CY1119824T1 - Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμη - Google Patents
Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμηInfo
- Publication number
- CY1119824T1 CY1119824T1 CY20181100090T CY181100090T CY1119824T1 CY 1119824 T1 CY1119824 T1 CY 1119824T1 CY 20181100090 T CY20181100090 T CY 20181100090T CY 181100090 T CY181100090 T CY 181100090T CY 1119824 T1 CY1119824 T1 CY 1119824T1
- Authority
- CY
- Cyprus
- Prior art keywords
- meloxicam
- dihydro
- fluoro
- dimethyl
- amine
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 3
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001929 meloxicam Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002831 pharmacologic agent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229960001850 droxicam Drugs 0.000 abstract 1
- OEHFRZLKGRKFAS-UHFFFAOYSA-N droxicam Chemical compound C12=CC=CC=C2S(=O)(=O)N(C)C(C2=O)=C1OC(=O)N2C1=CC=CC=N1 OEHFRZLKGRKFAS-UHFFFAOYSA-N 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- -1 lonoxicam Chemical compound 0.000 abstract 1
- 229960002702 piroxicam Drugs 0.000 abstract 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 abstract 1
- 229960002871 tenoxicam Drugs 0.000 abstract 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003896 | 2012-05-18 | ||
| EP13724168.3A EP2849746B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and meloxicam |
| PCT/EP2013/001469 WO2013170970A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an oxicam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119824T1 true CY1119824T1 (el) | 2018-06-27 |
Family
ID=48470899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100090T CY1119824T1 (el) | 2012-05-18 | 2018-01-24 | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμη |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9308196B2 (https=) |
| EP (1) | EP2849746B1 (https=) |
| JP (1) | JP6116677B2 (https=) |
| CN (2) | CN104302288A (https=) |
| AU (1) | AU2013262076B2 (https=) |
| BR (1) | BR112014028569A2 (https=) |
| CA (1) | CA2873863A1 (https=) |
| CY (1) | CY1119824T1 (https=) |
| DK (1) | DK2849746T3 (https=) |
| EA (1) | EA026719B1 (https=) |
| ES (1) | ES2659948T3 (https=) |
| HR (1) | HRP20171843T1 (https=) |
| HU (1) | HUE035122T2 (https=) |
| IL (1) | IL235652B (https=) |
| LT (1) | LT2849746T (https=) |
| MX (1) | MX354685B (https=) |
| NO (1) | NO2849746T3 (https=) |
| PL (1) | PL2849746T3 (https=) |
| PT (1) | PT2849746T (https=) |
| RS (1) | RS56830B1 (https=) |
| SI (1) | SI2849746T1 (https=) |
| WO (1) | WO2013170970A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
| JP7373904B2 (ja) | 2016-02-29 | 2023-11-06 | パーク・セラピューティクス・インコーポレイテッド | セブラノパドールの滴定 |
| GB202405898D0 (en) * | 2024-04-26 | 2024-06-12 | Univ Surrey | Mycobacterial infections |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068838B1 (en) | 1981-06-26 | 1986-09-17 | The Upjohn Company | Analgesic process and composition |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| KR0156231B1 (ko) | 1989-05-22 | 1998-11-16 | 존 레이 비핀 | 인도메타신의 2가 전이 금속염을 함유하는 조성물 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| DE69905380T2 (de) * | 1998-09-10 | 2003-11-27 | Nycomed Danmark A/S, Roskilde | Pharmazeutische zusammensetzungen mit schneller freisetzung von wirkstoffen |
| EP1219304B1 (de) | 2000-12-28 | 2004-10-20 | Fresenius Kabi Austria GmbH | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| EP1374906B1 (en) | 2002-06-17 | 2007-04-18 | CHIESI FARMACEUTICI S.p.A. | A process for the preparation of piroxicam: beta-cyclodextrin inclusion compounds |
