CO6220856A2 - Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octano - Google Patents
Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octanoInfo
- Publication number
- CO6220856A2 CO6220856A2 CO09089674A CO09089674A CO6220856A2 CO 6220856 A2 CO6220856 A2 CO 6220856A2 CO 09089674 A CO09089674 A CO 09089674A CO 09089674 A CO09089674 A CO 09089674A CO 6220856 A2 CO6220856 A2 CO 6220856A2
- Authority
- CO
- Colombia
- Prior art keywords
- crystalline
- salt form
- crystalline salt
- peaks
- forms
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
En la invención se provee una sal cristalina de sulfato de 3-endo-(8-{2-[ciclohexilmetil-((S)-2,3-dihidroxi-propionil)amino]etil}-8-aza-biciclo[3,2,1]oct-3-il)benzamida o un solvato de ésta. En la invención también se proveen composiciones farmacéuticas que comprenden estas formas de sales cristalinas, métodos para usar estas formas de sales cristalinas para tratar enfermedades asociadas con la actividad del receptor de opiáceos y procesos útiles para preparar estas formas de sales cristalinas. 1.- Una forma de sal cristalina que es la sal de sulfato de 3-endo-(8-{2-[ciclohexilmetil-((S)-2,3-dihidroxi-propionil)amino]etil}-8-aza-biciclo[3,2,1)oct-3-il)benzamida o un solvato de ésta.2.- La forma de sal cristalina de la reivindicación 1, donde la forma de sal cristalina es una sal cristalina de sulfato.3.- La forma de sal cristalina de la reivindicación 2, donde la forma de sal cristalina se caracteriza por un patrón de difracción de rayos X en polvo que tiene dos o más picos de difracción con valores 2? seleccionados entre6,58±0,20, 7,52±0,20, 9,35±0,20, 14,69±0,20, 16,01±0,20, 17,45±0,20, 17,99±0,20, 18,62±0,20, 19,76±0,20, 21,11±0,20, 22,07±0,20, 23,18±0,20, 23,74±0,20, 24,56±0,20, 25,63±0,20, 26,45±0,20, 27,86±0,20, 28,31±0,20, 29,54±0,20, 30,59±0,20, 31,58±0,20, 33,89±0,20 y 36,02±0,20.4.- La forma de sal cristalina de la reivindicación 3, donde el patrón de difracción de rayos X en polvo comprende dos o más picos de difracción con valores 2? seleccionados entre 14,69±0,20, 16,01±0,20, 21,11±0,20, 22,07±0,20 y 23,18±0,20.5.- La forma de sal cristalina de la reivindicación 2, donde la forma de sal cristalina se caracteriza por un patrón de difracción de rayos X en polvo donde las posiciones de los picos son sustancialmente acordes con las posiciones de los picos que se ilustran en la Figura 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90409007P | 2007-02-28 | 2007-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220856A2 true CO6220856A2 (es) | 2010-11-19 |
Family
ID=39620376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09089674A CO6220856A2 (es) | 2007-02-28 | 2009-08-26 | Formas cristalinas de un compuesto de 8-azabiciclo[3,2,1]octano |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US7943772B2 (es) |
| EP (1) | EP2132204B1 (es) |
| JP (2) | JP5512289B2 (es) |
| KR (1) | KR101480530B1 (es) |
| CN (1) | CN101616916B (es) |
| AR (2) | AR065554A1 (es) |
| AU (1) | AU2008219615B2 (es) |
| BR (1) | BRPI0807974B8 (es) |
| CA (1) | CA2678073C (es) |
| CL (1) | CL2008000573A1 (es) |
| CO (1) | CO6220856A2 (es) |
| CY (1) | CY1115077T1 (es) |
| DK (1) | DK2132204T3 (es) |
| ES (1) | ES2402031T3 (es) |
| HK (1) | HK1139399A1 (es) |
| HR (1) | HRP20130193T1 (es) |
| IL (1) | IL200131A (es) |
| MX (1) | MX2009009141A (es) |
| MY (1) | MY148318A (es) |
| NZ (1) | NZ578871A (es) |
| PL (1) | PL2132204T3 (es) |
| PT (1) | PT2132204E (es) |
| RU (1) | RU2458061C2 (es) |
| SI (1) | SI2132204T1 (es) |
| TW (1) | TWI409067B (es) |
| WO (1) | WO2008106159A1 (es) |
| ZA (1) | ZA200905832B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| US7947710B2 (en) * | 2007-08-27 | 2011-05-24 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| US7691878B2 (en) * | 2007-08-27 | 2010-04-06 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| ES2390195T3 (es) * | 2007-08-27 | 2012-11-07 | Theravance, Inc. | Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu |
| CN104958298A (zh) * | 2009-09-18 | 2015-10-07 | 阿得罗公司 | 阿片样受体拮抗剂用于胃肠道疾病的用途 |
| TW201642856A (zh) * | 2015-04-02 | 2016-12-16 | 施萬生物製藥研發Ｉｐ有限責任公司 | Ｍｕ類鴉片受體拮抗劑與類鴉片藥劑之組合劑型 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| GB9810671D0 (en) | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| US6467084B1 (en) * | 1999-12-16 | 2002-10-15 | Emware, Inc. | Systems and methods for reprogramming an embedded device with program code using relocatable program code |
