CY1119496T1 - Θεραπευτικος παραγοντας για ασθενεια που βασιζεται στην ανασταλτικη δραση στον παραγοντα αναστολης της μεταναστευσης μακροφαγων - Google Patents
Θεραπευτικος παραγοντας για ασθενεια που βασιζεται στην ανασταλτικη δραση στον παραγοντα αναστολης της μεταναστευσης μακροφαγωνInfo
- Publication number
- CY1119496T1 CY1119496T1 CY20171101008T CY171101008T CY1119496T1 CY 1119496 T1 CY1119496 T1 CY 1119496T1 CY 20171101008 T CY20171101008 T CY 20171101008T CY 171101008 T CY171101008 T CY 171101008T CY 1119496 T1 CY1119496 T1 CY 1119496T1
- Authority
- CY
- Cyprus
- Prior art keywords
- factor
- optionally substituted
- macrofag
- migration
- restricting
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
Abstract
Ένα παράγωγο βενζοπυράνης που αντιπροσωπεύεται από τον γενικό τύπο [1], ή ένα άλας αυτού, είναι χρήσιμο στη θεραπευτική ή προληπτική αγωγή μιας νόσου, όπου η εν λόγω θεραπευτική ή προληπτική αγωγή είναι αποτελεσματική επειδή το εν λόγω παράγωγο της βενζοπυράνης ή το άλας αυτού, συνδέεται με τον MIF, έχει ανασταλτική δράση στον MIF και αναστέλλει τον MIF. [Στον τύπο, το R1 αντιπροσωπεύει μία προαιρετικά υποκατεστημένη C1-6 αλκυλ- ομάδα, ένα από τα R2 και R3 αντιπροσωπεύει ένα άτομο υδρογόνου, και το άλλο από τα R2 και R3 αντιπροσωπεύει ένα άτομο υδρογόνου, μία προαιρετικά υποκατεστημένη αμινο ομάδα, μια προαιρετικά υποκατεστημένη ακυλαμινο ομάδα, μία προαιρετικά υποκατεστημένη καρβαμοϋλο ομάδα, ή μία προαιρετικά υποκατεστημένη αρυλο ομάδα.]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013149690 | 2013-07-18 | ||
| EP14826811.3A EP2929880B1 (en) | 2013-07-18 | 2014-07-17 | Therapeutic agent for disease based on inhibitory effect of macrophage migration inhibitory factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119496T1 true CY1119496T1 (el) | 2018-03-07 |
Family
ID=52346269
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101077T CY1118140T1 (el) | 2013-07-18 | 2016-10-25 | Θεραπευτικος παραγοντας για ασθενεια που βασιζεται στην ανασταλτικη δραση στον παραγοντα αναστολης της μεταναστευσης μακροφαγων |
| CY20171101008T CY1119496T1 (el) | 2013-07-18 | 2017-09-26 | Θεραπευτικος παραγοντας για ασθενεια που βασιζεται στην ανασταλτικη δραση στον παραγοντα αναστολης της μεταναστευσης μακροφαγων |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101077T CY1118140T1 (el) | 2013-07-18 | 2016-10-25 | Θεραπευτικος παραγοντας για ασθενεια που βασιζεται στην ανασταλτικη δραση στον παραγοντα αναστολης της μεταναστευσης μακροφαγων |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20150353519A1 (el) |
| EP (2) | EP3078372B1 (el) |
| JP (2) | JP5802868B2 (el) |
| CN (1) | CN105407887B (el) |
| AU (1) | AU2014291149B2 (el) |
| CA (1) | CA2918325C (el) |
| CY (2) | CY1118140T1 (el) |
| DK (2) | DK3078372T3 (el) |
| ES (2) | ES2593527T3 (el) |
| HK (1) | HK1222556A1 (el) |
| HR (2) | HRP20161317T1 (el) |
| HU (2) | HUE029800T2 (el) |
| IL (1) | IL243550B (el) |
| LT (2) | LT2929880T (el) |
| NO (1) | NO3078372T3 (el) |
| PL (2) | PL3078372T3 (el) |
| PT (2) | PT2929880T (el) |
| RS (2) | RS56489B1 (el) |
| RU (2) | RU2750540C2 (el) |
| SI (2) | SI3078372T1 (el) |
| SM (1) | SMT201700080B (el) |
| TW (1) | TWI603965B (el) |
| WO (1) | WO2015008827A1 (el) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018137708A1 (zh) * | 2017-01-26 | 2018-08-02 | 重庆莱美药业股份有限公司 | 一种纳米炭-铁复合体系及其组合物、制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
