PL2767531T3 - Cykliczne N,N'-diarylotiomoczniki i N,N'-diarylomoczniki jako antagoniści receptora androgenu, lek przeciwnowotworowy, sposób ich wytwarzania i stosowania - Google Patents
Cykliczne N,N'-diarylotiomoczniki i N,N'-diarylomoczniki jako antagoniści receptora androgenu, lek przeciwnowotworowy, sposób ich wytwarzania i stosowaniaInfo
- Publication number
- PL2767531T3 PL2767531T3 PL14001526T PL14001526T PL2767531T3 PL 2767531 T3 PL2767531 T3 PL 2767531T3 PL 14001526 T PL14001526 T PL 14001526T PL 14001526 T PL14001526 T PL 14001526T PL 2767531 T3 PL2767531 T3 PL 2767531T3
- Authority
- PL
- Poland
- Prior art keywords
- diarylthioureas
- diarylureas
- cyclic
- producing
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010130618/04A RU2434851C1 (ru) | 2010-07-22 | 2010-07-22 | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения |
| EP14001526.4A EP2767531B1 (en) | 2010-07-22 | 2011-07-01 | Cyclic n,n'-diarylthioureas and n,n'-diarylureas as androgen receptor antagonists, anti-cancer agent, method for producing and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2767531T3 true PL2767531T3 (pl) | 2017-08-31 |
Family
ID=45318163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14001526T PL2767531T3 (pl) | 2010-07-22 | 2011-07-01 | Cykliczne N,N'-diarylotiomoczniki i N,N'-diarylomoczniki jako antagoniści receptora androgenu, lek przeciwnowotworowy, sposób ich wytwarzania i stosowania |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9073874B2 (pl) |
| EP (2) | EP2597086A4 (pl) |
| JP (1) | JP5897566B2 (pl) |
| KR (1) | KR101738866B1 (pl) |
| AU (1) | AU2011280297B2 (pl) |
| CA (1) | CA2806051C (pl) |
| CY (1) | CY1119184T1 (pl) |
| DK (1) | DK2767531T3 (pl) |
| EA (1) | EA020681B1 (pl) |
| ES (1) | ES2618891T3 (pl) |
| GE (1) | GEP20166450B (pl) |
| HR (1) | HRP20170450T1 (pl) |
| HU (1) | HUE031999T2 (pl) |
| LT (1) | LT2767531T (pl) |
| PL (1) | PL2767531T3 (pl) |
| PT (1) | PT2767531T (pl) |
| RS (1) | RS55876B1 (pl) |
| RU (1) | RU2434851C1 (pl) |
| SI (1) | SI2767531T1 (pl) |
| UA (1) | UA112161C2 (pl) |
| WO (1) | WO2012011840A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2598854C2 (ru) | 2011-03-10 | 2016-09-27 | Сучжоу Кинтор Фармасьютикалз, Инк. | Производные тиогидантоина, полезные в качестве антагонистов рецептора андрогена |
| BR112015004637B1 (pt) | 2012-09-04 | 2022-04-05 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Derivados de imidazolina, seus usos e seus processos de preparação, e composição farmacêutica |
| CA2889756C (en) | 2012-10-26 | 2023-03-14 | Memorial Sloan-Kettering Cancer Center | Thiohydantoin compounds as androgen receptor modulators |
| RU2520134C1 (ru) * | 2013-02-27 | 2014-06-20 | Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") | Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения |
| CN104844521B (zh) * | 2014-02-13 | 2017-08-15 | 成都伊诺达博医药科技有限公司 | 抗前列腺癌药物恩杂鲁胺的合成方法 |
| CN104844520B (zh) * | 2014-02-13 | 2017-09-05 | 成都伊诺达博医药科技有限公司 | 一种合成恩杂鲁胺的方法 |
| RU2557235C1 (ru) * | 2014-07-08 | 2015-07-20 | Александр Васильевич Иващенко | Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты |
| TWI613194B (zh) * | 2015-06-10 | 2018-02-01 | 台灣神隆股份有限公司 | 用於製備恩雜魯胺的新穎方法 |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| CA3124130A1 (en) | 2018-12-19 | 2020-06-25 | Celgene Corporation | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
