1
• NIIFATPFLFNFDC-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 NIIFATPFLFNFDC-UHFFFAOYSA-N 0.000 description 1
• SJFQLSYUKRTNOU-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 SJFQLSYUKRTNOU-UHFFFAOYSA-N 0.000 description 1
• NCWCHZLMFLJFSD-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 NCWCHZLMFLJFSD-UHFFFAOYSA-N 0.000 description 1
• STSHGWSIIOPVKP-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 STSHGWSIIOPVKP-UHFFFAOYSA-N 0.000 description 1
• LLTFUIQWYJEHQB-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C LLTFUIQWYJEHQB-UHFFFAOYSA-N 0.000 description 1
• MBPRBRJSFLJAQJ-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 MBPRBRJSFLJAQJ-UHFFFAOYSA-N 0.000 description 1
• DEAWIOWRUBAKBE-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 DEAWIOWRUBAKBE-UHFFFAOYSA-N 0.000 description 1
• YRQOKDGBOCJENI-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 YRQOKDGBOCJENI-UHFFFAOYSA-N 0.000 description 1
• YGPJTQLGGGOFCG-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 YGPJTQLGGGOFCG-UHFFFAOYSA-N 0.000 description 1
• SUNFIRUXKVGGFP-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 SUNFIRUXKVGGFP-UHFFFAOYSA-N 0.000 description 1
• KUUACDSWLMEWDR-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 KUUACDSWLMEWDR-UHFFFAOYSA-N 0.000 description 1
• ZSLDAQVWGPQNQA-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 ZSLDAQVWGPQNQA-UHFFFAOYSA-N 0.000 description 1
• WZVFDNOJXHCQMT-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 WZVFDNOJXHCQMT-UHFFFAOYSA-N 0.000 description 1
• YVZMOOZVLCIYDO-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 YVZMOOZVLCIYDO-UHFFFAOYSA-N 0.000 description 1
• VESODORORZCYSZ-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 VESODORORZCYSZ-UHFFFAOYSA-N 0.000 description 1
• BAMHVKVQNBHVAW-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 BAMHVKVQNBHVAW-UHFFFAOYSA-N 0.000 description 1
• HTEUCYCWCASXNQ-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C HTEUCYCWCASXNQ-UHFFFAOYSA-N 0.000 description 1
• ZJKWIUPCRXRBSB-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 ZJKWIUPCRXRBSB-UHFFFAOYSA-N 0.000 description 1
• XRYBNLXWDHWHPM-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 XRYBNLXWDHWHPM-UHFFFAOYSA-N 0.000 description 1
• IUALFYCDLXFULY-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 IUALFYCDLXFULY-UHFFFAOYSA-N 0.000 description 1
• IMDQHVZLPJMVEI-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 IMDQHVZLPJMVEI-UHFFFAOYSA-N 0.000 description 1
• PJMHMTGFOGOCPK-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 PJMHMTGFOGOCPK-UHFFFAOYSA-N 0.000 description 1
• IGKZDUZCCHAKAT-UHFFFAOYSA-N n-[4-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 IGKZDUZCCHAKAT-UHFFFAOYSA-N 0.000 description 1
• DQOOQJVNCFXCJD-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperazin-1-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCNCC4)=CC=3)N=2)=C1 DQOOQJVNCFXCJD-UHFFFAOYSA-N 0.000 description 1
• XVVBSVQANZENTF-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCCCC4)=CC=3)N=2)=C1 XVVBSVQANZENTF-UHFFFAOYSA-N 0.000 description 1
• JTDRHPDEFXRRJZ-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCCC4)=CC=3)N=2)=C1 JTDRHPDEFXRRJZ-UHFFFAOYSA-N 0.000 description 1
• YWRNHWYDGXNXIE-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCSCC4)=CC=3)N=2)=C1 YWRNHWYDGXNXIE-UHFFFAOYSA-N 0.000 description 1
• CVWHUZBGJFSAKS-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4ON=CC=4)=CC=3)N=2)CC)=C1 CVWHUZBGJFSAKS-UHFFFAOYSA-N 0.000 description 1
• ZFTNXWULURLGHD-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4OC=NC=4)=CC=3)N=2)CC)=C1 ZFTNXWULURLGHD-UHFFFAOYSA-N 0.000 description 1
• YJLHMDUNHZAFLU-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4N=CNC=4)=CC=3)N=2)CC)=C1 YJLHMDUNHZAFLU-UHFFFAOYSA-N 0.000 description 1
• MNWUZXDJDJZHRK-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C4=NNC=C4)=CC=3)N=2)CC)=C1 MNWUZXDJDJZHRK-UHFFFAOYSA-N 0.000 description 1
• ZXCQORXJEXFYLF-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4NC=CC=4)=CC=3)N=2)CC)=C1 ZXCQORXJEXFYLF-UHFFFAOYSA-N 0.000 description 1
• OEXFIBSKXKNMJG-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C4=C(N=C(C)S4)C)=CC=3)N=2)CC)=C1 OEXFIBSKXKNMJG-UHFFFAOYSA-N 0.000 description 1
• QCEAYXMWSATNRT-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4OC=CC=4)=CC=3)N=2)CC)=C1 QCEAYXMWSATNRT-UHFFFAOYSA-N 0.000 description 1
• DDZIGLSOYLHULQ-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4C=NC=CC=4)=CC=3)N=2)CC)=C1 DDZIGLSOYLHULQ-UHFFFAOYSA-N 0.000 description 1
• KHVPSZMLFBIFOK-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4C=CN=CC=4)=CC=3)N=2)CC)=C1 KHVPSZMLFBIFOK-UHFFFAOYSA-N 0.000 description 1
• CRNBZTDSYDAWOQ-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4N=CC=CN=4)=CC=3)N=2)CC)=C1 CRNBZTDSYDAWOQ-UHFFFAOYSA-N 0.000 description 1
• XQEJRGYFTNWIPM-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(CC=3C=CC(NC(=O)C=4SC=CC=4)=CC=3)N=2)CC)=C1 XQEJRGYFTNWIPM-UHFFFAOYSA-N 0.000 description 1
• FWMCYSXMYOKDFS-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4ON=CC=4)=CC=3)N=2)CC)=C1 FWMCYSXMYOKDFS-UHFFFAOYSA-N 0.000 description 1
• QUBPQOOQRVUNHL-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4OC=NC=4)=CC=3)N=2)CC)=C1 QUBPQOOQRVUNHL-UHFFFAOYSA-N 0.000 description 1
• FAZHVDFEDSFWHQ-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4N=CNC=4)=CC=3)N=2)CC)=C1 FAZHVDFEDSFWHQ-UHFFFAOYSA-N 0.000 description 1
• SENWOWNSZPEKFT-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C4=NNC=C4)=CC=3)N=2)CC)=C1 SENWOWNSZPEKFT-UHFFFAOYSA-N 0.000 description 1
• PQYGSINJOFXHRT-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4NC=CC=4)=CC=3)N=2)CC)=C1 PQYGSINJOFXHRT-UHFFFAOYSA-N 0.000 description 1
• USEROBSZEPTVQT-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C4=C(N=C(C)S4)C)=CC=3)N=2)CC)=C1 USEROBSZEPTVQT-UHFFFAOYSA-N 0.000 description 1
• AFCMFNULXQMBTG-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4OC=CC=4)=CC=3)N=2)CC)=C1 AFCMFNULXQMBTG-UHFFFAOYSA-N 0.000 description 1
• OAMFAKCOGPDBJZ-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4N=CC=NC=4)=CC=3)N=2)CC)=C1 OAMFAKCOGPDBJZ-UHFFFAOYSA-N 0.000 description 1
• ABRVWHORWIIDAY-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4C=NC=CC=4)=CC=3)N=2)CC)=C1 ABRVWHORWIIDAY-UHFFFAOYSA-N 0.000 description 1
• KWVXRZLNQRPUAD-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4C=CN=CC=4)=CC=3)N=2)CC)=C1 KWVXRZLNQRPUAD-UHFFFAOYSA-N 0.000 description 1
• UWWGWIGZJWOAGK-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4N=CC=CN=4)=CC=3)N=2)CC)=C1 UWWGWIGZJWOAGK-UHFFFAOYSA-N 0.000 description 1
• BJQBHSXDUGHPPC-UHFFFAOYSA-N n-[4-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(CC=3C=CC(NC(=O)C=4SC=CC=4)=CC=3)N=2)CC)=C1 BJQBHSXDUGHPPC-UHFFFAOYSA-N 0.000 description 1
• IICZOVABVJYGAV-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-5-ethyl-2-oxo-1,3,4-thiadiazinan-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C1(CC)NN(CC=2C=CC(NC(=O)C3=NNC=C3)=CC=2)C(=O)SC1 IICZOVABVJYGAV-UHFFFAOYSA-N 0.000 description 1
• TUATZHQJOWEQNY-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 TUATZHQJOWEQNY-UHFFFAOYSA-N 0.000 description 1
• OBLODZUFJMHOCP-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 OBLODZUFJMHOCP-UHFFFAOYSA-N 0.000 description 1
• ZXBBQPVOSQFHOL-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 ZXBBQPVOSQFHOL-UHFFFAOYSA-N 0.000 description 1
• GSGJSKFECPUWSC-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=NNC=C1 GSGJSKFECPUWSC-UHFFFAOYSA-N 0.000 description 1
• MLDKIMRIJUKDHW-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 MLDKIMRIJUKDHW-UHFFFAOYSA-N 0.000 description 1
• QEWCYEBNQNRPRO-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 QEWCYEBNQNRPRO-UHFFFAOYSA-N 0.000 description 1
• FDXRBQRYDXBYHD-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 FDXRBQRYDXBYHD-UHFFFAOYSA-N 0.000 description 1
• IUCOFHLCCOTNAA-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 IUCOFHLCCOTNAA-UHFFFAOYSA-N 0.000 description 1
• KSQZCXTVXDZFNW-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 KSQZCXTVXDZFNW-UHFFFAOYSA-N 0.000 description 1
• VBLYEHPUXPHGCE-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 VBLYEHPUXPHGCE-UHFFFAOYSA-N 0.000 description 1
• JJXGWCKDLALUKO-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(OC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 JJXGWCKDLALUKO-UHFFFAOYSA-N 0.000 description 1
• XMTKGMREAJGREH-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 XMTKGMREAJGREH-UHFFFAOYSA-N 0.000 description 1
• VZARUHDYWPOCPJ-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 VZARUHDYWPOCPJ-UHFFFAOYSA-N 0.000 description 1
• GUKDNGHURUFHJZ-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 GUKDNGHURUFHJZ-UHFFFAOYSA-N 0.000 description 1
• WABJOKAIHFWSKJ-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 WABJOKAIHFWSKJ-UHFFFAOYSA-N 0.000 description 1
• BWCZLKQGSJFRPI-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=C(C)N=C(C)S1 BWCZLKQGSJFRPI-UHFFFAOYSA-N 0.000 description 1
• IHFWXDSXAFWICS-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 IHFWXDSXAFWICS-UHFFFAOYSA-N 0.000 description 1
• JIIHDJJGFIEPOV-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 JIIHDJJGFIEPOV-UHFFFAOYSA-N 0.000 description 1
• TVQLEDZLOIDVEY-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 TVQLEDZLOIDVEY-UHFFFAOYSA-N 0.000 description 1
• KNJPDLIXXICZTP-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 KNJPDLIXXICZTP-UHFFFAOYSA-N 0.000 description 1
• KGAPJJGLFUCQBE-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 KGAPJJGLFUCQBE-UHFFFAOYSA-N 0.000 description 1
• WQGNGGOSYQQFAH-UHFFFAOYSA-N n-[4-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 WQGNGGOSYQQFAH-UHFFFAOYSA-N 0.000 description 1
• RPRXSHWATGQZRE-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperazin-1-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCNCC1 RPRXSHWATGQZRE-UHFFFAOYSA-N 0.000 description 1
• MXJOTSDMZQXSEL-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCCC1 MXJOTSDMZQXSEL-UHFFFAOYSA-N 0.000 description 1
• ITNWKXFGKMQMLG-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCCC1 ITNWKXFGKMQMLG-UHFFFAOYSA-N 0.000 description 1
• NLOYZMXDAAJADP-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CN1CCSCC1 NLOYZMXDAAJADP-UHFFFAOYSA-N 0.000 description 1
• NBGPLUCFCWETAV-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCNCC1 NBGPLUCFCWETAV-UHFFFAOYSA-N 0.000 description 1
• ZUWPPCJQBXUWHL-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCCC1 ZUWPPCJQBXUWHL-UHFFFAOYSA-N 0.000 description 1
• YSQGQWOHIHMOAJ-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCCC1 YSQGQWOHIHMOAJ-UHFFFAOYSA-N 0.000 description 1
• YTYQERXHIKUXGH-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propan-2-yloxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-thiomorpholin-4-ylpropanamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1C(CSC1=O)=NN1CC(C=C1)=CC=C1NC(=O)CCN1CCSCC1 YTYQERXHIKUXGH-UHFFFAOYSA-N 0.000 description 1
• RGCVSEKBHQGKEH-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-piperidin-1-ylacetamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCCCC4)=CC=3)N=2)=C1 RGCVSEKBHQGKEH-UHFFFAOYSA-N 0.000 description 1
• XVUACFUWTHCREB-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCCC4)=CC=3)N=2)=C1 XVUACFUWTHCREB-UHFFFAOYSA-N 0.000 description 1
• IFGPGZYBRYEOKI-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2-thiomorpholin-4-ylacetamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CN4CCSCC4)=CC=3)N=2)=C1 IFGPGZYBRYEOKI-UHFFFAOYSA-N 0.000 description 1
• RTYGVTBMBUKDND-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperazin-1-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCNCC4)=CC=3)N=2)=C1 RTYGVTBMBUKDND-UHFFFAOYSA-N 0.000 description 1
• FKXVNTGJXNZCPG-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-piperidin-1-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCCCC4)=CC=3)N=2)=C1 FKXVNTGJXNZCPG-UHFFFAOYSA-N 0.000 description 1
• QTWYLRQQEGNRJT-UHFFFAOYSA-N n-[4-[[5-(4-methoxy-3-propoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-3-pyrrolidin-1-ylpropanamide Chemical compound C1=C(OC)C(OCCC)=CC(C=2CSC(=O)N(CC=3C=CC(NC(=O)CCN4CCCC4)=CC=3)N=2)=C1 QTWYLRQQEGNRJT-UHFFFAOYSA-N 0.000 description 1
• WVJPQVXWZGQLRU-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 WVJPQVXWZGQLRU-UHFFFAOYSA-N 0.000 description 1
• PMGWOMRBLHNKFL-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 PMGWOMRBLHNKFL-UHFFFAOYSA-N 0.000 description 1
• BOCBGNUHERDNGP-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 BOCBGNUHERDNGP-UHFFFAOYSA-N 0.000 description 1
• VERDNJQZRJNMMF-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 VERDNJQZRJNMMF-UHFFFAOYSA-N 0.000 description 1
• OUBBGYUQXGSHNR-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 OUBBGYUQXGSHNR-UHFFFAOYSA-N 0.000 description 1
• RDMQWOMALRKQNJ-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C RDMQWOMALRKQNJ-UHFFFAOYSA-N 0.000 description 1
• SGDCOKZLKIWTFF-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 SGDCOKZLKIWTFF-UHFFFAOYSA-N 0.000 description 1
• MJGAWGNTFVXWDW-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 MJGAWGNTFVXWDW-UHFFFAOYSA-N 0.000 description 1
• YJPKPDWAVAAPQF-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 YJPKPDWAVAAPQF-UHFFFAOYSA-N 0.000 description 1
• PAOHQIWROUNNGL-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 PAOHQIWROUNNGL-UHFFFAOYSA-N 0.000 description 1
• OUEARGLNZADRKL-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 OUEARGLNZADRKL-UHFFFAOYSA-N 0.000 description 1
• GQPJKNRHYLHPAI-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 GQPJKNRHYLHPAI-UHFFFAOYSA-N 0.000 description 1
• CNRKQZWKAXCJSW-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 CNRKQZWKAXCJSW-UHFFFAOYSA-N 0.000 description 1
• VPMIHAUDCOLPOL-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 VPMIHAUDCOLPOL-UHFFFAOYSA-N 0.000 description 1
• BJUODKZVQBARNV-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 BJUODKZVQBARNV-UHFFFAOYSA-N 0.000 description 1
• GYNZNNOVHGXOJO-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 GYNZNNOVHGXOJO-UHFFFAOYSA-N 0.000 description 1
• LORBLGBKJOTMDU-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 LORBLGBKJOTMDU-UHFFFAOYSA-N 0.000 description 1
• QBVAPSOTBFMLAZ-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C QBVAPSOTBFMLAZ-UHFFFAOYSA-N 0.000 description 1
• PFZPNQOIEIQZRA-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 PFZPNQOIEIQZRA-UHFFFAOYSA-N 0.000 description 1
• VQPPORHXBBVMRR-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 VQPPORHXBBVMRR-UHFFFAOYSA-N 0.000 description 1
• YBXIJYPFNHOYOT-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 YBXIJYPFNHOYOT-UHFFFAOYSA-N 0.000 description 1
• LSNDQZXUNPBPBS-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 LSNDQZXUNPBPBS-UHFFFAOYSA-N 0.000 description 1
• WIMLZXHLOOECQA-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 WIMLZXHLOOECQA-UHFFFAOYSA-N 0.000 description 1
• MNMZTMWURSWGSK-UHFFFAOYSA-N n-[4-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 MNMZTMWURSWGSK-UHFFFAOYSA-N 0.000 description 1
• VHJCWLBAWQIFCW-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 VHJCWLBAWQIFCW-UHFFFAOYSA-N 0.000 description 1
• GPYWUKORFDEDIU-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 GPYWUKORFDEDIU-UHFFFAOYSA-N 0.000 description 1
• NDZAEBJYWWCEQU-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 NDZAEBJYWWCEQU-UHFFFAOYSA-N 0.000 description 1
• LNSQZOOXCPLENL-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 LNSQZOOXCPLENL-UHFFFAOYSA-N 0.000 description 1
• FCKRWJSPWARFTL-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 FCKRWJSPWARFTL-UHFFFAOYSA-N 0.000 description 1
• LWTPZXLNRYGBET-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C LWTPZXLNRYGBET-UHFFFAOYSA-N 0.000 description 1
• MPMGABCATZHDGC-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 MPMGABCATZHDGC-UHFFFAOYSA-N 0.000 description 1
• XXMGHBGBKFAZQK-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 XXMGHBGBKFAZQK-UHFFFAOYSA-N 0.000 description 1
• LDLFZANTZSQBCY-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 LDLFZANTZSQBCY-UHFFFAOYSA-N 0.000 description 1
• UNVROPMFPSQCRY-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 UNVROPMFPSQCRY-UHFFFAOYSA-N 0.000 description 1
• OEVJELYBCVQBFO-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 OEVJELYBCVQBFO-UHFFFAOYSA-N 0.000 description 1
• USGHHFANKHJGPR-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 USGHHFANKHJGPR-UHFFFAOYSA-N 0.000 description 1
• KHLFICOSZWKPDD-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 KHLFICOSZWKPDD-UHFFFAOYSA-N 0.000 description 1
• FDNGCDRYZZGJGN-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 FDNGCDRYZZGJGN-UHFFFAOYSA-N 0.000 description 1
• GROKJEHYLCFKNW-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 GROKJEHYLCFKNW-UHFFFAOYSA-N 0.000 description 1
• MALVQIVZYNZPIA-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 MALVQIVZYNZPIA-UHFFFAOYSA-N 0.000 description 1
• UNZTUPCMJLHYAF-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 UNZTUPCMJLHYAF-UHFFFAOYSA-N 0.000 description 1
• OVUULFLDIUYNIS-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C OVUULFLDIUYNIS-UHFFFAOYSA-N 0.000 description 1
• ZBZOBKXSUKPEAE-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 ZBZOBKXSUKPEAE-UHFFFAOYSA-N 0.000 description 1
• IFZFFDGYPLMNPT-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 IFZFFDGYPLMNPT-UHFFFAOYSA-N 0.000 description 1
• KFSPIESXSCKPEV-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 KFSPIESXSCKPEV-UHFFFAOYSA-N 0.000 description 1
• CXEJSGZVAOEVGG-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 CXEJSGZVAOEVGG-UHFFFAOYSA-N 0.000 description 1
• HDBPQFRFGBAFSR-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 HDBPQFRFGBAFSR-UHFFFAOYSA-N 0.000 description 1
• BRXZTRABFZOEPB-UHFFFAOYSA-N n-[4-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 BRXZTRABFZOEPB-UHFFFAOYSA-N 0.000 description 1
• CQUVIGNXMGAFLG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 CQUVIGNXMGAFLG-UHFFFAOYSA-N 0.000 description 1
