CY1120060T1 - Δευτεριωμενα παραγωγα βενζοκινολινης ως αναστολεις του κυστιδικου μεταφορεα 2 της μονοαμινης - Google Patents
Δευτεριωμενα παραγωγα βενζοκινολινης ως αναστολεις του κυστιδικου μεταφορεα 2 της μονοαμινηςInfo
- Publication number
- CY1120060T1 CY1120060T1 CY20181100152T CY181100152T CY1120060T1 CY 1120060 T1 CY1120060 T1 CY 1120060T1 CY 20181100152 T CY20181100152 T CY 20181100152T CY 181100152 T CY181100152 T CY 181100152T CY 1120060 T1 CY1120060 T1 CY 1120060T1
- Authority
- CY
- Cyprus
- Prior art keywords
- venzokinoline
- cystidate
- monoamine
- subjects
- suspensions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9789608P | 2008-09-18 | 2008-09-18 | |
| EP09820972.9A EP2326643B1 (en) | 2008-09-18 | 2009-09-18 | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| EP13160950.5A EP2610254B1 (en) | 2008-09-18 | 2009-09-18 | Deuterated benzoquinoline derivatives as inhibitors of vesicular monoamine transporter 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120060T1 true CY1120060T1 (el) | 2018-12-12 |
Family
ID=42107127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100152T CY1120060T1 (el) | 2008-09-18 | 2018-02-07 | Δευτεριωμενα παραγωγα βενζοκινολινης ως αναστολεις του κυστιδικου μεταφορεα 2 της μονοαμινης |
Country Status (20)
| Country | Link |
|---|---|
| US (16) | US8524733B2 (index.php) |
| EP (4) | EP2610254B1 (index.php) |
| JP (3) | JP5616345B2 (index.php) |
| CN (2) | CN102186848B (index.php) |
| AU (1) | AU2009303758B8 (index.php) |
| BR (1) | BRPI0913457B8 (index.php) |
| CA (2) | CA2736409C (index.php) |
| CY (1) | CY1120060T1 (index.php) |
| DK (2) | DK3061760T3 (index.php) |
| ES (4) | ES2896678T3 (index.php) |
| HR (1) | HRP20180239T1 (index.php) |
| HU (1) | HUE038158T2 (index.php) |
| LT (1) | LT3061760T (index.php) |
| NO (1) | NO3061760T3 (index.php) |
| NZ (1) | NZ591615A (index.php) |
| PL (1) | PL3061760T3 (index.php) |
| PT (1) | PT3061760T (index.php) |
| SI (1) | SI3061760T1 (index.php) |
| SM (1) | SMT201800067T1 (index.php) |
| WO (1) | WO2010044981A2 (index.php) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102186848B (zh) | 2008-09-18 | 2014-11-12 | 奥斯拜客斯制药有限公司 | 囊泡单胺转运体2的苯并喹啉抑制剂 |
| EP2947082A1 (en) * | 2009-11-10 | 2015-11-25 | Pfizer Inc | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS |
| CN103003275A (zh) * | 2010-06-01 | 2013-03-27 | 奥斯拜客斯制药有限公司 | Vmat2的苯并喹啉酮抑制剂 |
| US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
| DK3210591T3 (en) | 2010-08-27 | 2019-04-15 | Sienna Biopharmaceuticals Inc | COMPOSITIONS AND METHODS OF TARGETED THERMO MODULATION |
| WO2012081031A1 (en) * | 2010-12-15 | 2012-06-21 | Enaltec Labs Pvt. Ltd. | Process for preparing tetrabenazine |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| EP2897615A4 (en) * | 2012-09-18 | 2016-04-27 | Auspex Pharmaceuticals Inc | PHARMACOKINETIC FORMULATIONS OF DEUTERATED BENZOCHINOL INHIBITORS OF THE VESICLE MONOAMINE TRANSPORTER 2 |
| IL316627A (en) | 2012-10-11 | 2024-12-01 | Nanocomposix Inc | Silver nanoplate compositions and methods |
| EP2951178A4 (en) | 2013-01-31 | 2016-07-06 | Auspex Pharmaceuticals Inc | VMAT2 INHIBITORS OF BENZOQUINOLONE TYPE |
| HK1221645A1 (zh) * | 2013-09-27 | 2017-06-09 | Auspex Pharmaceuticals, Inc. | Vmat2的苯并喹啉抑制剂 |
| EP3071565A4 (en) * | 2013-11-22 | 2017-08-02 | Auspex Pharmaceuticals, Inc. | Methods of treating abnormal muscular activity |
