CY1115582T1 - Νεα πρωτεϊνη υποδοχεα αιμοποιητινης, nr10 - Google Patents
Νεα πρωτεϊνη υποδοχεα αιμοποιητινης, nr10Info
- Publication number
- CY1115582T1 CY1115582T1 CY20141100484T CY141100484T CY1115582T1 CY 1115582 T1 CY1115582 T1 CY 1115582T1 CY 20141100484 T CY20141100484 T CY 20141100484T CY 141100484 T CY141100484 T CY 141100484T CY 1115582 T1 CY1115582 T1 CY 1115582T1
- Authority
- CY
- Cyprus
- Prior art keywords
- novel
- receptor
- hemopoietin
- receptors
- hematopoietic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Οι εφευρέτες πέτυχαν την απομόνωση ενός νέου γονίδιου υποδοχέα αιμοποιητίνης (NR10), χρησιμοποιώντας μια ακολουθία που προβλέπεται από το μοτίβο που έχει εξαχθεί και διατηρείται στις ακολουθίες αμινοξέων γνωστών υποδοχέων αιμοποιητίνης. Αναμένονταν ότι θα υπάρχουν δύο μορφές της NR10, μια διαμεμβράνιου τύπου και μια διαλυτή μορφή. Η έκφραση του προηγούμενου τύπου ανιχνεύθηκε στους ιστούς που περιέχουν τα αιμοποιητικά κύτταρα. Επομένως, η NR10 είναι ένα νέο μόριο υποδοχέα αιμοποιητίνης που εμπλέκεται στη ρύθμιση του ανοσοποιητικού συστήματος ή στην αιμοποίηση in vivo. Οι νέοι αυτοί υποδοχείς είναι χρήσιμοι στη διαδικασία διαλογής για νέους αιμοποιητικούς παράγοντες που έχουν την ικανότητα να δεσμεύονται λειτουργικά στον υποδοχέα ή στην ανάπτυξη φαρμάκων για την αντιμετώπιση ασθενειών σχετικών με το ανοσοποιητικό σύστημα ή το αιμοποιητικό σύστημα.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15579799 | 1999-06-02 | ||
JP21779799 | 1999-07-30 | ||
EP09012659.0A EP2135953B1 (en) | 1999-06-02 | 2000-06-01 | Novel hemopoietin receptor protein, Nr. 10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115582T1 true CY1115582T1 (el) | 2017-01-04 |
Family
ID=26483716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100484T CY1115582T1 (el) | 1999-06-02 | 2014-07-01 | Νεα πρωτεϊνη υποδοχεα αιμοποιητινης, nr10 |
Country Status (11)
Country | Link |
---|---|
US (6) | US7482440B2 (el) |
EP (3) | EP2325316B8 (el) |
JP (7) | JP2007111051A (el) |
AT (1) | ATE455852T1 (el) |
AU (1) | AU4952400A (el) |
CY (1) | CY1115582T1 (el) |
DE (1) | DE60043728D1 (el) |
DK (1) | DK1188830T3 (el) |
ES (1) | ES2339843T3 (el) |
PT (1) | PT1188830E (el) |
WO (1) | WO2000075314A1 (el) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2325316B8 (en) | 1999-06-02 | 2017-04-19 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, NR10 |
EP1221482B1 (en) * | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | Hemopoietin receptor protein, nr12 |
DK1325115T3 (en) * | 2000-06-26 | 2016-11-21 | Zymogenetics Inc | CYTOKINRECEPTOR ZCYTOR17 |
US20030096339A1 (en) | 2000-06-26 | 2003-05-22 | Sprecher Cindy A. | Cytokine receptor zcytor17 |
US7317075B2 (en) * | 2000-07-20 | 2008-01-08 | Genentech, Inc. | PRO21384 polypeptides |
US20030059871A1 (en) * | 2000-10-06 | 2003-03-27 | Cosman David J. | Hematopoietin receptors HPR1 and HPR2 |
WO2002077230A1 (fr) * | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
EP2338910B1 (en) | 2002-01-18 | 2015-07-08 | ZymoGenetics, Inc. | Cytokine receptor Zcytor17 multimers |