• SPUIHAJCIALUAJ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 SPUIHAJCIALUAJ-UHFFFAOYSA-N 0.000 description 1
• URHUBOUQEAJHHL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 URHUBOUQEAJHHL-UHFFFAOYSA-N 0.000 description 1
• PDVJTPJCSUQGPC-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 PDVJTPJCSUQGPC-UHFFFAOYSA-N 0.000 description 1
• NGDMBSVCFABAHU-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C NGDMBSVCFABAHU-UHFFFAOYSA-N 0.000 description 1
• TYMBPFLMPRGDAN-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 TYMBPFLMPRGDAN-UHFFFAOYSA-N 0.000 description 1
• FGDJNCZEMIKQQR-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 FGDJNCZEMIKQQR-UHFFFAOYSA-N 0.000 description 1
• TVZFGXGARZVSOE-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 TVZFGXGARZVSOE-UHFFFAOYSA-N 0.000 description 1
• XMRLTPRPPOTDMO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 XMRLTPRPPOTDMO-UHFFFAOYSA-N 0.000 description 1
• GGENALAEORLZTO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 GGENALAEORLZTO-UHFFFAOYSA-N 0.000 description 1
• NOQXNESRSGKTFJ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 NOQXNESRSGKTFJ-UHFFFAOYSA-N 0.000 description 1
• ZTWYIGCZXAOAFJ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 ZTWYIGCZXAOAFJ-UHFFFAOYSA-N 0.000 description 1
• LWPUOIZRWFJRMJ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 LWPUOIZRWFJRMJ-UHFFFAOYSA-N 0.000 description 1
• JFPUFZMXQNPSMC-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 JFPUFZMXQNPSMC-UHFFFAOYSA-N 0.000 description 1
• OIRHOIVRGRBXRD-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 OIRHOIVRGRBXRD-UHFFFAOYSA-N 0.000 description 1
• WWMLBGLTEMAWNE-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 WWMLBGLTEMAWNE-UHFFFAOYSA-N 0.000 description 1
• KAUYIHAPSFCBCV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C KAUYIHAPSFCBCV-UHFFFAOYSA-N 0.000 description 1
• BFGRCGZDIYLECS-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 BFGRCGZDIYLECS-UHFFFAOYSA-N 0.000 description 1
• AOIJXALTBQMXIA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 AOIJXALTBQMXIA-UHFFFAOYSA-N 0.000 description 1
• ONHZWEMLVZYBPK-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 ONHZWEMLVZYBPK-UHFFFAOYSA-N 0.000 description 1
• RZUAKMIFMCWHSR-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 RZUAKMIFMCWHSR-UHFFFAOYSA-N 0.000 description 1
• SVPBAYDUKKEHJU-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 SVPBAYDUKKEHJU-UHFFFAOYSA-N 0.000 description 1
• SBCGKVSMZUREQY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(O)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 SBCGKVSMZUREQY-UHFFFAOYSA-N 0.000 description 1
• SGMHSIDXQVMIBM-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 SGMHSIDXQVMIBM-UHFFFAOYSA-N 0.000 description 1
• WUBIQICARCNDQY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 WUBIQICARCNDQY-UHFFFAOYSA-N 0.000 description 1
• MPUKDDAFKABDIZ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 MPUKDDAFKABDIZ-UHFFFAOYSA-N 0.000 description 1
• DGHWXTOOSICEIA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 DGHWXTOOSICEIA-UHFFFAOYSA-N 0.000 description 1
• HXXOLFQTYNTYJR-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 HXXOLFQTYNTYJR-UHFFFAOYSA-N 0.000 description 1
• XOAYCDGRVMPNMX-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C XOAYCDGRVMPNMX-UHFFFAOYSA-N 0.000 description 1
• HHLIYXVHFBWTFE-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 HHLIYXVHFBWTFE-UHFFFAOYSA-N 0.000 description 1
• PPBHBMATAQWMJR-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 PPBHBMATAQWMJR-UHFFFAOYSA-N 0.000 description 1
• IIIXBGKWQDHWMM-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 IIIXBGKWQDHWMM-UHFFFAOYSA-N 0.000 description 1
• VDBMZPVJPVEVAK-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 VDBMZPVJPVEVAK-UHFFFAOYSA-N 0.000 description 1
• KEOBXULSARRQLL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 KEOBXULSARRQLL-UHFFFAOYSA-N 0.000 description 1
• XTCFIESFEUFMLX-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 XTCFIESFEUFMLX-UHFFFAOYSA-N 0.000 description 1
• ZJGZHBDMCUNKMG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 ZJGZHBDMCUNKMG-UHFFFAOYSA-N 0.000 description 1
• JLSWMEWANMGEPZ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 JLSWMEWANMGEPZ-UHFFFAOYSA-N 0.000 description 1
• RKYNHTHRNYQZOT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 RKYNHTHRNYQZOT-UHFFFAOYSA-N 0.000 description 1
• KWQLFVPWOMNUBN-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 KWQLFVPWOMNUBN-UHFFFAOYSA-N 0.000 description 1
• NUZPBGBGIGMHCL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 NUZPBGBGIGMHCL-UHFFFAOYSA-N 0.000 description 1
• NQEJXWODCLZCLO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C NQEJXWODCLZCLO-UHFFFAOYSA-N 0.000 description 1
• VCGAJXNMDFUVLW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 VCGAJXNMDFUVLW-UHFFFAOYSA-N 0.000 description 1
• AEWSJCVSKORAAG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 AEWSJCVSKORAAG-UHFFFAOYSA-N 0.000 description 1
• MNHZFOIZVAWEQP-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 MNHZFOIZVAWEQP-UHFFFAOYSA-N 0.000 description 1
• OMKIBXMRFOILKW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 OMKIBXMRFOILKW-UHFFFAOYSA-N 0.000 description 1
• BIKGERYYORZYJY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 BIKGERYYORZYJY-UHFFFAOYSA-N 0.000 description 1
• XQGUWGOZFNYPDS-UHFFFAOYSA-N n-[4-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=CC(=CC=2)S(C)(=O)=O)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 XQGUWGOZFNYPDS-UHFFFAOYSA-N 0.000 description 1
• WXWWDUXSHZFHHV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 WXWWDUXSHZFHHV-UHFFFAOYSA-N 0.000 description 1
• WGIINYHBXQACAR-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 WGIINYHBXQACAR-UHFFFAOYSA-N 0.000 description 1
• YSQSRIFFZUXGGT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 YSQSRIFFZUXGGT-UHFFFAOYSA-N 0.000 description 1
• UKTXXLJGXMFRKL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 UKTXXLJGXMFRKL-UHFFFAOYSA-N 0.000 description 1
