DK3450553T3 - Mrna-terapi til behandling af øjensygdomme - Google Patents
Mrna-terapi til behandling af øjensygdomme Download PDFInfo
- Publication number
- DK3450553T3 DK3450553T3 DK18201321.9T DK18201321T DK3450553T3 DK 3450553 T3 DK3450553 T3 DK 3450553T3 DK 18201321 T DK18201321 T DK 18201321T DK 3450553 T3 DK3450553 T3 DK 3450553T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- eye diseases
- mrna therapy
- mrna
- therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461969483P | 2014-03-24 | 2014-03-24 | |
EP15767977.0A EP3122878B1 (en) | 2014-03-24 | 2015-03-19 | Mrna therapy for the treatment of ocular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3450553T3 true DK3450553T3 (da) | 2020-02-10 |
Family
ID=54196241
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15767977.0T DK3122878T3 (da) | 2014-03-24 | 2015-03-19 | Mrna-terapi til behandling af øjensygdomme |
DK18201321.9T DK3450553T3 (da) | 2014-03-24 | 2015-03-19 | Mrna-terapi til behandling af øjensygdomme |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15767977.0T DK3122878T3 (da) | 2014-03-24 | 2015-03-19 | Mrna-terapi til behandling af øjensygdomme |
Country Status (15)
Country | Link |
---|---|
US (2) | US20170143848A1 (da) |
EP (3) | EP3122878B1 (da) |
CY (1) | CY1121348T1 (da) |
DK (2) | DK3122878T3 (da) |
ES (2) | ES2707969T3 (da) |
HR (1) | HRP20190117T1 (da) |
HU (1) | HUE041940T2 (da) |
LT (1) | LT3122878T (da) |
ME (1) | ME03314B (da) |
PL (1) | PL3122878T3 (da) |
PT (1) | PT3122878T (da) |
RS (1) | RS58337B1 (da) |
SI (1) | SI3122878T1 (da) |
TR (1) | TR201900649T4 (da) |
WO (1) | WO2015148247A1 (da) |
Families Citing this family (62)
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DK2506857T3 (da) | 2009-12-01 | 2018-05-07 | Translate Bio Inc | Levering af mrna til forstærkning af proteiner og enzymer i human-genetiske sygdomme |
EP3674292B1 (en) | 2011-06-08 | 2024-04-10 | Translate Bio, Inc. | Cleavable lipids |
CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
MX2016004249A (es) | 2013-10-03 | 2016-11-08 | Moderna Therapeutics Inc | Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad. |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP4079847A1 (en) | 2014-07-30 | 2022-10-26 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
MA46316A (fr) | 2015-10-22 | 2021-03-24 | Modernatx Inc | Vaccin contre le cytomégalovirus humain |
IL258821B (en) | 2015-10-23 | 2022-07-01 | Harvard College | Nucleobase editors and their uses |
CA3007955A1 (en) * | 2015-12-10 | 2017-06-15 | Modernatx, Inc. | Lipid nanoparticles for delivery of therapeutic agents |
CN108712911A (zh) | 2015-12-30 | 2018-10-26 | 科达制药股份有限公司 | 抗体及其缀合物 |
US20210206818A1 (en) | 2016-01-22 | 2021-07-08 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
US20190167811A1 (en) | 2016-04-13 | 2019-06-06 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
WO2018075980A1 (en) | 2016-10-21 | 2018-04-26 | Modernatx, Inc. | Human cytomegalovirus vaccine |
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WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
DK3585892T3 (da) | 2017-02-27 | 2022-08-22 | Translate Bio Inc | Fremgangsmåder til oprensning af messenger-rna |
EP3585891B1 (en) | 2017-02-27 | 2021-10-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
KR102687373B1 (ko) | 2017-03-23 | 2024-07-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
