CY1113932T1 - Χρηση πεπτιδιων που παραγονται απο το συν-πολυμερες-1 σαν παραγοντων σημανσης μοριακου βαρους - Google Patents
Χρηση πεπτιδιων που παραγονται απο το συν-πολυμερες-1 σαν παραγοντων σημανσης μοριακου βαρουςInfo
- Publication number
- CY1113932T1 CY1113932T1 CY20131100310T CY131100310T CY1113932T1 CY 1113932 T1 CY1113932 T1 CY 1113932T1 CY 20131100310 T CY20131100310 T CY 20131100310T CY 131100310 T CY131100310 T CY 131100310T CY 1113932 T1 CY1113932 T1 CY 1113932T1
- Authority
- CY
- Cyprus
- Prior art keywords
- molecular weight
- polymers
- glatiramer acetate
- copolymers
- factors produced
- Prior art date
Links
- 108010072051 Glatiramer Acetate Proteins 0.000 abstract 3
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 abstract 3
- 229920001577 copolymer Polymers 0.000 abstract 3
- 229960003776 glatiramer acetate Drugs 0.000 abstract 3
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pain & Pain Management (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει παράγοντες σήμανσης μοριακού βάρους για τον ακριβή προσδιορισμό του μοριακού βάρους του glatiramer acetate και άλλων συν-πολυμερών (copolymers). Η παρούσα εφεύρεση παρέχει περαιτέρω μία πολλαπλότητα παραγόντων σήμανσης μοριακού βάρους για τον προσδιορισμό του μοριακού βάρους του glatiramer acetate και άλλων συν-πολυμερών (copolymers) που εμφανίζουν γραμμικές σχέσεις μεταξύ της μοριακής ελλειπτικότητας και του μοριακού βάρους και μεταξύ του χρόνου κράτησης και του λογαρίθμου του μοριακού βάρους. Οι παράγοντες σήμανσης μοριακού βάρους επίσης επιδεικνύουν βέλτιστα βιολογική δραστικότητα παρόμοια με το glatiramer acetate ή αντίστοιχων συν-πολυμερών (copolymers) και μπορούν να χρησιμοποιηθούν για την θεραπεία ή την πρόληψη διαφόρων ασθενειών ανοσοποίησης.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10169398P | 1998-09-25 | 1998-09-25 | |
| EP10171553A EP2239269B1 (en) | 1998-09-25 | 1999-09-24 | Use of peptides derived from copolymer-1 as molecular weight markers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113932T1 true CY1113932T1 (el) | 2016-07-27 |
Family
ID=22285926
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100835T CY1110490T1 (el) | 1998-09-25 | 2009-08-06 | Πεπτιδια που σχετιζονται με το συν-πολυμερες (copolymer) 1 για χρηση σαν παραγοντες σημανσης μοριακου βαρους και για θεραπευτικη χρηση |
| CY20111100947T CY1112197T1 (el) | 1998-09-25 | 2011-10-05 | Πεπτιδια που σχετιζονται με το συν-πολυμερες (copolymer) 1 για χρηση σαν παραγοντες σημανσης μοριακου βαρους και για θεραπευτικη χρηση |
| CY20131100310T CY1113932T1 (el) | 1998-09-25 | 2013-04-15 | Χρηση πεπτιδιων που παραγονται απο το συν-πολυμερες-1 σαν παραγοντων σημανσης μοριακου βαρους |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100835T CY1110490T1 (el) | 1998-09-25 | 2009-08-06 | Πεπτιδια που σχετιζονται με το συν-πολυμερες (copolymer) 1 για χρηση σαν παραγοντες σημανσης μοριακου βαρους και για θεραπευτικη χρηση |
| CY20111100947T CY1112197T1 (el) | 1998-09-25 | 2011-10-05 | Πεπτιδια που σχετιζονται με το συν-πολυμερες (copolymer) 1 για χρηση σαν παραγοντες σημανσης μοριακου βαρους και για θεραπευτικη χρηση |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP2090583B1 (el) |
| JP (2) | JP4629229B2 (el) |
| AT (2) | ATE431359T1 (el) |
| AU (1) | AU757413B2 (el) |
| CA (2) | CA2794705C (el) |
| CY (3) | CY1110490T1 (el) |
| DE (2) | DE09004306T1 (el) |
| DK (3) | DK1115743T3 (el) |
| ES (3) | ES2369642T3 (el) |
| HK (3) | HK1040521A1 (el) |
| HU (3) | HU229289B1 (el) |
| IL (4) | IL142116A0 (el) |
| NO (2) | NO329877B1 (el) |
| NZ (1) | NZ511020A (el) |
| PT (3) | PT2090583E (el) |
| SI (1) | SI1115743T1 (el) |
| WO (1) | WO2000018794A1 (el) |
| ZA (1) | ZA200102269B (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527760T3 (es) | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
| EP1098902A4 (en) | 1998-07-23 | 2002-07-24 | Yeda Res & Dev | TREATMENT OF AUTOIMMUNE DISEASES BY COPOLYMER 1 AND SIMILAR COPOLYMERS AND PEPTIDES |
| US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| US7022663B2 (en) | 2000-02-18 | 2006-04-04 | Yeda Research And Development Co., Ltd. | Oral, nasal and pulmonary dosage formulations of copolymer 1 |
| US20020077278A1 (en) | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
| WO2002076503A1 (en) | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Treatment of central nervous system diseases by antibodies against glatiramer acetate |
| IL148202A0 (en) * | 2000-06-20 | 2002-09-12 | Caprion Pharmaceuticals Inc | Copolymers and methods of treating prion-related diseases |
| US20040037828A1 (en) * | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
| IL161121A0 (en) * | 2001-10-03 | 2004-08-31 | Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| ES2349033T3 (es) | 2001-12-04 | 2010-12-22 | Teva Pharmaceutical Industries, Ltd. | Procedimientos para la medida de la actividad del acetato de glatiramer. |
| MXPA05007711A (es) | 2003-01-21 | 2005-09-30 | Yeda Res & Dev | Copolimero 1 para el tratamiento de enfermedades inflamatorias del intestino. |
| NZ545086A (en) | 2003-08-07 | 2011-06-30 | Healor Ltd | Pharmaceutical compositions and methods for accelerating wound healing |
| RU2006134701A (ru) * | 2004-03-01 | 2008-04-10 | Пептиммьюн | Способы и композиции для лечения аутоиммунных заболеваний |
| US7655221B2 (en) | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
| PL1797109T3 (pl) | 2004-09-09 | 2016-11-30 | Mieszaniny polipeptydów, kompozycje zawierające je i procesy ich wytwarzania oraz ich zastosowania | |
| US7858337B2 (en) | 2007-03-08 | 2010-12-28 | Novartis Ag | Process for the manufacture of a composite material |
| PL2949335T3 (pl) | 2009-08-20 | 2017-07-31 | Yeda Research & Development Company, Ltd. | Terapia octanem glatirameru podawanym z niewielką częstotliwością |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
| MX347871B (es) | 2010-10-11 | 2017-05-16 | Teva Pharmaceutical Ind Ltd * | Biomarcadores de citoquina como marcadores predictivos de respuesta clínica para acetato de glatirámero. |
| RU2604521C2 (ru) | 2011-02-14 | 2016-12-10 | Юсв Прайвит Лимитед | Сополимер-1, способы его получения и аналитические методы |
| AU2012323345A1 (en) | 2011-10-10 | 2014-05-22 | Teva Pharmaceutical Industries Ltd. | Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate |
| US9617596B2 (en) | 2012-10-10 | 2017-04-11 | Teva Pharmaceutical Industries, Ltd. | Biomarkers predictive for clinical response for glatiramer acetate |
| CN104098655B (zh) * | 2013-04-09 | 2018-01-30 | 深圳翰宇药业股份有限公司 | 用于合成醋酸格拉替雷的质谱内标的多肽 |
| UY35790A (es) | 2013-10-21 | 2015-05-29 | Teva Pharma | Marcadores genéticos que predicen la respuesta al acetato de glatiramer |
| CN105218646B (zh) * | 2014-06-24 | 2018-09-21 | 深圳翰宇药业股份有限公司 | 一种用于检测醋酸格拉替雷样本的uplc方法 |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
| CN112649537B (zh) * | 2015-04-28 | 2024-03-29 | 深圳翰宇药业股份有限公司 | 多肽混合物高效液相色谱分析方法 |
| ES2744179T3 (es) * | 2015-09-24 | 2020-02-24 | Chemi Spa | Análisis de la distribución de peso molecular de mezclas de polipéptidos complejas |
| CA3050086A1 (en) | 2017-03-26 | 2018-10-04 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2009996A1 (en) * | 1989-02-17 | 1990-08-17 | Kathleen S. Cook | Process for making genes encoding random polymers of amino acids |
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
-
1999
- 1999-09-24 WO PCT/US1999/022402 patent/WO2000018794A1/en active IP Right Grant
- 1999-09-24 ES ES09004306T patent/ES2369642T3/es not_active Expired - Lifetime
- 1999-09-24 AU AU62695/99A patent/AU757413B2/en not_active Expired
- 1999-09-24 DK DK99949923T patent/DK1115743T3/da active
- 1999-09-24 HU HU0103889A patent/HU229289B1/hu unknown
- 1999-09-24 IL IL14211699A patent/IL142116A0/xx unknown
- 1999-09-24 PT PT09004306T patent/PT2090583E/pt unknown
- 1999-09-24 AT AT99949923T patent/ATE431359T1/de active
- 1999-09-24 DE DE09004306T patent/DE09004306T1/de active Pending
- 1999-09-24 PT PT99949923T patent/PT1115743E/pt unknown
- 1999-09-24 NZ NZ511020A patent/NZ511020A/xx not_active IP Right Cessation
- 1999-09-24 ZA ZA200102269A patent/ZA200102269B/en unknown
- 1999-09-24 ES ES99949923T patent/ES2327301T3/es not_active Expired - Lifetime
- 1999-09-24 PT PT101715530T patent/PT2239269E/pt unknown
- 1999-09-24 DK DK09004306.8T patent/DK2090583T3/da active
- 1999-09-24 DE DE69940888T patent/DE69940888D1/de not_active Expired - Lifetime
- 1999-09-24 EP EP09004306A patent/EP2090583B1/en not_active Expired - Lifetime
- 1999-09-24 SI SI9931035T patent/SI1115743T1/sl unknown
- 1999-09-24 AT AT09004306T patent/ATE516297T1/de active
- 1999-09-24 JP JP2000572252A patent/JP4629229B2/ja not_active Expired - Lifetime
- 1999-09-24 EP EP10171553A patent/EP2239269B1/en not_active Expired - Lifetime
- 1999-09-24 CA CA2794705A patent/CA2794705C/en not_active Expired - Lifetime
- 1999-09-24 HU HU1300337A patent/HU229720B1/hu unknown
- 1999-09-24 DK DK10171553.0T patent/DK2239269T3/da active
- 1999-09-24 ES ES10171553T patent/ES2408706T3/es not_active Expired - Lifetime
- 1999-09-24 HU HU1300505A patent/HU229719B1/hu unknown
- 1999-09-24 CA CA2343929A patent/CA2343929C/en not_active Expired - Lifetime
- 1999-09-24 EP EP99949923A patent/EP1115743B1/en not_active Expired - Lifetime
-
2001
- 2001-03-20 IL IL142116A patent/IL142116A/en not_active IP Right Cessation
- 2001-03-21 NO NO20011441A patent/NO329877B1/no not_active IP Right Cessation
-
2002
- 2002-01-18 HK HK02100390.4A patent/HK1040521A1/xx not_active IP Right Cessation
-
2009
- 2009-08-06 CY CY20091100835T patent/CY1110490T1/el unknown
- 2009-12-09 HK HK09111514.5A patent/HK1133021A1/xx not_active IP Right Cessation
-
2010
- 2010-03-25 NO NO20100442A patent/NO336685B1/no not_active IP Right Cessation
- 2010-06-23 JP JP2010142689A patent/JP4903886B2/ja not_active Expired - Lifetime
- 2010-11-07 IL IL209189A patent/IL209189A/en not_active IP Right Cessation
- 2010-11-07 IL IL209190A patent/IL209190A/en not_active IP Right Cessation
-
2011
- 2011-04-08 HK HK11103596.9A patent/HK1149279A1/xx not_active IP Right Cessation
- 2011-10-05 CY CY20111100947T patent/CY1112197T1/el unknown
-
2013
- 2013-04-15 CY CY20131100310T patent/CY1113932T1/el unknown
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| NO871329D0 (no) | Snepp-klemme for avlange instrumenter. | |
| DE428516T1 (de) | Vorrichtung zur linearfuehrung. | |
| FI883225A0 (fi) | Sterilisationsindikator foer gassterilisering. | |
| NO853381L (no) | Kirurgisk instrument. |