CZ20032547A3 - Pregabalin lactose conjugates - Google Patents
Pregabalin lactose conjugates Download PDFInfo
- Publication number
- CZ20032547A3 CZ20032547A3 CZ20032547A CZ20032547A CZ20032547A3 CZ 20032547 A3 CZ20032547 A3 CZ 20032547A3 CZ 20032547 A CZ20032547 A CZ 20032547A CZ 20032547 A CZ20032547 A CZ 20032547A CZ 20032547 A3 CZ20032547 A3 CZ 20032547A3
- Authority
- CZ
- Czechia
- Prior art keywords
- ylmethyl
- trihydroxy
- isobutyl
- pyrrolidin
- yloxy
- Prior art date
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- 239000008101 lactose Substances 0.000 title claims abstract description 42
- 229960001233 pregabalin Drugs 0.000 title abstract description 48
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 title abstract description 46
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 title abstract description 28
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
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- AZUXUOROLIYZMA-IEPCQTTFSA-N (4s)-4-(2-methylpropyl)-1-[(2,3,4,5-tetrahydroxyoxan-2-yl)methyl]pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(O)C(O)CO1 AZUXUOROLIYZMA-IEPCQTTFSA-N 0.000 claims description 35
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- BAZBIXRKAXNTCJ-IEPCQTTFSA-N (4s)-4-(2-methylpropyl)-1-[[2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl]pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(O)C(CO)O1 BAZBIXRKAXNTCJ-IEPCQTTFSA-N 0.000 claims description 18
- RCDRJCSOBMHAGQ-CHXUSJIQSA-N (4s)-1-[[2,3-dihydroxy-5-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl]-4-(2-methylpropyl)pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 RCDRJCSOBMHAGQ-CHXUSJIQSA-N 0.000 claims description 13
- XDWMEMJQXHTKBB-CHXUSJIQSA-N (4s)-4-(2-methylpropyl)-1-[[2,3,5-trihydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl]pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(O)CO1 XDWMEMJQXHTKBB-CHXUSJIQSA-N 0.000 claims description 11
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28017601P | 2001-03-30 | 2001-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ20032547A3 true CZ20032547A3 (en) | 2004-04-14 |
Family
ID=23072002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20032547A CZ20032547A3 (en) | 2001-03-30 | 2002-02-25 | Pregabalin lactose conjugates |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3693258B2 (ja) | 1996-07-24 | 2005-09-07 | ワーナー―ランバート・コンパニー | イソブチルｇａｂａまたはその誘導体を含有する鎮静剤 |
| CA2619472A1 (en) * | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin |
| DE102007019071A1 (de) | 2007-04-23 | 2008-10-30 | Ratiopharm Gmbh | Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin |
| SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| US20100087525A1 (en) * | 2008-06-23 | 2010-04-08 | Lilach Hedvati | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| WO2010115612A2 (en) | 2009-04-10 | 2010-10-14 | Synthon B.V. | Pregabalin compositions |
| WO2010150221A1 (en) | 2009-06-25 | 2010-12-29 | Wockhardt Research Centre | Taste masked pharmaceutical compositions of pregabalin |
| HU230031B1 (hu) * | 2010-03-01 | 2015-05-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Pregabalint és izomaltot tartalmazó stabilizált gyógyszerkészítmény |
| CN103494796B (zh) * | 2013-09-30 | 2016-01-20 | 浙江华义医药有限公司 | 普瑞巴林稳定的药物组合物及其制备方法 |
| CN104311608B (zh) * | 2014-10-28 | 2016-10-05 | 河南中烟工业有限责任公司 | 亲水型烟草增香保润剂Mal-Hyp、制备方法及其应用 |
| CN104370986B (zh) * | 2014-10-28 | 2017-07-04 | 河南中烟工业有限责任公司 | 糖衍生物烟用增香保润剂Mal‑Pro、制备方法及其应用 |
| CN105434395B (zh) * | 2015-12-31 | 2018-12-11 | 常州市阳光药业有限公司 | 普瑞巴林胶囊及其制备方法 |
| CN105520918B (zh) * | 2015-12-31 | 2018-12-11 | 常州市阳光药业有限公司 | 普瑞巴林胶囊 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| FR2781793B1 (fr) * | 1998-08-03 | 2001-07-20 | Prographarm Lab | Procede de fabrication de granules de gabapentine enrobes |
| NZ510920A (en) * | 1998-10-16 | 2002-08-28 | Warner Lambert Co | Use of (S)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) to treat acute and chronic mania in humans |
| WO2002043762A2 (en) * | 2000-11-30 | 2002-06-06 | Pfizer Products Inc. | Combination of gaba agonists and sorbitol dehydrogenase inhibitors |
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2002
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- 2002-02-25 MX MXPA03007437A patent/MXPA03007437A/es active IP Right Grant
- 2002-02-25 EA EA200300954A patent/EA200300954A1/ru unknown
- 2002-02-25 AP APAP/P/2003/002873A patent/AP2003002873A0/en unknown
- 2002-02-25 CA CA002440468A patent/CA2440468C/en not_active Expired - Fee Related
- 2002-02-25 OA OA1200300232A patent/OA12456A/en unknown
- 2002-02-25 WO PCT/IB2002/000647 patent/WO2002078747A2/en not_active Ceased
- 2002-02-25 KR KR10-2003-7012714A patent/KR20040008146A/ko not_active Ceased
- 2002-02-25 CZ CZ20032547A patent/CZ20032547A3/cs unknown
- 2002-02-25 IL IL15787902A patent/IL157879A0/xx unknown
- 2002-02-25 PL PL02369179A patent/PL369179A1/xx not_active Application Discontinuation
- 2002-02-25 JP JP2002577011A patent/JP2004524357A/ja active Pending
- 2002-02-25 CN CNA028067509A patent/CN1511043A/zh active Pending
- 2002-02-25 EE EEP200300480A patent/EE200300480A/xx unknown
- 2002-02-25 BR BR0208439-2A patent/BR0208439A/pt not_active IP Right Cessation
- 2002-02-25 HU HU0303956A patent/HUP0303956A2/hu unknown
- 2002-02-25 EP EP02702614A patent/EP1377318A2/en not_active Withdrawn
- 2002-02-25 SK SK1183-2003A patent/SK11832003A3/sk not_active Application Discontinuation
- 2002-03-07 DO DO2002000356A patent/DOP2002000356A/es unknown
- 2002-03-19 GT GT200200051A patent/GT200200051A/es unknown
- 2002-03-22 SV SV2002000928A patent/SV2003000928A/es not_active Application Discontinuation
- 2002-03-27 UY UY27233A patent/UY27233A1/es not_active Application Discontinuation
- 2002-03-27 PE PE2002000252A patent/PE20021016A1/es not_active Application Discontinuation
- 2002-03-27 PA PA20028542101A patent/PA8542101A1/es unknown
- 2002-03-27 AR ARP020101140A patent/AR033024A1/es unknown
- 2002-03-29 TN TNTNSN02038A patent/TNSN02038A1/fr unknown
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2003
- 2003-08-14 IS IS6912A patent/IS6912A/is unknown
- 2003-08-21 EC EC2003004740A patent/ECSP034740A/es unknown
- 2003-08-25 ZA ZA200306608A patent/ZA200306608B/en unknown
- 2003-09-17 MA MA27315A patent/MA27004A1/fr unknown
- 2003-09-24 BG BG108193A patent/BG108193A/xx unknown
- 2003-09-29 NO NO20034348A patent/NO20034348D0/no not_active Application Discontinuation
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