CY1115077T1 - Κρυσταλλικες μορφες της ενωσης του 8-αζαδικυκλο[3.2.1]οκτανιου - Google Patents

Κρυσταλλικες μορφες της ενωσης του 8-αζαδικυκλο[3.2.1]οκτανιου

Info

Publication number
CY1115077T1
CY1115077T1 CY20131100293T CY131100293T CY1115077T1 CY 1115077 T1 CY1115077 T1 CY 1115077T1 CY 20131100293 T CY20131100293 T CY 20131100293T CY 131100293 T CY131100293 T CY 131100293T CY 1115077 T1 CY1115077 T1 CY 1115077T1
Authority
CY
Cyprus
Prior art keywords
azadicylic
octane
union
crystal forms
crystalline
Prior art date
Application number
CY20131100293T
Other languages
English (en)
Inventor
Sean Dalziel
Leticia M Preza
Miroslav Rapta
Pierre-Jean Colson
Original Assignee
Theravance, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39620376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1115077(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance, Inc. filed Critical Theravance, Inc.
Publication of CY1115077T1 publication Critical patent/CY1115077T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η εφεύρεση παρέχει ένα κρυσταλλικό θειικό άλας του 3-ενδο-(8-{2-[κυκλοεξυλομεθυλο-((S)-2,3-διϋδροξυ-προπιονυλ)αμινο]αιθυλο}-8-αζα-δικυκλο[3.2.1]οκτ-3-υλο)βενζαμιδίου ή ένα επιδιαλυτωμένο άλας αυτού. Η εφεύρεση παρέχει επίσης φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες κρυσταλλικές αλατούχες μορφές, μεθόδους χρήσης τέτοιων κρυσταλλικών αλατούχων μορφών για την αντιμετώπιση νόσων που σχετίζονται με τη δραστικότητα των μ-οπιοειδών υποδοχέων και διεργασίες χρήσιμες για την παρασκευή τέτοιων κρυσταλλικών αλατούχων μορφών.
CY20131100293T 2007-02-28 2013-04-08 Κρυσταλλικες μορφες της ενωσης του 8-αζαδικυκλο[3.2.1]οκτανιου CY1115077T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90409007P 2007-02-28 2007-02-28
EP08726162A EP2132204B1 (en) 2007-02-28 2008-02-27 Crystalline forms of an 8-azabicyclo[3.2.1]octane compound

Publications (1)

Publication Number Publication Date
CY1115077T1 true CY1115077T1 (el) 2016-12-14

Family

ID=39620376

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100293T CY1115077T1 (el) 2007-02-28 2013-04-08 Κρυσταλλικες μορφες της ενωσης του 8-αζαδικυκλο[3.2.1]οκτανιου

Country Status (27)

Country Link
US (7) US7943772B2 (el)
EP (1) EP2132204B1 (el)
JP (2) JP5512289B2 (el)
KR (1) KR101480530B1 (el)
CN (1) CN101616916B (el)
AR (2) AR065554A1 (el)
AU (1) AU2008219615B2 (el)
BR (1) BRPI0807974B8 (el)
CA (1) CA2678073C (el)
CL (1) CL2008000573A1 (el)
CO (1) CO6220856A2 (el)
CY (1) CY1115077T1 (el)
DK (1) DK2132204T3 (el)
ES (1) ES2402031T3 (el)
HK (1) HK1139399A1 (el)
HR (1) HRP20130193T1 (el)
IL (1) IL200131A (el)
MX (1) MX2009009141A (el)
MY (1) MY148318A (el)
NZ (1) NZ578871A (el)
PL (1) PL2132204T3 (el)
PT (1) PT2132204E (el)
RU (1) RU2458061C2 (el)
SI (1) SI2132204T1 (el)
TW (1) TWI409067B (el)
WO (1) WO2008106159A1 (el)
ZA (1) ZA200905832B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
US7691878B2 (en) * 2007-08-27 2010-04-06 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029252A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
US7947710B2 (en) * 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2011035142A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of opioid receptor antagonist for gastrointestinal tract disorders
KR20170132325A (ko) * 2015-04-02 2017-12-01 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 뮤 오피오이드 수용체 길항제 및 오피오이드 제제의 조합 제형

