CY1118255T1 - Υποκατεστημενα 6-αμινο-νικοτιναμιδια τα οποια φερουν μια ομαδα που περιεχει οη ως διαμορφωτες των kcnq2/3 - Google Patents
Υποκατεστημενα 6-αμινο-νικοτιναμιδια τα οποια φερουν μια ομαδα που περιεχει οη ως διαμορφωτες των kcnq2/3Info
- Publication number
- CY1118255T1 CY1118255T1 CY20161101222T CY161101222T CY1118255T1 CY 1118255 T1 CY1118255 T1 CY 1118255T1 CY 20161101222 T CY20161101222 T CY 20161101222T CY 161101222 T CY161101222 T CY 161101222T CY 1118255 T1 CY1118255 T1 CY 1118255T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nicotinamides
- amino
- substituted
- kcnq2
- modulators
- Prior art date
Links
- ZLWYEPMDOUQDBW-UHFFFAOYSA-N 6-aminonicotinamide Chemical class NC(=O)C1=CC=C(N)N=C1 ZLWYEPMDOUQDBW-UHFFFAOYSA-N 0.000 title abstract 2
- 102000005453 KCNQ2 Potassium Channel Human genes 0.000 title 1
- 108010006746 KCNQ2 Potassium Channel Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12002709 | 2012-04-18 | ||
| EP13719386.8A EP2888233B1 (en) | 2012-04-18 | 2013-04-17 | Substituted 6-amino-nicotinamides bearing an oh-containing group as kcnq2/3 modulators |
| PCT/EP2013/001134 WO2013156154A1 (en) | 2012-04-18 | 2013-04-17 | Substituted 6-amino-nicotinamides bearing an oh-containing group as kcnq2/3 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118255T1 true CY1118255T1 (el) | 2017-06-28 |
Family
ID=48227140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101222T CY1118255T1 (el) | 2012-04-18 | 2016-11-24 | Υποκατεστημενα 6-αμινο-νικοτιναμιδια τα οποια φερουν μια ομαδα που περιεχει οη ως διαμορφωτες των kcnq2/3 |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP2888233B1 (https=) |
| JP (1) | JP6033403B2 (https=) |
| CN (1) | CN104428287A (https=) |
| AR (1) | AR090739A1 (https=) |
| AU (1) | AU2013248637A1 (https=) |
| BR (1) | BR112014025840A2 (https=) |
| CA (1) | CA2870573A1 (https=) |
| CY (1) | CY1118255T1 (https=) |
| DK (1) | DK2888233T3 (https=) |
| EA (1) | EA201401142A1 (https=) |
| ES (1) | ES2605947T3 (https=) |
| HK (1) | HK1210173A1 (https=) |
| HR (1) | HRP20161424T1 (https=) |
| HU (1) | HUE030859T2 (https=) |
| IL (1) | IL235030A0 (https=) |
| LT (1) | LT2888233T (https=) |
| MX (1) | MX2014012494A (https=) |
| PT (1) | PT2888233T (https=) |
| RS (1) | RS55466B1 (https=) |
| SI (1) | SI2888233T1 (https=) |
| WO (1) | WO2013156154A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201809184VA (en) * | 2016-04-22 | 2018-11-29 | Ono Pharmaceutical Co | Crystal polymorphism of kcnq2-5 channel activator |
| JP7262468B2 (ja) * | 2017-12-29 | 2023-04-21 | スリーエム イノベイティブ プロパティズ カンパニー | 熱硬化性２剤型加工用接着剤組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2230392A1 (de) | 1972-06-22 | 1974-01-31 | Cassella Farbwerke Mainkur Ag | Substituierte pyridinverbindungen und verfahren zu ihrer herstellung |
| DE2513949A1 (de) | 1975-03-29 | 1976-10-07 | Bayer Ag | Azofarbstoffe |
