KR20050028900A - 포스포디에스테라아제 ⅳ 억제제의 용도 - Google Patents

포스포디에스테라아제 ⅳ 억제제의 용도 Download PDF

Info

Publication number
KR20050028900A
KR20050028900A KR1020047005415A KR20047005415A KR20050028900A KR 20050028900 A KR20050028900 A KR 20050028900A KR 1020047005415 A KR1020047005415 A KR 1020047005415A KR 20047005415 A KR20047005415 A KR 20047005415A KR 20050028900 A KR20050028900 A KR 20050028900A
Authority
KR
South Korea
Prior art keywords
ethyl
dihydro
dimethoxyphenyl
methoxyphenyl
tetrahydropyridazin
Prior art date
Application number
KR1020047005415A
Other languages
English (en)
Inventor
에겐바일러한스-미하엘
볼프미하엘
Original Assignee
메르크 파텐트 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7702358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20050028900(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 메르크 파텐트 게엠베하 filed Critical 메르크 파텐트 게엠베하
Publication of KR20050028900A publication Critical patent/KR20050028900A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 골다공증, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 당뇨병, 궤양성 대장염 및 AIDS 의 치료용 약제의 제조에서의 포스포디에스테라아제 Ⅳ 억제제 및/또는 이의 생리학적 허용염의 용도에 관한 것이다.

Description

포스포디에스테라아제 Ⅳ 억제제의 용도 {USE OF PHOSPHORODIESTERASE Ⅳ INHIBITORS}
본 발명은 골다공증, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 당뇨병, 궤양성 대장염 및 AIDS 의 치료용 약제의 제조를 위한 하기 화합물 및/또는 이의 생리학적 허용염의 용도에 관한 것이다:
a) EP 0 738 715 A2 에 기재된 하기 화학식 I 의 화합물,
(상기 식중,
R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
R3 및 R4 는 각각 서로 독립적으로, -OH, -OR10, -S-R10, -SO-R 10, -SO2-R10, Hal, 메틸렌디옥시, -NO2, -NH2, -NHR10 또는 -NR10R11 이며,
R5 는 비치환되거나, R6 및/또는 R7 로 일치환 또는 이치환되는 페닐 라디칼이고,
Q 는 존재하지 않거나, 탄소수 1 내지 6 의 알킬렌이며,
R6 및 R7 은 각각 서로 독립적으로, -NH2, -NR8R9, -NHR10, -NR10R11, -NO2, Hal, -CN, -OA, -COOH 또는 -COOA 이고,
R8 및 R9 는 각각 서로 독립적으로, H, 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 8 의 아실, 또는 -COOA, -SO-A, -SO2A, -CONH2, -CONHA, -CONA2, -CO-COOH, -CO-COOA, -CO-CONH2, -CO-CONHA 또는 -CO-CONA2 이며,
A 는 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 6 의 알킬이고,
R10 및 R11 은 각각 서로 독립적으로, A, 탄소수 3 내지 7 의 시클로알킬, 탄소수 4 내지 8 의 메틸렌시클로알킬 또는 탄소수 2 내지 8 의 알케닐이며,
Hal 은 F, Cl, Br 또는 I 이다)
b) EP 0 723 962 B1 에 기재된 하기 화학식 I 의 화합물,
(상기 식중,
R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
R3 및 R4 는 각각 서로 독립적으로, -OH, -OR10, -S-R10, -SO-R 10, -SO2-R10, Hal, 메틸렌디옥시, -NO2, -NH2, -NHR10 또는 -NR10R11 이며,
R5 는 비치환되거나, R6 및/또는 R7 로 일치환 또는 이치환되는 페닐 라디칼이고,
Q 는 존재하지 않거나, 탄소수 1 내지 6 의 알킬렌이며,
R6 및 R7 은 각각 서로 독립적으로, -NH2, -NR8R9, -NHR10, -NR10R11, -NO2, Hal, -CN, -OA, -COOH 또는 -COOA 이고,
R8 및 R9 는 각각 서로 독립적으로, H, 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 8 의 아실, 또는 -COOA, -SO-A, -SO2A, -CONH2, -CONHA, -CONA2, -CO-COOH, -CO-COOA, -CO-CONH2, -CO-CONHA 또는 -CO-CONA2 이며,
A 는 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 6 의 알킬이고,
R10 및 R11 은 각각 서로 독립적으로, A, 탄소수 3 내지 7 의 시클로알킬, 탄소수 4 내지 8 의 메틸렌시클로알킬 또는 탄소수 2 내지 8 의 알케닐이며,
Hal 은 F, Cl, Br 또는 I 이다)
c) EP 0 763 534 A1 에 기재된 하기 화학식 I 의 화합물,
(상기 식중,
B 는 치환되지 않거나, Hal, A 및/또는 OA 로 일치환, 이치환 또는 삼치환될 수 있고, 또한 벤젠 또는 피리딘 고리에 융합될 수 있는, N 또는 C 를 통해 결합된, 1 내지 4 개의 N, O 및/또는 S 원자를 갖는 방향족 헤테로시클릭 라디칼이며,
Q 는 존재하지 않거나, 탄소수 1 내지 6 의 알킬렌이고,
X 는 CH2, S 또는 O 이며,
R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
R3 및 R4 는 각각 서로 독립적으로, -OH, -OR5, -S-R5, -SO-R 5, -SO2-R5, Hal, 메틸렌디옥시, -NO2, -NH2, -NHR5 또는 -NR5R6 이며,
R5 및 R6 은 각각 서로 독립적으로, A, 탄소수 3 내지 7 의 시클로알킬, 탄소수 4 내지 8 의 메틸렌시클로알킬 또는 탄소수 2 내지 8 의 알케닐이고,
A 는 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 10 의 알킬이며,
Hal 은 F, Cl, Br 또는 I 이다)
d) EP 0 539 806 B1 에 기재된 하기 화학식 I 의 화합물,
(상기 식중,
R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
R3 은 H, OA 또는 O-CmH2m+1-nXn 이며,
R4 는 -O-CmH2m+1-nXn 이고,
X 는 F 또는 Cl 이며,
A 는 탄소수 1 내지 6 의 알킬이고,
m 은 1, 2, 3, 4, 5 또는 6 이며,
n 은 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 또는 13 이다)
e) EP 0 618 201 A1 에 기재된 하기 화학식 I 의 화합물,
(상기 식중,
R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
R3 및 R4 는 각각 서로 독립적으로, OH, OA, SA, SOA, SO2A, Hal, 메틸렌디옥시, 탄소수 3 내지 7 의 시클로알콕시 또는 O-CmH2m+1-kFk 이며,
R5 는 -NR6R7 또는 (여기서, 하나의 CH2 기는 또한 산소로 대체될 수 있음) 이고,
R6 및 R7 은 각각 서로 독립적으로, H 또는 A 이고,
Q 는 탄소수 1 내지 6 의 알킬렌이며,
A 는 탄소수 1 내지 6 의 알킬이고,
Hal 은 F, Cl, Br 또는 I 이며,
m 은 1, 2, 3, 4, 5 또는 6 이고,
n 은 3, 4, 5 또는 6 이며,
k 는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 또는 13 이다)
f) DE 196 04 388 A1 에 기재된 하기 화학식 I 의 화합물,
(상기 식중,
R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
R3 및 R4 는 각각 서로 독립적으로, -OH, -OA, -S-A, -SO-A, -SO2-A, Hal, 메틸렌디옥시, -NO2, -NH2, -NHA 또는 -NAA' 이며,
A 및 A' 는 각각 서로 독립적으로, 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 10 의 알킬, 또는 탄소수 3 내지 7 의 시클로알킬 또는 탄소수 4 내지 8 의 메틸렌시클로알킬이고,
B 는 -Y-R5 또는 -O-Y-R5 이며,
Q 는 존재하지 않거나, 탄소수 1 내지 4 의 알킬렌이고,
Y 는 존재하지 않거나, 탄소수 1 내지 10 의 알킬렌이며,
X 는 CH2 또는 S 이고,
R5 는 치환되지 않거나, A 또는 OH 로 일치환되며, 또한 또다른 CH2 기는 NH, NA, S 또는 O 로 대체될 수 있는, 하나 이상의 N 원자를 갖는 포화 3 내지 8 원 헤테로시클릭 라디칼, NAA', NHA 또는 NH2 이며,
Hal 은 F, Cl, Br 또는 I 이다).
본 발명은 화학식 I 의 화합물, 특히 약제를 제조할 수 있는 것들의 새로운 용도를 발견함을 목적으로 하였다.
화학식 I 의 화합물 및 이의 염은 매우 유익한 약물학적 성질을 가지며, 충분한 내성이 있는 것으로 알려져 있다.
특히, 이들은 cAMP 의 세포내 증가와 함께, 선택적인 포스포디에스테라아제 IV 억제를 나타낸다 (N. Sommer et al., Nature Medicine, 1, 244-248 (1995)). PDE IV 억제는, 예를 들면 문헌 [C.W. Davis in Biochim. Biophys, Acta 797, 354-362 (1984)] 와 비슷하게 설명될 수 있다.
본 발명에 따른 화합물은 천식 질환의 치료에 사용될 수 있다. PDE IV 억제제의 항천식 작용은, 예를 들면 T.N. Torphy et al. 에 의해 문헌 [Thorax, 46, 512-523 (1991)] 에 기재되어 있으며, 예를 들면 [T. Olsson, Acta allergologica 26, 438-447 (1971)] 의 방법에 의해 설명될 수 있다.
cAMP 는 뼈 퇴화 세포를 억제하고 뼈 형성 세포를 자극하기 때문에 (S. Kasugai et al., M 681 and K.Miyamoto, M682, in Abstracts of the American Society for Bone and Mineral Research, 18th Annual Meeting, 1996), 본 발명에 따른 화합물은 골다공증의 치료에 사용될 수 있다.
또한, 상기 화합물은 TNF (종양 괴사 인자) 의 형성에 대해 억제 작용을 나타내며, 따라서 알레르기성 및 염증성 질환, 자가면역 질환 및 이식 거부 반응의 치료에 적합하다. 이들은 기억 장애, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 크론병, 아토피성 피부염, 당뇨병, 궤양성 대장염 및 AIDS 의 치료에 사용될 수 있다.
천식, 염증성 질환, 당뇨병, 아토피성 피부염, 건선, AIDS, 종양 성장 또는 종양 전이의 치료에서 PDE IV 억제제의 작용은, 예를 들면 EP 779 291 에 기재되어 있다.
본 발명에 따른 물질의 항염증 작용 및, 예를 들어 자가면역 질환, 복합 경화증 또는 류머티즘성 관절염의 치료에 대한 상기 물질의 효능은 문헌 [N.Sommer et al., Nature Medicine 1, 244-248 (1995)] 또는 [L.Sekut et al., Clin. Exp. Immunol. 100, 126-132 (1995)] 의 방법과 비슷하게 결정될 수 있다.
종양 치료에서의 PDE IV 억제제의 작용은, 예를 들면 WO 95/35281, WO 95/17399 및 WO 96/00215 에 기재되어 있다.
놀랍게도, 화학식 I 의 화합물은 암 치료에 적합한 것으로 발견되었다.
본 발명은 또한 종양 세포의 성장 억제용 약제의 제조를 위한, 화학식 I 의 화합물 및 이의 생리학적 허용염 및/또는 용매화물의 용도에 관한 것이다.
용어 종양 세포는 암 세포를 의미하는 것으로 주어진다.
본 발명은 특히 암 질환의 치료 및/또는 예방용 약제의 제조를 위한, 화학식 I 의 화합물 및 이의 생리학적 허용염 및/또는 용매화물의 용도에 관한 것이다.
본 발명은 또한 종양성 손상의 치료용 약제의 제조를 위한, 화학식 I 의 화합물 및 이의 생리학적 허용염 및/또는 용매화물의 용도에 관한 것이다.
본 발명은 또한 발암성 손상의 치료용 약제의 제조를 위한, 화학식 I 의 화합물 및 이의 생리학적 허용염 및/또는 용매화물의 용도에 관한 것이다.
용어 발암성 손상은, 예를 들면 장 암을 유발할 수 있는 장내의 양성 종양을 의미하는 것으로 주어진다.
용어 발암성 손상은 특히 US 5,948,911 의 컬럼 4, 49-60 행에 언급된 장애를 의미하는 것으로 주어진다.
세포소멸 (세포 고사) 의 불규칙성은 발암성 손상의 형성 역할을 한다.
또한, 세포소멸의 규제는, 예컨대 양성 전립선 과형성과 같은 비정상적 세포 성장과 관련된 질환, 예컨대 파킨슨병과 같은 신경변성 질환, 복합 경화증을 포함한 자가면역 질환, 및 류머티즘성 관절염, 또는 AIDS 와 같은 감염 질환에 중요한 역할을 하는 것으로 알려져 있다.
화학식 I 의 화합물은 세포소멸을 조절하며, 암 질환의 치료 또는 예방에 사용된다.
따라서, 본 발명은 사람 세포에서 세포소멸의 규제용 약제의 제조를 위한, 화학식 I 의 화합물 및 이의 생리학적 허용염 및/또는 용매화물의 용도에 관한 것이다.
화학식 I 의 화합물은 사람 및 동물 의학에서 약제 활성 성분으로서 사용될 수 있다. 이들은 또한 다른 약제 활성 성분 제조용 중간체로서 사용될 수 있다.
화학식 I 의 화합물은 키랄 센터를 가질 수 있으며, 따라서 다수의 입체이성질체 형태를 나타낼 수 있다. 모든 이들 형태 (예컨대, R 및 S 형태) 및 이의 혼합물 (예컨대, R,S 형태) 이 화학식 I 에 포함된다.
화학식 I 의 이들 화합물은 사람 또는 동물 의학에서 약제로서 사용될 수 있다. 적합한 부형제는 소장내 (예컨대, 경구), 비경구 또는 국소 투여에 적합하고, 신규 화합물과 반응하지 않는 유기 또는 무기 물질, 예를 들면 물, 식물성 오일, 벤질 알코올, 알킬렌 글리콜, 폴리에틸렌 글리콜, 글리세롤 트리아세테이트, 젤라틴, 탄수화물, 예컨대 락토오스 또는 전분, 마그네슘 스테아레이트, 탈크 또는 바셀린이다. 경구 투여용으로는 특히 정제, 환약, 당의정, 캡슐, 분말, 과립, 시럽, 즙 또는 적제가 적합하고, 직장 투여용으로는 좌제가 적합하며, 비경구 투여용으로는 용액, 바람직하게는 유계 또는 수성 용액, 더욱이 현탁액, 유상액 또는 임플런트가 적합하고, 국소 투여용으로는 연고, 크림 또는 분말이 적합하다. 신규 화합물은 또한 친액성일 수 있으며, 수득되는 친액물질은, 예를 들면 주사용 제제의 제조에 사용될 수 있다. 상기 언급된 제제는 살균될 수 있으며/있거나 윤활제, 방부제, 안정화제 및/또는 습윤제, 유화제, 삼투압 조절용 염, 완충 물질, 착색제 및 향미료 및/또는 하나 이상의 추가의 활성 물질, 예컨대 하나 이상의 비타민과 같은 보조제를 포함할 수 있다.
