CY1122745T1 - Εμβολιο βιοχημικως σταθεροποιημενου τριμερους μανδυα hiv-1 - Google Patents
Εμβολιο βιοχημικως σταθεροποιημενου τριμερους μανδυα hiv-1Info
- Publication number
- CY1122745T1 CY1122745T1 CY20201100062T CY201100062T CY1122745T1 CY 1122745 T1 CY1122745 T1 CY 1122745T1 CY 20201100062 T CY20201100062 T CY 20201100062T CY 201100062 T CY201100062 T CY 201100062T CY 1122745 T1 CY1122745 T1 CY 1122745T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hiv
- biochemically
- trimer
- vaccine
- covered
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16171—Demonstrated in vivo effect
Abstract
Παρέχονται σταθεροποιημένα τριμερή ενός στελέχους του κλάδου Α και ενός στελέχους του κλάδου C του HIV-1. Παρέχονται επίσης οι μέθοδοι για την ευρέως εξουδετέρωση των αντιορών κατά του HIV-1, την παραγωγή των ευρέως εξουδετεροποιημένων αντιορών κατά του HIV-1, την ευρέως εξουδετέρωση εμβολίων κατά του HIV-1, καθώς και οι μέθοδοι για τη θεραπεία των υποκειμένων που είναι μολυσμένα με HIV, την πρόληψη της μόλυνσης με HIV και την αναστολή των δράσεων μέσω του HIV.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10444908P | 2008-10-10 | 2008-10-10 | |
EP09820044.7A EP2340038B1 (en) | 2008-10-10 | 2009-10-13 | Biochemically stabilized hiv-1 env trimer vaccine |
PCT/US2009/060494 WO2010042942A2 (en) | 2008-10-10 | 2009-10-13 | Biochemically stabilized hiv-1 env trimer vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122745T1 true CY1122745T1 (el) | 2021-01-27 |
Family
ID=42101262
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100190T CY1119921T1 (el) | 2008-10-10 | 2018-02-15 | Εμβολιο βιοχημικως σταθεροποιημενου τριμερους μανδυα hiv-1 |
CY20201100062T CY1122745T1 (el) | 2008-10-10 | 2020-01-23 | Εμβολιο βιοχημικως σταθεροποιημενου τριμερους μανδυα hiv-1 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100190T CY1119921T1 (el) | 2008-10-10 | 2018-02-15 | Εμβολιο βιοχημικως σταθεροποιημενου τριμερους μανδυα hiv-1 |
Country Status (14)
Country | Link |
---|---|
US (6) | US9707289B2 (el) |
EP (2) | EP2340038B1 (el) |
AU (1) | AU2009303284B2 (el) |
CY (2) | CY1119921T1 (el) |
DK (2) | DK2340038T3 (el) |
ES (2) | ES2659875T3 (el) |
HR (2) | HRP20180281T1 (el) |
HU (2) | HUE049393T2 (el) |
LT (2) | LT3335728T (el) |
PL (2) | PL3335728T3 (el) |
PT (2) | PT3335728T (el) |
SI (2) | SI3335728T1 (el) |
TR (1) | TR201802130T4 (el) |
WO (1) | WO2010042942A2 (el) |
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EP1868651A4 (en) | 2005-04-12 | 2010-10-06 | Univ Duke | METHOD FOR INDUCING ANTIBODIES THAT NEUTRALIZE THE HUMAN IMMUNODEFICIENCY VIRUS |
CA2683752A1 (en) | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
US20120070488A1 (en) * | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
LT3335728T (lt) | 2008-10-10 | 2020-03-10 | Children`S Medical Center Corporation | Biocheminiu požiūriu stabilizuota živ-1 env trimero vakcina |
WO2010114628A2 (en) | 2009-04-03 | 2010-10-07 | Duke University | Formulation for inducing broadly reactive neutralizing anti-hiv antibodies |
US9060984B2 (en) * | 2010-10-30 | 2015-06-23 | George Dacai Liu | Recombinant HIV-1 envelope proteins comprising stabilizing two-cysteine mini-domains in gp41 |
WO2014022475A2 (en) * | 2012-08-03 | 2014-02-06 | Dana-Faber Cancer Institute, Inc. | Compositions and methods for conformationally stabilizing primate immunodeficiency virus envelope glycoprotein trimers |
SG11201505229XA (en) * | 2013-01-07 | 2015-08-28 | Beth Israel Hospital | Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same |
AU2014224049B2 (en) | 2013-02-28 | 2018-11-29 | Therabiol, Inc. | HIV antigens and antibodies |
US9675687B2 (en) | 2013-03-15 | 2017-06-13 | University Of Massachusetts | Compositions and methods to treat AIDS |
US10076567B2 (en) | 2013-09-27 | 2018-09-18 | Duke University | MPER-liposome conjugates and uses thereof |
WO2015051270A1 (en) | 2013-10-04 | 2015-04-09 | Beth Israel Deaconess Medical Center, Inc. | Stabilized human immunodeficiency virus (hiv) clade c envelope (env) trimer vaccines and methods of using same |
NZ728072A (en) | 2014-07-11 | 2018-06-29 | Gilead Sciences Inc | Modulators of toll-like receptors for the treatment of hiv |
