CY1120111T1 - Αντιβακτηριακα παραγωγα 2η-ινδαζολης - Google Patents
Αντιβακτηριακα παραγωγα 2η-ινδαζοληςInfo
- Publication number
- CY1120111T1 CY1120111T1 CY20181100362T CY181100362T CY1120111T1 CY 1120111 T1 CY1120111 T1 CY 1120111T1 CY 20181100362 T CY20181100362 T CY 20181100362T CY 181100362 T CY181100362 T CY 181100362T CY 1120111 T1 CY1120111 T1 CY 1120111T1
- Authority
- CY
- Cyprus
- Prior art keywords
- indazole
- antibacterial derivatives
- antibacterial
- derivatives
- halogen
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
Abstract
Η εφεύρεση σχετίζεται με αντιβακτηριακές ενώσεις του χημικού τύπου I όπου το R1 είναι Η ή το αλογόνο ˙ το R2 είναι αλκυνυλοξυ ή η ομάδα Μ ˙ το R3 είναι Η ή το αλογόνο ˙ το Μ είναι μία από τις ομάδες (Α, Β, C, D), όπου το Α είναι ένας δεσμός, CH2CH2, CH=CH ή C=C και τα R1A, R2A, R3A, R1B και R1C είναι όπως ορίζονται στην αξίωση 1 ˙ και τα άλατα αυτού.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013058537 | 2013-09-13 | ||
| PCT/IB2014/064458 WO2015036964A1 (en) | 2013-09-13 | 2014-09-12 | Antibacterial 2h-indazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120111T1 true CY1120111T1 (el) | 2018-12-12 |
Family
ID=51688371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100362T CY1120111T1 (el) | 2013-09-13 | 2018-03-30 | Αντιβακτηριακα παραγωγα 2η-ινδαζολης |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9802901B2 (el) |
| EP (1) | EP3044211B1 (el) |
| JP (1) | JP6353909B2 (el) |
| KR (1) | KR20160055889A (el) |
| CN (1) | CN105531264B (el) |
| AR (1) | AR097617A1 (el) |
| AU (1) | AU2014319966B2 (el) |
| BR (1) | BR112016007757A8 (el) |
| CA (1) | CA2923146A1 (el) |
| CL (1) | CL2016000568A1 (el) |
| CY (1) | CY1120111T1 (el) |
| DK (1) | DK3044211T3 (el) |
| EA (1) | EA031562B1 (el) |
| ES (1) | ES2662894T3 (el) |
| HR (1) | HRP20180484T1 (el) |
| HU (1) | HUE038519T2 (el) |
| IL (1) | IL244500B (el) |
| LT (1) | LT3044211T (el) |
| MA (1) | MA38948B1 (el) |
| MX (1) | MX361733B (el) |
| MY (1) | MY179283A (el) |
| PH (1) | PH12016500480A1 (el) |
| PL (1) | PL3044211T3 (el) |
| PT (1) | PT3044211T (el) |
| SG (1) | SG11201601889YA (el) |
| SI (1) | SI3044211T1 (el) |
| TW (1) | TWI646084B (el) |
| UA (1) | UA116484C2 (el) |
| WO (1) | WO2015036964A1 (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9624206B2 (en) | 2013-12-19 | 2017-04-18 | Actelion Pharmaceuticals Ltd | Antibacterial 1H-indazole and 1H-indole derivatives |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| JP2017515906A (ja) | 2014-05-16 | 2017-06-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性キナゾロン−４（３ｈ）−オン誘導体 |
| BR112017010474A2 (pt) | 2014-11-19 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados antibacterianos de benzotiazol |
| AR105646A1 (es) * | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| MA42679A (fr) * | 2015-08-28 | 2018-07-04 | Idorsia Pharmaceuticals Ltd | Dérivés de pyrrolidin-2-one annelés antibactériens |
| AR105848A1 (es) * | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| BR112018073580A2 (pt) * | 2016-05-17 | 2019-03-19 | Idorsia Pharmaceuticals Ltd | derivados de 6-(buta-1,3-diyn-1-il) benzo [d] tiazol |
| WO2019038362A1 (en) | 2017-08-24 | 2019-02-28 | Idorsia Pharmaceuticals Ltd | ANTIBACTERIAL PYRROLOIMIDAZOLONES |
| CN113372276B (zh) * | 2021-05-25 | 2022-04-22 | 三峡大学 | 吲唑类衍生物及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1453847A1 (en) | 2001-12-05 | 2004-09-08 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials |
| US6806279B2 (en) | 2001-12-17 | 2004-10-19 | Sunesis Pharmaceuticals, Inc. | Small-molecule inhibitors of interleukin-2 |
| NZ535158A (en) | 2002-03-13 | 2007-06-29 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| DE102004017930A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| WO2006063281A2 (en) | 2004-12-10 | 2006-06-15 | Emory University | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
