CY1113334T1 - Ενωσεις, συνθεσεις και χρησεις παραγωγων βενζοθειαζολης - Google Patents
Ενωσεις, συνθεσεις και χρησεις παραγωγων βενζοθειαζοληςInfo
- Publication number
- CY1113334T1 CY1113334T1 CY20121101106T CY121101106T CY1113334T1 CY 1113334 T1 CY1113334 T1 CY 1113334T1 CY 20121101106 T CY20121101106 T CY 20121101106T CY 121101106 T CY121101106 T CY 121101106T CY 1113334 T1 CY1113334 T1 CY 1113334T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- compositions
- disease
- benzothiesol
- producers
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 108010060159 Apolipoprotein E4 Proteins 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000003941 amyloidogenesis Effects 0.000 abstract 1
- -1 benzothiazole derivative compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/388,173 US7270800B2 (en) | 2000-08-24 | 2003-03-14 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US10/645,847 US20050043523A1 (en) | 2003-08-22 | 2003-08-22 | Benzothiazole derivative compounds, compositions and uses |
| EP04720788A EP1611115B1 (en) | 2003-03-14 | 2004-03-15 | Benzothiazole derivative compounds, compositions and uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113334T1 true CY1113334T1 (el) | 2015-12-09 |
Family
ID=35057877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101106T CY1113334T1 (el) | 2003-03-14 | 2012-11-16 | Ενωσεις, συνθεσεις και χρησεις παραγωγων βενζοθειαζολης |
| CY2015007C CY2015007I1 (el) | 2003-03-14 | 2015-03-04 | Ενωσεις, συνθεσεις και χρησεις παραγωγων βενζοθειαζολης |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2015007C CY2015007I1 (el) | 2003-03-14 | 2015-03-04 | Ενωσεις, συνθεσεις και χρησεις παραγωγων βενζοθειαζολης |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1611115B1 (enExample) |
| JP (1) | JP4875487B2 (enExample) |
| CN (2) | CN1784392A (enExample) |
| AU (2) | AU2004221897B2 (enExample) |
| BE (1) | BE2015C005I2 (enExample) |
| BR (1) | BRPI0408274B8 (enExample) |
| CY (2) | CY1113334T1 (enExample) |
| DK (1) | DK1611115T3 (enExample) |
| ES (1) | ES2393921T3 (enExample) |
| FR (1) | FR15C0005I2 (enExample) |
| HU (1) | HUS1500006I1 (enExample) |
| NO (3) | NO330861B1 (enExample) |
| PL (1) | PL1611115T3 (enExample) |
| PT (1) | PT1611115E (enExample) |
| RU (1) | RU2440995C2 (enExample) |
| SI (1) | SI1611115T1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1334091E (pt) * | 2000-08-24 | 2013-01-07 | Univ Pittsburgh | Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer |
| US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| CN101198598A (zh) * | 2004-05-20 | 2008-06-11 | 弗尔德里克斯制药股份有限公司 | 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法 |
| GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
| AU2008211786B2 (en) * | 2007-01-30 | 2014-07-03 | Ge Healthcare Limited | Tools for aiding in the diagnosis of neurodegenerative diseases |
| CN101293878B (zh) * | 2007-04-25 | 2010-12-15 | 中国科学院上海应用物理研究所 | 苯并噻唑苯胺类化合物及其制备方法和应用 |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| EP2338059B1 (en) * | 2008-09-23 | 2015-04-08 | WisTa Laboratories Ltd. | Ligands for aggregated tau molecules |
