CY2127B1 - Condensed cycloaliphatir-anmidino-hydrazon salts as S-adenosylmethionin decarboxylase inhibitors - Google Patents

Condensed cycloaliphatir-anmidino-hydrazon salts as S-adenosylmethionin decarboxylase inhibitors

Info

Publication number
CY2127B1
CY2127B1 CY9900005A CY9900005A CY2127B1 CY 2127 B1 CY2127 B1 CY 2127B1 CY 9900005 A CY9900005 A CY 9900005A CY 9900005 A CY9900005 A CY 9900005A CY 2127 B1 CY2127 B1 CY 2127B1
Authority
CY
Cyprus
Prior art keywords
acids
acid
unsubstituted
substituted
apart
Prior art date
Application number
CY9900005A
Other languages
English (en)
Inventor
Jaroslav Dr Stanek
Joerg Dr Frei
Giorgio Dr Caravatti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2127B1 publication Critical patent/CY2127B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cereal-Derived Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
CY9900005A 1991-10-16 1999-02-03 Condensed cycloaliphatir-anmidino-hydrazon salts as S-adenosylmethionin decarboxylase inhibitors CY2127B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH304191 1991-10-16

Publications (1)

Publication Number Publication Date
CY2127B1 true CY2127B1 (en) 2002-06-21

Family

ID=4247296

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9900005A CY2127B1 (en) 1991-10-16 1999-02-03 Condensed cycloaliphatir-anmidino-hydrazon salts as S-adenosylmethionin decarboxylase inhibitors

Country Status (24)

Country Link
EP (1) EP0538193B1 (fi)
JP (1) JP2788579B2 (fi)
KR (1) KR100265307B1 (fi)
AT (1) ATE145896T1 (fi)
AU (1) AU658931B2 (fi)
CA (1) CA2080545C (fi)
CY (1) CY2127B1 (fi)
CZ (1) CZ279601B6 (fi)
DE (1) DE59207617D1 (fi)
DK (1) DK0538193T3 (fi)
ES (1) ES2095444T3 (fi)
FI (1) FI112212B (fi)
GR (1) GR3021903T3 (fi)
HK (1) HK1005023A1 (fi)
HU (1) HU226954B1 (fi)
IL (1) IL103448A (fi)
MX (1) MX9205934A (fi)
NO (1) NO178108C (fi)
NZ (1) NZ244725A (fi)
RU (1) RU2081108C1 (fi)
SA (1) SA93130417B1 (fi)
SG (1) SG43185A1 (fi)
SK (1) SK279938B6 (fi)
ZA (1) ZA927957B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103166B1 (es) * 1992-08-26 1998-04-01 Ciba Geigy Ag Procedimiento para la obtencion de amidinohidrazonas biciclicas.
CA2210533C (en) * 1995-01-26 2007-12-04 Novartis Ag Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors
AU2003221482A1 (en) * 2002-03-04 2003-09-16 Boehringer Ingelheim Pharma Gmbh And Co. Kg Novel cinnamate salts, method for production and use thereof as medicaments
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones

Also Published As

Publication number Publication date
FI924650A0 (fi) 1992-10-14
IL103448A (en) 1998-01-04
EP0538193A2 (de) 1993-04-21
IL103448A0 (en) 1993-03-15
RU2081108C1 (ru) 1997-06-10
HUT63149A (en) 1993-07-28
EP0538193B1 (de) 1996-12-04
NO178108C (no) 1996-01-24
DK0538193T3 (da) 1996-12-23
CA2080545A1 (en) 1993-04-17
NO924001D0 (no) 1992-10-15
KR930007896A (ko) 1993-05-20
MX9205934A (es) 1993-04-01
ES2095444T3 (es) 1997-02-16
NO924001L (no) 1993-04-19
ZA927957B (en) 1993-04-26
ATE145896T1 (de) 1996-12-15
SK315292A3 (en) 1995-04-12
HU226954B1 (en) 2010-03-29
GR3021903T3 (en) 1997-03-31
DE59207617D1 (de) 1997-01-16
SA93130417B1 (ar) 2005-11-12
NO178108B (no) 1995-10-16
HU9203234D0 (en) 1992-12-28
AU658931B2 (en) 1995-05-04
NZ244725A (en) 1995-05-26
CA2080545C (en) 2005-11-29
FI924650A (fi) 1993-04-17
AU2704092A (en) 1993-04-22
SK279938B6 (sk) 1999-06-11
KR100265307B1 (ko) 2000-09-15
SG43185A1 (en) 1997-10-17
EP0538193A3 (en) 1993-06-16
CZ279601B6 (cs) 1995-05-17
HK1005023A1 (en) 1998-12-18
FI112212B (fi) 2003-11-14
JPH05239011A (ja) 1993-09-17
JP2788579B2 (ja) 1998-08-20
CZ315292A3 (en) 1993-05-12

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