CY1122602T1 - Αντιμετωπιση των nafld και nash - Google Patents

Αντιμετωπιση των nafld και nash

Info

Publication number
CY1122602T1
CY1122602T1 CY20191101347T CY191101347T CY1122602T1 CY 1122602 T1 CY1122602 T1 CY 1122602T1 CY 20191101347 T CY20191101347 T CY 20191101347T CY 191101347 T CY191101347 T CY 191101347T CY 1122602 T1 CY1122602 T1 CY 1122602T1
Authority
CY
Cyprus
Prior art keywords
treatment
nafld
nash
mbx
salt
Prior art date
Application number
CY20191101347T
Other languages
Greek (el)
English (en)
Inventor
Brian Roberts
Xueyan Wang
Yun-Jung Choi
David KARPF
Robert Martin
Charles A. Mcwherter
Original Assignee
Cymabay Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53373532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1122602(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cymabay Therapeutics, Inc. filed Critical Cymabay Therapeutics, Inc.
Publication of CY1122602T1 publication Critical patent/CY1122602T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CY20191101347T 2014-04-11 2019-12-20 Αντιμετωπιση των nafld και nash CY1122602T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461978335P 2014-04-11 2014-04-11
PCT/US2015/025416 WO2015157697A1 (en) 2014-04-11 2015-04-10 Treatment of nafld and nash

Publications (1)

Publication Number Publication Date
CY1122602T1 true CY1122602T1 (el) 2021-03-12

Family

ID=53373532

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101347T CY1122602T1 (el) 2014-04-11 2019-12-20 Αντιμετωπιση των nafld και nash

Country Status (27)

