PT2132204E - Formas cristalinas de um composto de 8-azabiciclo[3.2.1]octano - Google Patents

Formas cristalinas de um composto de 8-azabiciclo[3.2.1]octano

Info

Publication number
PT2132204E
PT2132204E PT87261624T PT08726162T PT2132204E PT 2132204 E PT2132204 E PT 2132204E PT 87261624 T PT87261624 T PT 87261624T PT 08726162 T PT08726162 T PT 08726162T PT 2132204 E PT2132204 E PT 2132204E
Authority
PT
Portugal
Prior art keywords
azabicyclo
crystalline forms
octane compound
octane
compound
Prior art date
Application number
PT87261624T
Other languages
English (en)
Inventor
Miroslav Rapta
Pierre-Jean Colson
Leticia M Preza
Sean Dalziel
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39620376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2132204(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of PT2132204E publication Critical patent/PT2132204E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT87261624T 2007-02-28 2008-02-27 Formas cristalinas de um composto de 8-azabiciclo[3.2.1]octano PT2132204E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90409007P 2007-02-28 2007-02-28

Publications (1)

Publication Number Publication Date
PT2132204E true PT2132204E (pt) 2013-03-25

Family

ID=39620376

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87261624T PT2132204E (pt) 2007-02-28 2008-02-27 Formas cristalinas de um composto de 8-azabiciclo[3.2.1]octano

Country Status (27)

Country Link
US (7) US7943772B2 (pt)
EP (1) EP2132204B1 (pt)
JP (2) JP5512289B2 (pt)
KR (1) KR101480530B1 (pt)
CN (1) CN101616916B (pt)
AR (2) AR065554A1 (pt)
AU (1) AU2008219615B2 (pt)
BR (1) BRPI0807974B8 (pt)
CA (1) CA2678073C (pt)
CL (1) CL2008000573A1 (pt)
CO (1) CO6220856A2 (pt)
CY (1) CY1115077T1 (pt)
DK (1) DK2132204T3 (pt)
ES (1) ES2402031T3 (pt)
HK (1) HK1139399A1 (pt)
HR (1) HRP20130193T1 (pt)
IL (1) IL200131A (pt)
MX (1) MX2009009141A (pt)
MY (1) MY148318A (pt)
NZ (1) NZ578871A (pt)
PL (1) PL2132204T3 (pt)
PT (1) PT2132204E (pt)
RU (1) RU2458061C2 (pt)
SI (1) SI2132204T1 (pt)
TW (1) TWI409067B (pt)
WO (1) WO2008106159A1 (pt)
ZA (1) ZA200905832B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
ES2390195T3 (es) * 2007-08-27 2012-11-07 Theravance, Inc. Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
DE602008005771D1 (de) * 2007-08-27 2011-05-05 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
EP2195313B1 (en) * 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
BR112012006069A8 (pt) * 2009-09-18 2017-10-10 Adolor Corp Método para tratar ou prevenir constipação induzida e disfunção intestinal induzida por opióide em um humano, e, uso de uma quantidade terapeuticamente efetiva de composto
CA2980328A1 (en) * 2015-04-02 2016-10-06 Theravance Biopharma R&D Ip, Llc Combination dosage form of a mu opioid receptor antagonist and an opioid agent

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
GB9810671D0 (en) * 1998-05-18 1998-07-15 Pfizer Ltd Anti-pruritic agents
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6469030B2 (en) * 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
US6467084B1 (en) * 1999-12-16 2002-10-15 Emware, Inc. Systems and methods for reprogramming an embedded device with program code using relocatable program code
US6552036B2 (en) 2000-03-03 2003-04-22 Ortho-Mcneil Pharmaceutical, Inc. 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
US20020025948A1 (en) * 2000-06-23 2002-02-28 Banks Bernard Joseph 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
DK1440059T3 (da) * 2001-10-22 2008-07-14 Pfizer Prod Inc 3-azabicyclo(3.1.0)hexanderivater som opioidreceptorantagonister
US7381721B2 (en) * 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
MXPA05011070A (es) * 2003-04-14 2005-12-12 Pfizer Prod Inc Derivados de 3-azabiciclo [3.2.1] octano.
US20040204453A1 (en) * 2003-04-14 2004-10-14 Pfizer Inc 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
US7056930B2 (en) 2003-04-14 2006-06-06 Pfizer Inc. 2-Azabicyclo[3.3.1]nonane derivatives
BRPI0409570A (pt) 2003-04-15 2006-04-18 Pfizer Prod Inc derivados de 3-benzidrilideno-8-aza-biciclo[3.2.1]octano com atividade receptora de opióides
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
EP1737853A1 (en) 2004-02-03 2007-01-03 Janssen Pharmaceutica N.V. 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
MX2009004965A (es) 2006-11-07 2009-06-05 Nektar Therapeutics Al Corp Formas de dosificacion y co-administracion de un agonista de opioides y un antagonista de opioides.
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型

Also Published As

Publication number Publication date
US20140080856A1 (en) 2014-03-20
ES2402031T3 (es) 2013-04-26
JP2013151564A (ja) 2013-08-08
CO6220856A2 (es) 2010-11-19
IL200131A (en) 2013-03-24
BRPI0807974A2 (pt) 2014-09-16
MY148318A (en) 2013-03-29
US9949963B2 (en) 2018-04-24
KR101480530B1 (ko) 2015-01-08
US20180200246A1 (en) 2018-07-19
SI2132204T1 (sl) 2013-05-31
CL2008000573A1 (es) 2008-05-16
MX2009009141A (es) 2009-09-03
AU2008219615B2 (en) 2013-05-09
CN101616916A (zh) 2009-12-30
AR065554A1 (es) 2009-06-17
US20080207676A1 (en) 2008-08-28
PL2132204T3 (pl) 2013-06-28
CA2678073C (en) 2016-01-05
ZA200905832B (en) 2010-05-26
AR109224A2 (es) 2018-11-07
NZ578871A (en) 2012-01-12
US8816091B2 (en) 2014-08-26
US10426766B2 (en) 2019-10-01
CY1115077T1 (el) 2016-12-14
EP2132204A1 (en) 2009-12-16
BRPI0807974B1 (pt) 2020-11-24
US7943772B2 (en) 2011-05-17
KR20090115767A (ko) 2009-11-05
RU2458061C2 (ru) 2012-08-10
JP5512289B2 (ja) 2014-06-04
JP2010520198A (ja) 2010-06-10
US20130072515A1 (en) 2013-03-21
BRPI0807974B8 (pt) 2021-05-25
WO2008106159A1 (en) 2008-09-04
US8247555B2 (en) 2012-08-21
TWI409067B (zh) 2013-09-21
US20160287572A1 (en) 2016-10-06
AU2008219615A1 (en) 2008-09-04
DK2132204T3 (da) 2013-04-29
RU2009135834A (ru) 2011-04-10
CA2678073A1 (en) 2008-09-04
US8536335B2 (en) 2013-09-17
US20150073014A1 (en) 2015-03-12
TW200845984A (en) 2008-12-01
US9290491B2 (en) 2016-03-22
IL200131A0 (en) 2010-04-15
HK1139399A1 (pt) 2010-09-17
HRP20130193T1 (hr) 2013-03-31
EP2132204B1 (en) 2013-01-23
CN101616916B (zh) 2011-10-12
US20110184008A1 (en) 2011-07-28

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