CY1121529T1 - Σηματοδοτηση slit-robo για διαγνωση και θεραπεια νεφρικης νοσου - Google Patents

Σηματοδοτηση slit-robo για διαγνωση και θεραπεια νεφρικης νοσου

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Publication number
CY1121529T1
CY1121529T1 CY20191100151T CY191100151T CY1121529T1 CY 1121529 T1 CY1121529 T1 CY 1121529T1 CY 20191100151 T CY20191100151 T CY 20191100151T CY 191100151 T CY191100151 T CY 191100151T CY 1121529 T1 CY1121529 T1 CY 1121529T1
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CY
Cyprus
Prior art keywords
kidney disease
slit
treatment
diagnosis
robo signaling
Prior art date
Application number
CY20191100151T
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English (en)
Inventor
Weining LU
Xueping FAN
David J. Salant
Original Assignee
Boston Medical Center Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Medical Center Corporation filed Critical Boston Medical Center Corporation
Publication of CY1121529T1 publication Critical patent/CY1121529T1/el

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Abstract

Στο παρόν παρέχονται μέθοδοι για την θεραπεία χρόνιας νεφρικής νόσου και πρωτεϊνουρίας και για την διάγνωση χρόνιας νεφρικής νόσου και παρακολούθησης των αποτελεσμάτων της θεραπείας στην εξέλιξη της χρόνιας νεφρικής νόσου και πρωτεϊνουρίας βάσει των μη αναμενόμενων ρόλων του μονοπατιού σηματοδότησης SLIT-ROBO στην ρύθμιση του κυτταροσκελετού F-ακτίνης των ποδοκυττάρων και της διαδικασίας δομής ποδοειδών προεκβολών στον νεφρό.
CY20191100151T 2012-01-05 2019-02-04 Σηματοδοτηση slit-robo για διαγνωση και θεραπεια νεφρικης νοσου CY1121529T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261583379P 2012-01-05 2012-01-05
PCT/US2013/020280 WO2013103811A2 (en) 2012-01-05 2013-01-04 Slit-robo signaling for diagnosis and treatment of kidney disease

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Publication Number Publication Date
CY1121529T1 true CY1121529T1 (el) 2020-05-29

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EP (1) EP2800578B1 (el)
JP (2) JP6153946B2 (el)
KR (1) KR102103323B1 (el)
CN (2) CN106390118B (el)
AU (2) AU2013207484B2 (el)
BR (1) BR112014016493A2 (el)
CA (1) CA2860558C (el)
CO (1) CO7020918A2 (el)
CY (1) CY1121529T1 (el)
DK (1) DK2800578T3 (el)
ES (1) ES2714700T3 (el)
HK (1) HK1202085A1 (el)
HR (1) HRP20190116T1 (el)
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WO (1) WO2013103811A2 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2914526A1 (en) * 2013-06-04 2014-12-11 The Hospital For Sick Children Methods and uses of slit for treating fibrosis
US11101021B2 (en) * 2014-08-08 2021-08-24 Icahn School Of Medicine At Mount Sinai Electronic phenotyping technique for diagnosing chronic kidney disease
KR102011957B1 (ko) 2016-06-08 2019-08-19 재단법인 아산사회복지재단 Slit-robo 시스템을 이용한 근감소증 예방 또는 치료용 조성물
WO2017213435A1 (ko) * 2016-06-08 2017-12-14 재단법인 아산사회복지재단 Slit-robo 시스템을 이용한 근감소증 예방 또는 치료용 조성물
WO2018070346A1 (ja) 2016-10-11 2018-04-19 国立大学法人徳島大学 腎臓様組織の製造方法
WO2018177949A1 (en) * 2017-03-25 2018-10-04 Charité-Universitätsmedizin Berlin Urine flow cytometry as biomarker of renal diseases
CN108929383B (zh) 2017-05-26 2021-10-15 阿思科力(苏州)生物科技有限公司 重组Slit2D2(C386S)-HSA融合蛋白及其在预防和/或治疗肺部炎症中的应用
JP7018458B2 (ja) * 2017-06-02 2022-02-10 ファイザー・インク 組換えｒｏｂｏ２タンパク質、組成物、方法およびそれらの使用
CA3061986A1 (en) * 2017-06-09 2018-12-13 Pfizer Inc. Anti-robo2 antibodies, compositions, methods and uses thereof
EP3672992A4 (en) 2017-08-24 2021-05-19 Bar-Ilan University ROUNDABOUT FAMILY RECEPTOR INHIBITORS (ROBO) AND CORRESPONDING USES
CN108753818B (zh) * 2018-04-24 2022-01-28 深圳市第二人民医院 RNA信号连接器、靶mRNA翻译调控方法、逻辑门及应用
KR20210021370A (ko) * 2018-06-15 2021-02-25 마이크로바 아이피 피티와이 리미티드 샘플 제조 및 마이크로바이옴 특성 규명 방법
CA3136663A1 (en) * 2019-04-23 2020-10-29 The Regents Of The University Of California Compositions and methods useful in promoting milk production
JP2023527435A (ja) 2020-05-29 2023-06-28 ロキット ヘルスケア インク． 網膜を利用した腎臓治療用組成物、それを含む腎臓治療用医療キット、及び、その硬化物を含む腎臓治療用フィルム
CN115068480B (zh) * 2022-08-09 2023-10-20 郑州大学第一附属医院 细胞分裂周期蛋白42小分子抑制剂在制备治疗慢性肾脏病药物中的应用
WO2024061158A1 (en) * 2022-09-20 2024-03-28 Everest Medicines (China) Co., Ltd. Slit2 related compositions and methods

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
AU676582B2 (en) 1993-05-28 1997-03-13 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
JP2003517262A (ja) * 1997-10-20 2003-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経誘導に含まれるポリペプチド及び核酸のファミリーであるｒｏｂｏ
US6365185B1 (en) 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US20030077616A1 (en) 2001-04-19 2003-04-24 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
WO2003017177A2 (en) 2001-08-13 2003-02-27 Beyong Genomics, Inc. Method and system for profiling biological systems
WO2003075860A2 (en) * 2002-03-08 2003-09-18 Abgent, Inc. Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof
AU2003239152A1 (en) 2002-04-23 2003-11-10 Millipore Corporation Sample preparation of biological fluids for proteomic applications
WO2007022248A2 (en) 2005-08-16 2007-02-22 Sloan Kettering Institute For Cancer Research Methods of detection of cancer using peptide profiles
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
UY33833A (es) 2010-12-23 2012-07-31 Sanofi Sa Proteína de fusión Robo1-Fc para su uso en el tratamiento del hepatocarcinoma

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