Country Link
US (7) US9381181B2 (cg-RX-API-DMAC7.html)
EP (1) EP3129018B1 (cg-RX-API-DMAC7.html)
JP (1) JP6865038B2 (cg-RX-API-DMAC7.html)
KR (1) KR102374499B1 (cg-RX-API-DMAC7.html)
CN (1) CN106163508A (cg-RX-API-DMAC7.html)
AU (1) AU2015243239B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016023269A8 (cg-RX-API-DMAC7.html)
CA (1) CA2944139C (cg-RX-API-DMAC7.html)
CL (1) CL2016002517A1 (cg-RX-API-DMAC7.html)
CY (1) CY1122602T1 (cg-RX-API-DMAC7.html)
DK (1) DK3129018T3 (cg-RX-API-DMAC7.html)
EA (1) EA036704B1 (cg-RX-API-DMAC7.html)
ES (1) ES2764467T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20192299T1 (cg-RX-API-DMAC7.html)
IL (1) IL248193B (cg-RX-API-DMAC7.html)
LT (1) LT3129018T (cg-RX-API-DMAC7.html)
MX (1) MX369921B (cg-RX-API-DMAC7.html)
NZ (1) NZ724740A (cg-RX-API-DMAC7.html)
PH (1) PH12016501978B1 (cg-RX-API-DMAC7.html)
PL (1) PL3129018T3 (cg-RX-API-DMAC7.html)
PT (1) PT3129018T (cg-RX-API-DMAC7.html)
RS (1) RS59637B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201608077PA (cg-RX-API-DMAC7.html)
SI (1) SI3129018T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202000019T1 (cg-RX-API-DMAC7.html)
UA (1) UA121208C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015157697A1 (cg-RX-API-DMAC7.html)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009288066B2 (en) 2008-09-02 2015-12-24 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
ES2712052T3 (es) * 2008-10-17 2019-05-09 Cymabay Therapeutics Inc Métodos para reducir partículas de LDL pequeñas y densas
DK3278665T3 (da) 2009-04-29 2020-11-30 Amarin Pharmaceuticals Ie Ltd Stabil farmaceutisk sammensætning og fremgangsmåder til anvendelse deraf
NZ807894A (en) 2009-04-29 2025-08-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
CA3129996C (en) 2009-06-15 2025-09-02 Amarin Pharmaceuticals Ireland Limited COMPOSITIONS AND METHODS FOR LOWERING TRIGLYCERIDES WITHOUT RAISED LDL-C LEVELS IN A SUBJECT UNDERGOING CONCOMITANT STATIN THERAPY
SG10201405994UA (en) 2009-09-23 2014-10-30 Amarin Pharmaceuticals Ie Ltd Pharmaceutical Composition Comprising Omega-3 Fatty Acid And Hydroxy-derivative Of A Statin And Methods Of Using Same
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
AU2011336856A1 (en) 2010-11-29 2013-07-04 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US20130131170A1 (en) 2011-11-07 2013-05-23 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
AU2013207368A1 (en) 2012-01-06 2014-07-24 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-CRP) in a subject
JP2015522029A (ja) 2012-06-29 2015-08-03 アマリン ファーマシューティカルス アイルランド リミテッド スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US9814733B2 (en) * 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN106102734B (zh) 2014-03-20 2019-05-14 西玛贝医药公司 肝内胆汁淤积性疾病的治疗
US10272058B2 (en) 2014-03-20 2019-04-30 Cymabay Therapeutics, Inc. Treatment of intrahepatic cholestatic diseases
PL3129018T3 (pl) 2014-04-11 2020-05-18 Cymabay Therapeutics, Inc. Leczenie NAFLD i NASH
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
HK1248537A1 (zh) * 2015-03-26 2018-10-19 T3D治疗有限责任公司 使用茚满乙酸衍生物治疗肝病的方法
CN107530306A (zh) 2015-04-28 2018-01-02 普罗诺瓦生物医药挪威公司 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途
US10940125B2 (en) 2015-09-18 2021-03-09 Duke University Methods and compositions for the treatment of steatosis-associated disorders
WO2017139708A1 (en) 2016-02-10 2017-08-17 Synlogic, Inc. Bacteria engineered to treat nonalcoholic steatohepatitis (nash)
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US12053445B2 (en) 2016-03-31 2024-08-06 Genfit Methods of treatment of cholestatic diseases
WO2017192997A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
GB201614455D0 (en) 2016-08-24 2016-10-05 Univ Oxford Innovation Ltd Biomarkers
NZ753051A (en) * 2016-11-04 2023-03-31 Children’S Hospital Medical Center Liver organoid compositions and methods of making and using same
US10493363B2 (en) * 2016-11-09 2019-12-03 Activision Publishing, Inc. Reality-based video game elements
KR102807995B1 (ko) 2016-12-05 2025-05-16 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
WO2018204775A1 (en) 2017-05-05 2018-11-08 Hepanova, Inc. Amino-aryl-benzamide compounds and methods of use thereof
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US10512622B2 (en) 2017-07-14 2019-12-24 Cymabay Therapeutics, Inc. Treatment of intrahepatic cholestatic diseases
EP3681537A1 (en) 2017-09-13 2020-07-22 Novartis AG Combinations comprising fxr agonists
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
EP3701953A4 (en) * 2017-10-27 2021-06-16 Samyang Corporation COMPOSITION FOR THE PREVENTION OR RELIEF OF NON-ALCOHOLIC FAT LIVER DISEASE
IL275002B2 (en) 2017-12-06 2024-04-01 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
SG11202100533VA (en) 2018-07-26 2021-02-25 Childrens Hospital Med Ct Hepato-biliary-pancreatic tissues and methods of making same
SG11202102431YA (en) 2018-09-12 2021-04-29 Childrens Hospital Med Ct Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
DK4056176T3 (da) 2018-09-24 2024-05-06 Amarin Pharmaceuticals Ie Ltd Fremgangsmåde til at reducere risikoen af kardiovaskulære hændelser hos et individ
MX2021005724A (es) * 2018-11-16 2021-07-21 Cymabay Therapeutics Inc Tratamiento combinado contra nafld y nash.
EP3880187A1 (en) 2018-11-16 2021-09-22 CymaBay Therapeutics, Inc. Treatment of obesity and its complications
CN121081472A (zh) 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2021050945A1 (en) 2019-09-12 2021-03-18 Terns, Inc. Thyroid hormone receptor beta agonist compounds
WO2021097120A1 (en) 2019-11-12 2021-05-20 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter
US20210145775A1 (en) 2019-11-14 2021-05-20 Cymabay Therapeutics, Inc. Treatment of intestinal barrier dysfunction and associated diseases
US20210145774A1 (en) 2019-11-14 2021-05-20 Cymabay Therapeutics, Inc. Treatment of alcoholic liver disease
EP4149452A4 (en) * 2020-05-13 2024-05-01 Terns Pharmaceuticals, Inc. COMBINATION TREATMENT OF LIVER DISEASES
KR20240012390A (ko) 2021-04-21 2024-01-29 애머린 파마슈티칼스 아일랜드 리미티드 심부전의 위험을 감소시키는 방법
CA3214214A1 (en) * 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101993B1 (en) 1990-01-11 2006-09-05 Isis Pharmaceuticals, Inc. Oligonucleotides containing 2′-O-modified purines
US7015315B1 (en) 1991-12-24 2006-03-21 Isis Pharmaceuticals, Inc. Gapped oligonucleotides
US5739135A (en) 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US6222025B1 (en) 1995-03-06 2001-04-24 Isis Pharmaceuticals, Inc. Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom
US6166197A (en) 1995-03-06 2000-12-26 Isis Pharmaceuticals, Inc. Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
CA2246229C (en) 1996-02-14 2011-08-23 Isis Pharmaceuticals Inc. Sugar-modified gapped oligonucleotides
US5883109A (en) 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
US6066653A (en) 1997-01-17 2000-05-23 Bristol-Myers Squibb Co. Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7511131B2 (en) 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US7301050B2 (en) 2003-09-19 2007-11-27 Janssen Pharmaceutical N.V. 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
KR20060129082A (ko) 2004-03-05 2006-12-14 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과연관된 질환 또는 질병의 치료 방법
JO3006B1 (ar) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
ES2712052T3 (es) 2008-10-17 2019-05-09 Cymabay Therapeutics Inc Métodos para reducir partículas de LDL pequeñas y densas
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
AU2014353246A1 (en) 2013-11-20 2016-06-16 Cymabay Therapeutics, Inc. Treatment of homozygous familial hypercholesterolemia
CN106102734B (zh) 2014-03-20 2019-05-14 西玛贝医药公司 肝内胆汁淤积性疾病的治疗
PL3129018T3 (pl) 2014-04-11 2020-05-18 Cymabay Therapeutics, Inc. Leczenie NAFLD i NASH
HK1231380A1 (zh) 2014-06-26 2017-12-22 Cymabay Therapeutics, Inc. 严重高甘油三酯血症的治疗

