CY1113351T1 - 8-βητα-υποκατεστημενα 16.αλφα.-φθορο-οιστρατριενια, ως επιλεκτικως ενεργα οιστρογονα - Google Patents
8-βητα-υποκατεστημενα 16.αλφα.-φθορο-οιστρατριενια, ως επιλεκτικως ενεργα οιστρογοναInfo
- Publication number
- CY1113351T1 CY1113351T1 CY20121101099T CY121101099T CY1113351T1 CY 1113351 T1 CY1113351 T1 CY 1113351T1 CY 20121101099 T CY20121101099 T CY 20121101099T CY 121101099 T CY121101099 T CY 121101099T CY 1113351 T1 CY1113351 T1 CY 1113351T1
- Authority
- CY
- Cyprus
- Prior art keywords
- substituted
- ostrone
- ostratrienia
- fluor
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η εφεύρεση αναφέρεται σε 8β-υποκατεστημένο οιστρα-1,3,5(10)-τριένιο παράγωγα του γενικού τύπου (I), την χρήση τους ως φαρμακευτικώς ενεργά συστατικά, τα οποία έχουν in vitro μία υψηλότερη χημική συγγένεια με παρασκευάσματα υποδοχέων οιστρογόνων από προστάτη αρουραίων από ό,τι με παρασκευάσματα υποδοχέων οιστρογόνων από μήτρα αρουραίων και in vivo μία προνομιακή δράση στην ωοθήκη σε σύγκριση με τη μήτρα, την παραγωγή τους, την θεραπευτική τους χρήση και τις φαρμακευτικές μορφές διανομής που περιέχουν τις νέες ενώσεις.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07075600A EP2014672A1 (en) | 2007-07-12 | 2007-07-12 | 8-beta-substituted estratrienes as selectively active estrogens |
EP08775031A EP2176282B1 (en) | 2007-07-12 | 2008-07-11 | 8-beta-substituted 16.alpha.-fluoro-estratrienes as selectively active estrogens |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113351T1 true CY1113351T1 (el) | 2016-06-22 |
Family
ID=38657613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121101099T CY1113351T1 (el) | 2007-07-12 | 2012-11-14 | 8-βητα-υποκατεστημενα 16.αλφα.-φθορο-οιστρατριενια, ως επιλεκτικως ενεργα οιστρογονα |
Country Status (34)
Country | Link |
---|---|
US (1) | US20090029957A1 (el) |
EP (2) | EP2014672A1 (el) |
JP (1) | JP2010533152A (el) |
KR (1) | KR20100037593A (el) |
CN (1) | CN101687902B (el) |
AR (1) | AR067507A1 (el) |
AU (1) | AU2008274198A1 (el) |
BR (1) | BRPI0814207A2 (el) |
CA (1) | CA2692727A1 (el) |
CL (1) | CL2008002027A1 (el) |
CO (1) | CO6270230A2 (el) |
CR (1) | CR11211A (el) |
CU (1) | CU23885B1 (el) |
CY (1) | CY1113351T1 (el) |
DK (1) | DK2176282T3 (el) |
DO (1) | DOP2010000017A (el) |
EA (1) | EA017124B1 (el) |
EC (1) | ECSP109872A (el) |
ES (1) | ES2393942T3 (el) |
HN (1) | HN2010000081A (el) |
HR (1) | HRP20120952T1 (el) |
MA (1) | MA31565B1 (el) |
NZ (1) | NZ582490A (el) |
PA (1) | PA8789401A1 (el) |
PE (1) | PE20090825A1 (el) |
PL (1) | PL2176282T3 (el) |
PT (1) | PT2176282E (el) |
RS (1) | RS52541B (el) |
SI (1) | SI2176282T1 (el) |
TN (1) | TN2010000007A1 (el) |
TW (1) | TW200911824A (el) |
UA (1) | UA99918C2 (el) |
UY (1) | UY31220A1 (el) |
WO (1) | WO2009007454A2 (el) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012234682A1 (en) * | 2011-03-25 | 2013-10-10 | Universite Laval | Inhibitors of 17beta-HSD1, 17beta-HSD3 and 17beta-HSD10 |
MX2019000025A (es) * | 2016-06-24 | 2019-10-30 | K&N Eng Inc | Filtro de aire compuesto. |
