CY1123926T1 - Αντισωματα κατα της τρανσγλουταμινασης 2 - Google Patents

Αντισωματα κατα της τρανσγλουταμινασης 2

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Publication number
CY1123926T1
CY1123926T1 CY20211100013T CY211100013T CY1123926T1 CY 1123926 T1 CY1123926 T1 CY 1123926T1 CY 20211100013 T CY20211100013 T CY 20211100013T CY 211100013 T CY211100013 T CY 211100013T CY 1123926 T1 CY1123926 T1 CY 1123926T1
Authority
CY
Cyprus
Prior art keywords
antibodies against
diseases
antibodies
transglutaminase
core
Prior art date
Application number
CY20211100013T
Other languages
English (en)
Inventor
Tim Johnson
Phil WATSON
David Matthews
Alex Brown
Original Assignee
Lifearc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifearc filed Critical Lifearc
Publication of CY1123926T1 publication Critical patent/CY1123926T1/el

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)

Abstract

Η εφεύρεση παρέχει αντισώματα και αντιγονοδεσμευτικά θραύσματα αυτών που δεσμεύονται επιλεκτικά σε ένα επίτοπο εντός της περιοχής πυρήνα της τρανσγλουταμινάσης τύπου 2 (TG2). Παρέχονται καινοτόμοι επίτοποι εντός του πυρήνα της TG2. Η εφεύρεση παρέχει αντισώματα αναστολής της ανθρώπινης TG2 και χρήσεις αυτών, ιδίως στην ιατρική, για παράδειγμα στη θεραπεία ή/και στη διάγνωση παθήσεων που συμπεριλαμβάνουν την κοιλιοκάκη, την ουλοποίηση, νόσους σχετιζόμενες με ίνωση, νευροεκφυλιστικές/νευρολογικές νόσους και καρκίνο.
CY20211100013T 2012-05-24 2021-01-11 Αντισωματα κατα της τρανσγλουταμινασης 2 CY1123926T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1209096.5A GB201209096D0 (en) 2012-05-24 2012-05-24 Compounds
EP13730049.7A EP2855530B1 (en) 2012-05-24 2013-05-24 Anti-transglutaminase 2 antibodies
PCT/GB2013/051373 WO2013175229A1 (en) 2012-05-24 2013-05-24 Anti -transglutaminase 2 antibodies

Publications (1)

Publication Number Publication Date
CY1123926T1 true CY1123926T1 (el) 2022-05-27

Family

ID=46546551

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20191100807T CY1121932T1 (el) 2012-05-24 2019-07-29 Αντισωματα κατα της τρανσγλουταμινασης 2
CY20211100013T CY1123926T1 (el) 2012-05-24 2021-01-11 Αντισωματα κατα της τρανσγλουταμινασης 2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20191100807T CY1121932T1 (el) 2012-05-24 2019-07-29 Αντισωματα κατα της τρανσγλουταμινασης 2

Country Status (39)

Country Link
US (3) US10005846B2 (el)
EP (2) EP2855530B1 (el)
JP (2) JP6411998B2 (el)
KR (1) KR102091223B1 (el)
CN (1) CN104321346B (el)
AU (1) AU2013265025B2 (el)
BR (1) BR112014029089B1 (el)
CA (1) CA2874488C (el)
CL (1) CL2014003125A1 (el)
CO (1) CO7151528A2 (el)
CY (2) CY1121932T1 (el)
DK (2) DK2855530T3 (el)
EA (1) EA036810B1 (el)
EC (1) ECSP14030942A (el)
ES (2) ES2728856T3 (el)
GB (1) GB201209096D0 (el)
HK (1) HK1203974A1 (el)
HR (2) HRP20191293T1 (el)
HU (2) HUE045539T2 (el)
IL (1) IL235369B (el)
IN (1) IN2014MN02231A (el)
LT (2) LT3521315T (el)
MA (1) MA37670B1 (el)
ME (1) ME03393B (el)
MX (1) MX367517B (el)
MY (1) MY185966A (el)
NZ (1) NZ701424A (el)
PE (1) PE20150346A1 (el)
PH (1) PH12014502582B1 (el)
PL (2) PL3521315T3 (el)
PT (2) PT3521315T (el)
RS (2) RS61286B1 (el)
SG (1) SG11201407053YA (el)
SI (2) SI3521315T1 (el)
TN (1) TN2014000458A1 (el)
TR (1) TR201906781T4 (el)
UA (1) UA117657C2 (el)
WO (1) WO2013175229A1 (el)
ZA (1) ZA201408213B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110055235A (zh) * 2019-05-14 2019-07-26 深圳市亚辉龙生物科技股份有限公司 用于转谷氨酰胺酶抗体检测的抗原及其制备方法、试剂盒及检测方法
GB202115127D0 (en) 2021-10-21 2021-12-08 Ucb Biopharma Sprl Formulations
GB202115121D0 (en) 2021-10-21 2021-12-08 Ucb Biopharma Sprl Formulations
TW202334240A (zh) 2021-11-18 2023-09-01 比利時商Ucb生物製藥公司 治療進行性慢性間質性肺部疾病之方法
GB202116665D0 (en) 2021-11-18 2022-01-05 UCB Biopharma SRL Method for the treatment of a scleroderma disease
GB202118010D0 (en) 2021-12-13 2022-01-26 UCB Biopharma SRL Method for detecting and/or quantifying crosslinks formed by transglutaminases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912120A (en) 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
AU1268192A (en) 1991-01-04 1992-08-17 Board Of Regents, The University Of Texas System Cloning and expression of tissue transglutaminases
WO1998004245A1 (en) 1996-07-25 1998-02-05 The Victoria University Of Manchester Use of transglutaminase modulators to promote wound healing
GB0103024D0 (en) * 2001-02-07 2001-03-21 Rsr Ltd Assay for Autoantibodies to tissue transglutaminase
CA2514942A1 (en) 2003-02-02 2004-08-19 Government Of The United States Of America, As Represented By The Secret Ary, Department Of Health And Human Services Methods and compositions for the treatment of parkinson's disease and other a-synucleinopathies
GB0314262D0 (en) 2003-06-19 2003-07-23 Univ Nottingham Trent Novel compounds and methods of using the same
WO2006100679A2 (en) * 2005-03-22 2006-09-28 Quark Pharmaceuticals, Inc. Recombinant antibodies against human type ii transglutaminase and uses thereof
WO2008063760A2 (en) 2006-10-18 2008-05-29 The University Of Texas M.D. Anderson Cancer Center Methods for treating cancer targeting transglutaminase
US8614296B2 (en) * 2008-04-24 2013-12-24 Gene Techno Science Co., Ltd. Humanized antibodies specific for amino acid sequence RGD of an extracellular matrix protein and the uses thereof
EP2408471B1 (en) 2009-03-19 2015-06-24 Queensland University Of Technology Targets for growth factor signalling and methods of therapy
HU0900195D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis and treatment of gluten-induced autoimmune diseases
HU0900199D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis of gluten-induced autoimmune diseases
EP2579861A2 (en) 2010-06-02 2013-04-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Transglutaminase 2 inhibitors for use in the prevention or treatment of rapidly progressive glomerulonephritis
GB2490655A (en) 2011-04-28 2012-11-14 Univ Aston Modulators of tissue transglutaminase