| BRPI0609719B8 (pt) | 2005-03-23 | 2021-05-25 | Hoffmann La Roche | derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2 |
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| DE102008044132A1 (de) | 2008-11-27 | 2010-06-02 | BSH Bosch und Siemens Hausgeräte GmbH | Kältegerät mit zweiseitig anschlagbarer Tür |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2010135536A2 (en) | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| WO2011021209A1 (en) | 2009-07-07 | 2011-02-24 | Portsmouth Technologies Llc | Histone deacetylase inhibitors |
| JP5671545B2 (ja) * | 2009-10-13 | 2015-02-18 | ファイザー・インク | 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体 |
| SI2512474T1 (sl) | 2009-12-16 | 2014-12-31 | Pfizer Inc. | N-vezani derivati hidroksamske kisline, uporabni kot protibakterijska sredstva |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| EP2638006A1 (en) | 2010-11-10 | 2013-09-18 | Achaogen, Inc. | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
| US8853213B2 (en) | 2011-01-03 | 2014-10-07 | Hanmi Pharm. Co., Ltd | Bicyclic compound for modulating G protein-coupled receptors |
| SG192766A1 (en) * | 2011-03-07 | 2013-09-30 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| CN103717582B (zh) | 2011-04-08 | 2015-09-30 | 辉瑞大药厂 | 用作抗菌剂的异*唑衍生物 |
| MX2013011432A (es) * | 2011-04-08 | 2013-12-09 | Pfizer | Derivados de imidazol, pirazol, y triazol utiles como agentes antibacterianos. |
| EP2847162A1 (en) | 2012-05-09 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| US9624206B2 (en) | 2013-12-19 | 2017-04-18 | Actelion Pharmaceuticals Ltd | Antibacterial 1H-indazole and 1H-indole derivatives |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| JP2017515906A (ja) | 2014-05-16 | 2017-06-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性キナゾロン−４（３ｈ）−オン誘導体 |
-
2014
- 2014-09-10 AR ARP140103376A patent/AR097617A1/es unknown
- 2014-09-12 EA EA201600248A patent/EA031562B1/ru not_active IP Right Cessation
- 2014-09-12 DK DK14781948.6T patent/DK3044211T3/en active
- 2014-09-12 MX MX2016003196A patent/MX361733B/es active IP Right Grant
- 2014-09-12 SI SI201430662T patent/SI3044211T1/en unknown
- 2014-09-12 BR BR112016007757A patent/BR112016007757A8/pt not_active Application Discontinuation
- 2014-09-12 AU AU2014319966A patent/AU2014319966B2/en not_active Ceased
- 2014-09-12 CA CA2923146A patent/CA2923146A1/en not_active Abandoned
- 2014-09-12 CN CN201480049877.8A patent/CN105531264B/zh not_active Expired - Fee Related
- 2014-09-12 TW TW103131666A patent/TWI646084B/zh not_active IP Right Cessation
- 2014-09-12 LT LTEP14781948.6T patent/LT3044211T/lt unknown
- 2014-09-12 WO PCT/IB2014/064458 patent/WO2015036964A1/en active Application Filing
- 2014-09-12 HU HUE14781948A patent/HUE038519T2/hu unknown
- 2014-09-12 JP JP2016542426A patent/JP6353909B2/ja not_active Expired - Fee Related
- 2014-09-12 ES ES14781948.6T patent/ES2662894T3/es active Active
- 2014-09-12 MA MA38948A patent/MA38948B1/fr unknown
- 2014-09-12 US US15/021,649 patent/US9802901B2/en not_active Expired - Fee Related
- 2014-09-12 PT PT147819486T patent/PT3044211T/pt unknown
- 2014-09-12 SG SG11201601889YA patent/SG11201601889YA/en unknown
- 2014-09-12 MY MYPI2016700850A patent/MY179283A/en unknown
- 2014-09-12 PL PL14781948T patent/PL3044211T3/pl unknown
- 2014-09-12 KR KR1020167009718A patent/KR20160055889A/ko not_active Application Discontinuation
- 2014-09-12 EP EP14781948.6A patent/EP3044211B1/en not_active Not-in-force
- 2014-12-09 UA UAA201603879A patent/UA116484C2/uk unknown
-
2016
- 2016-03-08 IL IL244500A patent/IL244500B/en not_active IP Right Cessation
- 2016-03-10 CL CL2016000568A patent/CL2016000568A1/es unknown
- 2016-03-11 PH PH12016500480A patent/PH12016500480A1/en unknown
-
2018
- 2018-03-23 HR HRP20180484TT patent/HRP20180484T1/hr unknown
- 2018-03-30 CY CY20181100362T patent/CY1120111T1/el unknown
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