CY1113135T1 - Ασυμmετρη διεργασια για την κατασκευη υποκατεστημενων 2-αμινο-θειαζολονων - Google Patents

Ασυμmετρη διεργασια για την κατασκευη υποκατεστημενων 2-αμινο-θειαζολονων

Info

Publication number
CY1113135T1
CY1113135T1 CY20121100824T CY121100824T CY1113135T1 CY 1113135 T1 CY1113135 T1 CY 1113135T1 CY 20121100824 T CY20121100824 T CY 20121100824T CY 121100824 T CY121100824 T CY 121100824T CY 1113135 T1 CY1113135 T1 CY 1113135T1
Authority
CY
Cyprus
Prior art keywords
thaizolon
amino
construction
asymmetric processing
processes
Prior art date
Application number
CY20121100824T
Other languages
English (en)
Inventor
Seb Caille
Sheng Cui
Xiang Wang
Margaret Faul
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1113135T1 publication Critical patent/CY1113135T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Η εφεύρεση παρέχει δύο διεργασίες για τη σύνθεση ενώσεων υποκατεστημένης αμινοθειαζολόνης ως αναστολέων της 11-β-υδροξυ στεροειδούς αφυδρογενάσης του τύπου 1. Οι διεργασίες επιτρέπουν τη στερεοεκλεκτική σύνθεση των επιθυμητών ενώσεων χωρίς τη χρήση των στοιχειομετρικών ποσοτήτων των χειρικών καταλυτών.
CY20121100824T 2008-07-29 2012-09-12 Ασυμmετρη διεργασια για την κατασκευη υποκατεστημενων 2-αμινο-θειαζολονων CY1113135T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8454908P 2008-07-29 2008-07-29
EP09790875A EP2321290B1 (en) 2008-07-29 2009-07-28 Asymmetric process for making substituted 2-amino-thiazolones

Publications (1)

Publication Number Publication Date
CY1113135T1 true CY1113135T1 (el) 2016-04-13

Family

ID=41020998

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100824T CY1113135T1 (el) 2008-07-29 2012-09-12 Ασυμmετρη διεργασια για την κατασκευη υποκατεστημενων 2-αμινο-θειαζολονων

Country Status (21)

Country Link
US (2) US8501954B2 (el)
EP (1) EP2321290B1 (el)
JP (1) JP2011529896A (el)
KR (1) KR20110048520A (el)
CN (1) CN102112454B (el)
AU (1) AU2009276757A1 (el)
BR (1) BRPI0916270A2 (el)
CA (1) CA2730711A1 (el)
CL (1) CL2011000120A1 (el)
CY (1) CY1113135T1 (el)
DK (1) DK2321290T3 (el)
EA (1) EA019573B1 (el)
ES (1) ES2386613T3 (el)
HK (1) HK1154000A1 (el)
IL (1) IL210562A (el)
MX (1) MX2011001009A (el)
PL (1) PL2321290T3 (el)
PT (1) PT2321290E (el)
SI (1) SI2321290T1 (el)
WO (1) WO2010014586A1 (el)
ZA (1) ZA201100358B (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009275964A1 (en) 2008-07-29 2010-02-04 Boehringer Ingelheim International Gmbh New compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014419B1 (ru) * 2004-05-24 2010-12-30 Эмджен Инк. 5,5-дизамещённые-2-амино-4-тиазолидиноны и способ их получения, фармацевтическая композиция и способ лечения
CA2630718A1 (en) * 2005-11-22 2007-05-31 Amgen Inc. Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
CA2630558A1 (en) * 2005-11-22 2007-05-31 Amgen, Inc. Catalyzed process of making c-5-substituted heterocyclic inhibitors of 11.beta.-hydroxy steroid dehydrogenase type 1
MX2009013869A (es) 2007-06-21 2010-03-17 Amgen Inc Proceso para hacer 2-amino-tiazolonas sustituidas.

Also Published As

Publication number Publication date
ZA201100358B (en) 2011-10-26
SI2321290T1 (sl) 2012-09-28
EA019573B1 (ru) 2014-04-30
JP2011529896A (ja) 2011-12-15
IL210562A0 (en) 2011-03-31
CN102112454B (zh) 2013-09-04
EP2321290A1 (en) 2011-05-18
BRPI0916270A2 (pt) 2018-10-16
US20130345432A1 (en) 2013-12-26
CA2730711A1 (en) 2010-02-04
PL2321290T3 (pl) 2012-11-30
KR20110048520A (ko) 2011-05-11
WO2010014586A1 (en) 2010-02-04
AU2009276757A1 (en) 2010-02-04
HK1154000A1 (en) 2012-04-13
US8501954B2 (en) 2013-08-06
DK2321290T3 (da) 2012-07-16
PT2321290E (pt) 2012-08-10
MX2011001009A (es) 2011-04-27
ES2386613T3 (es) 2012-08-23
CL2011000120A1 (es) 2011-06-24
EP2321290B1 (en) 2012-06-20
EA201170072A1 (ru) 2011-08-30
US20110178307A1 (en) 2011-07-21
CN102112454A (zh) 2011-06-29
IL210562A (en) 2013-11-28

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