EP1961811B1 (en) | 2002-01-18 | 2010-08-25 | ZymoGenetics, Inc. | Cytokine ligand for the treatment of asthma and airway hyper-responsiveness |
US9738700B2 (en) | 2002-01-18 | 2017-08-22 | Zymogenetics Inc. | ZCYTOR17 heterodimeric cytokine receptor |
US20050255545A1 (en) * | 2002-02-01 | 2005-11-17 | Smith Timothy J | Regulation of human hematopoietin receptor-like protein |
CA2477249A1 (en) * | 2002-02-25 | 2003-09-04 | Genentech, Inc. | Novel type-1 cytokine receptor glm-r |
MX2007009718A (es) | 2005-02-14 | 2007-09-26 | Zymogenetics Inc | Metodos para tratar trastornos cutaneos utilizando un antagonista il-31ra. |
US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
EP2301969B1 (en) | 2005-05-06 | 2015-12-23 | ZymoGenetics, Inc. | IL-31 monoclonal antibodies and methods of use |
EP2001906A2 (en) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
DK3056568T3 (da) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik |
PE20080333A1 (es) * | 2006-06-08 | 2008-06-15 | Chugai Pharmaceutical Co Ltd | Agentes para prevenir o tratar enfermedades inflamatorias |
JP5334319B2 (ja) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Cdrのアミノ酸置換により抗体の等電点を改変する方法 |
SG193868A1 (en) | 2007-09-26 | 2013-10-30 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
CN101939424B (zh) | 2007-12-05 | 2016-12-28 | 中外制药株式会社 | 抗nr10抗体及其应用 |
RU2596397C2 (ru) | 2007-12-05 | 2016-09-10 | Чугаи Сейяку Кабусики Кайся | Терапевтическое средство от зуда |
ES2660036T3 (es) | 2007-12-07 | 2018-03-20 | Zymogenetics, Inc. | Moléculas de anticuerpo humanizadas específicas para IL-31 |
EP3521311A1 (en) | 2008-04-11 | 2019-08-07 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
CN102257635A (zh) * | 2008-10-23 | 2011-11-23 | 奥塔装置公司 | 光伏器件的薄吸收层 |
JP5139517B2 (ja) * | 2008-12-05 | 2013-02-06 | 中外製薬株式会社 | 抗nr10抗体、およびその利用 |
KR20160062207A (ko) * | 2008-12-05 | 2016-06-01 | 추가이 세이야쿠 가부시키가이샤 | 항nr10 항체 및 그의 이용 |
JP2010210772A (ja) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
TWI544077B (zh) | 2009-03-19 | 2016-08-01 | Chugai Pharmaceutical Co Ltd | Antibody constant region change body |
RU2642318C2 (ru) | 2010-11-30 | 2018-01-24 | Чугаи Сейяку Кабусики Кайся | Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул |
RU2749512C2 (ru) | 2015-04-14 | 2021-06-11 | Чугаи Сейяку Кабусики Кайся | Фармацевтическая композиция для профилактики и/или лечения атопического дерматита, включающая антагонист ил-31 в качестве активного ингредиента |
AU2019219608A1 (en) | 2018-02-09 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Nemolizumab in the treatment of atopic dermatitis with moderate to severe excoriation |
US11236157B2 (en) | 2019-01-28 | 2022-02-01 | Galderma Holding SA | Treatment of skin lesions and pruritus in prurigo nodularis patients |
CA3156713A1 (en) | 2019-11-20 | 2021-05-27 | Daisuke Kameoka | Antibody-containing preparation |
US20230391878A1 (en) | 2020-09-01 | 2023-12-07 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for prevention and/or treatment of dialysis pruritus containing il-31 antagonist as active ingredient |
TW202304510A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商葛德瑪控股公司 | 結節性癢疹之治療 |
AU2022337073A1 (en) | 2021-08-30 | 2024-04-11 | Chugai Seiyaku Kabushiki Kaisha | Treatments for atopic dermatitis |
WO2024047497A1 (en) | 2022-09-02 | 2024-03-07 | Galderma Holding SA | Treatments for prurigo nodularis |
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EP0239102A3 (en) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Process for the formation of human-human hybridoma |
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AUPN564195A0 (en) * | 1995-09-26 | 1995-10-19 | Walter And Eliza Hall Institute Of Medical Research, The | A novel haemopoietin receptor and genetic sequences encoding same |
CA2238080C (en) * | 1995-10-23 | 2012-03-13 | Amrad Operations Pty. Ltd. | A novel haemopoietin receptor and genetic sequences encoding same |
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US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
CA2330547A1 (en) | 1998-06-24 | 1999-12-29 | Chugai Research Institute For Molecular Medicine, Inc. | Novel hemopoietin receptor proteins |
DE60041697D1 (de) | 1999-06-01 | 2009-04-16 | Schering Corp | Säugetier-rezeptorproteine; ähnliche reagentien und methoden |
US20030082734A1 (en) | 1999-06-01 | 2003-05-01 | Dowling Lynette M. | Mammalian receptor proteins; related reagents and methods |
EP2325316B8 (en) | 1999-06-02 | 2017-04-19 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, NR10 |
EP1221482B1 (en) | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | Hemopoietin receptor protein, nr12 |
CZ304022B6 (cs) | 2000-05-10 | 2013-08-28 | Merck Sharp & Dohme Corp. | Savcí receptorové proteiny, cinidla a metody, které se jich týkají |
DK1325115T3 (en) | 2000-06-26 | 2016-11-21 | Zymogenetics Inc | CYTOKINRECEPTOR ZCYTOR17 |
US20030059871A1 (en) | 2000-10-06 | 2003-03-27 | Cosman David J. | Hematopoietin receptors HPR1 and HPR2 |
WO2002077230A1 (fr) | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
EP2338910B1 (en) | 2002-01-18 | 2015-07-08 | ZymoGenetics, Inc. | Cytokine receptor Zcytor17 multimers |
EP1961811B1 (en) | 2002-01-18 | 2010-08-25 | ZymoGenetics, Inc. | Cytokine ligand for the treatment of asthma and airway hyper-responsiveness |
CA2477249A1 (en) | 2002-02-25 | 2003-09-04 | Genentech, Inc. | Novel type-1 cytokine receptor glm-r |
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AU2003225256B2 (en) | 2002-05-01 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants |
EP1671642A1 (en) | 2004-12-15 | 2006-06-21 | Universite D'angers | Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof. |
WO2006081573A2 (en) | 2005-01-28 | 2006-08-03 | Zymogenetics, Inc. | Homogeneous preparations of il-31 |
EP1856539B1 (en) | 2005-02-14 | 2015-10-21 | ZymoGenetics, Inc. | Methods of predicting therapeutic response in atopic dermatitis to il-31 antagonists |
MX2007009718A (es) | 2005-02-14 | 2007-09-26 | Zymogenetics Inc | Metodos para tratar trastornos cutaneos utilizando un antagonista il-31ra. |
EP2301969B1 (en) | 2005-05-06 | 2015-12-23 | ZymoGenetics, Inc. | IL-31 monoclonal antibodies and methods of use |
EP2001906A2 (en) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
