CY1116486T1 - Βελτιωμενο συστημα εκφρασης ανθρωπινης μακρας πεντραξινης 3 και χρησεις αυτης - Google Patents

Βελτιωμενο συστημα εκφρασης ανθρωπινης μακρας πεντραξινης 3 και χρησεις αυτης

Info

Publication number
CY1116486T1
CY1116486T1 CY20131100942T CY131100942T CY1116486T1 CY 1116486 T1 CY1116486 T1 CY 1116486T1 CY 20131100942 T CY20131100942 T CY 20131100942T CY 131100942 T CY131100942 T CY 131100942T CY 1116486 T1 CY1116486 T1 CY 1116486T1
Authority
CY
Cyprus
Prior art keywords
long pentraxin
expression system
human long
improved human
nucleotide sequence
Prior art date
Application number
CY20131100942T
Other languages
English (en)
Inventor
Marica Sassano
Adelaide Esposito
Vincenzo Rivieccio
Giovanni Cassani
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of CY1116486T1 publication Critical patent/CY1116486T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε έναν ευκαρυωτικό φορέα έκφρασης που περιλαμβάνει μια αλληλουχία νουκλεοτιδίων για την ανθρώπινη πρωτεΐνη μακρά πεντραξίνη ΡΤΧ3 υπό τον έλεγχο ενός δραστικού εκκινητή και μια αλληλουχία νουκλεοτιδίων για έναν επιλέξιμο δείκτη, που κωδικοποιούν ανασυνδυαζόμενο ανθρώπινο κύτταρο ικανό να παρέχει έκφραση πρωτεϊνών που κωδικοποιούνται από το φορέα και μέθοδο για την παραγωγή της ανθρώπινης πρωτεΐνης μακράς πεντραξίνης ΡΤΧ3.
CY20131100942T 2009-07-29 2013-10-25 Βελτιωμενο συστημα εκφρασης ανθρωπινης μακρας πεντραξινης 3 και χρησεις αυτης CY1116486T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09166759 2009-07-29
EP10740573.0A EP2459721B1 (en) 2009-07-29 2010-07-20 Improved human long pentraxin 3 expression system and uses thereof

Publications (1)

Publication Number Publication Date
CY1116486T1 true CY1116486T1 (el) 2017-03-15

Family

ID=41120115

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100942T CY1116486T1 (el) 2009-07-29 2013-10-25 Βελτιωμενο συστημα εκφρασης ανθρωπινης μακρας πεντραξινης 3 και χρησεις αυτης

Country Status (23)

Country Link
US (1) US8883446B2 (el)
EP (1) EP2459721B1 (el)
JP (1) JP5859963B2 (el)
KR (1) KR101767695B1 (el)
CN (1) CN102549160B (el)
AU (1) AU2010277786B2 (el)
BR (1) BR112012001980A2 (el)
CA (1) CA2769257C (el)
CY (1) CY1116486T1 (el)
DK (1) DK2459721T3 (el)
EA (1) EA023191B1 (el)
ES (1) ES2432242T3 (el)
HK (1) HK1172649A1 (el)
HR (1) HRP20130947T1 (el)
IL (1) IL217696A (el)
ME (1) ME01566B (el)
MX (1) MX2012001109A (el)
PL (1) PL2459721T3 (el)
PT (1) PT2459721E (el)
RS (1) RS53006B (el)
SG (1) SG177756A1 (el)
SI (1) SI2459721T1 (el)
WO (1) WO2011012496A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10253321B2 (en) 2013-05-01 2019-04-09 Dna2.0, Inc. Methods, compositions and kits for a one-step DNA cloning system
US9206433B2 (en) * 2013-05-01 2015-12-08 Dna Twopointo, Inc. Methods, compositions and kits for a one-step DNA cloning system
TWI528969B (zh) * 2013-06-07 2016-04-11 國立成功大學 胺基酸序列用於製備抑制ｐｔｘ３治療鼻咽癌之醫藥組合物之用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1298487B1 (it) 1997-12-19 2000-01-10 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
US7192737B2 (en) * 2002-03-29 2007-03-20 Xoma Technology Ltd. Methods and materials for increasing expression of recombinant polypeptides
EP1832295A1 (en) * 2006-03-10 2007-09-12 Tecnogen S.P.A. Use of PTX3 for the treatment of viral diseases
WO2009095403A1 (en) * 2008-01-29 2009-08-06 Tecnogen S.P.A. Expression system and uses thereof for the production of human long pentraxin 3

Also Published As

Publication number Publication date
WO2011012496A1 (en) 2011-02-03
SI2459721T1 (sl) 2013-11-29
EA023191B1 (ru) 2016-05-31
US8883446B2 (en) 2014-11-11
DK2459721T3 (da) 2013-11-04
CA2769257A1 (en) 2011-02-03
SG177756A1 (en) 2012-02-28
HK1172649A1 (en) 2013-04-26
BR112012001980A2 (pt) 2015-09-01
EA201200198A1 (ru) 2012-06-29
AU2010277786A1 (en) 2012-03-01
MX2012001109A (es) 2012-03-26
PT2459721E (pt) 2013-10-31
HRP20130947T1 (hr) 2013-11-08
IL217696A (en) 2017-06-29
PL2459721T3 (pl) 2014-01-31
CA2769257C (en) 2017-12-05
CN102549160B (zh) 2014-04-02
AU2010277786B2 (en) 2016-04-14
EP2459721A1 (en) 2012-06-06
CN102549160A (zh) 2012-07-04
ES2432242T3 (es) 2013-12-02
JP2013504304A (ja) 2013-02-07
US20120301873A1 (en) 2012-11-29
KR20120047259A (ko) 2012-05-11
JP5859963B2 (ja) 2016-02-16
EP2459721B1 (en) 2013-09-18
RS53006B (en) 2014-04-30
KR101767695B1 (ko) 2017-08-11
ME01566B (me) 2014-09-20

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