| WO2015077521A1 (en) * | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CA2930744A1 (en) | 2013-12-03 | 2015-06-11 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| AU2015209330A1 (en) * | 2014-01-27 | 2016-07-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| EP4049681B1 (en) * | 2014-02-07 | 2026-01-07 | Neurocrine Biosciences, Inc. | Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof |
| LT3139925T (lt) | 2014-05-06 | 2022-01-25 | Neurocrine Biosciences, Inc. | Valbenazino dozavimo režimas, skirtas gydyti hiperkinetinio judėjimo sutrikimus |
| MA41557A (fr) * | 2015-02-18 | 2017-12-26 | Auspex Pharmaceuticals Inc | Inhibiteurs diméthoxyphényles du transporteur vésiculaire des monoamines 2 |
| HK1249860A1 (zh) * | 2015-03-06 | 2018-11-16 | 奥斯拜客斯制药有限公司 | 用於治疗异常不自主运动障碍的方法 |
| WO2016154017A1 (en) * | 2015-03-20 | 2016-09-29 | Sienna Biopharmaceuticals, Inc. | Enhanced efficacy and targeted topical delivery of drugs to skin with nanoparticles |
| LT3875459T (lt) | 2015-10-30 | 2024-02-26 | Neurocrine Biosciences, Inc. | Valbenazino dihidrochlorido druskos ir jų polimorfai |
| MA44127A (fr) | 2015-12-23 | 2018-10-31 | Neurocrine Biosciences Inc | Procédés de synthèse pour la préparation de di(4-méthylbenzènesulfonate) de 2-amino-3-méthylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-diméthoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1,-a]isoquinoléin-2-yl |
| US10479787B2 (en) | 2016-04-22 | 2019-11-19 | Lupin Limited | Process for preparation of tetrabenazine and deutetrabenazine |
| WO2017221169A1 (en) | 2016-06-24 | 2017-12-28 | Lupin Limited | Premixes of deutetrabenazine |
| CN107936008B (zh) * | 2016-10-13 | 2022-06-14 | 泰州华元医药科技有限公司 | 氘代化合物及其医药用途 |
| JP2020500875A (ja) | 2016-12-02 | 2020-01-16 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| EP3568394A1 (en) | 2017-01-10 | 2019-11-20 | Sandoz AG | Crystalline valbenazine free base |
| JP7199359B2 (ja) | 2017-01-27 | 2023-01-05 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| EP3585787A1 (en) | 2017-02-27 | 2020-01-01 | Sandoz AG | Crystalline forms of valbenazine salts |
| WO2018164996A1 (en) | 2017-03-06 | 2018-09-13 | Neurocrine Biosciences, Inc. | Dosing regimen for valbenazine |
| EP3596077A1 (en) * | 2017-03-15 | 2020-01-22 | Auspex Pharmaceuticals, Inc. | Analogs of deutetrabenazine, their preparation and use |
| JOP20190239A1 (ar) | 2017-04-19 | 2019-10-09 | Neurocrine Biosciences Inc | مركبات مثبطة لـ vmat2 وتركيبات منها |
| US20200179352A1 (en) | 2017-04-26 | 2020-06-11 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
| IL273300B2 (en) | 2017-09-21 | 2024-06-01 | Neurocrine Biosciences Inc | High dose valbenazine formulation and related preparations, methods and kits |
| US10786495B2 (en) * | 2017-10-10 | 2020-09-29 | The Regents Of The University Of California | Vesicular monoamine transporter 2 inhibitors for treating stuttering |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| KR20200066661A (ko) | 2017-10-10 | 2020-06-10 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| WO2019130252A2 (en) * | 2017-12-29 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing deutetrabenazine |
| EP3749290A4 (en) | 2018-01-29 | 2022-01-26 | Jonathan Sackner-Bernstein | METHODS OF DOPAMINE MODULATION IN HUMAN NEUROLOGICAL DISEASES |
| US11505549B2 (en) * | 2018-02-01 | 2022-11-22 | Lakshmi Prasad ALAPARTHI | Process for preparation of Deutetrabenazine |
| WO2019166962A1 (en) | 2018-03-01 | 2019-09-06 | Mylan Laboratories Ltd | Deutetrabenazine polymorphs and methods for their preparation |
| US12144899B2 (en) | 2018-04-25 | 2024-11-19 | Shinkei Therapeutics, Inc. | Tetrabenazine transdermal delivery device |
