PT2340038T - Vacina de trímero de envelope para hiv-1 bioquimicamente estabilizada - Google Patents
Vacina de trímero de envelope para hiv-1 bioquimicamente estabilizadaInfo
- Publication number
- PT2340038T PT2340038T PT98200447T PT09820044T PT2340038T PT 2340038 T PT2340038 T PT 2340038T PT 98200447 T PT98200447 T PT 98200447T PT 09820044 T PT09820044 T PT 09820044T PT 2340038 T PT2340038 T PT 2340038T
- Authority
- PT
- Portugal
- Prior art keywords
- env trimer
- stabilized hiv
- vaccine
- biochemically
- biochemically stabilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10444908P | 2008-10-10 | 2008-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2340038T true PT2340038T (pt) | 2018-02-21 |
Family
ID=42101262
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98200447T PT2340038T (pt) | 2008-10-10 | 2009-10-13 | Vacina de trímero de envelope para hiv-1 bioquimicamente estabilizada |
PT181508433T PT3335728T (pt) | 2008-10-10 | 2009-10-13 | Vacina de trímero de envelope para hiv-1 bioquimicamente estabilizada |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT181508433T PT3335728T (pt) | 2008-10-10 | 2009-10-13 | Vacina de trímero de envelope para hiv-1 bioquimicamente estabilizada |
Country Status (14)
Country | Link |
---|---|
US (6) | US9707289B2 (pt) |
EP (2) | EP3335728B8 (pt) |
AU (1) | AU2009303284B2 (pt) |
CY (2) | CY1119921T1 (pt) |
DK (2) | DK2340038T3 (pt) |
ES (2) | ES2765890T3 (pt) |
HR (2) | HRP20180281T1 (pt) |
HU (2) | HUE037270T2 (pt) |
LT (2) | LT2340038T (pt) |
PL (2) | PL2340038T3 (pt) |
PT (2) | PT2340038T (pt) |
SI (2) | SI2340038T1 (pt) |
TR (1) | TR201802130T4 (pt) |
WO (1) | WO2010042942A2 (pt) |
Families Citing this family (29)
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WO2006110831A2 (en) | 2005-04-12 | 2006-10-19 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
JP2010523676A (ja) | 2007-04-13 | 2010-07-15 | デューク ユニバーシティ | ヒト免疫不全ウイルスに対する中和抗体を誘導する方法 |
US20120070488A1 (en) * | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
ES2765890T3 (es) | 2008-10-10 | 2020-06-11 | Childrens Medical Center | Vacuna de trímero de Env VIH-1 bioquímicamente estabilizado |
WO2010114628A2 (en) | 2009-04-03 | 2010-10-07 | Duke University | Formulation for inducing broadly reactive neutralizing anti-hiv antibodies |
US9060984B2 (en) * | 2010-10-30 | 2015-06-23 | George Dacai Liu | Recombinant HIV-1 envelope proteins comprising stabilizing two-cysteine mini-domains in gp41 |
US20130302366A1 (en) * | 2012-05-09 | 2013-11-14 | Christopher Marshall | Conformationally Specific Viral Immunogens |
WO2014022475A2 (en) * | 2012-08-03 | 2014-02-06 | Dana-Faber Cancer Institute, Inc. | Compositions and methods for conformationally stabilizing primate immunodeficiency virus envelope glycoprotein trimers |
EP2983686B1 (en) * | 2013-01-07 | 2024-05-29 | Beth Israel Deaconess Medical Center, Inc. | Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same |
EP2961427B1 (en) | 2013-02-28 | 2020-03-25 | Gnvie, Llc | Hiv antigens and antibodies |
WO2014151687A2 (en) | 2013-03-15 | 2014-09-25 | University Of Massachusetts | Compositions and methods to treat aids |
WO2015048635A1 (en) | 2013-09-27 | 2015-04-02 | Duke University | Mper-liposome conjugates and uses thereof |
US10716845B2 (en) | 2013-10-04 | 2020-07-21 | Beth Israel Deaconess Medical Center, Inc. | Stabilized human immunodeficiency virus (HIV) clade C envelope (Env) trimer vaccines and methods of using same |
AU2015287773B2 (en) | 2014-07-11 | 2018-03-29 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of HIV |
PL3197489T3 (pl) | 2014-09-26 | 2021-11-08 | Beth Israel Deaconess Medical Center, Inc. | Sposoby i kompozycje do indukowania ochronnej odporności przeciwo zakażeniu ludzkim wirusem niedoboru odporności |
WO2016196471A1 (en) | 2015-06-02 | 2016-12-08 | Cooper Human Systems Llc | Methods and compositions for treatment of hiv infection |