화학식 I 의 화합물 및 이의 생리학적 허용염은 cAMP (시클로아데노신 모노포스페이트) 함량의 증가가 염증 억제 또는 방지 및 근육 이완을 야기하는 질병을 제거하는데 사용될 수 있다. 본 발명에 따른 화합물은 특히 골다공증, 종양, 종양 전이, 천식, 만성 기관지염, 아토피성 피부염, 건선 및 피부 질환 및 자가면역 질환의 치료에 사용될 수 있다.
본 발명에 따른 물질은 통상적으로 투여 단위당, 바람직하게는 약 1 내지 500 ㎎, 특히 5 내지 100 ㎎ 의 투여량으로 투여된다. 일일 투여량은 바람직하게는 약 0.02 내지 10 ㎎/체중 ㎏ 이다. 그러나, 개개의 환자에 대한 특정한 투여량은 다양한 인자, 예를 들면 사용되는 특정 화합물의 효능, 연령, 체중, 전반적인 건강 상태, 성별, 규정식, 투여 시간 및 방법, 배설률, 약제 조화성 및 치료하고자 하는 특정 질병의 심각성에 따라 다르다. 경구 투여가 바람직하다.
화학식 I 의 화합물은 하나 이상의 비대칭 중심을 가질 수 있다. 이 경우, 이들은 통상적으로 라세믹체 형태를 가진다. 수득되는 라세믹체는 자체로 공지된 방법에 의해서 기계적으로 또는 화학적으로 이들의 거울상이성질체로 분리될 수 있다. 바람직하게는, 광학 활성 분해제와의 반응에 의해서 라세믹 혼합물로부터 쌍성이성질체가 형성된다.
본 발명은 특히 골다공증, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 당뇨병, 궤양성 대장염 및 AIDS 의 치료용 약제의 제조를 위한 하기 화합물 및/또는 이의 생리학적 허용염의 용도에 관한 것이다:
a) 하기로 구성된 군에서 선택되는, EP 0 738 715 A2 에 기재된 화합물:
2-(4-니트로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 126°;
2-(3-니트로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 122°;
2-(2-니트로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,3-디니트로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,4-디니트로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-메톡시벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-클로로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,6-디클로로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시아노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-카르복시벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-니트로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-니트로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,3-디니트로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,4-디니트로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-메톡시벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-클로로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,6-디클로로벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시아노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-카르복시벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 184°;
2-(3-아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 140°;
2-(2-아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,3-디아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,4-디아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 49°;
2-(2-아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,3-디아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2,4-디아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 109°;
2-(4-아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 112°;
2-(4-카르복시벤질)-6-(3,4-디히드록시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 148°;
2-(4-아세트아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 183°;
2-(4-트리플루오로아세트아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 210°;
2-(4-메틸술폰아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 138°;
2-(4-프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 176°;
2-(4-tert-부틸카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 155°;
2-(4-이소부티릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 147°;
2-(4-메톡살릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 133°;
2-(4-메틸술폰아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 81°;
2-(4-tert-부틸카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 117°;
2-(4-이소부티릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 144°;
2-(4-피발릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 154°;
2-(4-메톡살릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도일벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 162°;
2-(4-메틸술폰아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 69°;
2-(4-tert-부틸카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 73°;
2-(4-메톡살릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아세트아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-트리플루오로아세트아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 142°;
2-(3-메틸술폰아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 126°;
2-(3-부티릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-이소부티릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-메톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피발릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-시클로펜틸카르바모일벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 54°;
2-(3-메톡살릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-우레이도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-펜타노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-헥사노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-펜타플루오로프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 170°;
2-(4-트리플루오로아세트아미도벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 128°;
2-(4-메톡살릴아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-tert-부틸카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-아세트아미도페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메틸술폰아미도페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-프로피오닐아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소부티릴아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피발릴아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-시클로펜틸카르바모일페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡살릴아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-우레이도페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타노일아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-헥사노일아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-펜타플루오로프로피오닐아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아세트아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 105°;
2-(3-트리플루오로아세트아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 136°;
2-(3-메틸술폰아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 177°;
2-(3-프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 152°;
2-(3-tert-부틸카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-부티릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-이소부티릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-메톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피발릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-시클로펜틸카르바모일벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 179°;
2-(3-메톡살릴아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-우레이도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-펜타노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-헥사노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-펜타플루오로프로피오닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아세트아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-트리플루오로아세트아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 70°;
2-(3-메틸술폰아미도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-프로피오닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 113°;
2-(3-tert-부틸카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-부티릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-이소부티릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-메톡시카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피발릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-시클로펜틸카르바모일벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-에톡시카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온, 융점 153°;
2-(3-메톡살릴아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-우레이도벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-펜타노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-헥사노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-펜타플루오로프로피오닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니트로벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 126°;
2-(4-니트로페닐)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
b) 하기로 구성된 군에서 선택되는, EP 0 763 534 에 기재된 화합물:
2-(4-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-니코티노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-니코티노일아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-이소니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-이소니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-이소니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-이소니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-이소니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-이소니코티노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-이소니코티노일아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-이소니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-이소니코티노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-이소니코티노일아미노페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-피콜리노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피콜리노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-피콜리노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피콜리노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-피콜리노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피콜리노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피콜리노일아미노페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-피콜리노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-피콜리노일아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피콜리노일아미노페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(푸란-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(푸란-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(푸란-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(푸란-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(푸란-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(푸란-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(푸란-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(푸란-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(푸란-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(푸란-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피롤-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(피롤-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피롤-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(피롤-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피롤-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피롤-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피롤-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(피롤-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피롤-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피롤-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(티오펜-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(티오펜-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(티오펜-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(티오펜-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(티오펜-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(티오펜-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 186°;
3-(3-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(티오펜-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(티오펜-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(티오펜-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(티오펜-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-피라진카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 197°;
2-(3-피라진카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-피라진카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피라진카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-피라진카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-피라진카르보닐아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노-페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-피라진카르보닐아미노-페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 202°;
3-(3-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-피라진카르보닐아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노-페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노-페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-피라진카르보닐아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-피라진카르보닐아미노벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노-페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-피라진카르보닐아미노-페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(4-메틸렌옥시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(6-클로로피리다진-3-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(4-메틸렌옥시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(6-클로로피리다진-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(6-클로로피리다진-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(이미다졸-4-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(이미다졸-4-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(이미다졸-4-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(이미다졸-4-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(이미다졸-4-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이미다졸-4-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이미다졸-4-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(2,4-디메틸티아졸-5-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이미다졸-4-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(2,4-디메틸티아졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(2,4-디메틸티아졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 217°;
2-(3-(이속사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(이속사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(이속사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(이속사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(이속사졸-5-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(이속사졸-5-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 196°;