Also Published As

Publication number Publication date
CL2016002517A1 (es) 2017-05-05
US20180228752A1 (en) 2018-08-16
RS59637B1 (sr) 2020-01-31
PH12016501978B1 (en) 2023-07-12
US9381181B2 (en) 2016-07-05
PH12016501978A1 (en) 2016-12-19
DK3129018T3 (da) 2020-01-20
US20210038546A1 (en) 2021-02-11
JP6865038B2 (ja) 2021-04-28
KR20160136451A (ko) 2016-11-29
EA201692050A1 (ru) 2017-01-30
US20200009092A1 (en) 2020-01-09
ES2764467T3 (es) 2020-06-03
BR112016023269A8 (pt) 2021-06-29
US20190142776A1 (en) 2019-05-16
SG11201608077PA (en) 2016-10-28
MX2016013375A (es) 2017-02-15
KR102374499B1 (ko) 2022-03-14
LT3129018T (lt) 2020-01-10
MX369921B (es) 2019-11-26
HRP20192299T1 (hr) 2020-03-06
CN106163508A (zh) 2016-11-23
CA2944139A1 (en) 2015-10-15
US10722483B2 (en) 2020-07-28
PL3129018T3 (pl) 2020-05-18
UA121208C2 (uk) 2020-04-27
US20150290154A1 (en) 2015-10-15
SI3129018T1 (sl) 2020-02-28
AU2015243239A1 (en) 2016-10-20
US20180008566A1 (en) 2018-01-11
SMT202000019T1 (it) 2020-03-13
WO2015157697A1 (en) 2015-10-15
US9616039B2 (en) 2017-04-11
NZ724740A (en) 2019-11-29
BR112016023269A2 (pt) 2017-08-15
AU2015243239B2 (en) 2019-11-14
JP2017513836A (ja) 2017-06-01
US20160324812A1 (en) 2016-11-10
US10342770B2 (en) 2019-07-09
EP3129018B1 (en) 2019-10-23
EP3129018A1 (en) 2017-02-15
US11179359B2 (en) 2021-11-23
CA2944139C (en) 2020-11-03
PT3129018T (pt) 2020-01-15
IL248193B (en) 2019-03-31
US10188620B2 (en) 2019-01-29
US9962346B2 (en) 2018-05-08
EA036704B1 (ru) 2020-12-10

Similar Documents

Publication Publication Date Title
CY1122602T1 (el) Αντιμετωπιση των nafld και nash
EP3463464A4 (en) ASSOCIATION TREATMENT
EP3651772A4 (en) ANTI-CANCER POLYTHERAPY
ECSP17015977A (es) Terapia de combinacion
DK3469425T3 (da) Strålingskilde
DK3212670T3 (da) Kombinationsterapi mod cancer
SI3283527T1 (sl) Kombinirana terapija proti raku
EP3601536A4 (en) TREATMENT PROCESSES
DK3612624T3 (da) Genterapi
EP3360010A4 (en) BI PHOTONS WITH VOTABLE SOURCE
DK3468496T3 (da) Elektrokirurgisk indretning med integreret mikrobølgekilde
IL268463A (en) Cancer treatment
PL3525774T3 (pl) Leczenie lazofoksyfenem raka piersi er+
CY1123019T1 (el) Σπειροκυκλικες ενωσεις
EP3413927A4 (en) CANCER THERAPY
EP3807320A4 (en) POLYTHERAPY INCLUDING A VACCINE BASED ON NEO ANTIGENS
DK3408265T3 (da) Terapeutiske forbindelser
EP3512553A4 (en) KLRG1 EXHAUST THERAPY
EP3576791A4 (en) CALRETICULIN-MEDIATION CANCER TREATMENT
DK3188599T3 (da) Medicinske behandlinger baseret på anamorelin
HUE040167T2 (hu) Rákkezelés
DK3688530T3 (da) Strålingskilde
DK3393478T3 (da) Kombinationsterapi
EP3597225A4 (en) TREATMENT PROCESS
DK3302478T3 (da) Pac-1 kombinations behandling