MD3584252T2 (ro) | 2015-12-15 | 2022-01-31 | Janssen Vaccines & Prevention Bv | Antigene, vectori, compoziții ale virusului imunodeficienței umane și metode de utilizare a acestora |
SG11201810549TA (en) | 2016-06-16 | 2018-12-28 | Janssen Vaccines & Prevention Bv | Hiv vaccine formulation |
CA3035759A1 (en) | 2016-09-02 | 2018-03-08 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
JP7178344B2 (ja) | 2016-09-15 | 2022-11-25 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 三量体安定化hivエンベロープタンパク質変異 |
WO2018075559A1 (en) | 2016-10-17 | 2018-04-26 | Beth Israel Deaconess Medical Center, Inc. | Signature-based human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same |
CN110958887B (zh) | 2017-06-15 | 2023-10-31 | 扬森疫苗与预防公司 | 编码hiv抗原的痘病毒载体及其使用方法 |
CA3069052A1 (en) | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations |
US20190022212A1 (en) | 2017-07-21 | 2019-01-24 | Beth Israel Deaconess Medical Center, Inc. | Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human |
WO2019055888A1 (en) | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHODS OF INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDER ANTIRETROVIRAL TREATMENT |
WO2020064621A1 (en) | 2018-09-25 | 2020-04-02 | Janssen Vaccines & Prevention B.V. | Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components |
WO2020237052A1 (en) | 2019-05-22 | 2020-11-26 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
JP7170942B1 (ja) | 2019-11-07 | 2022-11-14 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | タンパク質精製 |
WO2023198815A1 (en) | 2022-04-14 | 2023-10-19 | Janssen Vaccines & Prevention B.V. | Sequential administration of adenoviruses |
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2009
- 2009-10-13 ES ES18150843T patent/ES2765890T3/es active Active
- 2009-10-13 LT LTEP09820044.7T patent/LT2340038T/lt unknown
- 2009-10-13 LT LTEP18150843.3T patent/LT3335728T/lt unknown
- 2009-10-13 EP EP18150843.3A patent/EP3335728B8/en active Active
- 2009-10-13 EP EP09820044.7A patent/EP2340038B1/en active Active
- 2009-10-13 WO PCT/US2009/060494 patent/WO2010042942A2/en active Application Filing
- 2009-10-13 PT PT98200447T patent/PT2340038T/pt unknown
- 2009-10-13 PT PT181508433T patent/PT3335728T/pt unknown
- 2009-10-13 AU AU2009303284A patent/AU2009303284B2/en not_active Ceased
- 2009-10-13 SI SI200931800T patent/SI2340038T1/en unknown
- 2009-10-13 HU HUE09820044A patent/HUE037270T2/hu unknown
- 2009-10-13 PL PL09820044T patent/PL2340038T3/pl unknown
- 2009-10-13 SI SI200932027T patent/SI3335728T1/sl unknown
- 2009-10-13 ES ES09820044.7T patent/ES2659875T3/es active Active
- 2009-10-13 PL PL18150843T patent/PL3335728T3/pl unknown
- 2009-10-13 HU HUE18150843A patent/HUE049393T2/hu unknown
- 2009-10-13 TR TR2018/02130T patent/TR201802130T4/tr unknown
- 2009-10-13 DK DK09820044.7T patent/DK2340038T3/en active
- 2009-10-13 DK DK18150843.3T patent/DK3335728T3/da active
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2011
- 2011-04-08 US US13/082,601 patent/US9707289B2/en active Active
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2017
- 2017-05-16 US US15/596,312 patent/US9950060B2/en active Active
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2018
- 2018-02-15 CY CY20181100190T patent/CY1119921T1/el unknown
- 2018-02-15 HR HRP20180281TT patent/HRP20180281T1/hr unknown
- 2018-03-13 US US15/919,834 patent/US10307478B2/en active Active
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2019
- 2019-04-16 US US16/385,438 patent/US10463729B2/en not_active Expired - Fee Related
- 2019-09-23 US US16/579,025 patent/US10653770B2/en not_active Expired - Fee Related
-
2020
- 2020-01-23 CY CY20201100062T patent/CY1122745T1/el unknown
- 2020-03-04 HR HRP20200370TT patent/HRP20200370T1/hr unknown
- 2020-04-27 US US16/858,808 patent/US11229696B2/en active Active
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