| AR040778A1 (es) * | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CA2612299A1 (en) | 2005-06-17 | 2006-12-21 | Pfizer Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
| ATE502629T1 (de) * | 2006-04-28 | 2011-04-15 | Gruenenthal Gmbh | Pharmazeutische kombination mit 3- (3- dimethylamino-1-ethyl-2-methyl-propyl) phenol und einem nsar |
| CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| KR101730924B1 (ko) * | 2008-09-05 | 2017-04-27 | 그뤼넨탈 게엠베하 | 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물 |
| AR073495A1 (es) * | 2008-09-05 | 2010-11-10 | Gruenenthal Gmbh | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1- (3-metoxi-fenil)-ciclohexano-1,3-diol y un nsaid |
| AU2011287952B2 (en) * | 2010-08-04 | 2014-08-21 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(N-methyl- or N,N-dimethyl-)-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane- 1,1'-pyrano[3,4,b]indol]-4-amine |
| KR20130097173A (ko) * | 2010-08-04 | 2013-09-02 | 그뤼넨탈 게엠베하 | 신경병증성 통증을 치료하기 위한 ６’플루오로（Ｎ메틸 또는 Ｎ，Ｎ디메틸）４페닐４’，９’디하이드로３’Ｈ스피로[사이클로헥산１，１’피라노[３，４，ｂ]인돌]４아민을 포함하는 약제학적 투여형 |
| WO2012016703A2 (en) * | 2010-08-04 | 2012-02-09 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
-
2013
- 2013-05-13 US US13/892,362 patent/US9308196B2/en active Active
- 2013-05-16 AU AU2013262076A patent/AU2013262076B2/en not_active Ceased
- 2013-05-16 SI SI201330919T patent/SI2849746T1/en unknown
- 2013-05-16 LT LTEP13724168.3T patent/LT2849746T/lt unknown
- 2013-05-16 MX MX2014012862A patent/MX354685B/es active IP Right Grant
- 2013-05-16 HU HUE13724168A patent/HUE035122T2/en unknown
- 2013-05-16 JP JP2015511956A patent/JP6116677B2/ja active Active
- 2013-05-16 EP EP13724168.3A patent/EP2849746B1/en not_active Not-in-force
- 2013-05-16 DK DK13724168.3T patent/DK2849746T3/en active
- 2013-05-16 PL PL13724168T patent/PL2849746T3/pl unknown
- 2013-05-16 BR BR112014028569A patent/BR112014028569A2/pt not_active IP Right Cessation
- 2013-05-16 HR HRP20171843TT patent/HRP20171843T1/hr unknown
- 2013-05-16 RS RS20180128A patent/RS56830B1/sr unknown
- 2013-05-16 CN CN201380025679.3A patent/CN104302288A/zh active Pending
- 2013-05-16 NO NO13724168A patent/NO2849746T3/no unknown
- 2013-05-16 ES ES13724168.3T patent/ES2659948T3/es active Active
- 2013-05-16 EA EA201401265A patent/EA026719B1/ru not_active IP Right Cessation
- 2013-05-16 CA CA2873863A patent/CA2873863A1/en not_active Abandoned
- 2013-05-16 CN CN201810667716.5A patent/CN108451956A/zh active Pending
- 2013-05-16 WO PCT/EP2013/001469 patent/WO2013170970A1/en not_active Ceased
- 2013-05-16 PT PT137241683T patent/PT2849746T/pt unknown
-
2014
- 2014-11-12 IL IL235652A patent/IL235652B/en active IP Right Grant
-
2018
- 2018-01-24 CY CY20181100090T patent/CY1119824T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2849746T3 (en) | 2017-12-04 |
| SI2849746T1 (en) | 2018-02-28 |
| PT2849746T (pt) | 2018-02-22 |
| MX354685B (es) | 2018-03-15 |
| HK1204939A1 (en) | 2015-12-11 |
| CN104302288A (zh) | 2015-01-21 |
| CN108451956A (zh) | 2018-08-28 |
| PL2849746T3 (pl) | 2018-04-30 |
| JP2015516450A (ja) | 2015-06-11 |
| US9308196B2 (en) | 2016-04-12 |
| MX2014012862A (es) | 2015-01-19 |
| EP2849746B1 (en) | 2017-11-15 |
| EA201401265A1 (ru) | 2015-05-29 |
| AU2013262076B2 (en) | 2017-10-26 |
| BR112014028569A2 (pt) | 2017-06-27 |
| IL235652B (en) | 2018-08-30 |
| RS56830B1 (sr) | 2018-04-30 |