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JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン-12(il12)ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
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US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
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US20210000879A1 (en) * | 2018-03-01 | 2021-01-07 | Georgia Tech Research Corporation | Methods and compositions for mrna-based modulation and detection of cell phenotypes |
MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
WO2019240946A1 (en) | 2018-06-11 | 2019-12-19 | The Regents Of The University Of California | Demethylation to treat eye disease |
US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
JP7425066B2 (ja) | 2018-09-04 | 2024-01-30 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 核酸を臓器特異的送達するための組成物および方法 |
GB2617429B (en) | 2018-09-04 | 2023-12-27 | Univ Texas | Compositions and methods for organ specific delivery of nucleic acids |
PL3864163T3 (pl) | 2018-10-09 | 2024-05-20 | The University Of British Columbia | Kompozycje i układy zawierające pęcherzyki zdolne do transfekcji wolne od rozpuszczalników organicznych i detergentów oraz związane z nimi sposoby postępowania |
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AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
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-
2015
- 2015-03-19 EP EP15767977.0A patent/EP3122878B1/en active Active
- 2015-03-19 RS RS20190099A patent/RS58337B1/sr unknown
- 2015-03-19 HU HUE15767977A patent/HUE041940T2/hu unknown
- 2015-03-19 ES ES15767977T patent/ES2707969T3/es active Active
- 2015-03-19 PL PL15767977T patent/PL3122878T3/pl unknown
- 2015-03-19 WO PCT/US2015/021403 patent/WO2015148247A1/en active Application Filing
- 2015-03-19 EP EP19218561.9A patent/EP3699274A1/en active Pending
- 2015-03-19 DK DK15767977.0T patent/DK3122878T3/da active
- 2015-03-19 DK DK18201321.9T patent/DK3450553T3/da active
- 2015-03-19 ES ES18201321T patent/ES2774552T3/es active Active
- 2015-03-19 EP EP18201321.9A patent/EP3450553B1/en active Active
- 2015-03-19 SI SI201530559T patent/SI3122878T1/sl unknown
- 2015-03-19 PT PT15767977T patent/PT3122878T/pt unknown
- 2015-03-19 LT LTEP15767977.0T patent/LT3122878T/lt unknown
- 2015-03-19 TR TR2019/00649T patent/TR201900649T4/tr unknown
- 2015-03-19 ME MEP-2019-13A patent/ME03314B/me unknown
- 2015-03-19 US US15/128,303 patent/US20170143848A1/en not_active Abandoned
-
2019
- 2019-01-18 HR HRP20190117TT patent/HRP20190117T1/hr unknown
- 2019-01-22 CY CY20191100085T patent/CY1121348T1/el unknown
-
2022
- 2022-02-03 US US17/592,335 patent/US20220354968A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3122878A1 (en) | 2017-02-01 |
RS58337B1 (sr) | 2019-03-29 |
EP3699274A1 (en) | 2020-08-26 |
HRP20190117T1 (hr) | 2019-04-19 |
CY1121348T1 (el) | 2020-05-29 |
HUE041940T2 (hu) | 2019-06-28 |
US20170143848A1 (en) | 2017-05-25 |
EP3122878A4 (en) | 2017-08-30 |
EP3450553A1 (en) | 2019-03-06 |
SI3122878T1 (sl) | 2019-05-31 |
US20220354968A1 (en) | 2022-11-10 |
EP3450553B1 (en) | 2019-12-25 |
DK3122878T3 (da) | 2019-02-04 |
ES2774552T3 (es) | 2020-07-21 |
PT3122878T (pt) | 2019-02-01 |
ES2707969T3 (es) | 2019-04-08 |
TR201900649T4 (tr) | 2019-02-21 |
LT3122878T (lt) | 2019-02-11 |
EP3122878B1 (en) | 2018-10-24 |
WO2015148247A1 (en) | 2015-10-01 |
ME03314B (me) | 2019-10-20 |
PL3122878T3 (pl) | 2019-06-28 |
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