CY1123341T1 - Μη επιλεκτικο καναλι κατιοντων στα νευρωνικα κυτταρα και ενωσεις που μπλοκαρουν το καναλι για χρηση στη θεραπευτικη αντιμετωπιση της εγκεφαλικης εξοιδησης - Google Patents

Μη επιλεκτικο καναλι κατιοντων στα νευρωνικα κυτταρα και ενωσεις που μπλοκαρουν το καναλι για χρηση στη θεραπευτικη αντιμετωπιση της εγκεφαλικης εξοιδησης

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Publication number
CY1123341T1
CY1123341T1 CY20201100647T CY201100647T CY1123341T1 CY 1123341 T1 CY1123341 T1 CY 1123341T1 CY 20201100647 T CY20201100647 T CY 20201100647T CY 201100647 T CY201100647 T CY 201100647T CY 1123341 T1 CY1123341 T1 CY 1123341T1
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CY
Cyprus
Prior art keywords
channel
cerebral
edition
subject
therapeutic treatment
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Application number
CY20201100647T
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English (en)
Inventor
J. Marc Simard
Mingkui Chen
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University Of Maryland, Baltimore
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Application filed by University Of Maryland, Baltimore filed Critical University Of Maryland, Baltimore
Publication of CY1123341T1 publication Critical patent/CY1123341T1/el

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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις που μπλοκάρουν το κανάλι NCca-ATP για χρήση στην (α) πρόληψη ή θεραπευτική αντιμετώπιση της εξοίδησης των νευρωνικών κυττάρων στον εγκέφαλο ενός υποκειμένου˙ β) την ανακούφιση των αρνητικών επιπτώσεων τραυματικής εγκεφαλικής κάκωσης ή εγκεφαλικής ισχαιμίας που οφείλεται σε εξοίδηση των νευρωνικών κυττάρων σε ένα υποκείμενο˙ γ) τη θεραπευτική αγωγή για ένα υποκείμενο που έχει βλάβη στο κεντρικό ή στο περιφερειακό νευρικό σύστημα˙ ή (δ) τη θεραπευτική αγωγή για ένα υποκείμενο που έχει αιμορραγία στον εγκέφαλο.
CY20201100647T 2002-03-20 2020-07-15 Μη επιλεκτικο καναλι κατιοντων στα νευρωνικα κυτταρα και ενωσεις που μπλοκαρουν το καναλι για χρηση στη θεραπευτικη αντιμετωπιση της εγκεφαλικης εξοιδησης CY1123341T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36593302P 2002-03-20 2002-03-20
PCT/US2003/008442 WO2003079987A2 (en) 2002-03-20 2003-03-20 A non-selective cation channel in neural cells and methods for treating brain swelling
EP03718003.1A EP1529058B1 (en) 2002-03-20 2003-03-20 A non-selective cation channel in neural cells and sur1 antagonists for treating brain swelling

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CY1123341T1 true CY1123341T1 (el) 2021-12-31

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US (8) US20030215889A1 (el)
EP (2) EP1529058B1 (el)
JP (1) JP4485806B2 (el)
AU (3) AU2003222020B2 (el)
CA (1) CA2477812C (el)
CY (1) CY1123341T1 (el)
DK (2) DK1529058T3 (el)
ES (2) ES2807274T3 (el)
HU (1) HUE051368T2 (el)
PT (1) PT2438913T (el)
SI (1) SI2438913T1 (el)
WO (1) WO2003079987A2 (el)

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US7872048B2 (en) * 2004-09-18 2011-01-18 University Of Maryland, Baltimore Methods for treating spinal cord injury with a compound that inhibits a NCCa-ATP channel
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
ES2807274T3 (es) 2002-03-20 2021-02-22 Univ Maryland Un canal catiónico no selectivo en células neurales y compuestos que bloquean el canal para su uso en el tratamiento de la inflamación del cerebro
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