CY1121348T1 - Mrna θεραπεια για την θεραπευτικη αγωγη οφθαλμικων ασθενειων - Google Patents
Mrna θεραπεια για την θεραπευτικη αγωγη οφθαλμικων ασθενειωνInfo
- Publication number
- CY1121348T1 CY1121348T1 CY20191100085T CY191100085T CY1121348T1 CY 1121348 T1 CY1121348 T1 CY 1121348T1 CY 20191100085 T CY20191100085 T CY 20191100085T CY 191100085 T CY191100085 T CY 191100085T CY 1121348 T1 CY1121348 T1 CY 1121348T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- mrna
- ophthalmic disease
- protein
- disease treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461969483P | 2014-03-24 | 2014-03-24 | |
PCT/US2015/021403 WO2015148247A1 (en) | 2014-03-24 | 2015-03-19 | Mrna therapy for the treatment of ocular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121348T1 true CY1121348T1 (el) | 2020-05-29 |
Family
ID=54196241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100085T CY1121348T1 (el) | 2014-03-24 | 2019-01-22 | Mrna θεραπεια για την θεραπευτικη αγωγη οφθαλμικων ασθενειων |
Country Status (15)
Country | Link |
---|---|
US (2) | US20170143848A1 (pl) |
EP (3) | EP3122878B1 (pl) |
CY (1) | CY1121348T1 (pl) |
DK (2) | DK3122878T3 (pl) |
ES (2) | ES2774552T3 (pl) |
HR (1) | HRP20190117T1 (pl) |
HU (1) | HUE041940T2 (pl) |
LT (1) | LT3122878T (pl) |
ME (1) | ME03314B (pl) |
PL (1) | PL3122878T3 (pl) |
PT (1) | PT3122878T (pl) |
RS (1) | RS58337B1 (pl) |
SI (1) | SI3122878T1 (pl) |
TR (1) | TR201900649T4 (pl) |
WO (1) | WO2015148247A1 (pl) |
Families Citing this family (60)
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RS58405B1 (sr) | 2009-12-01 | 2019-04-30 | Translate Bio Inc | Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima |
CN103748078B (zh) | 2011-06-08 | 2016-11-09 | 夏尔人类遗传性治疗公司 | 可裂解脂质 |
CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
WO2017070613A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
EP4269577A3 (en) | 2015-10-23 | 2024-01-17 | President and Fellows of Harvard College | Nucleobase editors and uses thereof |
AU2016366978B2 (en) | 2015-12-10 | 2022-07-28 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
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US20210206818A1 (en) | 2016-01-22 | 2021-07-08 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
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WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
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DK3585892T3 (da) | 2017-02-27 | 2022-08-22 | Translate Bio Inc | Fremgangsmåder til oprensning af messenger-rna |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
EP3592777A1 (en) | 2017-03-10 | 2020-01-15 | President and Fellows of Harvard College | Cytosine to guanine base editor |
CN110914426A (zh) | 2017-03-23 | 2020-03-24 | 哈佛大学的校长及成员们 | 包含核酸可编程dna结合蛋白的核碱基编辑器 |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
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WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
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US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
JP2021500036A (ja) | 2017-10-16 | 2021-01-07 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | アデノシン塩基編集因子の使用 |
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KR20210020008A (ko) | 2018-06-11 | 2021-02-23 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 눈 질환을 치료하는 탈메틸화 |
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RS65449B1 (sr) | 2018-10-09 | 2024-05-31 | The Univ Of British Columbia | Supstance i sistemi koji obuhvataju vezikule kompetentne za transfekciju bez organskih rastvarača i deterdženata i metode za to |
CN113166790A (zh) | 2018-11-08 | 2021-07-23 | 川斯勒佰尔公司 | 信使rna纯化的方法和组合物 |
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CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
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-
2015
- 2015-03-19 SI SI201530559T patent/SI3122878T1/sl unknown
- 2015-03-19 LT LTEP15767977.0T patent/LT3122878T/lt unknown
- 2015-03-19 DK DK15767977.0T patent/DK3122878T3/en active
- 2015-03-19 TR TR2019/00649T patent/TR201900649T4/tr unknown
- 2015-03-19 EP EP15767977.0A patent/EP3122878B1/en active Active
- 2015-03-19 WO PCT/US2015/021403 patent/WO2015148247A1/en active Application Filing
- 2015-03-19 ES ES18201321T patent/ES2774552T3/es active Active
- 2015-03-19 ME MEP-2019-13A patent/ME03314B/me unknown
- 2015-03-19 PT PT15767977T patent/PT3122878T/pt unknown
- 2015-03-19 DK DK18201321.9T patent/DK3450553T3/da active
- 2015-03-19 EP EP18201321.9A patent/EP3450553B1/en active Active
- 2015-03-19 HU HUE15767977A patent/HUE041940T2/hu unknown
- 2015-03-19 US US15/128,303 patent/US20170143848A1/en not_active Abandoned
- 2015-03-19 ES ES15767977T patent/ES2707969T3/es active Active
- 2015-03-19 EP EP19218561.9A patent/EP3699274A1/en active Pending
- 2015-03-19 PL PL15767977T patent/PL3122878T3/pl unknown
- 2015-03-19 RS RS20190099A patent/RS58337B1/sr unknown
-
2019
- 2019-01-18 HR HRP20190117TT patent/HRP20190117T1/hr unknown
- 2019-01-22 CY CY20191100085T patent/CY1121348T1/el unknown
-
2022
- 2022-02-03 US US17/592,335 patent/US20220354968A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3450553B1 (en) | 2019-12-25 |
EP3122878A1 (en) | 2017-02-01 |
EP3122878B1 (en) | 2018-10-24 |
EP3450553A1 (en) | 2019-03-06 |
HUE041940T2 (hu) | 2019-06-28 |
WO2015148247A1 (en) | 2015-10-01 |
EP3699274A1 (en) | 2020-08-26 |
HRP20190117T1 (hr) | 2019-04-19 |
ME03314B (me) | 2019-10-20 |
US20170143848A1 (en) | 2017-05-25 |
DK3122878T3 (en) | 2019-02-04 |
PT3122878T (pt) | 2019-02-01 |
ES2707969T3 (es) | 2019-04-08 |
EP3122878A4 (en) | 2017-08-30 |
TR201900649T4 (tr) | 2019-02-21 |
US20220354968A1 (en) | 2022-11-10 |
DK3450553T3 (da) | 2020-02-10 |
ES2774552T3 (es) | 2020-07-21 |
RS58337B1 (sr) | 2019-03-29 |
LT3122878T (lt) | 2019-02-11 |
SI3122878T1 (sl) | 2019-05-31 |
PL3122878T3 (pl) | 2019-06-28 |
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