CY1116505T1 - Μεθοδοι δημιουργιας ενωσεων και ενδιαμεσων προϊοντων προφαρμακων αναστολης προσκολλησης toy hiv - Google Patents

Μεθοδοι δημιουργιας ενωσεων και ενδιαμεσων προϊοντων προφαρμακων αναστολης προσκολλησης toy hiv

Info

Publication number
CY1116505T1
CY1116505T1 CY20151100631T CY151100631T CY1116505T1 CY 1116505 T1 CY1116505 T1 CY 1116505T1 CY 20151100631 T CY20151100631 T CY 20151100631T CY 151100631 T CY151100631 T CY 151100631T CY 1116505 T1 CY1116505 T1 CY 1116505T1
Authority
CY
Cyprus
Prior art keywords
products
methods
hiv
creating units
suspended toy
Prior art date
Application number
CY20151100631T
Other languages
English (en)
Inventor
Jonathan Clive Tripp
Dayne Dustan Fanfair
Mitchell J Schultz
Saravanababu Murugesan
Richard J Fox
Chung-Pin H Chen
Sabrina E Ivy
Joseph Francis Payack
Wendel W Doubleday
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1116505T1 publication Critical patent/CY1116505T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Στο παρόν ορίζεται μέθοδος για τη δημιουργία της ένωσης του χημικού τύπου (I), χρησιμοποιώντας διαδικασίες αλκυλίωσης, αμιδίωσης, χλωρίωσης και εγκατάστασης φωσφορικού.
CY20151100631T 2011-01-31 2015-07-17 Μεθοδοι δημιουργιας ενωσεων και ενδιαμεσων προϊοντων προφαρμακων αναστολης προσκολλησης toy hiv CY1116505T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437821P 2011-01-31 2011-01-31
EP20120704960 EP2670751B1 (en) 2011-01-31 2012-01-27 Methods of making hiv attachment inhibitor prodrug compound and intermediates

Publications (1)

Publication Number Publication Date
CY1116505T1 true CY1116505T1 (el) 2017-03-15

Family

ID=45688987

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100631T CY1116505T1 (el) 2011-01-31 2015-07-17 Μεθοδοι δημιουργιας ενωσεων και ενδιαμεσων προϊοντων προφαρμακων αναστολης προσκολλησης toy hiv

Country Status (25)

Country Link
US (1) US8436168B2 (el)
EP (1) EP2670751B1 (el)
JP (1) JP6006236B2 (el)
KR (1) KR101848533B1 (el)
CN (1) CN103339130B (el)
AR (1) AR085052A1 (el)
AU (1) AU2012212508B2 (el)
BR (1) BR112013018159A2 (el)
CA (1) CA2826260C (el)
CY (1) CY1116505T1 (el)
DK (1) DK2670751T3 (el)
EA (1) EA021726B1 (el)
ES (1) ES2539908T3 (el)
HR (1) HRP20150616T1 (el)
HU (1) HUE026880T2 (el)
IL (1) IL227302A (el)
MX (1) MX2013008371A (el)
PL (1) PL2670751T3 (el)
PT (1) PT2670751E (el)
RS (1) RS54055B1 (el)
SG (1) SG191841A1 (el)
SI (1) SI2670751T1 (el)
SM (1) SMT201500169B (el)
TW (1) TW201309692A (el)
WO (1) WO2012106189A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
WO2010085456A1 (en) 2009-01-20 2010-07-29 Guided Delivery Systems Inc. Anchor deployment devices and related methods
CA2864087A1 (en) 2012-02-08 2013-08-15 Bristol-Myers Squibb Company Methods for the preparation of hiv attachment inhibitor piperazine prodrug compound
US10546661B2 (en) * 2014-06-23 2020-01-28 Free Form Fibers, Llc Additive manufacturing technique for placing nuclear reactor fuel within fibers
AU2015364600B2 (en) 2014-12-18 2018-05-10 ViiV Healthcare UK (No.4) Limited A process for preparing halogenated azaindole compounds using boroxine
AU2015364535A1 (en) 2014-12-18 2017-07-06 Viiv Healthcare Uk (No. 4) Limited A process for preparing halogenated azaindole compounds using PyBroP
WO2016141358A1 (en) * 2015-03-05 2016-09-09 Guided Delivery Systems Inc. Devices and methods of visualizing and determining depth of penetration in cardiac tissue
EP3911651B1 (en) 2019-01-17 2024-01-10 ViiV Healthcare UK (No.4) Limited Process for preparing fostemsavir

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US7776863B2 (en) 2004-03-24 2010-08-17 Bristol-Myers Squibb Company Methods of treating HIV infection
US7601715B2 (en) * 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine

Also Published As

Publication number Publication date
EP2670751A1 (en) 2013-12-11
EA201391123A1 (ru) 2013-12-30
EP2670751B1 (en) 2015-04-22
SG191841A1 (en) 2013-08-30
CA2826260A1 (en) 2012-08-09
AU2012212508A1 (en) 2013-09-19
JP6006236B2 (ja) 2016-10-12
DK2670751T3 (en) 2015-07-20
CN103339130B (zh) 2015-05-06
RS54055B1 (en) 2015-10-30
SI2670751T1 (sl) 2015-07-31
MX2013008371A (es) 2013-08-12
WO2012106189A1 (en) 2012-08-09
TW201309692A (zh) 2013-03-01
HRP20150616T1 (hr) 2015-07-03
IL227302A0 (en) 2013-09-30
AU2012212508B2 (en) 2016-01-14
HUE026880T2 (en) 2016-08-29
BR112013018159A2 (pt) 2018-09-11
JP2014503594A (ja) 2014-02-13
IL227302A (en) 2016-10-31
CN103339130A (zh) 2013-10-02
SMT201500169B (it) 2015-09-07
CA2826260C (en) 2018-09-04
EA021726B1 (ru) 2015-08-31
PT2670751E (pt) 2015-07-29
KR101848533B1 (ko) 2018-04-12
ES2539908T3 (es) 2015-07-07
US20130030178A1 (en) 2013-01-31
US8436168B2 (en) 2013-05-07
AR085052A1 (es) 2013-08-07
PL2670751T3 (pl) 2015-09-30
KR20140014154A (ko) 2014-02-05

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