CY1124776T1 - Συνδυασμενη θεραπεια που περιεχει αναστολεα της b-raf και εναν δευτερο αναστολεα - Google Patents
Συνδυασμενη θεραπεια που περιεχει αναστολεα της b-raf και εναν δευτερο αναστολεαInfo
- Publication number
- CY1124776T1 CY1124776T1 CY20211100626T CY211100626T CY1124776T1 CY 1124776 T1 CY1124776 T1 CY 1124776T1 CY 20211100626 T CY20211100626 T CY 20211100626T CY 211100626 T CY211100626 T CY 211100626T CY 1124776 T1 CY1124776 T1 CY 1124776T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitor
- raf
- raf inhibitor
- therapy containing
- combination therapy
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 7
- 102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 title 1
- 108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 abstract 3
- 101100381978 Mus musculus Braf gene Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000004077 genetic alteration Effects 0.000 abstract 2
- 231100000118 genetic alteration Toxicity 0.000 abstract 2
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 abstract 1
- 102000006311 Cyclin D1 Human genes 0.000 abstract 1
- 108010058546 Cyclin D1 Proteins 0.000 abstract 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 1
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 abstract 1
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 abstract 1
- 102100023266 Dual specificity mitogen-activated protein kinase kinase 2 Human genes 0.000 abstract 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 abstract 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 abstract 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 abstract 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 abstract 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 abstract 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 abstract 1
- 102100029974 GTPase HRas Human genes 0.000 abstract 1
- 102100030708 GTPase KRas Human genes 0.000 abstract 1
- 102100039788 GTPase NRas Human genes 0.000 abstract 1
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 abstract 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 abstract 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 abstract 1
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 abstract 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 abstract 1
- 108010068342 MAP Kinase Kinase 1 Proteins 0.000 abstract 1
- 108010068353 MAP Kinase Kinase 2 Proteins 0.000 abstract 1
- 101100523539 Mus musculus Raf1 gene Proteins 0.000 abstract 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 abstract 1
- 102100032543 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Human genes 0.000 abstract 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 abstract 1
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 abstract 1
- 229940000425 combination drug Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000002651 drug therapy Methods 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
Αντιστροφή της αντίστασης σε αναστολέα της B-Raf για τη θεραπευτική αντιμετώπιση μιας παραγωγικής νόσου μέσω της λήψης ενός δείγματος όγκου από ασθενή και εξέτασης του για γενετικές τροποποιήσεις σε ένα πλαίσιο γονιδίων το οποίο περιλαμβάνει τα BRAF, CRAF, CCND1, CDK4, HER2, IGF-1R, cMET, FGFR1, FGFR2, FGFR3 EGFR, MAP2K1, ΜΑΡ2Κ2, NRAS, KRAS HRAS, PTEN, PIK3CA και Ρ16 και μέσω της χορήγησης μιας συνδυαστικής θεραπείας φαρμάκων που περιέχει τον αναστολέα της B-Raf και έναν δεύτερο αναστολέα και η οποία υπερβαίνει την αντίσταση στον αναστολέα της B-Raf, όπου ο δεύτερος αναστολέας επιλέγεται βάσει των γενετικών τροποποιήσεων που ανακαλύπτονται στο δείγμα όγκου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361804056P | 2013-03-21 | 2013-03-21 | |
PCT/IB2014/059975 WO2014147573A2 (en) | 2013-03-21 | 2014-03-19 | Combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124776T1 true CY1124776T1 (el) | 2022-11-25 |
Family
ID=50439443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100626T CY1124776T1 (el) | 2013-03-21 | 2021-07-13 | Συνδυασμενη θεραπεια που περιεχει αναστολεα της b-raf και εναν δευτερο αναστολεα |
Country Status (34)
Country | Link |
---|---|
US (3) | US9913844B2 (el) |
EP (1) | EP2976106B1 (el) |
JP (2) | JP6449234B2 (el) |
KR (2) | KR102258698B1 (el) |
CN (2) | CN105209073A (el) |
AR (1) | AR095699A1 (el) |
AU (1) | AU2014233805B2 (el) |
BR (1) | BR112015023483B8 (el) |
CA (1) | CA2907704C (el) |
CL (2) | CL2015002807A1 (el) |
CY (1) | CY1124776T1 (el) |
DK (1) | DK2976106T3 (el) |
EA (1) | EA201591842A1 (el) |
ES (1) | ES2870716T3 (el) |
GT (1) | GT201500249A (el) |
HK (1) | HK1214135A1 (el) |
HU (1) | HUE055072T2 (el) |
IL (2) | IL241188B (el) |
JO (1) | JOP20140128B1 (el) |
MA (2) | MA44934B1 (el) |
MX (1) | MX2015013466A (el) |
MY (1) | MY181085A (el) |
NZ (1) | NZ712184A (el) |
PE (1) | PE20151785A1 (el) |
PH (1) | PH12015502040A1 (el) |
PL (1) | PL2976106T3 (el) |
PT (1) | PT2976106T (el) |
SG (2) | SG11201507730UA (el) |
SI (1) | SI2976106T1 (el) |
TN (1) | TN2015000389A1 (el) |
TW (1) | TWI603734B (el) |
UA (1) | UA118846C2 (el) |
WO (1) | WO2014147573A2 (el) |
ZA (1) | ZA201800424B (el) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105209073A (zh) | 2013-03-21 | 2015-12-30 | 诺华股份有限公司 | 包含B-Raf抑制剂和第二抑制剂的组合疗法 |
US20170204187A1 (en) * | 2014-06-13 | 2017-07-20 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance |
CN105753869B (zh) * | 2015-04-01 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
EP4197530A1 (en) * | 2015-04-16 | 2023-06-21 | Novartis AG | Ribociclib tablet |
TWI812581B (zh) * | 2015-05-22 | 2023-08-21 | 美商普雷辛肯公司 | 激酶調節及其適應症 |
CN105732642B (zh) * | 2015-11-18 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
JP7051693B2 (ja) * | 2016-02-19 | 2022-04-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | PIK3CA関連過成長症候群(PROS CLOVaS症候群)の処置に使用するためのBYL719(アルペリシブ) |
HUE060653T2 (hu) | 2016-06-03 | 2023-04-28 | Array Biopharma Inc | Gyógyászati kombinációk |
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