MX2016013375A - Tratamiento de la hgna y ehna. - Google Patents
Tratamiento de la hgna y ehna.Info
- Publication number
- MX2016013375A MX2016013375A MX2016013375A MX2016013375A MX2016013375A MX 2016013375 A MX2016013375 A MX 2016013375A MX 2016013375 A MX2016013375 A MX 2016013375A MX 2016013375 A MX2016013375 A MX 2016013375A MX 2016013375 A MX2016013375 A MX 2016013375A
- Authority
- MX
- Mexico
- Prior art keywords
- nafld
- nash
- treatment
- mbx
- therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Abstract
La presente invención se refiere al tratamiento del NAFLD y la NASH por terapia con MBX-8025 o una sal de MBX-8025.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461978335P | 2014-04-11 | 2014-04-11 | |
PCT/US2015/025416 WO2015157697A1 (en) | 2014-04-11 | 2015-04-10 | Treatment of nafld and nash |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016013375A true MX2016013375A (es) | 2017-02-15 |
MX369921B MX369921B (es) | 2019-11-26 |
Family
ID=53373532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016013375A MX369921B (es) | 2014-04-11 | 2015-04-10 | Tratamiento de la hgna y ehna. |
Country Status (26)
Country | Link |
---|---|
US (7) | US9381181B2 (es) |
EP (1) | EP3129018B1 (es) |
JP (1) | JP6865038B2 (es) |
KR (1) | KR102374499B1 (es) |
CN (1) | CN106163508A (es) |
AU (1) | AU2015243239B2 (es) |
BR (1) | BR112016023269A8 (es) |
CA (1) | CA2944139C (es) |
CL (1) | CL2016002517A1 (es) |
CY (1) | CY1122602T1 (es) |
DK (1) | DK3129018T3 (es) |
EA (1) | EA036704B1 (es) |
ES (1) | ES2764467T3 (es) |
HR (1) | HRP20192299T1 (es) |
IL (1) | IL248193B (es) |
LT (1) | LT3129018T (es) |
MX (1) | MX369921B (es) |
NZ (1) | NZ724740A (es) |
PH (1) | PH12016501978A1 (es) |
PL (1) | PL3129018T3 (es) |
PT (1) | PT3129018T (es) |
RS (1) | RS59637B1 (es) |
SG (1) | SG11201608077PA (es) |
SI (1) | SI3129018T1 (es) |
UA (1) | UA121208C2 (es) |
WO (1) | WO2015157697A1 (es) |
Families Citing this family (55)
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EP2334295B1 (en) | 2008-09-02 | 2017-06-28 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
CA2740874C (en) | 2008-10-17 | 2018-02-27 | Metabolex, Inc. | Use of ppar.gamma.agonists to reduce small dense ldl particles |
MX2011011538A (es) | 2009-04-29 | 2012-06-13 | Amarin Pharma Inc | Composicion farmaceutica estable y metodos de uso de la misma. |
NZ771180A (en) | 2009-04-29 | 2022-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
ES2856959T3 (es) | 2009-06-15 | 2021-09-28 | Amarin Pharmaceuticals Ie Ltd | Composiciones y métodos para el tratamiento del ictus en un sujeto en terapia simultánea con estatina |
EP2480248B1 (en) | 2009-09-23 | 2015-09-02 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
NZ727980A (en) | 2010-11-29 | 2018-08-31 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
EP2800469B1 (en) | 2012-01-06 | 2021-08-25 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
RS61557B1 (sr) | 2012-06-29 | 2021-04-29 | Amarin Pharmaceuticals Ie Ltd | Postupci za smanjenje rizika od kardiovaskularnog događaja kod pacijenta na terapiji statinom primenom etil estra eikozapentaenske kiseline |
US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
EP3119384B1 (en) | 2014-03-20 | 2018-09-12 | CymaBay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
RS59637B1 (sr) * | 2014-04-11 | 2020-01-31 | Cymabay Therapeutics Inc | Tretiranje nafld i nash |
AU2015267148B2 (en) | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
MX2017012319A (es) * | 2015-03-26 | 2018-05-11 | T3D Therapeutics Inc | Metodos para tratar enfermedad hepática utilizando derivados de acido indano acético. |
BR112017023164A2 (pt) | 2015-04-28 | 2018-07-24 | Pronova Biopharma Norge As | composto, e, método de prevenir e/ou tratar a esteato-hepatite não alcoólica em um indivíduo em necessidade do mesmo |
WO2017049157A1 (en) * | 2015-09-18 | 2017-03-23 | Duke University | Methods and compositions for the treatment of steatosis-associated disorders |
WO2017139708A1 (en) | 2016-02-10 | 2017-08-17 | Synlogic, Inc. | Bacteria engineered to treat nonalcoholic steatohepatitis (nash) |
US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
GB201614455D0 (en) * | 2016-08-24 | 2016-10-05 | Univ Oxford Innovation Ltd | Biomarkers |
NZ753051A (en) * | 2016-11-04 | 2023-03-31 | Children’S Hospital Medical Center | Liver organoid compositions and methods of making and using same |
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SG10202105768WA (en) | 2016-12-05 | 2021-06-29 | Childrens Hospital Med Ct | Colonic organoids and methods of making and using same |
