DE69132530D1 - Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf) - Google Patents

Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf)

Info

Publication number
DE69132530D1
DE69132530D1 DE69132530T DE69132530T DE69132530D1 DE 69132530 D1 DE69132530 D1 DE 69132530D1 DE 69132530 T DE69132530 T DE 69132530T DE 69132530 T DE69132530 T DE 69132530T DE 69132530 D1 DE69132530 D1 DE 69132530D1
Authority
DE
Germany
Prior art keywords
cells
ehm
growth factor
pct
heparin binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69132530T
Other languages
English (en)
Inventor
Michael Klagsbrun
A Abraham
Shigeki Higashiyama
E Besner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Scios LLC
Original Assignee
Childrens Medical Center Corp
Scios LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center Corp, Scios LLC filed Critical Childrens Medical Center Corp
Application granted granted Critical
Publication of DE69132530D1 publication Critical patent/DE69132530D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
DE69132530T 1990-10-16 1991-10-16 Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf) Expired - Lifetime DE69132530D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59808290A 1990-10-16 1990-10-16
PCT/US1991/007691 WO1992006705A1 (en) 1990-10-16 1991-10-16 Heparin binding mitogen with homology to epidermal growth factor (egf)

Publications (1)

Publication Number Publication Date
DE69132530D1 true DE69132530D1 (de) 2001-03-15

Family

ID=24394159

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132530T Expired - Lifetime DE69132530D1 (de) 1990-10-16 1991-10-16 Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf)

Country Status (8)

Country Link
US (1) US5811393A (de)
EP (1) EP0559769B1 (de)
JP (1) JPH06502538A (de)
AT (1) ATE199095T1 (de)
AU (1) AU663298B2 (de)
CA (1) CA2094045A1 (de)
DE (1) DE69132530D1 (de)
WO (1) WO1992006705A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008293A1 (en) * 1992-12-23 1996-03-21 Patrick Edison Kane Injection molded water-soluble golf ball
WO1996008274A2 (en) * 1994-09-13 1996-03-21 Prizm Pharmaceuticals, Inc. Conjugates of heparin-binding epidermal growth factor-like growth factor with targeted agents
WO1999001738A2 (en) 1997-06-30 1999-01-14 University Of Maryland, Baltimore Heparin binding-epidermal growth factor in the diagnosis of interstitial cystitis
US5876730A (en) * 1997-08-07 1999-03-02 Childrens Hospital Research Foundation Heparin-binding growth factor (HBGF) polypeptides
US6191109B1 (en) * 1997-10-31 2001-02-20 Children's Hospital, Inc. Methods of treating intestinal ischemia using heparin-binding epidermal growth factor
CA2328774A1 (en) * 1998-04-17 1999-10-28 John Warren Method of treating interstitial cystitis with recombinant heparin-binding epidermal growth factor-like growth factor (hb-egf)
CA2337964A1 (en) * 1998-08-07 2000-02-17 The General Hospital Corporation Treatment of central nervous system ischemia or trauma with epidermal growth factor-like polypeptides
AU6262700A (en) * 1999-06-09 2001-01-02 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh Nucleic acid encoding novel egf-like growth factors
HUE051368T2 (hu) 2002-03-20 2021-03-01 Univ Maryland Nem szelektív kationcsatorna idegsejtekben és a csatornát blokkoló vegyületek az agyduzzanat kezelésére
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
WO2004057330A1 (ja) * 2002-12-20 2004-07-08 Shigeki Higashiyama 細胞増殖抑制剤のスクリーニング方法および細胞増殖抑制剤
US9079936B2 (en) * 2003-07-01 2015-07-14 University Of Maryland, Baltimore Derivatives of APF and methods of use
US20050096263A1 (en) 2003-10-30 2005-05-05 Keay Susan K. Novel antiproliferative factor and methods of use
DE602005024704D1 (de) * 2004-09-18 2010-12-23 Univ Maryland Therapeutische mittel zum targeting des nc ca-atp-kanals und verwendungsverfahren dafür
EP2359832A3 (de) * 2004-09-18 2011-11-23 University of Maryland, Baltimore Therapeutische mittel zum targeting des ncca-atp-kanals und verwendungsverfahren dafür
EP1848541A4 (de) * 2005-02-07 2013-01-16 Pharmalight Inc Verfahren und vorrichtung zur ophthalmischen verabreichung von pharmazeutischen wirksstoffen
WO2007058843A2 (en) * 2005-11-15 2007-05-24 Lentigen Corporation Web based vector design
CA2637216A1 (en) * 2006-02-10 2007-08-16 Dermagen Ab Novel antimicrobial peptides and use thereof
US20100055113A1 (en) * 2006-07-27 2010-03-04 The University Of Maryland, Baltimore Cellular receptor for antiproliferative factor
EP3103451A1 (de) * 2007-01-12 2016-12-14 University of Maryland, Baltimore Targeting des ncca-atp-kanals für organschutz nach einer ischämischen episode
CA2618099C (en) * 2007-02-09 2016-09-20 University Of Maryland, Baltimore Antagonists of a non-selective cation channel in neural cells
US8093213B2 (en) * 2007-04-30 2012-01-10 Nationwide Children's Hospital, Inc. Heparin binding epidermal growth factor (HB-EGF) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation
WO2009002832A2 (en) 2007-06-22 2008-12-31 University Of Maryland, Baltimore Inhibitors of ncca-atp channels for therapy
AU2009282625A1 (en) 2008-08-18 2010-02-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Derivatives of APF and methods of use
US20160022873A1 (en) 2013-03-14 2016-01-28 Research Institute At Nationwide Children's Hospital, Inc. Tissue engineered intestine
AU2015336008B2 (en) * 2014-10-21 2019-11-21 The Board Of Trustees Of The Leland Stanford Junior University Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI890312A (fi) * 1988-01-25 1989-07-26 Oncogen Amfiregulin: ett nytt bifunktionellt tillvaext modulerande glykoprotein.
DE8802464U1 (de) * 1988-02-25 1989-06-22 Robert Bosch Gmbh, 7000 Stuttgart Kraftstoffeinspritzventil
IL89661A (en) * 1988-03-17 1999-05-09 Novo Nordisk As Heparin binding proteins
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence

Also Published As

Publication number Publication date
US5811393A (en) 1998-09-22
EP0559769A1 (de) 1993-09-15
EP0559769A4 (en) 1994-06-08
CA2094045A1 (en) 1992-04-17
ATE199095T1 (de) 2001-02-15
WO1992006705A1 (en) 1992-04-30
JPH06502538A (ja) 1994-03-24
AU663298B2 (en) 1995-10-05
AU9086991A (en) 1992-05-20
EP0559769B1 (de) 2001-02-07

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