| AU2013262076A1 (en) | 2015-01-22 |
| NO2849746T3 (https=) | 2018-04-14 |
| EA026719B1 (ru) | 2017-05-31 |
| EP2849746A1 (en) | 2015-03-25 |
| WO2013170970A1 (en) | 2013-11-21 |
| US20130310371A1 (en) | 2013-11-21 |
| CA2873863A1 (en) | 2013-11-21 |
| ES2659948T3 (es) | 2018-03-20 |
| IL235652A0 (en) | 2015-01-29 |
| JP6116677B2 (ja) | 2017-04-19 |
| HRP20171843T1 (hr) | 2018-01-12 |
| HUE035122T2 (en) | 2018-05-02 |
| LT2849746T (lt) | 2018-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201792046A1 (ru) | Модуляторы рецептора андрогенов и их применение | |
| CL2013000225A1 (es) | Forma de dosificacion farmaceutica que contiene 6´-fluoro-(n-metil)-o-n,n,-dimetil)-4-fenil-4´,9´-dihidro-3´-h-espiro[ciclohexan-1,1´-pirano[3,4,b])indol]-4-amina para el tratamiento de dolor neuropatico. | |
| EA201490287A1 (ru) | Новые замещенные производные индола в качестве модуляторов гамма-секретазы | |
| EA201300146A1 (ru) | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ МОДУЛЯТОРА c-МЕТ | |
| CO6640316A2 (es) | Forma de dosificación famaceutica que comprende 6´fluoro-(n-metil-o n,n.dimetil)-4-fenil-4´9-dhidro-3 h espiro[ciclohexan-1´1-pirano[3.4,b[indol]-4-amina | |
| ECSP13012788A (es) | Derivados de biciclo[3,2,1]octilamida y sus usos | |
| EA201491607A1 (ru) | Модуляторы толлподобных рецепторов | |
| MX379355B (es) | Enlazadores autodestructivos hidrofilos y conjugados de los mismos. | |
| ATE502921T1 (de) | Substituierte indole | |
| CO6640317A2 (es) | Aucforma de dosificación famaceutica que comprende 6´fluoro-(n-metil-o n,n.dimetil)-4-fenil-4´9-dhidro-3 h espiro[ciclohexan-1´1-pirano[3.4,b[indol]-4-amina | |
| CY1119887T1 (el) | ΦΑΡΜΑΚΕΥΤΙΚΗ ΜΟΡΦΗ ΔΟΣΟΛΟΓΙΑΣ ΠΟΥ ΠΕΡΙΛΑΜΒΑΝΕΙ 6'-ΦΘΟΡΟ-(Ν-ΜΕΘΥΛΟ- Ή Ν,Ν-ΔΙΜΕΘΥΛΟ-)-4-ΦΑΙΝΥΛΟ-4',9'-ΔΙΥΔΡΟ-3'Η-ΣΠΕΙΡΟ [ΚΥΚΛΟΕΞΑΝΟ-1,1'-ΠΥΡΑΝΟ[3,4,b] ΙΝΔΟΛ]-4-ΑΜΙΝΗ | |
| EA201170722A1 (ru) | Лактамы в качестве ингибиторов бета-секретазы | |
| EA201400120A1 (ru) | Кристаллический (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'н-спиро[циклогексан-1,1'-пирано[3,4,в]индол]-4-амин | |
| EA201290229A1 (ru) | Производные спиролактама и их применение | |
| CY1119824T1 (el) | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμη | |
| CY1119777T1 (el) | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και γκαμπαπεντινοειδες | |
| EA201400444A1 (ru) | Производные 2-оксопиперидинила | |
| CY1119825T1 (el) | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και ντουλοξετινη | |
| CY1118132T1 (el) | ΣΤΕΡΕΕΣ ΜΟΡΦΕΣ ΤΗΣ ΥΔΡΟΧΛΩΡΙΚΗΣ (1R,4R)-6'-ΦΘΟΡΟ-Ν,Ν-ΔΙΜΕΘΥΛ-4-ΦΑΙΝΥΛ-4',9'-ΔΙΥΔΡΟ-3´H-ΣΠΕΙΡΟ-[ΚΥΚΛΟΕΞΑΝΟ-1,1'-ΠΥΡΑΝΟ[3,4,b]ΙΝΔΟΛ]-4-ΑΜΙΝΗΣ | |
| BR112014028571A2 (pt) | composição farmacêutica compreendendo ( 1r , 4r )-6'-fluoro-n , n-dimetil-4' ,9-di-hidro-3'h-espiro[ciclo-hexano-1 ,1'-pirano-[3,4,b]indol]-4-amina e um derivado de ácido propiónico . | |
| CY1119781T1 (el) | Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη | |
| CY1119610T1 (el) | Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπιρο[κυκλοεξαν-1,1'-πυρανο'[3,4,b]ινδολ]-4-αμινη παρακεταμολη ή προπακεταμολη | |
| EA201690236A1 (ru) | Производные индол-3-карбинола | |
| CY1119692T1 (el) | Φαρμακευτικη συνθεση η οποια περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3ή-σπιρο [κυκλο-εξανο-1,1'-πυρανο-(3,4,b)ινδολ)-αμινη και ακετυλο-σαλικυλικο οξυ | |
| EA201170950A1 (ru) | Новая комбинация активных ингредиентов, содержащая нестероидное противовоспалительное лекарственное средство и производное колхикозида |