| CA3043075A1 (en) | 2018-05-14 | 2019-11-14 | Apotex Inc | Novel crystalline forms of benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| KR20210021006A (ko) | 2018-06-14 | 2021-02-24 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | Vmat2 억제제 화합물, 조성물 및 그와 관련된 방법 |
| CN108794337A (zh) * | 2018-07-10 | 2018-11-13 | 上海华堇生物技术有限责任公司 | 一种3,4-二羟基-β-硝基苯乙烯的新制备方法 |
| CA3104693A1 (en) | 2018-08-15 | 2020-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| KR102848971B1 (ko) | 2018-10-18 | 2025-08-21 | 온코펩타이드즈 이노베이션 아베 | 중수소 함유 화합물 |
| TWI784220B (zh) * | 2018-12-13 | 2022-11-21 | 美商奧斯拜客斯製藥有限公司 | 腦性麻痺運動障礙之治療方法 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| HUE065723T2 (hu) | 2020-06-10 | 2024-06-28 | Auspex Pharmaceuticals Inc | Deutetrabenazint tartalmazó ozmotikus adagolási formák és eljárás ezek alkalmazására |
| JP2023542676A (ja) * | 2020-09-17 | 2023-10-11 | オースペックス ファーマシューティカルズ インコーポレイテッド | デューテトラベナジンを含む多粒子投薬形態 |
| JP2023545289A (ja) | 2020-10-12 | 2023-10-27 | オースペックス ファーマシューティカルズ インコーポレイテッド | デューテトラベナジンを含む胃内保持型投薬形態 |
| CR20230448A (es) | 2021-03-22 | 2023-10-27 | Neurocrine Biosciences Inc | Inhibidores de vmat2 y métodos de uso |
| WO2023278987A1 (en) | 2021-06-30 | 2023-01-05 | Neurocrine Biosciences, Inc. | Valbenazine for use in the add-on treatment of schizophrenia |
| MX2024003271A (es) | 2021-09-17 | 2024-06-21 | Auspex Pharmaceuticals Inc | Formas farmaceuticas multiparticulas que comprenden deutetrabenazina. |
| CA3242612A1 (en) | 2022-01-05 | 2023-07-13 | Terrence Joseph Connolly | Deuterium-enriched piperidinyl-methyl-purine amines and related compounds and their use in treating diseases and conditions |
| WO2023172849A1 (en) | 2022-03-07 | 2023-09-14 | Neurocrine Biosciences, Inc. | Valbenazine, a vmat2 inhibitor, as a free base a tosylate or ditosylate salt, for use in the treatment of chorea associated with huntington's disease |
| CA3257711A1 (en) | 2022-06-08 | 2023-12-14 | Auspex Pharmaceuticals Llc | Osmotic dosage forms comprising deutetrabenazine and methods of use thereof |
| TW202521119A (zh) | 2023-08-17 | 2025-06-01 | 美商紐羅克里生物科學有限公司 | 用於投與特定vmat2抑制劑之方法 |
| WO2025038959A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| WO2025096823A1 (en) | 2023-11-01 | 2025-05-08 | Neurocrine Biosciences, Inc. | Improvement, maintenance or reduction of decline of motor function associated with huntington disease using valbenazine |
| WO2025259267A1 (en) | 2024-06-11 | 2025-12-18 | Vector Vitale Ip Llc | Pharmaceutical compositions for modulating inflammation and oxidative stress comprising chemically enriched elements |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2830993A (en) | 1958-04-15 | Quinolizine derivatives | ||
| US3045021A (en) * | 1959-09-24 | 1962-07-17 | Hoffmann La Roche | Preparation of substituted 2-oxobenzoquinolizines |
| AT238201B (de) * | 1961-03-28 | 1965-01-25 | Mta | Verfahren zur Herstellung von Chinolizinderivaten |
| US4316897A (en) * | 1980-09-10 | 1982-02-23 | Hoffmann-La Roche Inc. | Method of lowering serum prolactin |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| JP3696884B2 (ja) * | 1994-03-25 | 2005-09-21 | アイソテクニカ、インコーポレーテッド | ジュウテリウム化による薬物の効能の増強 |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| ES2193921T3 (es) * | 1999-12-03 | 2003-11-16 | Pfizer Prod Inc | Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos. |
| EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| ATE399026T1 (de) * | 2003-11-21 | 2008-07-15 | Memory Pharm Corp | Zusammensetzungen enhaltend l-typ- calciumcanalblockern und cholinesterase-hemmern |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| WO2006053067A2 (en) | 2004-11-09 | 2006-05-18 | Prestwick Pharmaceuticals, Inc. | Combination of amantadine and a tetrabenazine compound for treating hyperkinetic disorders |
| BRPI0606318B8 (pt) | 2005-01-19 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, composição, e, uso de um composto |
| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| PL2012833T3 (pl) | 2006-05-02 | 2015-05-29 | Univ Pennsylvania | Znakowane radiologicznie pochodne dihydrotrabenazyny i ich zastosowanie jako środki do obrazowania |
| KR101500766B1 (ko) | 2006-11-08 | 2015-03-16 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 치환된 3-이소부틸-9,10-디메톡시-1,3,4,6,7,11ｂ-헥사히드로-2Ｈ-피리도[2,1-ａ]이소퀴놀린-2-올 화합물 및 그와 관련된 방법 |
| CA2673137C (en) | 2006-11-21 | 2015-02-10 | Rigel Pharmaceuticals, Inc. | Prodrug salts of 2,4-pyrimidinediamine compounds and their uses |
| WO2008112278A2 (en) | 2007-03-12 | 2008-09-18 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for modulating insulin secretion and glucose metabolism |
| US7897768B2 (en) * | 2007-06-08 | 2011-03-01 | General Electric Company | Method for making tetrabenazine compounds |
| WO2009003226A1 (en) | 2007-06-29 | 2009-01-08 | Clarencew Pty Ltd | Treatment or prophylaxis or neurological or neuropsychiatric disorders via ocular administration |
| WO2009124357A1 (en) | 2008-04-10 | 2009-10-15 | Malvin Leonard Eutick | Fast dissolving oral formulations for critical drugs |
| WO2011019956A2 (en) | 2009-08-12 | 2011-02-17 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2462611A (en) | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| CN102186848B (zh) * | 2008-09-18 | 2014-11-12 | 奥斯拜客斯制药有限公司 | 囊泡单胺转运体2的苯并喹啉抑制剂 |
| US20100113496A1 (en) * | 2008-09-25 | 2010-05-06 | Auspex Pharmaceuticals, Inc. | Piperidine modulators of vmat2 |
| JP2013520501A (ja) | 2010-02-24 | 2013-06-06 | オースペックス ファーマシューティカルズ，インク． | チロシンキナーゼのトリメトキシフェニルインヒビター |
| CN103003275A (zh) * | 2010-06-01 | 2013-03-27 | 奥斯拜客斯制药有限公司 | Vmat2的苯并喹啉酮抑制剂 |
-
2009
- 2009-09-18 CN CN200980141378.0A patent/CN102186848B/zh active Active
- 2009-09-18 NZ NZ591615A patent/NZ591615A/en unknown
- 2009-09-18 SI SI200931797T patent/SI3061760T1/en unknown
- 2009-09-18 WO PCT/US2009/057480 patent/WO2010044981A2/en not_active Ceased
- 2009-09-18 CA CA2736409A patent/CA2736409C/en active Active
- 2009-09-18 NO NO15185548A patent/NO3061760T3/no unknown
- 2009-09-18 ES ES17199778T patent/ES2896678T3/es active Active
- 2009-09-18 EP EP13160950.5A patent/EP2610254B1/en not_active Not-in-force
- 2009-09-18 EP EP15185548.3A patent/EP3061760B1/en active Active
- 2009-09-18 AU AU2009303758A patent/AU2009303758B8/en active Active
- 2009-09-18 ES ES13160950.5T patent/ES2563820T3/es active Active
- 2009-09-18 US US12/562,621 patent/US8524733B2/en active Active
- 2009-09-18 PL PL15185548T patent/PL3061760T3/pl unknown
- 2009-09-18 SM SM20180067T patent/SMT201800067T1/it unknown
- 2009-09-18 LT LTEP15185548.3T patent/LT3061760T/lt unknown
- 2009-09-18 CN CN201410524867.7A patent/CN104311552A/zh active Pending
- 2009-09-18 EP EP17199778.6A patent/EP3345905B1/en active Active
- 2009-09-18 BR BRPI0913457A patent/BRPI0913457B8/pt active IP Right Grant
- 2009-09-18 ES ES15185548.3T patent/ES2652289T3/es active Active
- 2009-09-18 EP EP09820972.9A patent/EP2326643B1/en active Active
- 2009-09-18 PT PT151855483T patent/PT3061760T/pt unknown
- 2009-09-18 CA CA2972242A patent/CA2972242A1/en not_active Abandoned
