CY1116787T1 - Υποκατεστημενα νικοτιναμιδια σαν διαμορφωτες kcnq2/3 - Google Patents
Υποκατεστημενα νικοτιναμιδια σαν διαμορφωτες kcnq2/3Info
- Publication number
- CY1116787T1 CY1116787T1 CY20151100914T CY151100914T CY1116787T1 CY 1116787 T1 CY1116787 T1 CY 1116787T1 CY 20151100914 T CY20151100914 T CY 20151100914T CY 151100914 T CY151100914 T CY 151100914T CY 1116787 T1 CY1116787 T1 CY 1116787T1
- Authority
- CY
- Cyprus
- Prior art keywords
- unsubstituted
- substituted
- unsaturated
- saturated
- alkyl
- Prior art date
Links
- 235000005152 nicotinamide Nutrition 0.000 title abstract 2
- 150000005480 nicotinamides Chemical class 0.000 title abstract 2
- 102000005453 KCNQ2 Potassium Channel Human genes 0.000 title 1
- 108010006746 KCNQ2 Potassium Channel Proteins 0.000 title 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 6
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09003598 | 2009-03-12 | ||
| EP10708139.0A EP2406226B1 (de) | 2009-03-12 | 2010-03-11 | Substituierte nicotinamide als kcnq2/3 modulatoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116787T1 true CY1116787T1 (el) | 2017-03-15 |
Family
ID=40933299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100914T CY1116787T1 (el) | 2009-03-12 | 2015-10-09 | Υποκατεστημενα νικοτιναμιδια σαν διαμορφωτες kcnq2/3 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8178684B2 (OSRAM) |
| EP (1) | EP2406226B1 (OSRAM) |
| JP (1) | JP5670359B2 (OSRAM) |
| KR (1) | KR20110132592A (OSRAM) |
| CN (1) | CN102369188B (OSRAM) |
| AR (1) | AR075540A1 (OSRAM) |
| AU (1) | AU2010223511B2 (OSRAM) |
| BR (1) | BRPI1008948A2 (OSRAM) |
| CA (1) | CA2754998C (OSRAM) |
| CO (1) | CO6410303A2 (OSRAM) |
| CY (1) | CY1116787T1 (OSRAM) |
| DK (1) | DK2406226T3 (OSRAM) |
| EC (1) | ECSP11011347A (OSRAM) |
| ES (1) | ES2556772T3 (OSRAM) |
| HR (1) | HRP20151260T1 (OSRAM) |
| HU (1) | HUE026170T2 (OSRAM) |
| IL (1) | IL214946A (OSRAM) |
| MX (1) | MX2011009127A (OSRAM) |
| NZ (1) | NZ595628A (OSRAM) |
| PE (1) | PE20120780A1 (OSRAM) |
| PL (1) | PL2406226T3 (OSRAM) |
| PT (1) | PT2406226E (OSRAM) |
| RU (1) | RU2529904C2 (OSRAM) |
| SI (1) | SI2406226T1 (OSRAM) |
| TW (1) | TWI475020B (OSRAM) |
| WO (1) | WO2010102809A1 (OSRAM) |
| ZA (1) | ZA201107442B (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011008825A (es) * | 2009-03-10 | 2011-09-21 | Gruenenthal Gmbh | 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3. |
| TWI504395B (zh) * | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TWI461197B (zh) * | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| SI2609086T1 (sl) | 2010-08-27 | 2015-04-30 | Gruenenthal Gmbh | Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji |
| TW201211007A (en) | 2010-08-27 | 2012-03-16 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
| BR112013004562A2 (pt) | 2010-08-27 | 2016-09-06 | Gruenenthal Gmbh | 2-óxi-quinolina-3-carboxamidas substituídas como moduladores kcnq2/3 |
| MX2013002295A (es) | 2010-09-01 | 2013-05-09 | Gruenenthal Gmbh | 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| US9168259B2 (en) | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| AU2015201122B2 (en) * | 2010-10-20 | 2016-02-25 | Grunenthal Gmbh | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| MX367623B (es) | 2010-10-20 | 2019-08-29 | Gruenenthal Gmbh | 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3. |