PE20080333A1 (es) | 2006-06-08 | 2008-06-15 | Chugai Pharmaceutical Co Ltd | Agentes para prevenir o tratar enfermedades inflamatorias |
-
2000
- 2000-06-01 EP EP10180785.7A patent/EP2325316B8/en not_active Expired - Lifetime
- 2000-06-01 DK DK00931646.4T patent/DK1188830T3/da active
- 2000-06-01 AU AU49524/00A patent/AU4952400A/en not_active Abandoned
- 2000-06-01 AT AT00931646T patent/ATE455852T1/de active
- 2000-06-01 WO PCT/JP2000/003556 patent/WO2000075314A1/ja active Application Filing
- 2000-06-01 DE DE60043728T patent/DE60043728D1/de not_active Expired - Lifetime
- 2000-06-01 ES ES00931646T patent/ES2339843T3/es not_active Expired - Lifetime
- 2000-06-01 EP EP09012659.0A patent/EP2135953B1/en not_active Expired - Lifetime
- 2000-06-01 EP EP00931646A patent/EP1188830B1/en not_active Expired - Lifetime
- 2000-06-01 PT PT00931646T patent/PT1188830E/pt unknown
-
2001
- 2001-12-03 US US10/006,265 patent/US7482440B2/en not_active Expired - Lifetime
-
2006
- 2006-10-25 JP JP2006289770A patent/JP2007111051A/ja not_active Withdrawn
-
2007
- 2007-10-30 US US11/980,117 patent/US8017731B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/980,135 patent/US8017738B2/en not_active Expired - Fee Related
-
2008
- 2008-10-17 US US12/253,506 patent/US8362223B2/en not_active Expired - Lifetime
- 2008-12-25 JP JP2008330001A patent/JP5634674B2/ja not_active Expired - Lifetime
-
2012
- 2012-02-02 JP JP2012020720A patent/JP2012147784A/ja not_active Withdrawn
- 2012-12-19 US US13/719,926 patent/US20130115620A1/en not_active Abandoned
-
2014
- 2014-02-28 JP JP2014038789A patent/JP2014168462A/ja not_active Withdrawn
- 2014-07-01 CY CY20141100484T patent/CY1115582T1/el unknown
-
2015
- 2015-07-21 JP JP2015143712A patent/JP2016000042A/ja not_active Withdrawn
-
2017
- 2017-09-15 US US15/705,720 patent/US20180002396A1/en not_active Abandoned
- 2017-10-03 JP JP2017193306A patent/JP2018033461A/ja not_active Withdrawn
-
2019
- 2019-10-30 JP JP2019197183A patent/JP2020036596A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2339843T3 (es) | 2010-05-26 |
US8017738B2 (en) | 2011-09-13 |
EP2135953B1 (en) | 2014-04-23 |
PT1188830E (pt) | 2010-04-09 |
US8362223B2 (en) | 2013-01-29 |
US20180002396A1 (en) | 2018-01-04 |
JP2016000042A (ja) | 2016-01-07 |
EP1188830B1 (en) | 2010-01-20 |
US20100016552A1 (en) | 2010-01-21 |
EP2325316B8 (en) | 2017-04-19 |
US8017731B2 (en) | 2011-09-13 |
ATE455852T1 (de) | 2010-02-15 |
JP2012147784A (ja) | 2012-08-09 |
JP2007111051A (ja) | 2007-05-10 |
JP5634674B2 (ja) | 2014-12-03 |
US20030125520A1 (en) | 2003-07-03 |
DK1188830T3 (da) | 2010-04-26 |
JP2018033461A (ja) | 2018-03-08 |
EP2325316B1 (en) | 2016-09-07 |
JP2014168462A (ja) | 2014-09-18 |
DE60043728D1 (de) | 2010-03-11 |
US20130115620A1 (en) | 2013-05-09 |
JP2009137978A (ja) | 2009-06-25 |
JP2020036596A (ja) | 2020-03-12 |
US7482440B2 (en) | 2009-01-27 |
US20100240145A1 (en) | 2010-09-23 |
EP2135953A1 (en) | 2009-12-23 |
EP1188830A1 (en) | 2002-03-20 |
EP2325316A1 (en) | 2011-05-25 |
EP1188830A4 (en) | 2005-02-09 |
AU4952400A (en) | 2000-12-28 |
WO2000075314A1 (fr) | 2000-12-14 |
US20100240096A1 (en) | 2010-09-23 |
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