3-(3-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(이속사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(이속사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(이속사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(이속사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(옥사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(옥사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(옥사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(옥사졸-5-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(옥사졸-5-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(옥사졸-5-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(옥사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(옥사졸-5-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(옥사졸-5-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(옥사졸-5-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피리미딘-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(피리미딘-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피리미딘-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(피리미딘-2-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피리미딘-2-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피리미딘-2-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피리미딘-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(피리미딘-2-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피리미딘-2-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피리미딘-2-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피라졸-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(피라졸-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피라졸-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(2-(피라졸-3-카르보닐아미노)벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-메톡시-4-트리플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-메톡시-4-디플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-메톡시-4-플루오로메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-디플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-트리플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-플루오로메톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-메톡시-4-에톡시-페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-히드록시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(4-메틸술포닐페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(4-메틸렌옥시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-(피라졸-3-카르보닐아미노)벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-(피라졸-3-카르보닐아미노)페네틸)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(3-(피라졸-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(2-(피라졸-3-카르보닐아미노)벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-트리플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-에톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-히드록시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(4-메틸술포닐페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(4-메틸렌옥시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(3-(피라졸-3-카르보닐아미노)벤질)-5-(3-시클로펜틸옥시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-옥사디아진-2-온;
3-(4-(피라졸-3-카르보닐아미노)페네틸)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-옥사디아진-2-온;
2-(3-니코티노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 204°;
2-(4-이소니코티노일아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 염산염, 융점 252°;
2-(4-피라진카르보닐아미노벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 202°;
2-(4-(이속사졸-5-카르보닐아미노)벤질)-6-(3-에톡시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 192°;
2-(4-니코티노일아미노벤질)-6-(3-시클로펜틸옥시-4-메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 융점 205°;
2-(4-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온, 염산염, 융점 212°;
d) 하기로 구성된 군에서 선택되는, EP 0 539 806 B1 에 기재된 화합물:
5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 97°;
5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-트리플루오로메톡시페닐)-6-메틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-디플루오로메톡시페닐)-6-메틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-메톡시-4-(1,1,2,2-테트라플루오로에톡시)페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-클로로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-클로로메톡시페닐)-6-메틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-펜타클로로에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-트리플루오로메톡시페닐)-6-프로필-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-디플루오로메톡시페닐)-6-프로필-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-메톡시-4-(1,1,2-트리플루오로에톡시)페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-메톡시-4-(1,1,2-트리플루오로에톡시)페닐]-6-메틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-디플루오로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 120°;
5-(3-메톡시-4-트리플루오로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(4-트리플루오로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-메톡시-4-(1,1,2,2-테트라플루오로에톡시)페닐]-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-클로로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-트리클로로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-펜타클로로에톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(4-디플루오로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-메톡시-4-(1,1,2,2,3-펜타플루오로프로폭시)-페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[비스-3,4-(디플루오로메톡시)-페닐]-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[비스-3,4-(디클로로메톡시)-페닐]-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[비스-3,4-(1,2-디플루오로에톡시)페닐]-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-에톡시-4-(1,1,2,2-테트라플루오로에톡시)페닐]-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[3-메톡시-4-(1,2,2-트리클로로에톡시)페닐]-3,6-디히드로-1,3,4-티아디아진-2-온;
5-[4-(2,2,2-트리플루오로에톡시)페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 102°;
5-[3-메톡시-4-(2,2,2-트리플루오로에톡시)페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 123-125°;
5-[3-메톡시-4-(2,2,2-트리플루오로에톡시)페닐]-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 120°;
5-[3-(2,2,2-트리플루오로에톡시)-4-메톡시페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 120-121°;
5-(3-디플루오로메톡시-4-메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온, 융점 105°;
e) 하기로 구성된 군에서 선택되는, EP 0 618 201 A1 에 기재된 화합물:
3-디메틸아미노프로필-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온, 융점 175°;
3-디메틸아미노프로필-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(4-메톡시-3-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-[4-메톡시-3-(2,2,2-트리플루오로에톡시)페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(4-메톡시-3-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(4-메톡시-3-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(3-메톡시-4-히드록시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(4-메톡시-3-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(4-메톡시-3-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(3-메톡시-4-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(4-메톡시-3-에톡시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-디메틸아미노에틸-5-(4-메톡시-3-히드록시-페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-[3-메톡시-4-(1,1,2,2,3-펜타플루오로프로폭시)-페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-[3,4-비스-(디플루오로메톡시)-페닐]-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-[3-메톡시-4-(1,1,2-트리플루오로에톡시)페닐]-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-[3,4-비스-(클로로메톡시)-페닐]-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피롤리디노프로필-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피롤리디노프로필-5-(3-메톡시-4-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(4-메톡시-3-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-(4-메톡시-3-에톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-(4-메톡시-3-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-[3-(2,2,2-트리플루오로에톡시)-4-메톡시페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-[3-(2,2,2-트리플루오로에톡시)-4-메톡시페닐]-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-모르폴리노에틸-5-(3-메톡시-4-플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