| FR2968661B1 (fr) * | 2010-12-14 | 2016-01-01 | Oreal | Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones |
| MX2014012491A (es) | 2012-04-18 | 2014-11-14 | Grünenthal GmbH | 4-aminobenzamidas sustituidas como moduladores de kcnq2/3. |
| AU2013248637A1 (en) * | 2012-04-18 | 2014-12-04 | Grünenthal GmbH | Substituted 6-amino-nicotinamides bearing an OH-containing group as KCNQ2/3 modulators |
| WO2014056620A1 (en) * | 2012-10-11 | 2014-04-17 | Grünenthal GmbH | Treatment and/or prophylaxis of tspo mediated diseases and/or disorders |
| US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| CA2892745A1 (en) | 2012-11-28 | 2014-06-05 | Grunenthal Gmbh | Specific carboxamides as kcnq2/3 modulators |
| CN104513171B (zh) * | 2013-09-30 | 2017-09-01 | 中国科学院过程工程研究所 | 一种玛咖酰胺的合成方法及其用途 |
| KR20170076673A (ko) * | 2014-10-24 | 2017-07-04 | 오노 야꾸힝 고교 가부시키가이샤 | Kcnq2∼5 채널 활성화제 |
| JP7120549B2 (ja) | 2016-12-15 | 2022-08-17 | 小野薬品工業株式会社 | Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ |
| DE102018212006B3 (de) | 2018-07-18 | 2019-10-31 | Universität Greifswald | Thioether als Modulatoren von Kv7.2/Kv7.3-Kanälen |
| CN111840267A (zh) * | 2020-08-05 | 2020-10-30 | 牡丹江医学院 | 一种治疗小儿口腔黏膜疾病的药物及其制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2532939A1 (fr) | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
| DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| EP0716077A1 (de) | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
| WO1996026925A1 (en) | 1995-03-01 | 1996-09-06 | Banyu Pharmaceutical Co., Ltd. | Arylthioacetamide derivatives |
| DE19738616A1 (de) | 1997-09-04 | 1999-03-11 | Clariant Gmbh | 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel |
| AU3033500A (en) | 1999-01-15 | 2000-08-01 | Agouron Pharmaceuticals, Inc. | Non-peptide glp-1 agonists |
| US6326385B1 (en) * | 1999-08-04 | 2001-12-04 | Icagen, Inc. | Methods for treating or preventing pain |
| WO2001010380A2 (en) | 1999-08-04 | 2001-02-15 | Icagen, Inc. | Benzanilides as potassium channel openers |
| PL213103B1 (pl) * | 2000-08-14 | 2013-01-31 | Ortho Mcneil Pharm Inc | Podstawiona pochodna pirazolu, jej zastosowanie i zawierajaca ja kompozycja farmaceutyczna |
| US6855829B2 (en) | 2001-02-20 | 2005-02-15 | Bristol-Myers Squibb Company | 3-fluoro-2-oxindole modulators of KCNQ potassium channels and use thereof in treating migraine and mechanistically related disease |
| HUP0303841A2 (hu) * | 2001-02-20 | 2004-03-01 | Bristol-Myers Squibb Company | 2,4-Diszubsztituált-5-pirimidinkarboxamid-származékok mint KCNQ káliumcsatorna modulátorok és ezeket tartalmazó gyógyszerkészítmények és előállításuk |
| US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| JP2004526756A (ja) | 2001-04-06 | 2004-09-02 | スミスクライン ビーチャム コーポレーション | ｈＹＡＫ１及びｈＹＡＫ３キナーゼのキノリン阻害剤 |
| US20040110947A1 (en) | 2002-09-17 | 2004-06-10 | Pharmacia Corporation | Aromatic liver X-receptor modulators |
| CA2505195C (en) | 2002-12-23 | 2012-07-10 | Icagen, Inc. | Quinazolinones as potassium channel modulators |
| EP1449841A1 (en) | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | New fungicidal compounds |