• XSKLURHSTVEXOW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 XSKLURHSTVEXOW-UHFFFAOYSA-N 0.000 description 1
• IDWKLDRELBOKNG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 IDWKLDRELBOKNG-UHFFFAOYSA-N 0.000 description 1
• XWBOIUCIHIIBCY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 XWBOIUCIHIIBCY-UHFFFAOYSA-N 0.000 description 1
• MIWCYKZXMFKNMQ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 MIWCYKZXMFKNMQ-UHFFFAOYSA-N 0.000 description 1
• WWHXWOIZBFJTGG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 WWHXWOIZBFJTGG-UHFFFAOYSA-N 0.000 description 1
• AESRLQMDRKXMDN-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 AESRLQMDRKXMDN-UHFFFAOYSA-N 0.000 description 1
• PFYORMWGPWOVQJ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 PFYORMWGPWOVQJ-UHFFFAOYSA-N 0.000 description 1
• WJRUGNFCODXZAT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 WJRUGNFCODXZAT-UHFFFAOYSA-N 0.000 description 1
• VRSVGRLFJSRBAF-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 VRSVGRLFJSRBAF-UHFFFAOYSA-N 0.000 description 1
• DLYPWYJUBUETNQ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 DLYPWYJUBUETNQ-UHFFFAOYSA-N 0.000 description 1
• DIWYZERJNMCUNM-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 DIWYZERJNMCUNM-UHFFFAOYSA-N 0.000 description 1
• RQJIJMWWRNFGPL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 RQJIJMWWRNFGPL-UHFFFAOYSA-N 0.000 description 1
• OTODEVDSASXVKY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 OTODEVDSASXVKY-UHFFFAOYSA-N 0.000 description 1
• HJLWHVIMIBLYIR-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 HJLWHVIMIBLYIR-UHFFFAOYSA-N 0.000 description 1
• UAFMOVXKROYYPW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 UAFMOVXKROYYPW-UHFFFAOYSA-N 0.000 description 1
• XLNHXRGALCNSMT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 XLNHXRGALCNSMT-UHFFFAOYSA-N 0.000 description 1
• OMWMQRQTOBUVKI-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 OMWMQRQTOBUVKI-UHFFFAOYSA-N 0.000 description 1
• FUSMIQCSTYXDOE-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 FUSMIQCSTYXDOE-UHFFFAOYSA-N 0.000 description 1
• OUNRRSSWYKMPEJ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 OUNRRSSWYKMPEJ-UHFFFAOYSA-N 0.000 description 1
• INXKIXHYWXJBMF-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 INXKIXHYWXJBMF-UHFFFAOYSA-N 0.000 description 1
• GCRIKPJRYKXGIV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 GCRIKPJRYKXGIV-UHFFFAOYSA-N 0.000 description 1
• HZYAGHBJPLRXEZ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C HZYAGHBJPLRXEZ-UHFFFAOYSA-N 0.000 description 1
• GCKIMDPRYWLACW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 GCKIMDPRYWLACW-UHFFFAOYSA-N 0.000 description 1
• CYINZAMZBSFCJQ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 CYINZAMZBSFCJQ-UHFFFAOYSA-N 0.000 description 1
• WNGWSLCIPONBGO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 WNGWSLCIPONBGO-UHFFFAOYSA-N 0.000 description 1
• KMPLXTQHUDSZDW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 KMPLXTQHUDSZDW-UHFFFAOYSA-N 0.000 description 1
• XGHQWOHFNFXCTO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 XGHQWOHFNFXCTO-UHFFFAOYSA-N 0.000 description 1
• CKSIMNKZHKGZSS-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 CKSIMNKZHKGZSS-UHFFFAOYSA-N 0.000 description 1
• UNHHYGFOMZNUCF-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 UNHHYGFOMZNUCF-UHFFFAOYSA-N 0.000 description 1
• JIXYOZSBXOQCBA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 JIXYOZSBXOQCBA-UHFFFAOYSA-N 0.000 description 1
• NPSRAORUBDWZDA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 NPSRAORUBDWZDA-UHFFFAOYSA-N 0.000 description 1
• CPEDCQBZPYVTEB-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 CPEDCQBZPYVTEB-UHFFFAOYSA-N 0.000 description 1
• GNIHODBXQFKGPY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 GNIHODBXQFKGPY-UHFFFAOYSA-N 0.000 description 1
• QVUYYMZZXKXDMT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C QVUYYMZZXKXDMT-UHFFFAOYSA-N 0.000 description 1
• SIHKZOBFTRYCNY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 SIHKZOBFTRYCNY-UHFFFAOYSA-N 0.000 description 1
• LBYILBLXEZAHOC-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 LBYILBLXEZAHOC-UHFFFAOYSA-N 0.000 description 1
• XJELXMPLFLYCHV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 XJELXMPLFLYCHV-UHFFFAOYSA-N 0.000 description 1
• MMTAGBXLUGGYSL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 MMTAGBXLUGGYSL-UHFFFAOYSA-N 0.000 description 1
• PHSCIHCCZYCIFT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 PHSCIHCCZYCIFT-UHFFFAOYSA-N 0.000 description 1
• NFIXNQYUPXDHSF-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 NFIXNQYUPXDHSF-UHFFFAOYSA-N 0.000 description 1
• IDKQRTQLMTYMRL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 IDKQRTQLMTYMRL-UHFFFAOYSA-N 0.000 description 1
• DONNJGSFMFQQDT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 DONNJGSFMFQQDT-UHFFFAOYSA-N 0.000 description 1
• ZMRUBTIFWPJXGY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 ZMRUBTIFWPJXGY-UHFFFAOYSA-N 0.000 description 1
• HVIFFPZYCZTWEL-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 HVIFFPZYCZTWEL-UHFFFAOYSA-N 0.000 description 1
• VPGOJDTVHAITLE-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 VPGOJDTVHAITLE-UHFFFAOYSA-N 0.000 description 1
• CGFMMTBCICNCCK-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C CGFMMTBCICNCCK-UHFFFAOYSA-N 0.000 description 1
• QTRJXXQTMJWMMQ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 QTRJXXQTMJWMMQ-UHFFFAOYSA-N 0.000 description 1
• WVBOYWRWHOEZRV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 WVBOYWRWHOEZRV-UHFFFAOYSA-N 0.000 description 1
• IPYZVENFEYSEBN-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 IPYZVENFEYSEBN-UHFFFAOYSA-N 0.000 description 1
• FFFUNDIKJASVFW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 FFFUNDIKJASVFW-UHFFFAOYSA-N 0.000 description 1
• IXTNKSPIPOXBIK-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 IXTNKSPIPOXBIK-UHFFFAOYSA-N 0.000 description 1