2-모르폴리노에틸-5-(3-메톡시-4-트리플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
f) 하기로 구성된 군에서 선택되는, DE 196 04 388 A1 에 기재된 화합물:
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트, 염산염, 융점 218°;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트, 융점 183°;
(4-히드록시-1-피페리딜)에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트, 염산염, 융점 161°;
2-(N,N-디에틸아미노)에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트, 융점 153°;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-6-에틸-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(3,6-디히드로-5-(3-플루오로메톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-모르폴리노아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-티오모르폴리노아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-피페리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-피페라지노아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-(4-메틸피페라지노)아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)-페닐]-2-피롤리디노아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페리디노아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페라지노아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드;
N-[3-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페라지노아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페라지노아세트아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페라지노아세트아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3-4-티아디아진-3-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H,1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-l,3,4-티아디아진-3-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-이소프로폭시-4-메톡시페닐)-2-옥소-2H-l,3,4-티아디아진-3-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H,1,3,4-티아디아진-3-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(3,6-디히드로-5-(3-시클로펜틸옥시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-3-피롤리디노프로피온아미드;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
(4-히드록시-l-피페리딜)에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-5-에틸-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2H-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-l-메틸에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디에틸아미노)에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디이소프로필아미노)에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
6-(N,N-디메틸아미노)헥실 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-(N,N-디메틸아미노)-1-메틸에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
1-메틸-4-피페리딜 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-모르폴리노에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-모르폴리노프로필 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-티오모르폴리노에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-티오모르폴리노프로필 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피페라지노에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피페라지노프로필 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
2-피롤리디노에틸 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-피롤리디노프로필 N-[4-(6-(3-플루오로메톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드, 융점 150°;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페라지노아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페라지노아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐l-3-피페라지노프로피온아미드;
N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)-2-피페라지노아세트아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)-2-피페라지노아세트아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-모르폴리닐)아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디에틸아미노)아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(N,N-디이소프로필아미노)아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-티오모르폴리노아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피페리디노아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-히드록시피페리디노)아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)-2-피페라지노아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-피롤리디노아세트아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(6-(3-프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(6-(3-이소프로폭시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피롤리디노프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-모르폴리닐)프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디에틸아미노)프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(N,N-디이소프로필아미노)프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-티오모르폴리노프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페리디노프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-(4-히드록시피페리디노)프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피페라지노프로피온아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-3-피롤리디노프로피온아미드;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트.
본 발명은 특히 골다공증, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 당뇨병, 궤양성 대장염 및 AIDS 의 치료용 약제의 제조를 위한 하기 화합물 및/또는 이의 생리학적 허용염의 용도에 관한 것이다:
a) 하기로 구성된 군에서 선택되는, EP 0 738 715 A2 에 기재된 화합물:
2-(4-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-메틸술폰아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(3-아세트아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-트리플루오로아세트아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-메톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
2-(4-부티릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
b) 하기로 구성된 군에서 선택되는, EP 0 723 962 B1 에 기재된 화합물:
3-(4-니트로벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-트리플루오로아세트아미도벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-아세트아미도벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-메톡시벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(2,6-디클로로벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
c) 하기로 구성된 군에서 선택되는, EP 0 763 534 Al 에 기재된 화합물:
3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-l,3,4-옥사디아진-2-온;
2-(4-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
d) 하기로 구성된 군에서 선택되는, EP 0 539 806 B1 에 기재된 화합물:
5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
5-(3-메톡시-4-디플루오로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
e) 하기로 구성된 군에서 선택되는, EP 0 618 201 Al 에 기재된 화합물:
3-디메틸아미노프로필-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노프로필-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-디메틸아미노에틸-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-피페리디노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
3-모르폴리노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
f) 하기로 구성된 군에서 선택되는, DE 196 04 388 Al 에 기재된 화합물:
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-l,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드;
N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드;
N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드.