| AU2001241676A1 (en) | 2000-03-03 | 2001-09-17 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives |
| US20020025948A1 (en) | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| DE60226161T2 (de) | 2001-10-22 | 2009-07-02 | Pfizer Products Inc., Groton | 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren |
| US7381721B2 (en) | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| BRPI0409307A (pt) | 2003-04-14 | 2006-04-25 | Pfizer Prod Inc | derivados de 3-azabiciclo[3.2.1]octano |
| US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
| US20040204453A1 (en) | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
| WO2004092165A1 (en) | 2003-04-15 | 2004-10-28 | Pfizer Products Inc. | 3-benzhydrylidene-8-aza-bicyclo[3.2.1]octane derivatives with opioid receptor activity |
| US6992090B2 (en) | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| EP1737853A1 (en) | 2004-02-03 | 2007-01-03 | Janssen Pharmaceutica N.V. | 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives |
| US7087749B2 (en) | 2004-03-11 | 2006-08-08 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| CA2667259A1 (en) | 2006-11-07 | 2008-05-15 | Nektar Therapeutics Al, Corporation | Dosage forms and co-administration of an opioid agonist and an opioid antagonist |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
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2008
- 2008-02-15 TW TW097105472A patent/TWI409067B/zh active
- 2008-02-25 CL CL200800573A patent/CL2008000573A1/es unknown
- 2008-02-27 MX MX2009009141A patent/MX2009009141A/es active IP Right Grant
- 2008-02-27 AU AU2008219615A patent/AU2008219615B2/en active Active
- 2008-02-27 ES ES08726162T patent/ES2402031T3/es active Active
- 2008-02-27 DK DK08726162.4T patent/DK2132204T3/da active
- 2008-02-27 MY MYPI20093401A patent/MY148318A/en unknown
- 2008-02-27 CN CN2008800059690A patent/CN101616916B/zh active Active
- 2008-02-27 EP EP08726162A patent/EP2132204B1/en active Active
- 2008-02-27 RU RU2009135834/04A patent/RU2458061C2/ru active
- 2008-02-27 SI SI200830928T patent/SI2132204T1/sl unknown
- 2008-02-27 PL PL08726162T patent/PL2132204T3/pl unknown
- 2008-02-27 US US12/072,534 patent/US7943772B2/en active Active
- 2008-02-27 KR KR1020097020094A patent/KR101480530B1/ko active IP Right Grant
- 2008-02-27 NZ NZ578871A patent/NZ578871A/en not_active IP Right Cessation
- 2008-02-27 JP JP2009551709A patent/JP5512289B2/ja active Active
- 2008-02-27 WO PCT/US2008/002583 patent/WO2008106159A1/en active Application Filing
- 2008-02-27 CA CA2678073A patent/CA2678073C/en active Active
- 2008-02-27 BR BRPI0807974A patent/BRPI0807974B8/pt active IP Right Grant
- 2008-02-27 PT PT87261624T patent/PT2132204E/pt unknown
- 2008-02-28 AR ARP080100850A patent/AR065554A1/es not_active Application Discontinuation
-
2009
- 2009-07-29 IL IL200131A patent/IL200131A/en active IP Right Grant
- 2009-08-21 ZA ZA200905832A patent/ZA200905832B/xx unknown
- 2009-08-26 CO CO09089674A patent/CO6220856A2/es active IP Right Grant
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2010
- 2010-06-15 HK HK10106008.5A patent/HK1139399A1/xx unknown
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2011
- 2011-04-06 US US13/081,162 patent/US8247555B2/en active Active
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2012
- 2012-07-17 US US13/550,781 patent/US8536335B2/en active Active
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2013
- 2013-03-05 HR HRP20130193AT patent/HRP20130193T1/hr unknown
- 2013-04-08 CY CY20131100293T patent/CY1115077T1/el unknown
- 2013-05-10 JP JP2013099851A patent/JP2013151564A/ja not_active Withdrawn
- 2013-08-13 US US13/965,691 patent/US8816091B2/en active Active
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2014
- 2014-07-16 US US14/333,003 patent/US9290491B2/en active Active
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2016
- 2016-02-10 US US15/040,191 patent/US9949963B2/en active Active
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2017
- 2017-07-31 AR ARP170102183A patent/AR109224A2/es unknown
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2018
- 2018-03-13 US US15/919,678 patent/US10426766B2/en active Active
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