| KR101770532B1 (ko) * | 2013-09-26 | 2017-08-22 | 에프. 호프만-라 로슈 아게 | 이미징 수단으로서의 이미다조[1,2-a]피리딘-7-아민 |
| JP6260967B2 (ja) * | 2013-11-06 | 2018-01-17 | 国立大学法人京都大学 | 放射性ヨウ素標識化合物、及び、これを含む放射性医薬 |
| CN103613589B (zh) * | 2013-11-29 | 2016-03-30 | 江苏华益科技有限公司 | 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法 |
| CA2959505A1 (en) * | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN109400615B (zh) * | 2017-08-18 | 2021-07-16 | 上海交通大学医学院附属新华医院 | 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用 |
| GR1009516B (el) * | 2018-03-22 | 2019-05-02 | Εκεφε Δημοκριτος | Τρικαρβονυλο-συμπλοκα μεταλλων μεταπτωσεως με βενζο-ετεροκυκλικο παραγωγο του κυκλοπενταδιενυλικου ανιοντος με υψηλη διαπερατοτητα του αιματοεγκεφαλικου φραγμου για εφαρμογες στη διαγνωση και θεραπεια νοσων του κνς |
| CN119462558B (zh) * | 2024-10-18 | 2025-09-19 | 河南中医药大学 | 一种布美他尼衍生物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID22275A (id) * | 1996-11-22 | 1999-09-23 | Elan Pharm Inc | Komposisi farmasi yang terdiri dari derivat asam amino n-(aril atau heteroaril) dan metode untuk menghambat pelepasan b-amiloid peptida dan atau sintesisnya dengan menggunakan senyawa tersebut |
| GB9919673D0 (en) * | 1999-08-20 | 1999-10-20 | Cancer Res Campaign Tech | 2-Arlybenzazole compounds |
| PT1334091E (pt) * | 2000-08-24 | 2013-01-07 | Univ Pittsburgh | Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer |
| US7045539B2 (en) * | 2000-12-22 | 2006-05-16 | Astrazeneca Ab | Therapeutic benzoxazole compounds |
| EP1381604B1 (en) * | 2001-04-23 | 2006-12-27 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
-
2004
- 2004-03-15 SI SI200431952T patent/SI1611115T1/sl unknown
- 2004-03-15 EP EP04720788A patent/EP1611115B1/en not_active Expired - Lifetime
- 2004-03-15 ES ES04720788T patent/ES2393921T3/es not_active Expired - Lifetime
- 2004-03-15 PL PL04720788T patent/PL1611115T3/pl unknown
- 2004-03-15 JP JP2006507179A patent/JP4875487B2/ja not_active Expired - Lifetime
- 2004-03-15 PT PT47207881T patent/PT1611115E/pt unknown
- 2004-03-15 DK DK04720788.1T patent/DK1611115T3/da active
- 2004-03-15 CN CNA2004800125035A patent/CN1784392A/zh active Pending
- 2004-03-15 RU RU2005131872/04A patent/RU2440995C2/ru not_active Application Discontinuation
- 2004-03-15 BR BRPI0408274A patent/BRPI0408274B8/pt not_active IP Right Cessation
- 2004-03-15 AU AU2004221897A patent/AU2004221897B2/en not_active Expired
- 2004-03-15 CN CN201110437182.5A patent/CN102532055B/zh not_active Expired - Lifetime
-
2005
- 2005-10-11 NO NO20054674A patent/NO330861B1/no active Protection Beyond IP Right Term
-
2011
- 2011-02-16 AU AU2011200667A patent/AU2011200667B2/en not_active Expired
- 2011-07-06 NO NO20110980A patent/NO20110980L/no not_active Application Discontinuation
-
2012
- 2012-11-16 CY CY20121101106T patent/CY1113334T1/el unknown
-
2015
- 2015-01-21 FR FR15C0005C patent/FR15C0005I2/fr active Active
- 2015-01-27 BE BE2015C005C patent/BE2015C005I2/fr unknown
- 2015-02-18 HU HUS1500006C patent/HUS1500006I1/hu unknown
- 2015-02-18 NO NO2015005C patent/NO2015005I1/no not_active IP Right Cessation
- 2015-03-04 CY CY2015007C patent/CY2015007I1/el unknown
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