CY2119B1 - Tetrazole derivatives of bile acids a process for their production and their use as medicines - Google Patents
Tetrazole derivatives of bile acids a process for their production and their use as medicinesInfo
- Publication number
- CY2119B1 CY2119B1 CY9800037A CY9800037A CY2119B1 CY 2119 B1 CY2119 B1 CY 2119B1 CY 9800037 A CY9800037 A CY 9800037A CY 9800037 A CY9800037 A CY 9800037A CY 2119 B1 CY2119 B1 CY 2119B1
- Authority
- CY
- Cyprus
- Prior art keywords
- medicines
- production
- bile acids
- tetrazole derivatives
- tetrazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315368 | 1993-05-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY2119B1 true CY2119B1 (en) | 2002-04-26 |
Family
ID=6487579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY9800037A CY2119B1 (en) | 1993-05-08 | 1998-09-29 | Tetrazole derivatives of bile acids a process for their production and their use as medicines |
Country Status (19)
Country | Link |
---|---|
US (1) | US5466815A (ja) |
EP (1) | EP0624596B1 (ja) |
JP (1) | JP3476157B2 (ja) |
KR (1) | KR100333149B1 (ja) |
AT (1) | ATE163938T1 (ja) |
AU (1) | AU666440B2 (ja) |
CA (1) | CA2123048C (ja) |
CY (1) | CY2119B1 (ja) |
CZ (1) | CZ289515B6 (ja) |
DE (1) | DE59405410D1 (ja) |
DK (1) | DK0624596T3 (ja) |
ES (1) | ES2115096T3 (ja) |
FI (1) | FI942075A (ja) |
GR (1) | GR3026496T3 (ja) |
HU (1) | HU217439B (ja) |
IL (1) | IL109581A (ja) |
NO (1) | NO304795B1 (ja) |
NZ (1) | NZ260469A (ja) |
TW (1) | TW289757B (ja) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0624593A3 (de) * | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
TW289020B (ja) * | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
US6323190B1 (en) * | 1998-07-31 | 2001-11-27 | The Univeristy Of Georgia Research Foundation, Inc. | Estrogen mimetics lacking reproductive tract effects |
EP1189922A4 (en) | 1999-04-30 | 2002-08-14 | Arch Dev Corp | STEROID DERIVATIVES |
US7086134B2 (en) * | 2000-08-07 | 2006-08-08 | Shipley Company, L.L.C. | Alignment apparatus and method for aligning stacked devices |
JP2005508281A (ja) * | 2001-02-08 | 2005-03-31 | ザ ユニバーシティー オブ シカゴ | ステロイド誘導体 |
US20070197484A1 (en) * | 2001-05-03 | 2007-08-23 | Ching Song | Method of treating disorder related to high cholesterol concentration |
DK1392713T3 (da) * | 2001-05-03 | 2008-02-18 | Univ Chicago | Lever-X-receptoragonister |
US7078396B2 (en) * | 2001-05-03 | 2006-07-18 | Arch Development Corporation | Method of treating disorder related to high cholesterol concentration |
US6816317B2 (en) * | 2002-01-31 | 2004-11-09 | Lightel Technologies Inc. | Collimator for ready fitting to an optical device with precise optical alignment without need for adjusting positions or angles to compensate for offsets or deviations during optical device assembly and method of making same |
EP1494533A2 (en) * | 2002-04-12 | 2005-01-12 | The University of Chicago | Farnesoid x-activated receptor agonists |
KR20070029247A (ko) * | 2004-07-08 | 2007-03-13 | 노보 노르디스크 에이/에스 | 폴리펩티드 연장 태그 |
US20070032464A1 (en) * | 2004-10-08 | 2007-02-08 | Shutsung Liao | Methods of treating cancers |
US7960439B1 (en) | 2006-06-12 | 2011-06-14 | Iowa State University Research Foundation, Inc. | Environmentally sensitive foldable oligomers |
EP2459581A4 (en) * | 2009-07-29 | 2012-12-26 | Univ Chicago | LIVER X RECEPTOR AGONISTS |
RS57778B1 (sr) | 2010-11-08 | 2018-12-31 | Albireo Ab | Inhibitori crevnog transportera žučne kiseline (ibat) za lečenje bolesti jetre |
CA2815698C (en) | 2010-11-08 | 2019-04-30 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
MX2017005935A (es) | 2014-11-06 | 2018-01-11 | Enanta Pharm Inc | Análogos de ácido biliar como agonistas fxr/tgr5 y métodos de uso de los mismos. |
EP3223823A4 (en) * | 2014-11-26 | 2018-10-17 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
AU2016219266A1 (en) | 2015-02-11 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
KR102681304B1 (ko) | 2015-03-31 | 2024-07-03 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유도체 및 이의 이용 방법 |
CN107250150B (zh) * | 2015-04-28 | 2019-11-22 | 江苏豪森药业集团有限公司 | 胆酸衍生物及其制备方法和医药用途 |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
CN108601745B (zh) | 2016-02-09 | 2021-12-07 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
US10323061B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
CA3045023A1 (en) | 2016-11-29 | 2018-06-07 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
US10472386B2 (en) | 2017-02-14 | 2019-11-12 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR agonists and methods of use thereof |
EP3606533B1 (en) | 2017-04-07 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
EP3664782A1 (en) | 2017-08-09 | 2020-06-17 | Albireo AB | Cholestyramine pellets, oral cholestyramine formulations and use thereof |
JP2020530448A (ja) | 2017-08-09 | 2020-10-22 | アルビレオ・アクチボラグ | コレスチラミン顆粒、経口コレスチラミン製剤、及びそれらの使用 |
TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
WO2019245449A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Pharmaceutical formulation of odevixibat |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
KR20210116523A (ko) * | 2019-01-14 | 2021-09-27 | 베이징 슈안이 파마사이언시스 컴퍼니, 리미티드 | 테트라졸론 치환된 스테로이드 및 이의 용도 |
FI3921028T3 (fi) | 2019-02-06 | 2023-01-31 | Bentsotiadiatsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina | |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
EP3921027B1 (en) | 2019-02-06 | 2023-07-19 | Albireo AB | Benzothiazepine compounds and their use as bile acid modulators |
EP4069359B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
AR120682A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
WO2021110887A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
TW202134223A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
TW202134220A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
CR20220315A (es) | 2019-12-04 | 2022-10-26 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar |
WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
EP4188541A1 (en) | 2020-08-03 | 2023-06-07 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
US20230338392A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
WO2023237097A1 (zh) * | 2022-06-09 | 2023-12-14 | 山东绿叶制药有限公司 | 19-去甲c3,3-二取代的c21-氮杂环取代类固醇及其使用方法 |
US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US20240207286A1 (en) | 2022-12-09 | 2024-06-27 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
US5250524A (en) * | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
-
1993
- 1993-11-23 TW TW082109825A patent/TW289757B/zh active
-
1994
- 1994-05-02 AT AT94106848T patent/ATE163938T1/de not_active IP Right Cessation
- 1994-05-02 EP EP94106848A patent/EP0624596B1/de not_active Expired - Lifetime
- 1994-05-02 ES ES94106848T patent/ES2115096T3/es not_active Expired - Lifetime
- 1994-05-02 DE DE59405410T patent/DE59405410D1/de not_active Expired - Lifetime
- 1994-05-02 DK DK94106848T patent/DK0624596T3/da active
- 1994-05-05 US US08/238,741 patent/US5466815A/en not_active Expired - Lifetime
- 1994-05-05 FI FI942075A patent/FI942075A/fi unknown
- 1994-05-06 NZ NZ260469A patent/NZ260469A/en unknown
- 1994-05-06 IL IL109581A patent/IL109581A/en not_active IP Right Cessation
- 1994-05-06 HU HU9401443A patent/HU217439B/hu not_active IP Right Cessation
- 1994-05-06 NO NO934800A patent/NO304795B1/no not_active IP Right Cessation
- 1994-05-06 CA CA002123048A patent/CA2123048C/en not_active Expired - Fee Related
- 1994-05-06 JP JP09442494A patent/JP3476157B2/ja not_active Expired - Fee Related
- 1994-05-06 CZ CZ19941135A patent/CZ289515B6/cs not_active IP Right Cessation
- 1994-05-06 AU AU61947/94A patent/AU666440B2/en not_active Ceased
- 1994-05-07 KR KR1019940009971A patent/KR100333149B1/ko not_active IP Right Cessation
-
1998
- 1998-04-03 GR GR980400679T patent/GR3026496T3/el unknown
- 1998-09-29 CY CY9800037A patent/CY2119B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NZ260469A (en) | 1995-03-28 |
NO941677D0 (no) | 1994-05-06 |
CZ113594A3 (en) | 1994-12-15 |
EP0624596A3 (de) | 1995-06-07 |
ES2115096T3 (es) | 1998-06-16 |
GR3026496T3 (en) | 1998-07-31 |
AU666440B2 (en) | 1996-02-08 |
KR100333149B1 (ko) | 2002-09-19 |
IL109581A0 (en) | 1994-08-26 |
EP0624596B1 (de) | 1998-03-11 |
IL109581A (en) | 1998-03-10 |
DK0624596T3 (da) | 1998-10-07 |
DE59405410D1 (de) | 1998-04-16 |
CA2123048A1 (en) | 1994-11-09 |
NO941677L (no) | 1994-11-09 |
US5466815A (en) | 1995-11-14 |
EP0624596A2 (de) | 1994-11-17 |
FI942075A (fi) | 1994-11-09 |
CA2123048C (en) | 2005-11-29 |
NO304795B1 (no) | 1999-02-15 |
FI942075A0 (fi) | 1994-05-05 |
CZ289515B6 (cs) | 2002-02-13 |
JP3476157B2 (ja) | 2003-12-10 |
HU217439B (hu) | 2000-01-28 |
HUT67390A (en) | 1995-04-28 |
TW289757B (ja) | 1996-11-01 |
ATE163938T1 (de) | 1998-03-15 |
JPH06329695A (ja) | 1994-11-29 |
AU6194794A (en) | 1994-11-10 |
HU9401443D0 (en) | 1994-08-29 |
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