- 2009-09-18 DK DK15185548.3T patent/DK3061760T3/en active
- 2009-09-18 JP JP2011527995A patent/JP5616345B2/ja active Active
- 2009-09-18 HU HUE15185548A patent/HUE038158T2/hu unknown
- 2009-09-18 DK DK09820972.9T patent/DK2326643T3/da active
- 2009-09-18 ES ES09820972T patent/ES2425623T3/es active Active
-
2013
- 2013-07-03 US US13/934,960 patent/US20130296360A1/en not_active Abandoned
-
2014
- 2014-03-25 US US14/225,010 patent/US20140206713A1/en not_active Abandoned
- 2014-03-25 US US14/224,883 patent/US20140206712A1/en not_active Abandoned
- 2014-08-08 US US14/454,911 patent/US20140350044A1/en not_active Abandoned
- 2014-09-11 JP JP2014185634A patent/JP5970037B2/ja active Active
- 2014-10-15 US US14/515,047 patent/US20150080427A1/en not_active Abandoned
-
2015
- 2015-07-23 US US14/807,364 patent/US20150328207A1/en not_active Abandoned
-
2016
- 2016-02-11 US US15/041,571 patent/US20160158220A1/en not_active Abandoned
- 2016-04-08 US US15/094,517 patent/US20160220558A1/en not_active Abandoned
- 2016-07-08 JP JP2016136178A patent/JP6138322B2/ja active Active
- 2016-09-01 US US15/254,912 patent/US20160367548A1/en not_active Abandoned
- 2016-09-06 US US15/257,372 patent/US20160375005A1/en not_active Abandoned
-
2017
- 2017-02-28 US US15/445,402 patent/US20170166562A1/en not_active Abandoned
-
2018
- 2018-02-07 CY CY20181100152T patent/CY1120060T1/el unknown
- 2018-02-07 HR HRP20180239TT patent/HRP20180239T1/hr unknown
- 2018-12-05 US US16/210,077 patent/US20190375746A1/en not_active Abandoned
-
2020
- 2020-03-17 US US16/821,067 patent/US20200347048A1/en not_active Abandoned
-
2021
- 2021-11-05 US US17/519,922 patent/US20220267317A1/en not_active Abandoned
-
2025
- 2025-03-17 US US19/081,808 patent/US20250326747A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1120060T1 (el) | Δευτεριωμενα παραγωγα βενζοκινολινης ως αναστολεις του κυστιδικου μεταφορεα 2 της μονοαμινης | |
| CY1123705T1 (el) | Αλατα και πολυμορφα μιας ενωσης τετρακυκλινης | |
| MY152114A (en) | Novel pyrazole-4-n-alkoxycarboxamides as microbiocides | |
| EA200901609A1 (ru) | Амиды пиразолкарбоновой кислоты, применимые в качестве микробиоцидов | |
| CY1118187T1 (el) | Χημικες ενωσεις | |
| CY1112595T1 (el) | Αμιδοφαινοξυινδαζολια χρησιμα ως αναστολεις του c-met | |
| PH12014502169A1 (en) | N-cyclylamides as nematicides | |
| UA103625C2 (en) | 5-hetrocyclylalkyl-3-hydroxy-2-phenylcyclopent-2-enons as herbicides | |
| EA200801428A1 (ru) | Производные пиридиазинона для лечения опухолей | |
| PH12012501905A1 (en) | Quinoline derivatives and their use as fungicides | |
| CO6390029A2 (es) | Polimorfos de (s)-3-amino-metil-7-(hidroxi-propoxi)-3h-benzo-[c][1,2]-oxaborol-1-ol | |
| EA201000395A1 (ru) | Фунгицидные производные 2-алкилтио-2-хинолинилоксиацетамида | |
| WO2009024342A3 (en) | Novel microbiocides | |
| EA201000269A1 (ru) | Новые гербициды | |
| EA201101148A1 (ru) | Новые гербициды | |
| CY1117565T1 (el) | Συνενωμενο δικυκλικο παραγωγο 2,4-διαμινοπυριδινης ως διπλος αναστολεας alk και fak | |
| UA102289C2 (ru) | Гербициды, полученные из циклопентадиона | |
| BRPI0923401A2 (pt) | Métodos para o preparo de aril amidas. | |
| UA106880C2 (uk) | Нові гербіциди | |
| EP3133073A3 (en) | Inhibitors of iap | |
| EA201101146A1 (ru) | Новые гербициды | |
| RU2012148909A (ru) | Новый синтез соединений тиазолидиндиона | |
| TN2011000355A1 (en) | Novel microbiocides | |
| WO2009127718A3 (en) | Novel microbiocides | |
| TR201818771T4 (tr) | Bilişsel Bozuklukların Tedavisinde Kullanıma Yönelik Bileşikler |