| US7598412B2 (en) * | 2003-10-08 | 2009-10-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| JP4054369B2 (ja) * | 2004-05-04 | 2008-02-27 | ファイザー株式会社 | オルト置換アリールまたはヘテロアリールアミド化合物 |
| EP1814856A1 (en) | 2004-11-12 | 2007-08-08 | Galapagos N.V. | Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes |
| WO2006092143A1 (en) | 2005-03-03 | 2006-09-08 | H. Lundbeck A/S | Substituted pyridine derivatives |
| DE602006007012D1 (de) | 2005-07-20 | 2009-07-09 | Lilly Co Eli | Pyridinderivate als dipeptedyl-peptidase-hemmer |
| US7670416B2 (en) * | 2005-08-04 | 2010-03-02 | I-Tech Ab | Use of a combination of substances to prevent biofouling organisms |
| WO2007030582A2 (en) | 2005-09-09 | 2007-03-15 | Bristol-Myers Squibb Company | Acyclic ikur inhibitors |
| WO2007057447A1 (en) | 2005-11-18 | 2007-05-24 | Neurosearch A/S | Novel quinazoline derivatives and their medical use |
| DE602007004638D1 (de) | 2006-07-20 | 2010-03-18 | Amgen Inc | Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin |
| CA2658190C (en) | 2006-07-20 | 2013-01-29 | Amgen Inc. | Di-amino-substituted heterocyclic compounds and methods of use |
| WO2008012532A2 (en) | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
| US20080039542A1 (en) * | 2006-08-11 | 2008-02-14 | General Electric Company | Composition and associated method |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
| DE102007044277A1 (de) * | 2007-09-17 | 2009-03-19 | Grünenthal GmbH | Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln |
| CA2702469A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Ccr10 antagonists |
| US8367700B2 (en) | 2008-12-17 | 2013-02-05 | Gruenenthal Gmbh | Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators |
| MX2011008825A (es) | 2009-03-10 | 2011-09-21 | Gruenenthal Gmbh | 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3. |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| TW201211007A (en) | 2010-08-27 | 2012-03-16 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
| US8445512B2 (en) | 2010-08-27 | 2013-05-21 | Gruenenthal Gmbh | Substituted quinoline-3-carboxamides as KCNQ2/3 modulators |
-
2010
- 2010-02-26 TW TW099105569A patent/TWI475020B/zh not_active IP Right Cessation
- 2010-03-10 US US12/720,894 patent/US8178684B2/en not_active Expired - Fee Related
- 2010-03-11 EP EP10708139.0A patent/EP2406226B1/de not_active Not-in-force
- 2010-03-11 HR HRP20151260TT patent/HRP20151260T1/hr unknown
- 2010-03-11 RU RU2011141186/04A patent/RU2529904C2/ru not_active IP Right Cessation
- 2010-03-11 AU AU2010223511A patent/AU2010223511B2/en not_active Ceased
- 2010-03-11 SI SI201031053T patent/SI2406226T1/sl unknown
- 2010-03-11 DK DK10708139.0T patent/DK2406226T3/en active
- 2010-03-11 PE PE2011001566A patent/PE20120780A1/es not_active Application Discontinuation
- 2010-03-11 BR BRPI1008948A patent/BRPI1008948A2/pt not_active IP Right Cessation
- 2010-03-11 PT PT107081390T patent/PT2406226E/pt unknown
- 2010-03-11 CA CA2754998A patent/CA2754998C/en not_active Expired - Fee Related
- 2010-03-11 WO PCT/EP2010/001507 patent/WO2010102809A1/de not_active Ceased
- 2010-03-11 PL PL10708139T patent/PL2406226T3/pl unknown
