CY1124392T1 - Χρηση σακχαροαλκοολων σε συνθεσεις τιβολονης - Google Patents

Χρηση σακχαροαλκοολων σε συνθεσεις τιβολονης

Info

Publication number
CY1124392T1
CY1124392T1 CY20211100694T CY211100694T CY1124392T1 CY 1124392 T1 CY1124392 T1 CY 1124392T1 CY 20211100694 T CY20211100694 T CY 20211100694T CY 211100694 T CY211100694 T CY 211100694T CY 1124392 T1 CY1124392 T1 CY 1124392T1
Authority
CY
Cyprus
Prior art keywords
saccharoalcohol
tivolone
compositions
sugar alcohols
tibolone
Prior art date
Application number
CY20211100694T
Other languages
English (en)
Inventor
Séverine JASPART
Original Assignee
Novalon S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novalon S.A. filed Critical Novalon S.A.
Publication of CY1124392T1 publication Critical patent/CY1124392T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση αφορά την χρήση μιας σακχαροαλκοόλης για την σταθεροποίηση της τιβολόνης σε μια στερεή φαρμακοτεχνική μορφή. Η εφεύρεση αφορά επίσης μια φαρμακευτική σύνθεση, συγκεκριμένα μια στερεή φαρμακοτεχνική μορφή όπως ένα δισκίο, η οποία περιλαμβάνει τιβολόνη και μια σακχαροαλκοόλη και ένα αραιωτικό που δεν είναι σακχαροαλκοόλη, όπου η κατά βάρος αναλογία της σακχαροαλκοόλης προς το αραιωτικό που δεν είναι σακχαροαλκοόλη είναι μεταξύ 4:1 και 1:4, και μια μέθοδο για την παρασκευή αυτής.
CY20211100694T 2016-05-04 2021-08-03 Χρηση σακχαροαλκοολων σε συνθεσεις τιβολονης CY1124392T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16168390 2016-05-04
PCT/EP2017/060676 WO2017191266A1 (en) 2016-05-04 2017-05-04 Use of sugar-alcohols in tibolone compositions

Publications (1)

Publication Number Publication Date
CY1124392T1 true CY1124392T1 (el) 2022-07-22

Family

ID=55919671

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100694T CY1124392T1 (el) 2016-05-04 2021-08-03 Χρηση σακχαροαλκοολων σε συνθεσεις τιβολονης

Country Status (13)

Country Link
US (1) US10736907B2 (el)
EP (1) EP3452019B1 (el)
AU (1) AU2017260799B2 (el)
BR (1) BR112018072371B1 (el)
CY (1) CY1124392T1 (el)
DK (1) DK3452019T3 (el)
ES (1) ES2889598T3 (el)
HU (1) HUE055164T2 (el)
MX (1) MX2018013274A (el)
PL (1) PL3452019T3 (el)
PT (1) PT3452019T (el)
WO (1) WO2017191266A1 (el)
ZA (1) ZA201807210B (el)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665514A (el) 1964-06-16
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
IE63051B1 (en) 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
IL123984A (en) 1997-04-22 2004-09-27 Akzo Nobel Nv Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable
DE60220699T2 (de) 2001-10-18 2008-03-06 Norton Healthcare Ltd. Tibolonformulierungen
TW200418525A (en) 2002-11-20 2004-10-01 Akzo Nobel Nv Coated pharmaceutical tablets containing Tibolone
DE502004001894D1 (de) * 2004-02-06 2006-12-14 Helm Ag Pharmazeutische Zubereitungen mit amorphem Tibolon
WO2005117899A1 (en) 2004-06-02 2005-12-15 Cipla Limited Pharmaceutical composition comprising tibolone and process for procuding the same
CZ300465B6 (cs) 2007-07-25 2009-05-27 Zentiva, A. S. Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
CN102085193B (zh) * 2009-12-08 2013-11-06 北京以岭生物工程技术有限公司 一种替勃龙口腔崩解片及其制备方法
WO2017047586A1 (ja) 2015-09-14 2017-03-23 日本新薬株式会社 錠剤

Also Published As

Publication number Publication date
ES2889598T3 (es) 2022-01-12
WO2017191266A1 (en) 2017-11-09
BR112018072371B1 (pt) 2024-04-30
EP3452019A1 (en) 2019-03-13
PT3452019T (pt) 2021-07-28
BR112018072371A2 (pt) 2019-02-19
EP3452019B1 (en) 2021-06-23
AU2017260799A1 (en) 2018-12-13
US10736907B2 (en) 2020-08-11
PL3452019T3 (pl) 2021-12-20
AU2017260799B2 (en) 2022-11-24
ZA201807210B (en) 2022-04-28
HUE055164T2 (hu) 2021-11-29
MX2018013274A (es) 2019-03-06
US20190134058A1 (en) 2019-05-09
DK3452019T3 (da) 2021-09-06

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CY1124392T1 (el) Χρηση σακχαροαλκοολων σε συνθεσεις τιβολονης