CY1124530T1 - Ενωσεις αιθυνυλιου, παρασκευη τους και θεραπευτικη τους χρηση για τη θεραπεια της ελονοσιας - Google Patents
Ενωσεις αιθυνυλιου, παρασκευη τους και θεραπευτικη τους χρηση για τη θεραπεια της ελονοσιαςInfo
- Publication number
- CY1124530T1 CY1124530T1 CY20211100842T CY211100842T CY1124530T1 CY 1124530 T1 CY1124530 T1 CY 1124530T1 CY 20211100842 T CY20211100842 T CY 20211100842T CY 211100842 T CY211100842 T CY 211100842T CY 1124530 T1 CY1124530 T1 CY 1124530T1
- Authority
- CY
- Cyprus
- Prior art keywords
- malaria
- compounds
- preparation
- treatment
- ethynylum
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα αποκάλυψη αναφέρεται σε ενώσεις του τύπου (Ι) ή ένα φαρμακευτικώς αποδεκτό άλας αυτών όπου το R1 σημαίνει ένα άτομο φθορίου ή μια υπεραλογονο γραμμική ρίζα αλκυλίου που περιέχει 1, 2 ή 3 άτομα άνθρακα· το R2 σημαίνει ένα άτομο χλωρίου, μια γραμμική ρίζα αλκυλίου που περιέχει 1, 2 ή 3 άτομα άνθρακα ή μια υπεραλογονο γραμμική ρίζα αλκυλίου που περιέχει 1, 2 ή 3 άτομα άνθρακα, και το R σημαίνει ένα άτομο υδρογόνου ή μια ρίζα του τύπου (la). Η παρούσα αποκάλυψη αναφέρεται επίσης σε διεργασίες για την παρασκευή τους καθώς και στις θεραπευτικές τους χρήσεις, ιδιαίτερα όπως για χρήση στη θεραπεία της ελονοσίας.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305866 | 2017-07-04 | ||
| PCT/EP2018/068079 WO2019008027A1 (en) | 2017-07-04 | 2018-07-04 | ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE IN THE TREATMENT OF MALARIA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124530T1 true CY1124530T1 (el) | 2022-07-22 |
Family
ID=59350831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100842T CY1124530T1 (el) | 2017-07-04 | 2021-09-27 | Ενωσεις αιθυνυλιου, παρασκευη τους και θεραπευτικη τους χρηση για τη θεραπεια της ελονοσιας |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11078160B2 (el) |
| EP (1) | EP3649109B1 (el) |
| JP (1) | JP7065898B2 (el) |
| CN (1) | CN110869350B (el) |
| BR (1) | BR112020000034B1 (el) |
| CA (1) | CA3069046A1 (el) |
| CY (1) | CY1124530T1 (el) |
| DK (1) | DK3649109T3 (el) |
| ES (1) | ES2894657T3 (el) |
| HR (1) | HRP20211806T1 (el) |
| HU (1) | HUE056766T2 (el) |
| LT (1) | LT3649109T (el) |
| PL (1) | PL3649109T3 (el) |
| PT (1) | PT3649109T (el) |
| RS (1) | RS62656B1 (el) |
| SI (1) | SI3649109T1 (el) |
| WO (1) | WO2019008027A1 (el) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59304166D1 (de) * | 1992-07-01 | 1996-11-21 | Hoechst Ag | 3,4,5-Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
| EP1399414B1 (en) * | 2001-04-24 | 2010-01-13 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| DE10338554A1 (de) * | 2003-08-22 | 2005-03-31 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US20110263901A1 (en) | 2008-01-23 | 2011-10-27 | Dhananjay Govind Sathe | Process of Preparation of Proguanil |
| US8796275B2 (en) * | 2008-07-28 | 2014-08-05 | The Trustees Of The University Of Pennsylvania | Anti-malarial compounds |
| WO2012149093A1 (en) * | 2011-04-26 | 2012-11-01 | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF ARMY | 2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof |
| EP2727911B1 (en) * | 2012-10-31 | 2016-12-21 | Medizinische Hochschule Hannover | Novel means and methods for treating malaria and other parasitic disorders |
-
2018
- 2018-07-04 EP EP18734258.9A patent/EP3649109B1/en active Active
- 2018-07-04 RS RS20211414A patent/RS62656B1/sr unknown
- 2018-07-04 CA CA3069046A patent/CA3069046A1/en active Pending
- 2018-07-04 ES ES18734258T patent/ES2894657T3/es active Active
- 2018-07-04 DK DK18734258.9T patent/DK3649109T3/da active
- 2018-07-04 JP JP2019572366A patent/JP7065898B2/ja active Active
- 2018-07-04 WO PCT/EP2018/068079 patent/WO2019008027A1/en unknown
- 2018-07-04 BR BR112020000034-5A patent/BR112020000034B1/pt active IP Right Grant
- 2018-07-04 LT LTEPPCT/EP2018/068079T patent/LT3649109T/lt unknown
- 2018-07-04 PT PT187342589T patent/PT3649109T/pt unknown
- 2018-07-04 HR HRP20211806TT patent/HRP20211806T1/hr unknown
- 2018-07-04 SI SI201830402T patent/SI3649109T1/sl unknown
- 2018-07-04 PL PL18734258T patent/PL3649109T3/pl unknown
- 2018-07-04 US US16/628,720 patent/US11078160B2/en active Active
- 2018-07-04 CN CN201880044927.1A patent/CN110869350B/zh active Active
- 2018-07-04 HU HUE18734258A patent/HUE056766T2/hu unknown
-
2021
- 2021-09-27 CY CY20211100842T patent/CY1124530T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3649109B1 (en) | 2021-09-01 |
| HRP20211806T1 (hr) | 2022-02-18 |
| DK3649109T3 (da) | 2021-11-22 |
| PT3649109T (pt) | 2021-09-10 |
| SI3649109T1 (sl) | 2021-11-30 |
| HUE056766T2 (hu) | 2022-03-28 |
| EP3649109A1 (en) | 2020-05-13 |
| BR112020000034A2 (pt) | 2020-09-29 |
| JP7065898B2 (ja) | 2022-05-12 |
| PL3649109T3 (pl) | 2022-01-31 |
| CN110869350A (zh) | 2020-03-06 |
| CA3069046A1 (en) | 2019-01-10 |
| BR112020000034B1 (pt) | 2023-10-10 |
| RS62656B1 (sr) | 2021-12-31 |
| US20200281909A1 (en) | 2020-09-10 |
| LT3649109T (lt) | 2021-09-27 |
| WO2019008027A1 (en) | 2019-01-10 |
| JP2020525496A (ja) | 2020-08-27 |
| CN110869350B (zh) | 2023-05-02 |
| US11078160B2 (en) | 2021-08-03 |
| ES2894657T3 (es) | 2022-02-15 |
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