CY1120175T1 - Ανταγωνιστες υποδοχεα clever-1 για αποκλεισμο των ανοσο-ανασταλτικων μακροφαγων τυπου 2 - Google Patents
Ανταγωνιστες υποδοχεα clever-1 για αποκλεισμο των ανοσο-ανασταλτικων μακροφαγων τυπου 2Info
- Publication number
- CY1120175T1 CY1120175T1 CY20181100423T CY181100423T CY1120175T1 CY 1120175 T1 CY1120175 T1 CY 1120175T1 CY 20181100423 T CY20181100423 T CY 20181100423T CY 181100423 T CY181100423 T CY 181100423T CY 1120175 T1 CY1120175 T1 CY 1120175T1
- Authority
- CY
- Cyprus
- Prior art keywords
- clever
- immuno
- exclusion
- antibodies
- type
- Prior art date
Links
- 101000832225 Homo sapiens Stabilin-1 Proteins 0.000 title 1
- 102100024471 Stabilin-1 Human genes 0.000 title 1
- 230000002860 competitive effect Effects 0.000 title 1
- 230000007717 exclusion Effects 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000000987 immune system Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000002787 Pregnancy Complications Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/202—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
Abstract
Η εφεύρεση αφορά σε ένα νέο κύτταρο που προέρχεται από το ανθρώπινο σώμα, όπου το εν λόγω κύτταρο περιλαμβάνει έναν υποδοχέα Clever-1, σε μια μέθοδο για τον επηρεασμό του ανοσοποιητικού συστήματος ενός ατόμου και για τη θεραπευτική αντιμετώπιση των ασθενειών ή των παθήσεων που σχετίζονται με τη λειτουργία του ανοσοποιητικού συστήματος, καθώς και σε μεθόδους για τη διαλογή των ασθενών με καρκίνο που μπορούν να ανταποκριθούν σε μια θεραπεία με αντι-Clever-1 ή για τη διάγνωση μιας επιπλοκής της εγκυμοσύνης ή για την εκτίμηση του κινδύνου μιας τέτοιας επιπλοκής σε μια έγκυο γυναίκα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20090161A FI20090161A0 (fi) | 2009-04-22 | 2009-04-22 | Uusi solu ja siihen pohjautuvia terapeuttisia ja diagnostisia menetelmiä |
| PCT/FI2010/050266 WO2010122217A1 (en) | 2009-04-22 | 2010-04-06 | A novel cell and therapeutical and diagnostical methods based thereon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120175T1 true CY1120175T1 (el) | 2018-12-12 |
Family
ID=40590220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100423T CY1120175T1 (el) | 2009-04-22 | 2018-04-23 | Ανταγωνιστες υποδοχεα clever-1 για αποκλεισμο των ανοσο-ανασταλτικων μακροφαγων τυπου 2 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8722045B2 (el) |
| EP (2) | EP3330281A1 (el) |
| JP (2) | JP5819285B2 (el) |
| CA (2) | CA3022659C (el) |
| CY (1) | CY1120175T1 (el) |
| DK (1) | DK2421888T3 (el) |
| ES (1) | ES2666185T3 (el) |
| FI (1) | FI20090161A0 (el) |
| HK (1) | HK1256330A1 (el) |
| HR (1) | HRP20180580T1 (el) |
| HU (1) | HUE037394T2 (el) |
| LT (1) | LT2421888T (el) |
| NO (1) | NO2421888T3 (el) |
| PL (1) | PL2421888T3 (el) |
| PT (1) | PT2421888T (el) |
| SI (1) | SI2421888T1 (el) |
| WO (1) | WO2010122217A1 (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201892313A1 (ru) | 2016-04-18 | 2019-03-29 | Фарон Фармасьютикалз Ой | Гуманизированные антитела против clever-1 и их применение |
| SI3445785T1 (sl) | 2016-04-18 | 2022-11-30 | Faron Pharmaceuticals Oy, | Humanizirana protitelesa proti CLEVER-1 in njihova uporaba |
| JP7081343B2 (ja) | 2018-07-02 | 2022-06-07 | カシオ計算機株式会社 | 押釦装置、押釦装置に適用される緩衝部材及び時計 |
| CA3113895A1 (en) | 2018-11-01 | 2020-05-07 | Faron Pharmaceuticals Oy | Tlr9 agonists for use in downregulating clever-1 expression on alternatively activated macrophages |
| WO2021100891A1 (ko) * | 2019-11-19 | 2021-05-27 | 경상대학교병원 | 구강암 예후 진단용 조성물 및 키트 |
| FI129383B (en) | 2020-06-15 | 2022-01-31 | Faron Pharmaceuticals Oy | STABLE ANTI-CLEVER-1 ANTIBODY FORMULATION |
| US20220227858A1 (en) | 2021-01-18 | 2022-07-21 | Faron Pharmaceuticals Oy | Controlling of immune activation by soluble clever-1 |
| WO2023105118A1 (en) * | 2021-12-07 | 2023-06-15 | Faron Pharmaceuticals Oy | Method for using inflammatory markers to guide anti-clever-1 cancer treatment |
| WO2023222953A1 (en) * | 2022-05-20 | 2023-11-23 | Faron Pharmaceuticals Oy | Method for identifying cancer patients that benefit from anti-clever-1 treatment |
| WO2023222952A1 (en) * | 2022-05-20 | 2023-11-23 | Faron Pharmaceuticals Oy | Method for identifying cancer patients that benefit from anti-clever-1 treatment |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| AU3395900A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| US20070026394A1 (en) | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| AU2001253140A1 (en) * | 2000-04-03 | 2001-10-15 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Tumor markers in ovarian cancer |
| US20030190635A1 (en) | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
| US20040019001A1 (en) | 2002-02-20 | 2004-01-29 | Mcswiggen James A. | RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| EP1463760B1 (en) * | 2002-01-09 | 2007-09-05 | Faron Pharmaceuticals OY | Common lymphatic endothelial and vascular endothelial receptor-1 (clever-1) and uses thereof |
| AU2003279004B2 (en) | 2002-09-28 | 2009-10-08 | Massachusetts Institute Of Technology | Influenza therapeutic |
| US20040191783A1 (en) * | 2003-03-31 | 2004-09-30 | Guy Leclercq | Low density micro-array analysis in human breast cancer |
| US20050043266A1 (en) | 2003-07-25 | 2005-02-24 | Sumedha Jayasena | Short interfering RNA as an antiviral agent for hepatitis C |
| EP1661915A1 (en) * | 2004-11-25 | 2006-05-31 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Preparation of antibodies against the human chitinase-like protein GL008 |
| FI20050640A0 (fi) | 2005-06-16 | 2005-06-16 | Faron Pharmaceuticals Oy | Yhdisteitä amiinioksidaasista riippuvien sairauksien tai häiriöiden hoitoon tai estoon |
| EP1889922A1 (en) | 2006-08-18 | 2008-02-20 | Burdach, Stefan | Methods for diagnosis of pediatric common acute lymphoblastic leukemia by determining the level of gene expression |
| WO2008097908A2 (en) * | 2007-02-05 | 2008-08-14 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and prognosing lung cancer |
| US10359425B2 (en) * | 2008-09-09 | 2019-07-23 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
-
2009
- 2009-04-22 FI FI20090161A patent/FI20090161A0/fi not_active Application Discontinuation
-
2010
- 2010-04-06 LT LTEP10766694.3T patent/LT2421888T/lt unknown
- 2010-04-06 NO NO10766694A patent/NO2421888T3/no unknown
- 2010-04-06 HU HUE10766694A patent/HUE037394T2/hu unknown
- 2010-04-06 ES ES10766694.3T patent/ES2666185T3/es active Active
- 2010-04-06 JP JP2012506538A patent/JP5819285B2/ja active Active
- 2010-04-06 PT PT107666943T patent/PT2421888T/pt unknown
- 2010-04-06 EP EP17197919.8A patent/EP3330281A1/en not_active Ceased
- 2010-04-06 US US13/262,088 patent/US8722045B2/en active Active
- 2010-04-06 CA CA3022659A patent/CA3022659C/en active Active
- 2010-04-06 WO PCT/FI2010/050266 patent/WO2010122217A1/en active Application Filing
- 2010-04-06 CA CA2757706A patent/CA2757706C/en active Active
- 2010-04-06 SI SI201031666T patent/SI2421888T1/en unknown
- 2010-04-06 EP EP10766694.3A patent/EP2421888B1/en active Active
- 2010-04-06 PL PL10766694T patent/PL2421888T3/pl unknown
- 2010-04-06 DK DK10766694.3T patent/DK2421888T3/en active
-
2014
- 2014-03-25 US US14/224,374 patent/US10526607B2/en active Active
-
2015
- 2015-07-30 JP JP2015150694A patent/JP6141919B2/ja active Active
-
2018
- 2018-04-11 HR HRP20180580TT patent/HRP20180580T1/hr unknown
- 2018-04-23 CY CY20181100423T patent/CY1120175T1/el unknown
- 2018-12-03 HK HK18115414.6A patent/HK1256330A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1256330A1 (zh) | 2019-09-20 |
| EP2421888A1 (en) | 2012-02-29 |
| WO2010122217A1 (en) | 2010-10-28 |
| ES2666185T3 (es) | 2018-05-03 |
| CA3022659C (en) | 2021-04-06 |
| US20120027770A1 (en) | 2012-02-02 |
| HUE037394T2 (hu) | 2018-08-28 |
| EP2421888A4 (en) | 2013-03-06 |
| JP6141919B2 (ja) | 2017-06-07 |
| JP2016020351A (ja) | 2016-02-04 |
| NO2421888T3 (el) | 2018-07-21 |
| CA2757706A1 (en) | 2010-10-28 |
| CA2757706C (en) | 2019-01-15 |
| CA3022659A1 (en) | 2010-10-28 |
| DK2421888T3 (en) | 2018-05-22 |
| EP2421888B1 (en) | 2018-02-21 |
| LT2421888T (lt) | 2018-05-25 |
| PT2421888T (pt) | 2018-05-09 |
| HRP20180580T1 (hr) | 2018-06-29 |
| SI2421888T1 (en) | 2018-06-29 |
| PL2421888T3 (pl) | 2018-07-31 |
| JP5819285B2 (ja) | 2015-11-24 |
| US8722045B2 (en) | 2014-05-13 |
| US20140294760A1 (en) | 2014-10-02 |
| US10526607B2 (en) | 2020-01-07 |
| JP2012524536A (ja) | 2012-10-18 |
| FI20090161A0 (fi) | 2009-04-22 |
| EP3330281A1 (en) | 2018-06-06 |
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