Also Published As

Publication number Publication date
ME03393B (me) 2020-01-20
US10961319B2 (en) 2021-03-30
SI2855530T1 (sl) 2019-08-30
TN2014000458A1 (en) 2016-03-30
EA201492162A1 (ru) 2015-03-31
PT2855530T (pt) 2019-07-08
UA117657C2 (uk) 2018-09-10
US20180355060A1 (en) 2018-12-13
SI3521315T1 (sl) 2020-12-31
TR201906781T4 (tr) 2019-05-21
RS61286B1 (sr) 2021-02-26
PL2855530T3 (pl) 2019-10-31
DK3521315T3 (da) 2020-11-09
CA2874488C (en) 2021-09-07
NZ701424A (en) 2016-08-26
CL2014003125A1 (es) 2015-08-21
JP6411998B2 (ja) 2018-10-24
MX367517B (es) 2019-08-26
DK2855530T3 (da) 2019-06-24
IL235369B (en) 2019-05-30
LT2855530T (lt) 2019-07-25
CA2874488A1 (en) 2013-11-28
ES2728856T3 (es) 2019-10-29
IN2014MN02231A (el) 2015-07-24
US20210101999A1 (en) 2021-04-08
CO7151528A2 (es) 2014-12-29
ES2835383T3 (es) 2021-06-22
HRP20191293T1 (hr) 2019-10-18
US20150218289A1 (en) 2015-08-06
LT3521315T (lt) 2020-12-28
PT3521315T (pt) 2020-10-29
BR112014029089A2 (pt) 2019-06-25
HK1203974A1 (en) 2015-11-06
ZA201408213B (en) 2020-02-26
CN104321346A (zh) 2015-01-28
EP2855530B1 (en) 2019-05-01
HUE052490T2 (hu) 2021-04-28
CN104321346B (zh) 2018-12-07
SG11201407053YA (en) 2014-12-30
AU2013265025A1 (en) 2014-12-04
EA036810B1 (ru) 2020-12-23
EP3521315B1 (en) 2020-10-14
HUE045539T2 (hu) 2019-12-30
KR102091223B1 (ko) 2020-03-20
KR20150013340A (ko) 2015-02-04
PH12014502582A1 (en) 2015-01-21
CY1121932T1 (el) 2020-10-14
MY185966A (en) 2021-06-14
PE20150346A1 (es) 2015-03-05
AU2013265025B2 (en) 2018-04-26
EP3521315A1 (en) 2019-08-07
BR112014029089B1 (pt) 2023-04-25
IL235369A0 (en) 2014-12-31
EP2855530A1 (en) 2015-04-08
WO2013175229A1 (en) 2013-11-28
PL3521315T3 (pl) 2021-08-23
MA37670A1 (fr) 2016-05-31
GB201209096D0 (en) 2012-07-04
US10005846B2 (en) 2018-06-26
PH12014502582B1 (en) 2015-01-21
HRP20202059T1 (hr) 2021-02-19
JP2018166510A (ja) 2018-11-01
MX2014014264A (es) 2015-05-15
RS59135B1 (sr) 2019-09-30
JP2015519897A (ja) 2015-07-16
ECSP14030942A (es) 2015-09-30
US11718686B2 (en) 2023-08-08
MA37670B1 (fr) 2019-12-31

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