| WO2020132016A1 (en) | 2018-12-19 | 2020-06-25 | Celgene Corporation | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
| MX2023001823A (es) | 2020-08-13 | 2023-03-13 | Pfizer | Terapia de combinacion. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2715402B1 (fr) * | 1994-01-05 | 1996-10-04 | Roussel Uclaf | Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| TW521073B (en) * | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
| FR2725206B1 (fr) * | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| WO2006031715A2 (en) * | 2004-09-10 | 2006-03-23 | Janssen Pharmaceutica N.V. | Novel imidazolidin-2-one derivatives as selective androgen receptor modulators (sarms) |
| RS52274B2 (sr) | 2005-05-13 | 2018-05-31 | Univ California | Jedinjenje diarilhidantoina |
| KR101456722B1 (ko) * | 2006-03-29 | 2014-10-31 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴티오히단토인 화합물 |
-
2010
- 2010-07-22 RU RU2010130618/04A patent/RU2434851C1/ru active
-
2011
- 2011-01-07 UA UAA201301869A patent/UA112161C2/uk unknown
- 2011-07-01 PL PL14001526T patent/PL2767531T3/pl unknown
- 2011-07-01 SI SI201131127A patent/SI2767531T1/sl unknown
- 2011-07-01 CA CA2806051A patent/CA2806051C/en not_active Expired - Fee Related
- 2011-07-01 US US13/811,282 patent/US9073874B2/en active Active
- 2011-07-01 LT LTEP14001526.4T patent/LT2767531T/lt unknown
- 2011-07-01 KR KR1020137004605A patent/KR101738866B1/ko active IP Right Grant
- 2011-07-01 EA EA201300122A patent/EA020681B1/ru unknown
- 2011-07-01 DK DK14001526.4T patent/DK2767531T3/en active
- 2011-07-01 RS RS20170292A patent/RS55876B1/sr unknown
- 2011-07-01 GE GEAP201113219A patent/GEP20166450B/en unknown
- 2011-07-01 WO PCT/RU2011/000476 patent/WO2012011840A1/ru active Application Filing
- 2011-07-01 EP EP11809933.2A patent/EP2597086A4/en not_active Withdrawn
- 2011-07-01 JP JP2013520687A patent/JP5897566B2/ja active Active
- 2011-07-01 HU HUE14001526A patent/HUE031999T2/en unknown
- 2011-07-01 AU AU2011280297A patent/AU2011280297B2/en active Active
- 2011-07-01 ES ES14001526.4T patent/ES2618891T3/es active Active
- 2011-07-01 PT PT140015264T patent/PT2767531T/pt unknown
- 2011-07-01 EP EP14001526.4A patent/EP2767531B1/en active Active
-
2017
- 2017-03-10 CY CY20171100307T patent/CY1119184T1/el unknown
- 2017-03-20 HR HRP20170450TT patent/HRP20170450T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA020681B1 (ru) | 2014-12-30 |
| AU2011280297A1 (en) | 2013-03-07 |
| EP2767531B1 (en) | 2016-12-21 |
| GEP20166450B (en) | 2016-03-25 |
| US9073874B2 (en) | 2015-07-07 |
| RU2434851C1 (ru) | 2011-11-27 |
| SI2767531T1 (sl) | 2017-04-26 |
| LT2767531T (lt) | 2017-04-10 |
| US20130116269A1 (en) | 2013-05-09 |
| HUE031999T2 (en) | 2017-09-28 |
| UA112161C2 (uk) | 2016-08-10 |
| JP2013532657A (ja) | 2013-08-19 |
| PT2767531T (pt) | 2017-03-23 |
| KR101738866B1 (ko) | 2017-05-23 |
| RS55876B1 (sr) | 2017-08-31 |
| HRP20170450T1 (hr) | 2017-05-19 |
| CA2806051A1 (en) | 2012-01-26 |
| DK2767531T3 (en) | 2017-03-13 |
| CA2806051C (en) | 2017-02-14 |
| AU2011280297B2 (en) | 2013-11-21 |
| JP5897566B2 (ja) | 2016-03-30 |
| KR20130046436A (ko) | 2013-05-07 |
| CY1119184T1 (el) | 2018-02-14 |
| WO2012011840A1 (ru) | 2012-01-26 |
| EP2597086A1 (en) | 2013-05-29 |
| ES2618891T3 (es) | 2017-06-22 |
| EP2597086A4 (en) | 2013-11-06 |
| EA201300122A1 (ru) | 2013-06-28 |
| EP2767531A1 (en) | 2014-08-20 |
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