| CA2438868A1 (en) | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| US20020183335A1 (en) * | 2001-02-20 | 2002-12-05 | Piyasena Hewawasam | 2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators |
| EP2086935A1 (de) * | 2006-10-16 | 2009-08-12 | Grünenthal GmbH | Substituierte sulfonamid-derivate als bradykinin 1 rezeptor modulatoren |
| DE102006049452A1 (de) | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
| HRP20120822T1 (hr) | 2008-10-24 | 2012-11-30 | Grünenthal GmbH | Supstituirani 4,5,6,7-tetrahidrotienopiridini kao kcnq2/3 modulatori za lijeäśenje boli, epilepsije i urinarne inkontinencije |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| PE20140199A1 (es) * | 2010-10-20 | 2014-02-16 | Gruenenthal Chemie | 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3 |
-
2013
- 2013-04-17 ES ES13719386.8T patent/ES2605947T3/es active Active
- 2013-04-17 DK DK13719386.8T patent/DK2888233T3/en active
- 2013-04-17 LT LTEP13719386.8T patent/LT2888233T/lt unknown
- 2013-04-17 HR HRP20161424TT patent/HRP20161424T1/hr unknown
- 2013-04-17 WO PCT/EP2013/001134 patent/WO2013156154A1/en not_active Ceased
- 2013-04-17 EP EP13719386.8A patent/EP2888233B1/en not_active Not-in-force
- 2013-04-17 MX MX2014012494A patent/MX2014012494A/es unknown
- 2013-04-17 HU HUE13719386A patent/HUE030859T2/en unknown
- 2013-04-17 EA EA201401142A patent/EA201401142A1/ru unknown
- 2013-04-17 SI SI201330394A patent/SI2888233T1/sl unknown
- 2013-04-17 AU AU2013248637A patent/AU2013248637A1/en not_active Abandoned
- 2013-04-17 HK HK15111080.1A patent/HK1210173A1/xx unknown
- 2013-04-17 RS RS20161120A patent/RS55466B1/sr unknown
- 2013-04-17 CN CN201380019282.3A patent/CN104428287A/zh active Pending
- 2013-04-17 CA CA2870573A patent/CA2870573A1/en not_active Abandoned
- 2013-04-17 BR BR112014025840A patent/BR112014025840A2/pt not_active IP Right Cessation
- 2013-04-17 JP JP2015506121A patent/JP6033403B2/ja not_active Expired - Fee Related
- 2013-04-17 PT PT137193868T patent/PT2888233T/pt unknown
- 2013-04-18 AR ARP130101283A patent/AR090739A1/es unknown
-
2014
- 2014-10-07 IL IL235030A patent/IL235030A0/en unknown
-
2016
- 2016-11-24 CY CY20161101222T patent/CY1118255T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2605947T3 (es) | 2017-03-17 |
| EP2888233A1 (en) | 2015-07-01 |
| DK2888233T3 (en) | 2017-01-09 |
| HUE030859T2 (en) | 2017-06-28 |
| MX2014012494A (es) | 2015-01-15 |
| JP6033403B2 (ja) | 2016-11-30 |
| SI2888233T1 (sl) | 2016-12-30 |
| RS55466B1 (sr) | 2017-04-28 |
| CA2870573A1 (en) | 2013-10-24 |
| BR112014025840A2 (pt) | 2017-07-18 |
| EA201401142A1 (ru) | 2015-03-31 |
| LT2888233T (lt) | 2017-01-10 |
| EP2888233B1 (en) | 2016-09-28 |
| CN104428287A (zh) | 2015-03-18 |
| PT2888233T (pt) | 2017-01-04 |
| JP2015514728A (ja) | 2015-05-21 |
| AU2013248637A1 (en) | 2014-12-04 |
| HK1210173A1 (en) | 2016-04-15 |
| WO2013156154A1 (en) | 2013-10-24 |
| HRP20161424T1 (hr) | 2016-12-16 |
| IL235030A0 (en) | 2014-12-31 |
| AR090739A1 (es) | 2014-12-03 |
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