Claims (5)

  1. 골다공증, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 당뇨병, 궤양성 대장염 및 AIDS 의 치료용 약제의 제조를 위한 하기 화합물 및/또는 이의 생리학적 허용염의 용도:
    a) EP 0 738 715 A2 에 기재된 하기 화학식 I 의 화합물,
    (상기 식중,
    R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
    R3 및 R4 는 각각 서로 독립적으로, -OH, -OR10, -S-R10, -SO-R 10, -SO2-R10, Hal, 메틸렌디옥시, -NO2, -NH2, -NHR10 또는 -NR10R11 이며,
    R5 는 비치환되거나, R6 및/또는 R7 로 일치환 또는 이치환되는 페닐 라디칼이고,
    Q 는 존재하지 않거나, 탄소수 1 내지 6 의 알킬렌이며,
    R6 및 R7 은 각각 서로 독립적으로, -NH2, -NR8R9, -NHR10, -NR10R11, -NO2, Hal, -CN, -OA, -COOH 또는 -COOA 이고,
    R8 및 R9 는 각각 서로 독립적으로, H, 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 8 의 아실, 또는 -COOA, -SO-A, -SO2A, -CONH2, -CONHA, -CONA2, -CO-COOH, -CO-COOA, -CO-CONH2, -CO-CONHA 또는 -CO-CONA2 이며,
    A 는 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 6 의 알킬이고,
    R10 및 R11 은 각각 서로 독립적으로, A, 탄소수 3 내지 7 의 시클로알킬, 탄소수 4 내지 8 의 메틸렌시클로알킬 또는 탄소수 2 내지 8 의 알케닐이며,
    Hal 은 F, Cl, Br 또는 I 이다)
    b) EP 0 723 962 B1 에 기재된 하기 화학식 I 의 화합물,
    (상기 식중,
    R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
    R3 및 R4 는 각각 서로 독립적으로, -OH, -OR10, -S-R10, -SO-R 10, -SO2-R10, Hal, 메틸렌디옥시, -NO2, -NH2, -NHR10 또는 -NR10R11 이며,
    R5 는 비치환되거나, R6 및/또는 R7 로 일치환 또는 이치환되는 페닐 라디칼이고,
    Q 는 존재하지 않거나, 탄소수 1 내지 6 의 알킬렌이며,
    R6 및 R7 은 각각 서로 독립적으로, -NH2, -NR8R9, -NHR10, -NR10R11, -NO2, Hal, -CN, -OA, -COOH 또는 -COOA 이고,
    R8 및 R9 는 각각 서로 독립적으로, H, 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 8 의 아실, 또는 -COOA, -SO-A, -SO2A, -CONH2, -CONHA, -CONA2, -CO-COOH, -CO-COOA, -CO-CONH2, -CO-CONHA 또는 -CO-CONA2 이며,
    A 는 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 6 의 알킬이고,
    R10 및 R11 은 각각 서로 독립적으로, A, 탄소수 3 내지 7 의 시클로알킬, 탄소수 4 내지 8 의 메틸렌시클로알킬 또는 탄소수 2 내지 8 의 알케닐이며,
    Hal 은 F, Cl, Br 또는 I 이다)
    c) EP 0 763 534 A1 에 기재된 하기 화학식 I 의 화합물,
    (상기 식중,
    B 는 치환되지 않거나, Hal, A 및/또는 OA 로 일치환, 이치환 또는 삼치환될 수 있고, 또한 벤젠 또는 피리딘 고리에 융합될 수 있는, N 또는 C 를 통해 결합된, 1 내지 4 개의 N, O 및/또는 S 원자를 갖는 방향족 헤테로시클릭 라디칼이며,
    Q 는 존재하지 않거나, 탄소수 1 내지 6 의 알킬렌이고,
    X 는 CH2, S 또는 O 이며,
    R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
    R3 및 R4 는 각각 서로 독립적으로, -OH, -OR5, -S-R5, -SO-R 5, -SO2-R5, Hal, 메틸렌디옥시, -NO2, -NH2, -NHR5 또는 -NR5R6 이며,
    R5 및 R6 은 각각 서로 독립적으로, A, 탄소수 3 내지 7 의 시클로알킬, 탄소수 4 내지 8 의 메틸렌시클로알킬 또는 탄소수 2 내지 8 의 알케닐이고,
    A 는 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 10 의 알킬이며,
    Hal 은 F, Cl, Br 또는 I 이다)
    d) EP 0 539 806 B1 에 기재된 하기 화학식 I 의 화합물,
    (상기 식중,
    R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
    R3 은 H, OA 또는 O-CmH2m+1-nXn 이며,
    R4 는 -O-CmH2m+1-nXn 이고,
    X 는 F 또는 Cl 이며,
    A 는 탄소수 1 내지 6 의 알킬이고,
    m 은 1, 2, 3, 4, 5 또는 6 이며,
    n 은 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 또는 13 이다)
    e) EP 0 618 201 A1 에 기재된 하기 화학식 I 의 화합물,
    (상기 식중,
    R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
    R3 및 R4 는 각각 서로 독립적으로, OH, OA, SA, SOA, SO2A, Hal, 메틸렌디옥시, 탄소수 3 내지 7 의 시클로알콕시 또는 O-CmH2m+1-kFk 이며,
    R5 는 -NR6R7 또는 (여기서, 하나의 CH2 기는 또한 산소로 대체될 수 있음) 이고,
    R6 및 R7 은 각각 서로 독립적으로, H 또는 A 이고,
    Q 는 탄소수 1 내지 6 의 알킬렌이며,
    A 는 탄소수 1 내지 6 의 알킬이고,
    Hal 은 F, Cl, Br 또는 I 이며,
    m 은 1, 2, 3, 4, 5 또는 6 이고,
    n 은 3, 4, 5 또는 6 이며,
    k 는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 또는 13 이다)
    f) DE 196 04 388 A1 에 기재된 하기 화학식 I 의 화합물,
    (상기 식중,
    R1 및 R2 는 각각 서로 독립적으로, H 또는 A 이고,
    R3 및 R4 는 각각 서로 독립적으로, -OH, -OA, -S-A, -SO-A, -SO2-A, Hal, 메틸렌디옥시, -NO2, -NH2, -NHA 또는 -NAA' 이며,
    A 및 A' 는 각각 서로 독립적으로, 1 내지 5 개의 F 및/또는 Cl 원자로 치환될 수 있는 탄소수 1 내지 10 의 알킬, 또는 탄소수 3 내지 7 의 시클로알킬 또는 탄소수 4 내지 8 의 메틸렌시클로알킬이고,
    B 는 -Y-R5 또는 -O-Y-R5 이며,
    Q 는 존재하지 않거나, 탄소수 1 내지 4 의 알킬렌이고,
    Y 는 존재하지 않거나, 탄소수 1 내지 10 의 알킬렌이며,
    X 는 CH2 또는 S 이고,
    R5 는 치환되지 않거나, A 또는 OH 로 일치환되며, 또한 또다른 CH2 기는 NH, NA, S 또는 O 로 대체될 수 있는, 하나 이상의 N 원자를 갖는 포화 3 내지 8 원 헤테로시클릭 라디칼, NAA', NHA 또는 NH2 이며,
    Hal 은 F, Cl, Br 또는 I 이다).
  2. 제 1 항에 있어서, 골다공증, 종양, 종양 전이, 아테롬성 동맥 경화증, 류머티즘성 관절염, 복합 경화증, 당뇨병, 궤양성 대장염 및 AIDS 의 치료용 약제의 제조를 위한 하기 화합물 및/또는 이의 생리학적 허용염의 용도:
    a) 하기로 구성된 군에서 선택되는, EP 0 738 715 A2 에 기재된 화합물:
    2-(4-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
    2-(3-메틸술폰아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
    2-(3-아세트아미도벤질)-6-(3,4-디메톡시페닐)-2,3,4,5-테트라히드로피리다진-3-온;
    2-(4-트리플루오로아세트아미도벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
    2-(4-에톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
    2-(4-메톡시카르보닐아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
    2-(4-부티릴아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
    b) 하기로 구성된 군에서 선택되는, EP 0 723 962 B1 에 기재된 화합물:
    3-(4-니트로벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-트리플루오로아세트아미도벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-아세트아미도벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-메톡시벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(2,6-디클로로벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    c) 하기로 구성된 군에서 선택되는, EP 0 763 534 Al 에 기재된 화합물:
    3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-피콜리노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-이소니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
    3-(4-니코티노일아미노벤질)-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-l,3,4-옥사디아진-2-온;
    2-(4-니코티노일아미노벤질)-6-(3,4-디메톡시페닐)-5-에틸-2,3,4,5-테트라히드로피리다진-3-온;
    d) 하기로 구성된 군에서 선택되는, EP 0 539 806 B1 에 기재된 화합물:
    5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아진-2-온;
    5-(3-메톡시-4-디플루오로메톡시페닐)-3,6-디히드로-1,3,4-티아디아진-2-온;
    e) 하기로 구성된 군에서 선택되는, EP 0 618 201 Al 에 기재된 화합물:
    3-디메틸아미노프로필-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
    3-디메틸아미노프로필-5-(3,4-디메톡시페닐)-3,6-디히드로-1,3,4-티아디아지논-2-온;
    3-디메틸아미노에틸-5-(3,4-디메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
    3-피페리디노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
    3-모르폴리노프로필-5-(3-메톡시-4-디플루오로메톡시페닐)-6-에틸-3,6-디히드로-1,3,4-티아디아지논-2-온;
    f) 하기로 구성된 군에서 선택되는, DE 196 04 388 Al 에 기재된 화합물:
    3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3,4-디메톡시페닐)-2-옥소-2H-l,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
    3-(N,N-디에틸아미노)프로필 N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]카르바메이트;
    3-(N,N-디에틸아미노)프로필 N-[4-(6-(3,4-디메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
    3-(N,N-디에틸아미노)프로필 N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]카르바메이트;
    N-[4-(6-(3-에톡시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드;
    N-[4-(6-(3-시클로펜틸옥시-4-메톡시페닐)-3-옥소-2,3,4,5-테트라히드로피리다진-2-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드;
    N-[4-(3,6-디히드로-5-(3-에톡시-4-메톡시페닐)-2-옥소-2H-1,3,4-티아디아진-3-일메틸)페닐]-2-(4-메틸피페라지노)아세트아미드.
  3. 제 1 항 또는 제 2 항에 있어서, 종양성 손상의 치료용 약제의 제조를 위한 용도.
  4. 제 1 항 또는 제 2 항에 있어서, 발암성 손상의 치료용 약제의 제조를 위한 용도.
  5. 제 1 항 또는 제 2 항에 있어서, 사람 세포에서의 세포소멸 조절용 약제의 제조를 위한 용도.
KR1020047005415A 2001-10-12 2002-09-19 포스포디에스테라아제 ⅳ 억제제의 용도 KR20050028900A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10150517.5 2001-10-12
DE10150517A DE10150517A1 (de) 2001-10-12 2001-10-12 Verwendung von Phosphodiesterase IV-Inhibitoren