| ES2160626T3 (es) * | 1993-04-09 | 2001-11-16 | Toyama Chemical Co Ltd | Inmunomodulador, inhibidor de la adherencia celular, y agente que permite tratar y prevenir enfermedades autoinmunes. |
| WO1997023714A1 (de) * | 1995-12-21 | 1997-07-03 | Siemens Aktiengesellschaft | Luftansaugvorrichtung mit variabler saugrohrlänge für eine brennkraftmaschine |
| DE10044091A1 (de) * | 2000-09-07 | 2002-04-04 | Merck Patent Gmbh | Chromanonderivate |
| GB0507695D0 (en) | 2005-04-15 | 2005-05-25 | Novartis Ag | Organic compounds |
| GB0507696D0 (en) * | 2005-04-15 | 2005-05-25 | Novartis Ag | Organic compounds |
| WO2007042035A2 (en) * | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders |
| CN103826624A (zh) | 2011-08-30 | 2014-05-28 | 富山化学工业株式会社 | 类风湿性关节炎等自身免疫疾病的处置的改善方法 |
-
2014
- 2014-07-17 CA CA2918325A patent/CA2918325C/en active Active
- 2014-07-17 RU RU2017131951A patent/RU2750540C2/ru active
- 2014-07-17 PL PL16169414T patent/PL3078372T3/pl unknown
- 2014-07-17 DK DK16169414.6T patent/DK3078372T3/en active
- 2014-07-17 RS RS20171061A patent/RS56489B1/sr unknown
- 2014-07-17 WO PCT/JP2014/069026 patent/WO2015008827A1/ja active Application Filing
- 2014-07-17 HU HUE14826811A patent/HUE029800T2/en unknown
- 2014-07-17 EP EP16169414.6A patent/EP3078372B1/en active Active
- 2014-07-17 HU HUE16169414A patent/HUE034661T2/en unknown
- 2014-07-17 ES ES14826811.3T patent/ES2593527T3/es active Active
- 2014-07-17 SI SI201430469T patent/SI3078372T1/en unknown
- 2014-07-17 LT LTEP14826811.3T patent/LT2929880T/lt unknown
- 2014-07-17 SI SI201430088A patent/SI2929880T1/sl unknown
- 2014-07-17 AU AU2014291149A patent/AU2014291149B2/en active Active
- 2014-07-17 PL PL14826811T patent/PL2929880T3/pl unknown
- 2014-07-17 PT PT148268113T patent/PT2929880T/pt unknown
- 2014-07-17 EP EP14826811.3A patent/EP2929880B1/en active Active
- 2014-07-17 JP JP2015527333A patent/JP5802868B2/ja active Active
- 2014-07-17 DK DK14826811.3T patent/DK2929880T3/da active
- 2014-07-17 ES ES16169414.6T patent/ES2642440T3/es active Active
- 2014-07-17 LT LTEP16169414.6T patent/LT3078372T/lt unknown
- 2014-07-17 US US14/647,931 patent/US20150353519A1/en not_active Abandoned
- 2014-07-17 CN CN201480040609.XA patent/CN105407887B/zh active Active
- 2014-07-17 PT PT161694146T patent/PT3078372T/pt unknown
- 2014-07-17 RU RU2016105141A patent/RU2641301C2/ru active
- 2014-07-17 NO NO16169414A patent/NO3078372T3/no unknown
- 2014-07-17 RS RS20161048A patent/RS55394B1/sr unknown
- 2014-07-18 TW TW103124716A patent/TWI603965B/zh active
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2015
- 2015-08-27 JP JP2015167851A patent/JP6060231B2/ja active Active
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2016
- 2016-01-11 IL IL243550A patent/IL243550B/en active IP Right Grant
- 2016-04-19 US US15/132,892 patent/US9918963B2/en active Active
- 2016-04-19 US US15/132,981 patent/US20160228406A1/en not_active Abandoned
- 2016-09-09 HK HK16110748.6A patent/HK1222556A1/zh unknown
- 2016-10-11 HR HRP20161317TT patent/HRP20161317T1/hr unknown
- 2016-10-25 CY CY20161101077T patent/CY1118140T1/el unknown
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2017
- 2017-02-03 SM SM201700080T patent/SMT201700080B/it unknown
- 2017-09-26 CY CY20171101008T patent/CY1119496T1/el unknown
- 2017-10-05 HR HRP20171497TT patent/HRP20171497T1/hr unknown
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