• NNIQGSLIOJVXDV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 NNIQGSLIOJVXDV-UHFFFAOYSA-N 0.000 description 1
• OTGWQSRJCLBSMP-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 OTGWQSRJCLBSMP-UHFFFAOYSA-N 0.000 description 1
• UAHQLLRXNQUGHV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 UAHQLLRXNQUGHV-UHFFFAOYSA-N 0.000 description 1
• MDXPVQWEUFSEHO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 MDXPVQWEUFSEHO-UHFFFAOYSA-N 0.000 description 1
• OBEQWGFUFKMYFV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 OBEQWGFUFKMYFV-UHFFFAOYSA-N 0.000 description 1
• LARUFORJGBPOHD-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 LARUFORJGBPOHD-UHFFFAOYSA-N 0.000 description 1
• RHQLMJLJAXYKMI-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C RHQLMJLJAXYKMI-UHFFFAOYSA-N 0.000 description 1
• YJMCUPKEXTXTOX-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 YJMCUPKEXTXTOX-UHFFFAOYSA-N 0.000 description 1
• BFHBQCPLZYFNCX-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 BFHBQCPLZYFNCX-UHFFFAOYSA-N 0.000 description 1
• CQHQQJVOSOKMLG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 CQHQQJVOSOKMLG-UHFFFAOYSA-N 0.000 description 1
• VQUAOBJUGNEALI-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 VQUAOBJUGNEALI-UHFFFAOYSA-N 0.000 description 1
• CUSIHDBNCPCVID-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 CUSIHDBNCPCVID-UHFFFAOYSA-N 0.000 description 1
• KMFZZKCDWWPVJF-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 KMFZZKCDWWPVJF-UHFFFAOYSA-N 0.000 description 1
• KCDLGGOMLDRSJG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 KCDLGGOMLDRSJG-UHFFFAOYSA-N 0.000 description 1
• RZRGZOMVJAGANO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 RZRGZOMVJAGANO-UHFFFAOYSA-N 0.000 description 1
• IKZYVBOILJVNQO-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 IKZYVBOILJVNQO-UHFFFAOYSA-N 0.000 description 1
• OMWVCBIXOKHERU-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 OMWVCBIXOKHERU-UHFFFAOYSA-N 0.000 description 1
• XKQDLLWATLSEQB-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C XKQDLLWATLSEQB-UHFFFAOYSA-N 0.000 description 1
• NUFOAPQXOSUXNB-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 NUFOAPQXOSUXNB-UHFFFAOYSA-N 0.000 description 1
• BEQUQBXDZIKCIV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 BEQUQBXDZIKCIV-UHFFFAOYSA-N 0.000 description 1
• BRTZKLYGDHLWDS-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 BRTZKLYGDHLWDS-UHFFFAOYSA-N 0.000 description 1
• HKVJNBSESBMPFG-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 HKVJNBSESBMPFG-UHFFFAOYSA-N 0.000 description 1
• WPWUEJISXNSZDM-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 WPWUEJISXNSZDM-UHFFFAOYSA-N 0.000 description 1
• UOMVEKQWUOSWAP-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)OC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 UOMVEKQWUOSWAP-UHFFFAOYSA-N 0.000 description 1
• BJIIABINWDMVHV-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,2-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NO1 BJIIABINWDMVHV-UHFFFAOYSA-N 0.000 description 1
• AQFLPKHWGXDKSA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1,3-oxazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CO1 AQFLPKHWGXDKSA-UHFFFAOYSA-N 0.000 description 1
• JYJVUCRFWZOIDA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-imidazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CNC=N1 JYJVUCRFWZOIDA-UHFFFAOYSA-N 0.000 description 1
• YKMOHERJIVQBJZ-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1C=CNN=1 YKMOHERJIVQBJZ-UHFFFAOYSA-N 0.000 description 1
• YJWZYFXJOUHWIN-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-1h-pyrrole-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN1 YJWZYFXJOUHWIN-UHFFFAOYSA-N 0.000 description 1
• MBHCQRPYMSWOEA-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C MBHCQRPYMSWOEA-UHFFFAOYSA-N 0.000 description 1
• CCVMYMJHCYMUMW-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]furan-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CO1 CCVMYMJHCYMUMW-UHFFFAOYSA-N 0.000 description 1
• FBZSEOOGGZKYBD-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrazine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CN=CC=N1 FBZSEOOGGZKYBD-UHFFFAOYSA-N 0.000 description 1
• JYDPSEORXMXCKT-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-3-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1 JYDPSEORXMXCKT-UHFFFAOYSA-N 0.000 description 1
• JRQUWKCWESEWJY-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyridine-4-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=NC=C1 JRQUWKCWESEWJY-UHFFFAOYSA-N 0.000 description 1
• NQXNDYDRURGVDM-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]pyrimidine-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=NC=CC=N1 NQXNDYDRURGVDM-UHFFFAOYSA-N 0.000 description 1
• SSDSJOKBPXUIJF-UHFFFAOYSA-N n-[4-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]methyl]phenyl]thiophene-2-carboxamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)SC(=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CS1 SSDSJOKBPXUIJF-UHFFFAOYSA-N 0.000 description 1
• KVWZLAMQUFYRPG-UHFFFAOYSA-N n-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-2-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2N=CC=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 KVWZLAMQUFYRPG-UHFFFAOYSA-N 0.000 description 1
• JODWOLKYTZBUBR-UHFFFAOYSA-N n-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=NC=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 JODWOLKYTZBUBR-UHFFFAOYSA-N 0.000 description 1
• ZBQRDZCIEGUFCQ-UHFFFAOYSA-N n-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 ZBQRDZCIEGUFCQ-UHFFFAOYSA-N 0.000 description 1
• MVSQLJWKEANWOS-UHFFFAOYSA-N n-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=CN=C1 MVSQLJWKEANWOS-UHFFFAOYSA-N 0.000 description 1
• YIKUPUHYTUYVQC-UHFFFAOYSA-N n-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=NC=C1 YIKUPUHYTUYVQC-UHFFFAOYSA-N 0.000 description 1
