CZ186492A3 - Insulin analog, process of its preparation and a pharmaceutical composition containing thereof - Google Patents

Insulin analog, process of its preparation and a pharmaceutical composition containing thereof Download PDF

Info

Publication number
CZ186492A3
CZ186492A3 CS921864A CS186492A CZ186492A3 CZ 186492 A3 CZ186492 A3 CZ 186492A3 CS 921864 A CS921864 A CS 921864A CS 186492 A CS186492 A CS 186492A CZ 186492 A3 CZ186492 A3 CZ 186492A3
Authority
CZ
Czechia
Prior art keywords
seq
xaa
asp
asn
group
Prior art date
Application number
CS921864A
Other languages
Czech (cs)
English (en)
Inventor
David Nettleship Brems
Ronald Eugene Chance
Bruce Hill Frank
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CZ186492A3 publication Critical patent/CZ186492A3/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS921864A 1991-06-21 1992-06-17 Insulin analog, process of its preparation and a pharmaceutical composition containing thereof CZ186492A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71857491A 1991-06-21 1991-06-21

Publications (1)

Publication Number Publication Date
CZ186492A3 true CZ186492A3 (en) 1993-01-13

Family

ID=24886590

Family Applications (1)

Application Number Title Priority Date Filing Date
CS921864A CZ186492A3 (en) 1991-06-21 1992-06-17 Insulin analog, process of its preparation and a pharmaceutical composition containing thereof

Country Status (17)

Country Link
EP (1) EP0519750A3 (fr)
JP (1) JPH05271283A (fr)
CN (1) CN1069737A (fr)
AU (1) AU1837792A (fr)
BR (1) BR9202322A (fr)
CA (1) CA2071382A1 (fr)
CZ (1) CZ186492A3 (fr)
FI (1) FI922882A (fr)
HU (1) HUT61581A (fr)
IE (1) IE921997A1 (fr)
IL (1) IL102240A0 (fr)
MX (1) MX9202987A (fr)
NO (1) NO922376L (fr)
NZ (1) NZ243229A (fr)
TW (1) TW222643B (fr)
YU (1) YU64192A (fr)
ZA (1) ZA924448B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2151134A1 (fr) * 1992-12-18 1994-07-07 Ronald Eugene Chance Analogues de l'insuline
US20020111461A1 (en) 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
JP2003528149A (ja) 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
JPWO2006093222A1 (ja) * 2005-03-02 2008-08-07 味の素株式会社 インスリンの多量体形成阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
NZ223630A (en) * 1987-02-25 1989-11-28 Novo Industri As Insulin derivative and pharmaceutical compositions
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29

Also Published As

Publication number Publication date
AU1837792A (en) 1992-12-24
CN1069737A (zh) 1993-03-10
FI922882A (fi) 1992-12-22
HUT61581A (en) 1993-01-28
EP0519750A3 (en) 1993-06-23
ZA924448B (en) 1993-12-17
JPH05271283A (ja) 1993-10-19
IE921997A1 (en) 1992-12-30
IL102240A0 (en) 1993-01-14
YU64192A (sh) 1994-06-10
FI922882A0 (fi) 1992-06-18
EP0519750A2 (fr) 1992-12-23
NZ243229A (en) 1994-09-27
BR9202322A (pt) 1993-01-19
HU9202048D0 (en) 1992-09-28
NO922376D0 (no) 1992-06-17
TW222643B (fr) 1994-04-21
CA2071382A1 (fr) 1992-12-22
MX9202987A (es) 1993-01-01
NO922376L (no) 1992-12-22

Similar Documents

Publication Publication Date Title
EP0894095B1 (fr) Derives de l'insuline et leur utilisation
JP4291900B2 (ja) 正しく結合したシスチン橋を有するインスリン前駆体を取得するための改良された方法
NO179587B (no) Analogifremgangsmåte for fremstilling av en terapeutisk aktiv insulinanalog og mellomprodukt
AU662731B2 (en) Growth hormone releasing factor analogs
CA2207078C (fr) Derives de l'insuline fixant davantage de zinc
US20030104981A1 (en) Human insulin analogues
JPS60155196A (ja) 成長ホルモン放出因子類似物
NZ231936A (en) Insulin analogues with lys or arg in position b28, and pharmaceutical compositions
CA2468100A1 (fr) Molecule d'insuline a duree d'action prolongee
CZ289343B6 (cs) Inzulinový derivát a farmaceutický prostředek pro léčení diabetes
CZ342492A3 (en) Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
JPH10503523A (ja) Asp▲上b1▼インシュリンアナログ
US5079230A (en) Stable bioactive somatotropins
AU680462B2 (en) Insulin analogs
AU757275B2 (en) Novel insulin analogs with enhanced zinc binding
Büllesbach et al. Functional importance of the A chain loop in relaxin and insulin.
CZ186492A3 (en) Insulin analog, process of its preparation and a pharmaceutical composition containing thereof
EP0002262B1 (fr) Analogues de la somatostatine et leur procédé de préparation
MXPA97005667A (en) Insulin derivatives with zinc increment
ZA200404273B (en) Insulin molecule having protracted time action.
JPH0150718B2 (fr)