CY1113942T1 - Παραγωγα σουλφοναμιδιου πυριμιδινης και τριαζινης σαν αναστολεις υποδοχεα βραδυκινινης β1 (β1r) για τη θεραπεια πονου - Google Patents
Παραγωγα σουλφοναμιδιου πυριμιδινης και τριαζινης σαν αναστολεις υποδοχεα βραδυκινινης β1 (β1r) για τη θεραπεια πονουInfo
- Publication number
- CY1113942T1 CY1113942T1 CY20131100330T CY131100330T CY1113942T1 CY 1113942 T1 CY1113942 T1 CY 1113942T1 CY 20131100330 T CY20131100330 T CY 20131100330T CY 131100330 T CY131100330 T CY 131100330T CY 1113942 T1 CY1113942 T1 CY 1113942T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bradykinin
- triazine
- pyrimidine
- inhibitors
- receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08018514 | 2008-10-23 | ||
| EP09740860A EP2356101B1 (de) | 2008-10-23 | 2009-10-22 | Pyrimidin- und triazin-sulfonamidderivate als bradykinin b1 rezeptor (b1r) inhibitoren zur behandlung von schmerz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113942T1 true CY1113942T1 (el) | 2016-07-27 |
Family
ID=40386034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100330T CY1113942T1 (el) | 2008-10-23 | 2013-04-23 | Παραγωγα σουλφοναμιδιου πυριμιδινης και τριαζινης σαν αναστολεις υποδοχεα βραδυκινινης β1 (β1r) για τη θεραπεια πονου |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8269000B2 (es) |
| EP (1) | EP2356101B1 (es) |
| JP (1) | JP2012506396A (es) |
| AR (1) | AR073919A1 (es) |
| AU (1) | AU2009306723A1 (es) |
| BR (1) | BRPI0920496A2 (es) |
| CA (1) | CA2741349A1 (es) |
| CY (1) | CY1113942T1 (es) |
| DK (1) | DK2356101T3 (es) |
| ES (1) | ES2409109T3 (es) |
| HR (1) | HRP20130423T1 (es) |
| MX (1) | MX2011004211A (es) |
| PL (1) | PL2356101T3 (es) |
| PT (1) | PT2356101E (es) |
| SI (1) | SI2356101T1 (es) |
| TW (1) | TW201022267A (es) |
| WO (1) | WO2010046109A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011078143A1 (ja) * | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| EP2825694A4 (en) * | 2012-03-16 | 2016-04-20 | Impossible Foods Inc | AFFINITY REAGENTS FOR PROTEIN CLEANING |
| EP2989080A1 (en) * | 2013-04-22 | 2016-03-02 | Reuter Chemische Apparatebau KG | Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN109265395B (zh) * | 2018-09-21 | 2021-10-26 | 中国烟草总公司郑州烟草研究院 | 一种二氯喹啉酸半抗原与抗原的制备方法及应用 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| MX2022001940A (es) | 2019-08-14 | 2022-05-10 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2. |
| PE20221905A1 (es) | 2019-10-11 | 2022-12-23 | Incyte Corp | Aminas biciclicas como inhibidoras de la cdk2 |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2379064A1 (en) * | 1999-07-15 | 2001-01-25 | Pharmacopeia, Inc. | Bradykinin b1 receptor antagonists |
| WO2007101007A2 (en) | 2006-02-23 | 2007-09-07 | Neurogen Corporation | Aryl sulfonyl heterocycles |
| WO2007140383A2 (en) | 2006-05-30 | 2007-12-06 | Neurogen Corporation | Spirocyclic sulfonamides and related compounds |
| SI2066659T1 (sl) | 2006-09-29 | 2013-10-30 | Grunenthal Gmbh | Substituirani sulfonamidni derivati |
| WO2008046573A1 (de) * | 2006-10-16 | 2008-04-24 | Grünenthal GmbH | Substituierte sulfonamid-derivate als bradykinin 1 rezeptor modulatoren |
-
2009
- 2009-09-11 TW TW098130643A patent/TW201022267A/zh unknown
- 2009-10-22 ES ES09740860T patent/ES2409109T3/es active Active
- 2009-10-22 AU AU2009306723A patent/AU2009306723A1/en not_active Abandoned
- 2009-10-22 JP JP2011532539A patent/JP2012506396A/ja not_active Withdrawn
- 2009-10-22 BR BRPI0920496A patent/BRPI0920496A2/pt not_active IP Right Cessation
- 2009-10-22 MX MX2011004211A patent/MX2011004211A/es not_active Application Discontinuation
- 2009-10-22 PT PT97408603T patent/PT2356101E/pt unknown
- 2009-10-22 AR ARP090104060A patent/AR073919A1/es not_active Application Discontinuation
- 2009-10-22 EP EP09740860A patent/EP2356101B1/de not_active Not-in-force
- 2009-10-22 WO PCT/EP2009/007568 patent/WO2010046109A1/de active Application Filing
- 2009-10-22 PL PL09740860T patent/PL2356101T3/pl unknown
- 2009-10-22 SI SI200930539T patent/SI2356101T1/sl unknown
- 2009-10-22 CA CA2741349A patent/CA2741349A1/en not_active Abandoned
- 2009-10-22 DK DK09740860.3T patent/DK2356101T3/da active
- 2009-10-23 US US12/604,691 patent/US8269000B2/en not_active Expired - Fee Related
-
2013
- 2013-04-23 CY CY20131100330T patent/CY1113942T1/el unknown
- 2013-05-14 HR HRP20130423AT patent/HRP20130423T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20130423T1 (en) | 2013-06-30 |
| EP2356101B1 (de) | 2013-02-27 |
| EP2356101A1 (de) | 2011-08-17 |
| BRPI0920496A2 (pt) | 2019-09-24 |
| ES2409109T3 (es) | 2013-06-25 |
| PL2356101T3 (pl) | 2013-07-31 |
| PT2356101E (pt) | 2013-06-03 |
| WO2010046109A1 (de) | 2010-04-29 |
| SI2356101T1 (sl) | 2013-04-30 |
| AR073919A1 (es) | 2010-12-09 |
| MX2011004211A (es) | 2011-05-24 |
| US8269000B2 (en) | 2012-09-18 |
| CA2741349A1 (en) | 2010-04-29 |
| JP2012506396A (ja) | 2012-03-15 |
| AU2009306723A1 (en) | 2010-04-29 |
| DK2356101T3 (da) | 2013-05-27 |
| US20100173889A1 (en) | 2010-07-08 |
| TW201022267A (en) | 2010-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1113942T1 (el) | Παραγωγα σουλφοναμιδιου πυριμιδινης και τριαζινης σαν αναστολεις υποδοχεα βραδυκινινης β1 (β1r) για τη θεραπεια πονου | |
| CY1123625T1 (el) | Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων | |
| EA201100580A1 (ru) | Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
| CY1118004T1 (el) | Αναστολεις cdk | |
| EA201390609A1 (ru) | ПРОИЗВОДНЫЕ ГИДАНТОИНА, ПОЛЕЗНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Kv3-КАНАЛОВ | |
| CY1116295T1 (el) | Αναστολεις της κινασης τυροσινης toy bruton | |
| CY1116628T1 (el) | Ενωσεις σπειρο-οξινδολιου και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| EA201170872A1 (ru) | Ингибиторы протеинкиназы | |
| EA200901442A1 (ru) | Комбинированная терапия соединением, проявляющим активность ингибитора рецептора адф на тромбоцитах | |
| EA201491607A1 (ru) | Модуляторы толлподобных рецепторов | |
| NO20065148L (no) | Monocykliske heterocykler som kinase inhibitorer | |
| EA200971077A1 (ru) | Гетероциклические модуляторы киназы | |
| ATE542813T1 (de) | 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren | |
| EA201170276A1 (ru) | Модуляторы рецептора tgr5 и способы их применения | |
| DK1761520T3 (da) | Kinaseinhibitorer | |
| CR20110028A (es) | Derivados de pirimidina como inhibidores de cinasa | |
| EA201071099A1 (ru) | СОЛЕВЫЕ ФОРМЫ ИНГИБИТОРА mTOR | |
| EA201000895A1 (ru) | Композиции и способы для лечения лизосомных болезней | |
| EA201270100A1 (ru) | Пиримидиноны в качестве ингибиторов pi3k | |
| EA201170151A1 (ru) | Пиперидиниловые агонисты gpcr | |
| EA201100030A1 (ru) | Пиразольные соединения 436 | |
| EA201001359A1 (ru) | Гетероциклические соединения в качестве ингибиторов cxcr2 | |
| EA200870409A1 (ru) | Антагонисты киназы pi3 | |
| EA201000113A1 (ru) | Пиразольные соединения | |
| EA201170154A1 (ru) | Производные пиридинопиридинонов, способ их получения и применение в терапии |