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WO2018213663A1 (en) | 2017-05-19 | 2018-11-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
US20200276178A1 (en) | 2017-09-13 | 2020-09-03 | Novartis Ag | Combinations comprising fxr agonists |
US11260066B2 (en) | 2017-10-27 | 2022-03-01 | Samyang Corporation | Inhibiting reduction of lean body mass and inhibiting accumulation of liver fat by administering allulose |
IL308604A (en) | 2017-12-06 | 2024-01-01 | Basf As | Fatty acid antecedents for the treatment of nonalcoholic fatty liver disease |
US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
MA51766A (fr) | 2018-09-24 | 2020-12-16 | Amarin Pharmaceuticals Ie Ltd | Procédés de réduction du risque d'événements cardiovasculaires chez un sujet |
EP3880187A1 (en) | 2018-11-16 | 2021-09-22 | CymaBay Therapeutics, Inc. | Treatment of obesity and its complications |
WO2020102337A1 (en) * | 2018-11-16 | 2020-05-22 | Cymabay Therapeutics, Inc. | Combination treatment of nafld and nash |
WO2021097027A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Seladelpar for use in the treatment of alcoholic liver disease |
US20210145775A1 (en) * | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of intestinal barrier dysfunction and associated diseases |
JP2023525571A (ja) * | 2020-05-13 | 2023-06-16 | ターンズ・ファーマシューティカルズ・インコーポレイテッド | 肝障害の併用処置 |
WO2022238445A1 (en) * | 2021-05-11 | 2022-11-17 | Genfit | Ppar-agonists for use in the treatment of liver failure |
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JOP20200043A1 (ar) | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
CA2930069A1 (en) | 2013-11-20 | 2015-05-28 | Cymabay Therapeutics, Inc. | Treatment of homozygous familial hypercholesterolemia |
EP3119384B1 (en) | 2014-03-20 | 2018-09-12 | CymaBay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
RS59637B1 (sr) * | 2014-04-11 | 2020-01-31 | Cymabay Therapeutics Inc | Tretiranje nafld i nash |
MX2016017081A (es) | 2014-06-26 | 2017-05-01 | Cymabay Therapeutics Inc | Tratamiento de hipertrigliceridemia grave. |
-
2015
- 2015-04-10 RS RS20191583A patent/RS59637B1/sr unknown
- 2015-04-10 ES ES15728222T patent/ES2764467T3/es active Active
- 2015-04-10 MX MX2016013375A patent/MX369921B/es active IP Right Grant
- 2015-04-10 CN CN201580018550.9A patent/CN106163508A/zh active Pending
- 2015-04-10 SG SG11201608077PA patent/SG11201608077PA/en unknown
- 2015-04-10 NZ NZ72474015A patent/NZ724740A/en unknown
- 2015-04-10 US US14/684,100 patent/US9381181B2/en active Active
- 2015-04-10 BR BR112016023269A patent/BR112016023269A8/pt not_active Application Discontinuation
- 2015-04-10 WO PCT/US2015/025416 patent/WO2015157697A1/en active Application Filing
- 2015-04-10 AU AU2015243239A patent/AU2015243239B2/en active Active
- 2015-04-10 EA EA201692050A patent/EA036704B1/ru unknown
- 2015-04-10 PT PT157282229T patent/PT3129018T/pt unknown
- 2015-04-10 EP EP15728222.9A patent/EP3129018B1/en active Active
- 2015-04-10 LT LTEP15728222.9T patent/LT3129018T/lt unknown
- 2015-04-10 UA UAA201609927A patent/UA121208C2/uk unknown
- 2015-04-10 CA CA2944139A patent/CA2944139C/en active Active
- 2015-04-10 KR KR1020167031356A patent/KR102374499B1/ko active IP Right Grant
- 2015-04-10 JP JP2016561799A patent/JP6865038B2/ja active Active
- 2015-04-10 DK DK15728222.9T patent/DK3129018T3/da active
- 2015-04-10 PL PL15728222T patent/PL3129018T3/pl unknown
- 2015-04-10 SI SI201531047T patent/SI3129018T1/sl unknown
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2016
- 2016-06-02 US US15/171,910 patent/US9616039B2/en active Active
- 2016-10-04 CL CL2016002517A patent/CL2016002517A1/es unknown
- 2016-10-05 IL IL248193A patent/IL248193B/en active IP Right Grant
- 2016-10-05 PH PH12016501978A patent/PH12016501978A1/en unknown
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2017
- 2017-03-02 US US15/447,895 patent/US9962346B2/en active Active
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2018
- 2018-04-03 US US15/943,936 patent/US10188620B2/en active Active
- 2018-12-17 US US16/222,379 patent/US10342770B2/en active Active
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2019
- 2019-05-23 US US16/420,465 patent/US10722483B2/en active Active
- 2019-12-20 CY CY20191101347T patent/CY1122602T1/el unknown
- 2019-12-20 HR HRP20192299TT patent/HRP20192299T1/hr unknown
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2020
- 2020-06-19 US US16/906,296 patent/US11179359B2/en active Active
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FG | Grant or registration |