Family Cites Families (21)

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US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
GB9810671D0 (en) * 1998-05-18 1998-07-15 Pfizer Ltd Anti-pruritic agents
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6469030B2 (en) * 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
US6467084B1 (en) * 1999-12-16 2002-10-15 Emware, Inc. Systems and methods for reprogramming an embedded device with program code using relocatable program code
KR20030009376A (ko) 2000-03-03 2003-01-29 오르토-맥네일 파마슈티칼, 인코퍼레이티드 3-(디아릴메틸렌)-8-아자비사이클로[3.2.1]옥탄 유도체
US20020025948A1 (en) * 2000-06-23 2002-02-28 Banks Bernard Joseph 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
SI1440059T1 (sl) * 2001-10-22 2008-08-31 Pfizer Prod Inc Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja
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US7056930B2 (en) * 2003-04-14 2006-06-06 Pfizer Inc. 2-Azabicyclo[3.3.1]nonane derivatives
US20040204453A1 (en) * 2003-04-14 2004-10-14 Pfizer Inc 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
MXPA05011163A (es) 2003-04-15 2005-12-14 Pfizer Prod Inc Derivados de 3-benzhidriliden-8-azabiciclo[3.2.1]octano con actividad de receptores opioides.
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
US7435822B2 (en) 2004-02-03 2008-10-14 Janssen Pharmaceutica N.V. 3-(diheteroarylmethylene)-8-azabicyclo[3.2.1]octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane derivatives
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
JP2010509227A (ja) 2006-11-07 2010-03-25 ネクター セラピューティックス エイエル，コーポレイション オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型

Also Published As

Publication number Publication date
KR101480530B1 (ko) 2015-01-08
US20150073014A1 (en) 2015-03-12
EP2132204A1 (en) 2009-12-16
US8816091B2 (en) 2014-08-26
US10426766B2 (en) 2019-10-01
BRPI0807974A2 (pt) 2014-09-16
BRPI0807974B1 (pt) 2020-11-24
MY148318A (en) 2013-03-29
US7943772B2 (en) 2011-05-17
DK2132204T3 (da) 2013-04-29
JP5512289B2 (ja) 2014-06-04
AU2008219615A1 (en) 2008-09-04
CN101616916A (zh) 2009-12-30
WO2008106159A1 (en) 2008-09-04
US20160287572A1 (en) 2016-10-06
JP2013151564A (ja) 2013-08-08
PL2132204T3 (pl) 2013-06-28
SI2132204T1 (sl) 2013-05-31
US8536335B2 (en) 2013-09-17
CA2678073C (en) 2016-01-05
NZ578871A (en) 2012-01-12
CN101616916B (zh) 2011-10-12
PT2132204E (pt) 2013-03-25
RU2009135834A (ru) 2011-04-10
CO6220856A2 (es) 2010-11-19
US20140080856A1 (en) 2014-03-20
US8247555B2 (en) 2012-08-21
HK1139399A1 (el) 2010-09-17
JP2010520198A (ja) 2010-06-10
ES2402031T3 (es) 2013-04-26
BRPI0807974B8 (pt) 2021-05-25
AR065554A1 (es) 2009-06-17
US20180200246A1 (en) 2018-07-19
TWI409067B (zh) 2013-09-21
US20130072515A1 (en) 2013-03-21
KR20090115767A (ko) 2009-11-05
US20080207676A1 (en) 2008-08-28
HRP20130193T1 (hr) 2013-03-31
TW200845984A (en) 2008-12-01
US20110184008A1 (en) 2011-07-28
IL200131A0 (en) 2010-04-15
IL200131A (en) 2013-03-24
AU2008219615B2 (en) 2013-05-09
CA2678073A1 (en) 2008-09-04
EP2132204B1 (en) 2013-01-23
AR109224A2 (es) 2018-11-07
US9290491B2 (en) 2016-03-22
MX2009009141A (es) 2009-09-03
US9949963B2 (en) 2018-04-24
CL2008000573A1 (es) 2008-05-16
RU2458061C2 (ru) 2012-08-10
ZA200905832B (en) 2010-05-26

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