USD905747S1 (en) | 2018-04-09 | 2020-12-22 | Mitsubishi Electric Corporation | Display screen with animated graphical user interface |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10019167A1 (de) * | 2000-04-12 | 2001-10-18 | Schering Ag | Substituierte Estratriene als selektiv wirksame Estrogene |
HUP0300335A2 (hu) * | 2000-04-12 | 2003-07-28 | Schering Ag. | 8béta-hidrokarbil-szubsztituált ösztratriének mint szelektív hatású ösztrogének, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
-
2007
- 2007-07-12 EP EP07075600A patent/EP2014672A1/en not_active Ceased
-
2008
- 2008-07-11 CN CN200880024423XA patent/CN101687902B/zh not_active Expired - Fee Related
- 2008-07-11 WO PCT/EP2008/059115 patent/WO2009007454A2/en active Application Filing
- 2008-07-11 CL CL2008002027A patent/CL2008002027A1/es unknown
- 2008-07-11 EP EP08775031A patent/EP2176282B1/en active Active
- 2008-07-11 PA PA20088789401A patent/PA8789401A1/es unknown
- 2008-07-11 PE PE2008001165A patent/PE20090825A1/es not_active Application Discontinuation
- 2008-07-11 KR KR1020107000527A patent/KR20100037593A/ko not_active Application Discontinuation
- 2008-07-11 DK DK08775031.1T patent/DK2176282T3/da active
- 2008-07-11 EA EA201000097A patent/EA017124B1/ru not_active IP Right Cessation
- 2008-07-11 RS RS20120516A patent/RS52541B/en unknown
- 2008-07-11 US US12/171,424 patent/US20090029957A1/en not_active Abandoned
- 2008-07-11 UA UAA201001369A patent/UA99918C2/ru unknown
- 2008-07-11 PL PL08775031T patent/PL2176282T3/pl unknown
- 2008-07-11 NZ NZ582490A patent/NZ582490A/en not_active IP Right Cessation
- 2008-07-11 AU AU2008274198A patent/AU2008274198A1/en not_active Abandoned
- 2008-07-11 SI SI200830826T patent/SI2176282T1/sl unknown
- 2008-07-11 AR ARP080102978A patent/AR067507A1/es unknown
- 2008-07-11 BR BRPI0814207-6A2A patent/BRPI0814207A2/pt not_active IP Right Cessation
- 2008-07-11 PT PT08775031T patent/PT2176282E/pt unknown
- 2008-07-11 ES ES08775031T patent/ES2393942T3/es active Active
- 2008-07-11 UY UY31220A patent/UY31220A1/es not_active Application Discontinuation
- 2008-07-11 CA CA 2692727 patent/CA2692727A1/en not_active Abandoned
- 2008-07-11 TW TW097126522A patent/TW200911824A/zh unknown
- 2008-07-11 JP JP2010515526A patent/JP2010533152A/ja not_active Ceased
-
2010
- 2010-01-07 MA MA32490A patent/MA31565B1/fr unknown
- 2010-01-07 TN TNP2010000007A patent/TN2010000007A1/fr unknown
- 2010-01-12 HN HN2010000081A patent/HN2010000081A/es unknown
- 2010-01-12 CO CO10002339A patent/CO6270230A2/es active IP Right Grant
- 2010-01-12 CR CR11211A patent/CR11211A/es not_active Application Discontinuation
- 2010-01-12 CU CU20100008A patent/CU23885B1/es not_active IP Right Cessation
- 2010-01-12 EC EC2010009872A patent/ECSP109872A/es unknown
- 2010-01-12 DO DO2010000017A patent/DOP2010000017A/es unknown
-
2012
- 2012-11-14 CY CY20121101099T patent/CY1113351T1/el unknown
- 2012-11-21 HR HRP20120952AT patent/HRP20120952T1/hr unknown
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