Publications (1)

Publication Number Publication Date
KR20050028900A true KR20050028900A (ko) 2005-03-23

Family

ID=7702358

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047005415A KR20050028900A (ko) 2001-10-12 2002-09-19 포스포디에스테라아제 ⅳ 억제제의 용도

Country Status (15)

Country Link
US (1) US20040235845A1 (ko)
EP (1) EP1435958A1 (ko)
JP (1) JP2005505604A (ko)
KR (1) KR20050028900A (ko)
CN (1) CN1564687A (ko)
AR (1) AR037741A1 (ko)
AU (1) AU2002338734B2 (ko)
CA (1) CA2460135C (ko)
CZ (1) CZ2004457A3 (ko)
DE (1) DE10150517A1 (ko)
HU (1) HUP0401641A3 (ko)
MX (1) MXPA04002639A (ko)
NO (1) NO20041938L (ko)
SK (1) SK1652004A3 (ko)
WO (1) WO2003032993A1 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101424826B1 (ko) * 2005-11-21 2014-08-01 메르크 파텐트 게엠베하 3,6-디히드로-2-옥소-6ｈ-1,3,4-티아디아진 유도체
KR101424825B1 (ko) * 2005-11-21 2014-08-01 메르크 파텐트 게엠베하 치환된 5-페닐-3,6-디히드로-2-옥소-6ｈ-［1,3,4］티아디아진

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504201A (ja) * 2003-09-05 2007-03-01 アルタナ　ファルマ　アクチエンゲゼルシャフト 真性糖尿病の治療のためのｐｄｅ４阻害剤の使用
EP1716123A1 (en) * 2004-02-04 2006-11-02 Altana Pharma AG Pyridazinone derivatives and their use as pde4 inhibitors
AU2005210042B2 (en) 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
US8017633B2 (en) 2005-03-08 2011-09-13 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
MX2009002282A (es) * 2006-09-07 2009-03-20 Nycomed Gmbh Tratamiento de combinacion para diabetes mellitius.
AP2015008663A0 (en) 2013-02-19 2015-08-31 Pfizer Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of cns and other disorders
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
CU20170007A7 (es) 2014-08-06 2017-06-05 Pfizer Compuestos de imidazopiridazina
RU2626677C1 (ru) * 2016-03-09 2017-07-31 Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" Применение фармацевтической композиции 2-морфолино-5-фенил-6н-1,3,4-тиадиазина с аскорбиновой кислотой в качестве средства коррекции аллоксанового сахарного диабета

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4134893A1 (de) * 1991-10-23 1993-04-29 Merck Patent Gmbh Thiadiazinone
DE4310699A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Thiadiazinone
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
DE19502699A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl-thiadiazinone
DE19514568A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Arylalkyl-pyridazinone
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
GB9525262D0 (en) * 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
DE19604388A1 (de) * 1996-02-07 1997-08-14 Merck Patent Gmbh Arylalkyl-diazinone
US5948911A (en) * 1998-11-20 1999-09-07 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101424826B1 (ko) * 2005-11-21 2014-08-01 메르크 파텐트 게엠베하 3,6-디히드로-2-옥소-6ｈ-1,3,4-티아디아진 유도체
KR101424825B1 (ko) * 2005-11-21 2014-08-01 메르크 파텐트 게엠베하 치환된 5-페닐-3,6-디히드로-2-옥소-6ｈ-［1,3,4］티아디아진

Also Published As

Publication number Publication date
NO20041938L (no) 2004-05-11
CZ2004457A3 (cs) 2005-04-13
HUP0401641A2 (hu) 2004-11-29
SK1652004A3 (sk) 2005-05-05
CN1564687A (zh) 2005-01-12
CA2460135C (en) 2010-08-24
CA2460135A1 (en) 2003-04-24
MXPA04002639A (es) 2004-06-07
HUP0401641A3 (en) 2007-02-28
JP2005505604A (ja) 2005-02-24
AR037741A1 (es) 2004-12-01
US20040235845A1 (en) 2004-11-25
DE10150517A1 (de) 2003-04-17
WO2003032993A1 (de) 2003-04-24
EP1435958A1 (de) 2004-07-14
AU2002338734B2 (en) 2007-11-08

Similar Documents

Publication Publication Date Title
ES2533065T3 (es) Bencenosulfonamidas útiles como inhibidores de los canales de sodio
JP5860045B2 (ja) 化合物
KR101345497B1 (ko) 설폰아미드 유도체
ES2532356T3 (es) N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
US7759348B2 (en) Pyridazine derivatives and their use as therapeutic agents
KR20050028900A (ko) 포스포디에스테라아제 ⅳ 억제제의 용도
JP5717031B2 (ja) 置換されたアゾール誘導体、この誘導体を含む医薬組成物、及びこれを利用したパーキンソン病の治療方法
WO2005011655A2 (en) Pyridazine derivatives and their use as therapeutic agents
TW200539885A (en) Diaminopyrimidines as p2x3 and p2x2/3 antagonists
TW201211038A (en) Oxazine derivatives and their use in the treatment of neurological disorders
WO2008077404A1 (en) Substituted acetophenones useful as pde4 inhibitors
KR20030007948A (ko) 페닐피리다진 유도체 및 이를 함유하는 의약
JPH0420435B2 (ko)
CA2435989A1 (en) Pharmaceutical composition for the therapy of lower urinary tract symptoms
TNSN00015A1 (fr) Nouveaux sels de morpholinobenzamide
ES2526982T3 (es) N-Sulfonilbenzamidas como inhibidores de canales de sodio dependientes de voltaje
JP2016029033A (ja) 組合せ物
JP2017516803A (ja) ナトリウムチャネル阻害剤として有用なベンゼンスルホンアミド
TW201206918A (en) Chemical compounds
JP2006036712A (ja) 脳梗塞予防または治療薬としてのビトロネクチン拮抗物質

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid