CY1113824T1 - Ενδορινικες συνθεσεις - Google Patents
Ενδορινικες συνθεσειςInfo
- Publication number
- CY1113824T1 CY1113824T1 CY20131100059T CY131100059T CY1113824T1 CY 1113824 T1 CY1113824 T1 CY 1113824T1 CY 20131100059 T CY20131100059 T CY 20131100059T CY 131100059 T CY131100059 T CY 131100059T CY 1113824 T1 CY1113824 T1 CY 1113824T1
- Authority
- CY
- Cyprus
- Prior art keywords
- apomorphine
- cyclodextrin
- intensive
- compositions
- intensive compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 abstract 2
- 229960004046 apomorphine Drugs 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- 229920001661 Chitosan Polymers 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07254426A EP2057982A1 (en) | 2007-11-09 | 2007-11-09 | Intranasal compositions |
| EP08847366A EP2214640B1 (en) | 2007-11-09 | 2008-11-10 | Intranasal compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113824T1 true CY1113824T1 (el) | 2016-07-27 |
Family
ID=39052379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100059T CY1113824T1 (el) | 2007-11-09 | 2013-01-23 | Ενδορινικες συνθεσεις |
Country Status (20)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| EP2545905A1 (en) * | 2011-07-11 | 2013-01-16 | Britannia Pharmaceuticals Limited | A new therapeutical composition containing apomorphine as active ingredient |
| HUE060093T2 (hu) | 2012-03-15 | 2023-01-28 | Boehringer Ingelheim Vetmedica Gmbh | Gyógyszerészeti tablettakészítmény az állatgyógyászati ágazat számára, eljárás annak elõállítására és annak alkalmazása |
| NZ703341A (en) * | 2012-06-05 | 2016-11-25 | Neuroderm Ltd | Compositions comprising apomorphine and organic acids and uses thereof |
| EP2863897B1 (en) * | 2012-06-21 | 2019-06-19 | Phosphorex Inc. | Nanoparticles of indirubin, derivatives thereof and methods of making and using same |
| GB201217419D0 (en) | 2012-09-28 | 2012-11-14 | Innotesto Bvba | Improvements in or relating to oromucosal apomorphine compositions |
| HUE054186T2 (hu) * | 2013-07-19 | 2021-08-30 | Boehringer Ingelheim Vetmedica Gmbh | Éterezett ciklodextrin-származékokat tartalmazó, tartósított, folyékony, vizes gyógyászati készítmény |
| ES2883448T3 (es) | 2013-12-04 | 2021-12-07 | Boehringer Ingelheim Vetmedica Gmbh | Composiciones farmacéuticas mejoradas de pimobendán |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| CN114980896A (zh) * | 2019-08-07 | 2022-08-30 | 阿克里普斯一有限公司 | (6AS)-6-甲基-5,6,6A,7-四氢-4H-二苯并[de,g]喹啉-10,11-二醇的药物组合物 |
| GB201912686D0 (en) * | 2019-09-04 | 2019-10-16 | Reown Pharma Inc | Pharmaceutical composition |
| CN115804754A (zh) * | 2022-12-16 | 2023-03-17 | 广州新济药业科技有限公司 | 吗啡鼻喷剂及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9103824D0 (en) * | 1991-02-23 | 1991-04-10 | Fisons Ag | Formulation |
| ATE290864T1 (de) * | 1993-03-26 | 2005-04-15 | Franciscus Wilhelmus He Merkus | Pharmazeutische zusammensetzungen zur intranasalen verabreichung von dihydroergotamin |
| GB9416884D0 (en) | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
| EP0834308A1 (en) * | 1996-09-30 | 1998-04-08 | LG Chemical Limited | Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin |
| GB9713980D0 (en) | 1997-07-03 | 1997-09-10 | Danbiosyst Uk | New conjugates |
| DE69831421T2 (de) * | 1997-12-02 | 2006-06-22 | Archimedes Development Ltd. | Zusammensetzungen zur nasalen verabreichung |
| US6436950B1 (en) | 1998-08-14 | 2002-08-20 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of apomorphine |
| US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| GB0403938D0 (en) * | 2004-02-21 | 2004-03-24 | West Pharm Serv Drug Res Ltd | Chitosan containing solution |
-
2007
- 2007-11-09 EP EP07254426A patent/EP2057982A1/en not_active Withdrawn
-
2008
- 2008-11-07 TW TW097143029A patent/TWI426928B/zh not_active IP Right Cessation
- 2008-11-10 SI SI200830875T patent/SI2214640T1/sl unknown
- 2008-11-10 NZ NZ585107A patent/NZ585107A/en not_active IP Right Cessation
- 2008-11-10 AU AU2008326220A patent/AU2008326220B2/en not_active Ceased
- 2008-11-10 MX MX2010005013A patent/MX2010005013A/es active IP Right Grant
- 2008-11-10 PT PT88473665T patent/PT2214640E/pt unknown
- 2008-11-10 KR KR1020107011658A patent/KR101522529B1/ko not_active Expired - Fee Related
- 2008-11-10 US US12/741,932 patent/US8309108B2/en not_active Expired - Fee Related
- 2008-11-10 WO PCT/GB2008/003782 patent/WO2009060226A1/en not_active Ceased
- 2008-11-10 DK DK08847366.5T patent/DK2214640T3/da active
- 2008-11-10 HR HRP20121036AT patent/HRP20121036T1/hr unknown
- 2008-11-10 CN CN200880115432XA patent/CN101883555B/zh not_active Expired - Fee Related
- 2008-11-10 JP JP2010532658A patent/JP5530931B2/ja not_active Expired - Fee Related
- 2008-11-10 PL PL08847366T patent/PL2214640T3/pl unknown
- 2008-11-10 EP EP08847366A patent/EP2214640B1/en not_active Not-in-force
- 2008-11-10 BR BRPI0819115-8A patent/BRPI0819115A2/pt not_active IP Right Cessation
- 2008-11-10 ES ES08847366T patent/ES2398267T3/es active Active
- 2008-11-10 CA CA2705153A patent/CA2705153C/en not_active Expired - Fee Related
-
2010
- 2010-05-05 ZA ZA2010/03172A patent/ZA201003172B/en unknown
-
2013
- 2013-01-23 CY CY20131100059T patent/CY1113824T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101883555B (zh) | 2012-07-11 |
| EP2214640B1 (en) | 2012-10-24 |
| EP2057982A1 (en) | 2009-05-13 |
| TWI426928B (zh) | 2014-02-21 |
| JP2011503044A (ja) | 2011-01-27 |
| US8309108B2 (en) | 2012-11-13 |
| EP2214640A1 (en) | 2010-08-11 |
| CN101883555A (zh) | 2010-11-10 |
| JP5530931B2 (ja) | 2014-06-25 |
| DK2214640T3 (da) | 2013-02-04 |
| KR101522529B1 (ko) | 2015-05-26 |
| US20100249170A1 (en) | 2010-09-30 |
| NZ585107A (en) | 2012-05-25 |
| ZA201003172B (en) | 2012-10-31 |
| WO2009060226A1 (en) | 2009-05-14 |
| CA2705153A1 (en) | 2009-05-14 |
| PL2214640T3 (pl) | 2013-03-29 |
| ES2398267T3 (es) | 2013-03-15 |
| CA2705153C (en) | 2016-05-24 |
| HRP20121036T1 (hr) | 2013-01-31 |
| AU2008326220B2 (en) | 2013-05-23 |
| KR20100094980A (ko) | 2010-08-27 |
| MX2010005013A (es) | 2010-05-27 |
| AU2008326220A1 (en) | 2009-05-14 |
| SI2214640T1 (sl) | 2013-02-28 |
| PT2214640E (pt) | 2013-01-16 |
| TW200936179A (en) | 2009-09-01 |
| BRPI0819115A2 (pt) | 2015-07-07 |
| AU2008326220A2 (en) | 2010-11-04 |
| HK1146711A1 (en) | 2011-07-08 |
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