CY1123685T1 - Μεθοδος πεγκυλιωσης - Google Patents

Μεθοδος πεγκυλιωσης

Info

Publication number
CY1123685T1
CY1123685T1 CY20201101014T CY201101014T CY1123685T1 CY 1123685 T1 CY1123685 T1 CY 1123685T1 CY 20201101014 T CY20201101014 T CY 20201101014T CY 201101014 T CY201101014 T CY 201101014T CY 1123685 T1 CY1123685 T1 CY 1123685T1
Authority
CY
Cyprus
Prior art keywords
pegylation method
pegylation
relates
present
interferon beta
Prior art date
Application number
CY20201101014T
Other languages
English (en)
Inventor
Robert S. Gronke
Orlando JAQUEZ
Original Assignee
Biogen Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc. filed Critical Biogen Ma Inc.
Publication of CY1123685T1 publication Critical patent/CY1123685T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μία μέθοδο για PEGυλίωση ιντερφερόνης βήτα.
CY20201101014T 2014-08-19 2020-10-27 Μεθοδος πεγκυλιωσης CY1123685T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461997000P 2014-08-19 2014-08-19
PCT/US2015/045678 WO2017030563A1 (en) 2014-08-19 2015-08-18 Pegylation method

Publications (1)

Publication Number Publication Date
CY1123685T1 true CY1123685T1 (el) 2022-03-24

Family

ID=59559468

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101014T CY1123685T1 (el) 2014-08-19 2020-10-27 Μεθοδος πεγκυλιωσης

Country Status (12)

Country Link
US (1) US11318207B2 (el)
EP (2) EP3782652A1 (el)
CO (1) CO2017002512A2 (el)
CY (1) CY1123685T1 (el)
DK (1) DK3183264T3 (el)
ES (1) ES2824028T3 (el)
HR (1) HRP20201725T1 (el)
LT (1) LT3183264T (el)
MX (1) MX2017002140A (el)
RS (1) RS61128B1 (el)
SI (1) SI3183264T1 (el)
WO (1) WO2017030563A1 (el)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
EP0082481B2 (en) 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (ja) 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
PT730470E (pt) 1993-11-10 2002-08-30 Enzon Inc Conjugados melhorados de interferao-polimero
JP4574007B2 (ja) 1998-04-28 2010-11-04 メルク・セローノ・ソシエテ・アノニム ポリオール−ｉｆｎ−ベータ複体
TWI266801B (en) 1999-07-26 2006-11-21 Applied Research Systems Polyol-IFN-beta conjugates
AU2003210564B2 (en) * 2002-01-18 2008-10-23 Biogen Ma Inc. Polyalkylene glycol with moiety for conjugating biologically active compound
ATE361761T1 (de) * 2002-09-27 2007-06-15 Hoffmann La Roche Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4
US20040180054A1 (en) * 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
CU23556A1 (es) 2005-11-30 2010-07-20 Ct Ingenieria Genetica Biotech Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
GB0908393D0 (en) 2009-05-15 2009-06-24 Almac Sciences Scotland Ltd Labelling method
WO2011075391A1 (en) * 2009-12-15 2011-06-23 Schering Corporation Formulations of acadesine
AR080993A1 (es) 2010-04-02 2012-05-30 Hanmi Holdings Co Ltd Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina
CN102453089B (zh) 2010-10-25 2014-06-04 北京凯因科技股份有限公司 重组集成干扰素变异体聚乙二醇偶联物的制备和应用
WO2014130811A1 (en) * 2013-02-22 2014-08-28 Biogen Idec Ma Inc Interferon beta formulation
CN103113466B (zh) 2013-03-01 2015-06-03 中国科学院过程工程研究所 聚乙二醇修饰的重组人干扰素β-1b及制备方法
CN103936847B (zh) 2013-12-24 2014-12-10 北京凯因科技股份有限公司 Peg-sa及其药物组合物

Also Published As

Publication number Publication date
HRP20201725T1 (hr) 2021-03-05
BR112017003162A2 (pt) 2017-11-28
US11318207B2 (en) 2022-05-03
EP3183264B1 (en) 2020-07-29
SI3183264T1 (sl) 2021-03-31
WO2017030563A1 (en) 2017-02-23
US20170232111A1 (en) 2017-08-17
EP3183264A1 (en) 2017-06-28
ES2824028T3 (es) 2021-05-11
LT3183264T (lt) 2021-01-11
MX2017002140A (es) 2017-08-21
EP3782652A1 (en) 2021-02-24
CO2017002512A2 (es) 2017-05-31
RS61128B1 (sr) 2020-12-31
WO2017030563A8 (en) 2017-03-16
DK3183264T3 (da) 2020-11-02

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