RS61902B1 (sr) | 2014-09-26 | 2021-06-30 | Beth Israel Deaconess Medical Ct Inc | Metodi i kompozicije za indukovanje zaštitnog imuniteta protiv infekcije virusom humane imunodeficijencije |
WO2016196471A1 (en) | 2015-06-02 | 2016-12-08 | Cooper Human Systems Llc | Methods and compositions for treatment of hiv infection |
AU2016369326B2 (en) | 2015-12-15 | 2019-02-21 | Janssen Vaccines & Prevention B.V. | Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof |
US10273268B2 (en) | 2016-06-16 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | HIV vaccine formulation |
AU2017318689A1 (en) | 2016-09-02 | 2019-04-11 | Beth Israel Deaconess Medical Center, Inc. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
HUE052008T2 (hu) | 2016-09-15 | 2021-04-28 | Janssen Vaccines & Prevention Bv | Trimert stabilizáló HIV-burokfehérje-mutációk |
US11230572B2 (en) | 2016-10-17 | 2022-01-25 | Beth Israel Deaconess Medical Center, Inc. | Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same |
MA49397A (fr) | 2017-06-15 | 2020-04-22 | Bavarian Nordic As | Vecteurs à poxvirus codant pour des antigènes du vih, et leurs procédés d'utilisation |
BR112020000867A2 (pt) | 2017-07-19 | 2020-07-21 | Janssen Vaccines & Prevention B.V. | mutações da proteína do envelope do hiv estabilizando o trímero |
US20190022212A1 (en) | 2017-07-21 | 2019-01-24 | Beth Israel Deaconess Medical Center, Inc. | Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human |
WO2019055888A1 (en) | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHODS OF INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDER ANTIRETROVIRAL TREATMENT |
WO2020064621A1 (en) | 2018-09-25 | 2020-04-02 | Janssen Vaccines & Prevention B.V. | Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components |
TW202110476A (zh) | 2019-05-22 | 2021-03-16 | 荷蘭商傑森疫苗防護公司 | 於接受抗反轉錄病毒治療之個體中誘發抗人類免疫缺乏病毒感染之免疫反應的方法 |
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2009
- 2009-10-13 LT LTEP18150843.3T patent/LT3335728T/lt unknown
- 2009-10-13 LT LTEP09820044.7T patent/LT2340038T/lt unknown
- 2009-10-13 ES ES09820044.7T patent/ES2659875T3/es active Active
- 2009-10-13 PT PT181508433T patent/PT3335728T/pt unknown
- 2009-10-13 SI SI200932027T patent/SI3335728T1/sl unknown
- 2009-10-13 HU HUE18150843A patent/HUE049393T2/hu unknown
- 2009-10-13 EP EP09820044.7A patent/EP2340038B1/en active Active
- 2009-10-13 SI SI200931800T patent/SI2340038T1/en unknown
- 2009-10-13 ES ES18150843T patent/ES2765890T3/es active Active
- 2009-10-13 PL PL18150843T patent/PL3335728T3/pl unknown
- 2009-10-13 WO PCT/US2009/060494 patent/WO2010042942A2/en active Application Filing
- 2009-10-13 TR TR2018/02130T patent/TR201802130T4/tr unknown
- 2009-10-13 EP EP18150843.3A patent/EP3335728B8/en active Active
- 2009-10-13 AU AU2009303284A patent/AU2009303284B2/en active Active
- 2009-10-13 PL PL09820044T patent/PL2340038T3/pl unknown
- 2009-10-13 PT PT98200447T patent/PT2340038T/pt unknown
- 2009-10-13 DK DK09820044.7T patent/DK2340038T3/en active
- 2009-10-13 DK DK18150843.3T patent/DK3335728T3/da active
- 2009-10-13 HU HUE09820044A patent/HUE037270T2/hu unknown
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2011
- 2011-04-08 US US13/082,601 patent/US9707289B2/en active Active
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2017
- 2017-05-16 US US15/596,312 patent/US9950060B2/en active Active
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2018
- 2018-02-15 CY CY20181100190T patent/CY1119921T1/el unknown
- 2018-02-15 HR HRP20180281TT patent/HRP20180281T1/hr unknown
- 2018-03-13 US US15/919,834 patent/US10307478B2/en active Active
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2019
- 2019-04-16 US US16/385,438 patent/US10463729B2/en not_active Expired - Fee Related
- 2019-09-23 US US16/579,025 patent/US10653770B2/en active Active
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2020
- 2020-01-23 CY CY20201100062T patent/CY1122745T1/el unknown
- 2020-03-04 HR HRP20200370TT patent/HRP20200370T1/hr unknown
- 2020-04-27 US US16/858,808 patent/US11229696B2/en active Active
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