CY1119184T1 - Κυκλικες ν,ν’-διαρυλοθειουριες και ν,ν’-διαρυλουριες ως ανταγωνιστες υποδοχεων ανδρογονων, αντι-καρκινικος παραγοντας, μεθοδος για παραγωγη και χρηση τους - Google Patents

Κυκλικες ν,ν’-διαρυλοθειουριες και ν,ν’-διαρυλουριες ως ανταγωνιστες υποδοχεων ανδρογονων, αντι-καρκινικος παραγοντας, μεθοδος για παραγωγη και χρηση τους

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Publication number
CY1119184T1
CY1119184T1 CY20171100307T CY171100307T CY1119184T1 CY 1119184 T1 CY1119184 T1 CY 1119184T1 CY 20171100307 T CY20171100307 T CY 20171100307T CY 171100307 T CY171100307 T CY 171100307T CY 1119184 T1 CY1119184 T1 CY 1119184T1
Authority
CY
Cyprus
Prior art keywords
dyl
androgen receptor
dynlars
dynarlifications
circular
Prior art date
Application number
CY20171100307T
Other languages
English (en)
Inventor
Alexandre Vasilievich Ivachtchenko
Oleg Dimitrievich Mitkin
Original Assignee
R-Pharm Overseas Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R-Pharm Overseas Inc. filed Critical R-Pharm Overseas Inc.
Publication of CY1119184T1 publication Critical patent/CY1119184T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

Η παρούσα εφεύρεση αφορά σε νέες κυκλικές Ν,Ν'-διαρυλοθειουρίες -ανταγωνιστές υποδοχέων ανδρογόνων, αντικαρκινικό παράγοντα, φαρμακευτική σύνθεση, φάρμακο και μέθοδο για τη θεραπευτική αντιμετώπιση των καρκινικών παθήσεων, μεταξύ αυτών και του καρκίνου του προστάτη.
CY20171100307T 2010-07-22 2017-03-10 Κυκλικες ν,ν’-διαρυλοθειουριες και ν,ν’-διαρυλουριες ως ανταγωνιστες υποδοχεων ανδρογονων, αντι-καρκινικος παραγοντας, μεθοδος για παραγωγη και χρηση τους CY1119184T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010130618/04A RU2434851C1 (ru) 2010-07-22 2010-07-22 Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
EP11809933.2A EP2597086A4 (en) 2010-07-22 2011-07-01 N, N'-DIARYLURATES AND CYCLIC N, N'-DIARYLTHIOURATES, ANTAGONISTS OF ANDROGEN RECEPTORS, ANTI-CANCER AGENT AND METHOD OF PRODUCTION AND APPLICATION

Publications (1)

Publication Number Publication Date
CY1119184T1 true CY1119184T1 (el) 2018-02-14

Family

ID=45318163

Family Applications (1)

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CY20171100307T CY1119184T1 (el) 2010-07-22 2017-03-10 Κυκλικες ν,ν’-διαρυλοθειουριες και ν,ν’-διαρυλουριες ως ανταγωνιστες υποδοχεων ανδρογονων, αντι-καρκινικος παραγοντας, μεθοδος για παραγωγη και χρηση τους

Country Status (21)

Country Link
US (1) US9073874B2 (el)
EP (2) EP2597086A4 (el)
JP (1) JP5897566B2 (el)
KR (1) KR101738866B1 (el)
AU (1) AU2011280297B2 (el)
CA (1) CA2806051C (el)
CY (1) CY1119184T1 (el)
DK (1) DK2767531T3 (el)
EA (1) EA020681B1 (el)
ES (1) ES2618891T3 (el)
GE (1) GEP20166450B (el)
HR (1) HRP20170450T1 (el)
HU (1) HUE031999T2 (el)
LT (1) LT2767531T (el)
PL (1) PL2767531T3 (el)
PT (1) PT2767531T (el)
RS (1) RS55876B1 (el)
RU (1) RU2434851C1 (el)
SI (1) SI2767531T1 (el)
UA (1) UA112161C2 (el)
WO (1) WO2012011840A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2598854C2 (ru) 2011-03-10 2016-09-27 Сучжоу Кинтор Фармасьютикалз, Инк. Производные тиогидантоина, полезные в качестве антагонистов рецептора андрогена
BR112015004637B1 (pt) 2012-09-04 2022-04-05 Shanghai Hengrui Pharmaceutical Co., Ltd. Derivados de imidazolina, seus usos e seus processos de preparação, e composição farmacêutica
CA2889756C (en) 2012-10-26 2023-03-14 Memorial Sloan-Kettering Cancer Center Thiohydantoin compounds as androgen receptor modulators
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
CN104844521B (zh) * 2014-02-13 2017-08-15 成都伊诺达博医药科技有限公司 抗前列腺癌药物恩杂鲁胺的合成方法
CN104844520B (zh) * 2014-02-13 2017-09-05 成都伊诺达博医药科技有限公司 一种合成恩杂鲁胺的方法
RU2557235C1 (ru) * 2014-07-08 2015-07-20 Александр Васильевич Иващенко Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты
TWI613194B (zh) * 2015-06-10 2018-02-01 台灣神隆股份有限公司 用於製備恩雜魯胺的新穎方法
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CA3124130A1 (en) 2018-12-19 2020-06-25 Celgene Corporation Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith
WO2020132016A1 (en) 2018-12-19 2020-06-25 Celgene Corporation Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith
MX2023001823A (es) 2020-08-13 2023-03-13 Pfizer Terapia de combinacion.

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FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
WO2006031715A2 (en) * 2004-09-10 2006-03-23 Janssen Pharmaceutica N.V. Novel imidazolidin-2-one derivatives as selective androgen receptor modulators (sarms)
RS52274B2 (sr) 2005-05-13 2018-05-31 Univ California Jedinjenje diarilhidantoina
KR101456722B1 (ko) * 2006-03-29 2014-10-31 더 리전트 오브 더 유니버시티 오브 캘리포니아 디아릴티오히단토인 화합물

Also Published As

Publication number Publication date
EA020681B1 (ru) 2014-12-30
AU2011280297A1 (en) 2013-03-07
EP2767531B1 (en) 2016-12-21
GEP20166450B (en) 2016-03-25
US9073874B2 (en) 2015-07-07
RU2434851C1 (ru) 2011-11-27
SI2767531T1 (sl) 2017-04-26
LT2767531T (lt) 2017-04-10
US20130116269A1 (en) 2013-05-09
HUE031999T2 (en) 2017-09-28
UA112161C2 (uk) 2016-08-10
JP2013532657A (ja) 2013-08-19
PT2767531T (pt) 2017-03-23
PL2767531T3 (pl) 2017-08-31
KR101738866B1 (ko) 2017-05-23
RS55876B1 (sr) 2017-08-31
HRP20170450T1 (hr) 2017-05-19
CA2806051A1 (en) 2012-01-26
DK2767531T3 (en) 2017-03-13
CA2806051C (en) 2017-02-14
AU2011280297B2 (en) 2013-11-21
JP5897566B2 (ja) 2016-03-30
KR20130046436A (ko) 2013-05-07
WO2012011840A1 (ru) 2012-01-26
EP2597086A1 (en) 2013-05-29
ES2618891T3 (es) 2017-06-22
EP2597086A4 (en) 2013-11-06
EA201300122A1 (ru) 2013-06-28
EP2767531A1 (en) 2014-08-20

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