- 2010-03-11 JP JP2011553350A patent/JP5670359B2/ja not_active Expired - Fee Related
- 2010-03-11 CN CN201080011221.9A patent/CN102369188B/zh not_active Expired - Fee Related
- 2010-03-11 HU HUE10708139A patent/HUE026170T2/en unknown
- 2010-03-11 NZ NZ595628A patent/NZ595628A/xx not_active IP Right Cessation
- 2010-03-11 KR KR1020117023798A patent/KR20110132592A/ko not_active Abandoned
- 2010-03-11 ES ES10708139.0T patent/ES2556772T3/es active Active
- 2010-03-11 MX MX2011009127A patent/MX2011009127A/es active IP Right Grant
- 2010-03-12 AR ARP100100778A patent/AR075540A1/es unknown
-
2011
- 2011-08-17 CO CO11104403A patent/CO6410303A2/es active IP Right Grant
- 2011-09-04 IL IL214946A patent/IL214946A/en not_active IP Right Cessation
- 2011-09-23 EC EC2011011347A patent/ECSP11011347A/es unknown
- 2011-10-11 ZA ZA2011/07442A patent/ZA201107442B/en unknown
-
2012
- 2012-03-30 US US13/434,915 patent/US8586755B2/en not_active Expired - Fee Related
-
2015
- 2015-10-09 CY CY20151100914T patent/CY1116787T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1116787T1 (el) | Υποκατεστημενα νικοτιναμιδια σαν διαμορφωτες kcnq2/3 | |
| CY1112465T1 (el) | Παραγωγα αμινοτριαζολης ως αγωνιστες alx | |
| CY1124000T1 (el) | Υποκατεστημενες 5-φθορο-1η-πυραζολοπυριδινες σε κρυσταλλικη μορφη | |
| GB201208793D0 (en) | Optoelectronic device | |
| CY1119134T1 (el) | Υποδοχεις της νεπριλυσινης | |
| CY1115945T1 (el) | Παραγωγα πυραζολοκινολινονης, η παρασκευη τους και η θεραπευτικη τους χρηση | |
| CY1110962T1 (el) | Τρικυκλικες ενωσεις και η χρηση τους ως διαμορφωτες του υποδοχεα γλυκοκορτικοειδων | |
| CO6491116A2 (es) | Derivados de 5-fluoropirimidinona | |
| EP2900665A4 (en) | TRIAZOLYL DERIVATIVES AS SYK-HEMMER | |
| CY1115585T1 (el) | Κρυσταλλικες μορφες του αλατος του νατριου της 5-αμινο-2,3-διυδροφθαλαζιν-1,4-διονης, οι οποιες περιεχουν φαρμακευτικα σκευασματα και διαδικασιες για την παρασκευη τους | |
| CY1118681T1 (el) | Αναστολεις νεπριλυσινης | |
| CY1115744T1 (el) | Παραγωγο σπειροϊμιδαζολονης | |
| EA201170884A1 (ru) | Производные пиперидина, пригодные в качестве антагонистов орексина | |
| ECSP13012788A (es) | Derivados de biciclo[3,2,1]octilamida y sus usos | |
| PL4517749T3 (pl) | Transpozycja harmonicznych rozszerzona o iloczyn wektorowy | |
| CY1110489T1 (el) | Παραγωγα ισοκινολινης | |
| BR112012030473A2 (pt) | pesticidas baseados em derivados pirrolidina espiroheterocíclicos | |
| EP2863914A4 (en) | PYRAZOLYL DERIVATIVES AS SYK-HEMMER | |
| BR112012032244A2 (pt) | processo para preparar derivados de antranilamida com tetrazole-substituído e polimorfos cristalinos novos e derivados destes | |
| EP2320737A4 (en) | PYRAZOLO- [1,5-A] -PYRIDINE AS MARK HEMMER | |
| BR112015006573A2 (pt) | derivados de 3-fenilisoxazolina com ação herbicida | |
| CY1112520T1 (el) | Βενζυλαμινες, μια διαδικασια για την παραγωγη τους και η χρηση τους ως αντι-φλεγμονωδεις παραγοντες | |
| CY1115800T1 (el) | Παραγωγα της 3-(ετεροαρυλο-αμινο)-1,2,3,4-τετραϋδρo-9η-καρβαζολης και η χρηση τους ως ρυθμιστες των υποδοχεων της προσταγλανδινης d2 | |
| EP2654748A4 (en) | INDAZONE DERIVATIVES AS ERK HEMMER | |
| CY1119040T1 (el) | Μεθοδος για την παρασκευη 1-([1,3]διοξολαν-4-υλομεθυλο)-1η-πυραζολ-3-υλαμινης |