• RUAPRHBWEDGFRO-UHFFFAOYSA-N n-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=NC=CC=2)C=2C=CC=CC=2)N=C1C(C=1)=CC=C(OC)C=1OC1CCCC1 RUAPRHBWEDGFRO-UHFFFAOYSA-N 0.000 description 1
• JIJOQYLAGHBOAW-UHFFFAOYSA-N n-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C(C=1)=CC=C(OC)C=1OC1CCCC1 JIJOQYLAGHBOAW-UHFFFAOYSA-N 0.000 description 1
• HWQHYVPCZZIGGI-UHFFFAOYSA-N n-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(C(NC(=O)C=3C=CN=CC=3)C=3C=CC=CC=3)N=2)CC)=C1 HWQHYVPCZZIGGI-UHFFFAOYSA-N 0.000 description 1
• VDWDGRWCTWDHBD-UHFFFAOYSA-N n-[[3-(4-ethoxy-3-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(CC1=O)CC)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=NC=C1 VDWDGRWCTWDHBD-UHFFFAOYSA-N 0.000 description 1
• FHWWURBHLVKMNA-UHFFFAOYSA-N n-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC(F)F)=C1 FHWWURBHLVKMNA-UHFFFAOYSA-N 0.000 description 1
• ZFJQKIKXFRWHNZ-UHFFFAOYSA-N n-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC(F)F)C(OC)=C1 ZFJQKIKXFRWHNZ-UHFFFAOYSA-N 0.000 description 1
• BHGDDZPVOWMCDF-UHFFFAOYSA-N n-[[4-ethyl-3-(3-hydroxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(O)=C1 BHGDDZPVOWMCDF-UHFFFAOYSA-N 0.000 description 1
• QLKIBGGOMOFZEU-UHFFFAOYSA-N n-[[4-ethyl-3-(4-methylsulfonylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(S(C)(=O)=O)C=C1 QLKIBGGOMOFZEU-UHFFFAOYSA-N 0.000 description 1
• FSRGKTVEQFTUFD-UHFFFAOYSA-N n-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OCF)=C1 FSRGKTVEQFTUFD-UHFFFAOYSA-N 0.000 description 1
• GFRAPVCGVLZZOI-UHFFFAOYSA-N n-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC(F)(F)F)C(OC)=C1 GFRAPVCGVLZZOI-UHFFFAOYSA-N 0.000 description 1
• FGWPRSRHXCFMEF-UHFFFAOYSA-N n-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OCF)C(OC)=C1 FGWPRSRHXCFMEF-UHFFFAOYSA-N 0.000 description 1
• DQMCSKSFLYSXNH-UHFFFAOYSA-N n-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1CC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC(F)(F)F)=C1 DQMCSKSFLYSXNH-UHFFFAOYSA-N 0.000 description 1
• AMGRSMSMRBJDMR-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=CC=N1 AMGRSMSMRBJDMR-UHFFFAOYSA-N 0.000 description 1
• CURQFGYHZTVNPT-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=CN=C1 CURQFGYHZTVNPT-UHFFFAOYSA-N 0.000 description 1
• ZBFLDFDVRGBOFO-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(COC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=NC=C1 ZBFLDFDVRGBOFO-UHFFFAOYSA-N 0.000 description 1
• HSHVUSGHCZQSPG-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=CC=N1 HSHVUSGHCZQSPG-UHFFFAOYSA-N 0.000 description 1
• YZDGONKMVJLDAJ-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CSC1=O)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=CN=C1 YZDGONKMVJLDAJ-UHFFFAOYSA-N 0.000 description 1
• LEAVWBSXEZNHPK-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-2-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2N=CC=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 LEAVWBSXEZNHPK-UHFFFAOYSA-N 0.000 description 1
• RQUURJMRCKLKJD-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=NC=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 RQUURJMRCKLKJD-UHFFFAOYSA-N 0.000 description 1
• PSHGLGWBLGANLM-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 PSHGLGWBLGANLM-UHFFFAOYSA-N 0.000 description 1
• WOIGJFHRMUYFML-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-2-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2N=CC=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 WOIGJFHRMUYFML-UHFFFAOYSA-N 0.000 description 1
• PHBRFHUPLZEPGA-UHFFFAOYSA-N n-[[5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=NC=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC)=C1 PHBRFHUPLZEPGA-UHFFFAOYSA-N 0.000 description 1
• JMOLPNYYTHNTLM-UHFFFAOYSA-N n-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=NC=CC=2)C=2C=CC=CC=2)N=C1C(C=1)=CC=C(OC)C=1OC1CCCC1 JMOLPNYYTHNTLM-UHFFFAOYSA-N 0.000 description 1
• BNAKAVJUEPRWCY-UHFFFAOYSA-N n-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C(C=1)=CC=C(OC)C=1OC1CCCC1 BNAKAVJUEPRWCY-UHFFFAOYSA-N 0.000 description 1
• MECVDRASCKQWHN-UHFFFAOYSA-N n-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-3-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=NC=CC=2)C=2C=CC=CC=2)N=C1C(C=1)=CC=C(OC)C=1OC1CCCC1 MECVDRASCKQWHN-UHFFFAOYSA-N 0.000 description 1
• IZLQESYZFUBRDK-UHFFFAOYSA-N n-[[5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C(C=1)=CC=C(OC)C=1OC1CCCC1 IZLQESYZFUBRDK-UHFFFAOYSA-N 0.000 description 1
• RLNRIUGAMJHBDW-UHFFFAOYSA-N n-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(OC(=O)N(C(NC(=O)C=3C=CN=CC=3)C=3C=CC=CC=3)N=2)CC)=C1 RLNRIUGAMJHBDW-UHFFFAOYSA-N 0.000 description 1
• FKZQWCYCZUYZDW-UHFFFAOYSA-N n-[[5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(SC(=O)N(C(NC(=O)C=3C=CN=CC=3)C=3C=CC=CC=3)N=2)CC)=C1 FKZQWCYCZUYZDW-UHFFFAOYSA-N 0.000 description 1
• ZRGJJOUAOFXHKE-UHFFFAOYSA-N n-[[5-(4-ethoxy-3-methoxyphenyl)-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound C1=C(OC)C(OCC)=CC=C1C(C(SC1=O)CC)=NN1C(C=1C=CC=CC=1)NC(=O)C1=CC=NC=C1 ZRGJJOUAOFXHKE-UHFFFAOYSA-N 0.000 description 1
• WGYSWLGMVFDZNX-UHFFFAOYSA-N n-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC(F)F)=C1 WGYSWLGMVFDZNX-UHFFFAOYSA-N 0.000 description 1
• URNBDLFVGXOEPU-UHFFFAOYSA-N n-[[5-[3-(difluoromethoxy)-4-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC(F)F)=C1 URNBDLFVGXOEPU-UHFFFAOYSA-N 0.000 description 1
• WJIHPPWIGWSCFK-UHFFFAOYSA-N n-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC(F)F)C(OC)=C1 WJIHPPWIGWSCFK-UHFFFAOYSA-N 0.000 description 1
• HJIVEHDFIGIXJF-UHFFFAOYSA-N n-[[5-[4-(difluoromethoxy)-3-methoxyphenyl]-6-ethyl-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC(F)F)C(OC)=C1 HJIVEHDFIGIXJF-UHFFFAOYSA-N 0.000 description 1
• FCHCLDQCKTYDKL-UHFFFAOYSA-N n-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(O)=C1 FCHCLDQCKTYDKL-UHFFFAOYSA-N 0.000 description 1
• MLWVXTVUZJJCMX-UHFFFAOYSA-N n-[[6-ethyl-5-(3-hydroxy-4-methoxyphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(O)=C1 MLWVXTVUZJJCMX-UHFFFAOYSA-N 0.000 description 1
• IYIJBRXVRSOHKW-UHFFFAOYSA-N n-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(S(C)(=O)=O)C=C1 IYIJBRXVRSOHKW-UHFFFAOYSA-N 0.000 description 1
• HAHAIMVUXSWYFC-UHFFFAOYSA-N n-[[6-ethyl-5-(4-methylsulfonylphenyl)-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(S(C)(=O)=O)C=C1 HAHAIMVUXSWYFC-UHFFFAOYSA-N 0.000 description 1
• RWYXTCNCJVXSLP-UHFFFAOYSA-N n-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OCF)=C1 RWYXTCNCJVXSLP-UHFFFAOYSA-N 0.000 description 1
• WTOLHDPDMXRCRP-UHFFFAOYSA-N n-[[6-ethyl-5-[3-(fluoromethoxy)-4-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OCF)=C1 WTOLHDPDMXRCRP-UHFFFAOYSA-N 0.000 description 1
• XWUNCZYBVOZQFY-UHFFFAOYSA-N n-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC(F)(F)F)C(OC)=C1 XWUNCZYBVOZQFY-UHFFFAOYSA-N 0.000 description 1
• GMTKYRHOCLWYKA-UHFFFAOYSA-N n-[[6-ethyl-5-[3-methoxy-4-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC(F)(F)F)C(OC)=C1 GMTKYRHOCLWYKA-UHFFFAOYSA-N 0.000 description 1
• IQFTUGUAGCTQFV-UHFFFAOYSA-N n-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OCF)C(OC)=C1 IQFTUGUAGCTQFV-UHFFFAOYSA-N 0.000 description 1
• LAHVXWXQPQYKCM-UHFFFAOYSA-N n-[[6-ethyl-5-[4-(fluoromethoxy)-3-methoxyphenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OCF)C(OC)=C1 LAHVXWXQPQYKCM-UHFFFAOYSA-N 0.000 description 1
• PELLXDGSKRIZCT-UHFFFAOYSA-N n-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-oxadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1OC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC(F)(F)F)=C1 PELLXDGSKRIZCT-UHFFFAOYSA-N 0.000 description 1
• RMQFVHBDVBNGNV-UHFFFAOYSA-N n-[[6-ethyl-5-[4-methoxy-3-(trifluoromethoxy)phenyl]-2-oxo-6h-1,3,4-thiadiazin-3-yl]-phenylmethyl]pyridine-4-carboxamide Chemical compound CCC1SC(=O)N(C(NC(=O)C=2C=CN=CC=2)C=2C=CC=CC=2)N=C1C1=CC=C(OC)C(OC(F)(F)F)=C1 RMQFVHBDVBNGNV-UHFFFAOYSA-N 0.000 description 1
• QPLARKVCHCFNTD-UHFFFAOYSA-N n-cyclopentyl-3-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1C(=O)NC1CCCC1 QPLARKVCHCFNTD-UHFFFAOYSA-N 0.000 description 1
• CDENDTKQVUVXDG-UHFFFAOYSA-N n-cyclopentyl-3-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=CC(C(=O)NC2CCCC2)=C1 CDENDTKQVUVXDG-UHFFFAOYSA-N 0.000 description 1
• RZQMAHJRZPVWLN-UHFFFAOYSA-N n-cyclopentyl-3-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=1)=CC=CC=1C(=O)NC1CCCC1 RZQMAHJRZPVWLN-UHFFFAOYSA-N 0.000 description 1
• BDYPNUZVTSHQIG-UHFFFAOYSA-N n-cyclopentyl-4-[2-[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]benzamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CCC(C=C1)=CC=C1C(=O)NC1CCCC1 BDYPNUZVTSHQIG-UHFFFAOYSA-N 0.000 description 1
• JXTICDYPIKTUDJ-UHFFFAOYSA-N n-cyclopentyl-4-[2-[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]ethyl]benzamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CCC1=CC=C(C(=O)NC2CCCC2)C=C1 JXTICDYPIKTUDJ-UHFFFAOYSA-N 0.000 description 1
• HQXMFPOTFKQTLG-UHFFFAOYSA-N n-cyclopentyl-4-[[3-(3,4-dimethoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 HQXMFPOTFKQTLG-UHFFFAOYSA-N 0.000 description 1
• LOOVROGXKXMALH-UHFFFAOYSA-N n-cyclopentyl-4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CCC1=O)=NN1CC1=CC=C(C(=O)NC2CCCC2)C=C1 LOOVROGXKXMALH-UHFFFAOYSA-N 0.000 description 1
• YYEXUKROVDZQFT-UHFFFAOYSA-N n-cyclopentyl-4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC3CCCC3)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 YYEXUKROVDZQFT-UHFFFAOYSA-N 0.000 description 1
• YXQONFBPQYWASH-UHFFFAOYSA-N n-cyclopentyl-4-[[3-(3-cyclopentyloxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound COC1=CC=C(C=2CCC(=O)N(CC=3C=CC(=CC=3)C(=O)NC3CCCC3)N=2)C=C1OC1CCCC1 YXQONFBPQYWASH-UHFFFAOYSA-N 0.000 description 1
• CWCBYXFUTDCBRM-UHFFFAOYSA-N n-cyclopentyl-4-[[3-(3-ethoxy-4-methoxyphenyl)-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound C1=C(OC)C(OCC)=CC(C=2C(CC(=O)N(CC=3C=CC(=CC=3)C(=O)NC3CCCC3)N=2)CC)=C1 CWCBYXFUTDCBRM-UHFFFAOYSA-N 0.000 description 1
• GUSICFIDQPASDG-UHFFFAOYSA-N n-cyclopentyl-4-[[3-(3-ethoxy-4-methoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound C1=C(OC)C(OCC)=CC(C=2CCC(=O)N(CC=3C=CC(=CC=3)C(=O)NC3CCCC3)N=2)=C1 GUSICFIDQPASDG-UHFFFAOYSA-N 0.000 description 1
• VLVXGMUYDSKVKD-UHFFFAOYSA-N n-cyclopentyl-4-[[3-[3-(difluoromethoxy)-4-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 VLVXGMUYDSKVKD-UHFFFAOYSA-N 0.000 description 1
• PTKJMQZCOZKLSR-UHFFFAOYSA-N n-cyclopentyl-4-[[3-[4-(difluoromethoxy)-3-methoxyphenyl]-4-ethyl-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 PTKJMQZCOZKLSR-UHFFFAOYSA-N 0.000 description 1
• QKFHZKUWYFXLMS-UHFFFAOYSA-N n-cyclopentyl-4-[[4-ethyl-3-[3-(fluoromethoxy)-4-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OCF)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 QKFHZKUWYFXLMS-UHFFFAOYSA-N 0.000 description 1
• IAARSOWFPQPFNS-UHFFFAOYSA-N n-cyclopentyl-4-[[4-ethyl-3-[3-methoxy-4-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC)C(OC(F)(F)F)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 IAARSOWFPQPFNS-UHFFFAOYSA-N 0.000 description 1
• YBOQYBKTBBEBIV-UHFFFAOYSA-N n-cyclopentyl-4-[[4-ethyl-3-[4-(fluoromethoxy)-3-methoxyphenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC)C(OCF)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 YBOQYBKTBBEBIV-UHFFFAOYSA-N 0.000 description 1
• PZAGWNHKROJUAV-UHFFFAOYSA-N n-cyclopentyl-4-[[4-ethyl-3-[4-methoxy-3-(trifluoromethoxy)phenyl]-6-oxo-4,5-dihydropyridazin-1-yl]methyl]benzamide Chemical compound N1=C(C=2C=C(OC(F)(F)F)C(OC)=CC=2)C(CC)CC(=O)N1CC(C=C1)=CC=C1C(=O)NC1CCCC1 PZAGWNHKROJUAV-UHFFFAOYSA-N 0.000 description 1
• MZLSLWAJTLPVGV-UHFFFAOYSA-N n-morpholin-4-ylpropanamide Chemical compound CCC(=O)NN1CCOCC1 MZLSLWAJTLPVGV-UHFFFAOYSA-N 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 239000000243 solution Substances 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 229960002622 triacetin Drugs 0.000 description 1
• 230000004614 tumor growth Effects 0.000 description 1
• JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
• 229940099259 vaseline Drugs 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1