BR112014025840A2 - 6-amino-nicotinamidas substituídas tendo um grupo contendo oh como moduladores de kcnq2/3. - Google Patents
6-amino-nicotinamidas substituídas tendo um grupo contendo oh como moduladores de kcnq2/3.Info
- Publication number
- BR112014025840A2 BR112014025840A2 BR112014025840A BR112014025840A BR112014025840A2 BR 112014025840 A2 BR112014025840 A2 BR 112014025840A2 BR 112014025840 A BR112014025840 A BR 112014025840A BR 112014025840 A BR112014025840 A BR 112014025840A BR 112014025840 A2 BR112014025840 A2 BR 112014025840A2
- Authority
- BR
- Brazil
- Prior art keywords
- kcnq2
- modulators
- substituted
- containing group
- nicotinamides
- Prior art date
Links
- 235000005152 nicotinamide Nutrition 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12002709 | 2012-04-18 | ||
| PCT/EP2013/001134 WO2013156154A1 (en) | 2012-04-18 | 2013-04-17 | Substituted 6-amino-nicotinamides bearing an oh-containing group as kcnq2/3 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014025840A2 true BR112014025840A2 (pt) | 2017-07-18 |
Family
ID=48227140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014025840A BR112014025840A2 (pt) | 2012-04-18 | 2013-04-17 | 6-amino-nicotinamidas substituídas tendo um grupo contendo oh como moduladores de kcnq2/3. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP2888233B1 (https=) |
| JP (1) | JP6033403B2 (https=) |
| CN (1) | CN104428287A (https=) |
| AR (1) | AR090739A1 (https=) |
| AU (1) | AU2013248637A1 (https=) |
| BR (1) | BR112014025840A2 (https=) |
| CA (1) | CA2870573A1 (https=) |
| CY (1) | CY1118255T1 (https=) |
| DK (1) | DK2888233T3 (https=) |
| EA (1) | EA201401142A1 (https=) |
| ES (1) | ES2605947T3 (https=) |
| HK (1) | HK1210173A1 (https=) |
| HR (1) | HRP20161424T1 (https=) |
| HU (1) | HUE030859T2 (https=) |
| IL (1) | IL235030A0 (https=) |
| LT (1) | LT2888233T (https=) |
| MX (1) | MX2014012494A (https=) |
| PT (1) | PT2888233T (https=) |
| RS (1) | RS55466B1 (https=) |
| SI (1) | SI2888233T1 (https=) |
| WO (1) | WO2013156154A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6265313B1 (ja) * | 2016-04-22 | 2018-01-24 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル活性化剤の結晶多形 |
| WO2019130185A1 (en) * | 2017-12-29 | 2019-07-04 | 3M Innovative Properties Company | Thermally curable two part processing adhesive composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2230392A1 (de) | 1972-06-22 | 1974-01-31 | Cassella Farbwerke Mainkur Ag | Substituierte pyridinverbindungen und verfahren zu ihrer herstellung |
| DE2513949A1 (de) | 1975-03-29 | 1976-10-07 | Bayer Ag | Azofarbstoffe |
| CA2438868A1 (en) | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| CZ20032233A3 (cs) | 2001-02-20 | 2004-12-15 | Bristol-Myers Squibb Company | Derivát 2,4-disubstituovaného pyrimidin-5-karboxamidu jako modulátor draslíkového kanálku KCNQ |
| JP5406722B2 (ja) * | 2006-10-16 | 2014-02-05 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ブラジキニン１受容体モジュレータとしての置換されたスルホンアミド誘導体 |
| DE102006049452A1 (de) | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
| ES2392758T3 (es) | 2008-10-24 | 2012-12-13 | Grünenthal GmbH | 4,5,6,7-Tetrahidrotienopiridinas sustituidas como moduladores de KCNQ2/3 para el tratamiento del dolor, la epilepsia y la incontinencia urinaria |
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| JP5947307B2 (ja) * | 2010-10-20 | 2016-07-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Ｋｃｎｑ２／３調節因子としての置換６−アミノ−ニコチンアミド |
-
2013
- 2013-04-17 LT LTEP13719386.8T patent/LT2888233T/lt unknown
- 2013-04-17 WO PCT/EP2013/001134 patent/WO2013156154A1/en not_active Ceased
- 2013-04-17 RS RS20161120A patent/RS55466B1/sr unknown
- 2013-04-17 ES ES13719386.8T patent/ES2605947T3/es active Active
- 2013-04-17 PT PT137193868T patent/PT2888233T/pt unknown
- 2013-04-17 HR HRP20161424TT patent/HRP20161424T1/hr unknown
- 2013-04-17 CN CN201380019282.3A patent/CN104428287A/zh active Pending
- 2013-04-17 EA EA201401142A patent/EA201401142A1/ru unknown
- 2013-04-17 JP JP2015506121A patent/JP6033403B2/ja not_active Expired - Fee Related
- 2013-04-17 MX MX2014012494A patent/MX2014012494A/es unknown
- 2013-04-17 EP EP13719386.8A patent/EP2888233B1/en not_active Not-in-force
- 2013-04-17 HK HK15111080.1A patent/HK1210173A1/xx unknown
- 2013-04-17 DK DK13719386.8T patent/DK2888233T3/en active
- 2013-04-17 CA CA2870573A patent/CA2870573A1/en not_active Abandoned
- 2013-04-17 AU AU2013248637A patent/AU2013248637A1/en not_active Abandoned
- 2013-04-17 HU HUE13719386A patent/HUE030859T2/en unknown
- 2013-04-17 SI SI201330394A patent/SI2888233T1/sl unknown
- 2013-04-17 BR BR112014025840A patent/BR112014025840A2/pt not_active IP Right Cessation
- 2013-04-18 AR ARP130101283A patent/AR090739A1/es unknown
-
2014
- 2014-10-07 IL IL235030A patent/IL235030A0/en unknown
-
2016
- 2016-11-24 CY CY20161101222T patent/CY1118255T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR090739A1 (es) | 2014-12-03 |
| WO2013156154A1 (en) | 2013-10-24 |
| CY1118255T1 (el) | 2017-06-28 |
| RS55466B1 (sr) | 2017-04-28 |
| PT2888233T (pt) | 2017-01-04 |
| LT2888233T (lt) | 2017-01-10 |
| IL235030A0 (en) | 2014-12-31 |
| EA201401142A1 (ru) | 2015-03-31 |
| CA2870573A1 (en) | 2013-10-24 |
| HK1210173A1 (en) | 2016-04-15 |
| JP6033403B2 (ja) | 2016-11-30 |
| JP2015514728A (ja) | 2015-05-21 |
| MX2014012494A (es) | 2015-01-15 |
| HUE030859T2 (en) | 2017-06-28 |
| EP2888233A1 (en) | 2015-07-01 |
| AU2013248637A1 (en) | 2014-12-04 |
| HRP20161424T1 (hr) | 2016-12-16 |
| CN104428287A (zh) | 2015-03-18 |
| EP2888233B1 (en) | 2016-09-28 |
| ES2605947T3 (es) | 2017-03-17 |
| SI2888233T1 (sl) | 2016-12-30 |
| DK2888233T3 (en) | 2017-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |