CY1112683T1 - Υποκατεστημενες καρβοξαμιδες ν-φαινυλ-διπυρρολιδινης και θεραπευτικες χρησεις τους - Google Patents
Υποκατεστημενες καρβοξαμιδες ν-φαινυλ-διπυρρολιδινης και θεραπευτικες χρησεις τουςInfo
- Publication number
- CY1112683T1 CY1112683T1 CY20111101272T CY111101272T CY1112683T1 CY 1112683 T1 CY1112683 T1 CY 1112683T1 CY 20111101272 T CY20111101272 T CY 20111101272T CY 111101272 T CY111101272 T CY 111101272T CY 1112683 T1 CY1112683 T1 CY 1112683T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phenyl
- substituted
- carboxamides
- dipyrrolidine
- therapeutic uses
- Prior art date
Links
- 150000003857 carboxamides Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- KFIOZBMCNUODPK-UHFFFAOYSA-N n-phenyl-1-pyrrolidin-1-ylpyrrolidine-2-carboxamide Chemical class C1CCN(N2CCCC2)C1C(=O)NC1=CC=CC=C1 KFIOZBMCNUODPK-UHFFFAOYSA-N 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060107P | 2007-10-17 | 2007-10-17 | |
| EP08839473A EP2212282B1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112683T1 true CY1112683T1 (el) | 2016-02-10 |
Family
ID=40243633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101272T CY1112683T1 (el) | 2007-10-17 | 2011-12-21 | Υποκατεστημενες καρβοξαμιδες ν-φαινυλ-διπυρρολιδινης και θεραπευτικες χρησεις τους |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8618159B2 (enExample) |
| EP (1) | EP2212282B1 (enExample) |
| JP (1) | JP5255644B2 (enExample) |
| KR (1) | KR20100092441A (enExample) |
| CN (1) | CN101903339B (enExample) |
| AT (1) | ATE525350T1 (enExample) |
| AU (1) | AU2008312638B2 (enExample) |
| BR (1) | BRPI0818626A2 (enExample) |
| CA (1) | CA2702482C (enExample) |
| CO (1) | CO6190616A2 (enExample) |
| CY (1) | CY1112683T1 (enExample) |
| DK (1) | DK2212282T3 (enExample) |
| ES (1) | ES2374116T3 (enExample) |
| HR (1) | HRP20110953T1 (enExample) |
| IL (1) | IL205003A0 (enExample) |
| MA (1) | MA31855B1 (enExample) |
| MX (1) | MX2010004094A (enExample) |
| MY (1) | MY149650A (enExample) |
| NZ (1) | NZ584688A (enExample) |
| PL (1) | PL2212282T3 (enExample) |
| PT (1) | PT2212282E (enExample) |
| RU (1) | RU2477719C2 (enExample) |
| SI (1) | SI2212282T1 (enExample) |
| WO (1) | WO2009052065A1 (enExample) |
| ZA (1) | ZA201001946B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100082349A (ko) | 2007-10-17 | 2010-07-16 | 사노피-아벤티스 | 치환된 ｎ－페닐-비피롤리딘 우레아 및 이의 치료적 용도 |
| DK2212283T3 (da) | 2007-10-17 | 2011-12-19 | Sanofi Sa | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf |
| EP2205558B1 (en) * | 2007-10-17 | 2012-07-25 | Sanofi | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
| AR074466A1 (es) * | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| EP2569294B1 (en) * | 2010-05-11 | 2015-03-11 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| AR081034A1 (es) * | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| JP2013526530A (ja) * | 2010-05-11 | 2013-06-24 | サノフイ | 置換されたｎ−フェニルスピロラクタムビピロリジン、その製造及び治療上の使用 |
| AR081908A1 (es) | 2010-05-11 | 2012-10-31 | Sanofi Aventis | N-heteroaril-espirolactama-bipirrolidinas sustituidas, preparacion y usos terapeuticos de las mismas |
| JP5766278B2 (ja) * | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| WO2011143161A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| CN103717757A (zh) * | 2011-05-24 | 2014-04-09 | 威斯特研究所 | 用于调节爱泼斯坦-巴尔核抗原1的活性的组合物和方法 |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE602006010833D1 (de) | 2005-03-17 | 2010-01-14 | Lilly Co Eli | Pyrrolidinderivate als histamin-h3-rezeptorantagonisten |
| CN101151244B (zh) * | 2005-04-01 | 2014-09-03 | 伊莱利利公司 | 组胺h3受体活性剂、制备和治疗用途 |
| EP2322506A1 (en) * | 2005-07-01 | 2011-05-18 | Eli Lilly and Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| US7943605B2 (en) * | 2005-10-27 | 2011-05-17 | Ucb Pharma S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| EP2205558B1 (en) * | 2007-10-17 | 2012-07-25 | Sanofi | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
| DK2212283T3 (da) | 2007-10-17 | 2011-12-19 | Sanofi Sa | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf |
| KR20100082349A (ko) * | 2007-10-17 | 2010-07-16 | 사노피-아벤티스 | 치환된 ｎ－페닐-비피롤리딘 우레아 및 이의 치료적 용도 |
-
2008
- 2008-10-14 SI SI200830482T patent/SI2212282T1/sl unknown
- 2008-10-14 PT PT08839473T patent/PT2212282E/pt unknown
- 2008-10-14 CA CA2702482A patent/CA2702482C/en not_active Expired - Fee Related
- 2008-10-14 JP JP2010530052A patent/JP5255644B2/ja not_active Expired - Fee Related
- 2008-10-14 ES ES08839473T patent/ES2374116T3/es active Active
- 2008-10-14 DK DK08839473.9T patent/DK2212282T3/da active
- 2008-10-14 EP EP08839473A patent/EP2212282B1/en active Active
- 2008-10-14 RU RU2010119560/04A patent/RU2477719C2/ru not_active IP Right Cessation
- 2008-10-14 AT AT08839473T patent/ATE525350T1/de active
- 2008-10-14 CN CN2008801211996A patent/CN101903339B/zh not_active Expired - Fee Related
- 2008-10-14 PL PL08839473T patent/PL2212282T3/pl unknown
- 2008-10-14 MY MYPI2010001276A patent/MY149650A/en unknown
- 2008-10-14 HR HR20110953T patent/HRP20110953T1/hr unknown
- 2008-10-14 BR BRPI0818626A patent/BRPI0818626A2/pt not_active IP Right Cessation
- 2008-10-14 NZ NZ584688A patent/NZ584688A/en not_active IP Right Cessation
- 2008-10-14 AU AU2008312638A patent/AU2008312638B2/en not_active Ceased
- 2008-10-14 MX MX2010004094A patent/MX2010004094A/es active IP Right Grant
- 2008-10-14 WO PCT/US2008/079760 patent/WO2009052065A1/en not_active Ceased
- 2008-10-14 KR KR1020107010545A patent/KR20100092441A/ko not_active Ceased
-
2010
- 2010-03-15 US US12/724,035 patent/US8618159B2/en not_active Expired - Fee Related
- 2010-03-18 ZA ZA201001946A patent/ZA201001946B/xx unknown
- 2010-04-11 IL IL205003A patent/IL205003A0/en unknown
- 2010-04-16 CO CO10044768A patent/CO6190616A2/es not_active Application Discontinuation
- 2010-05-17 MA MA32846A patent/MA31855B1/fr unknown
-
2011
- 2011-12-21 CY CY20111101272T patent/CY1112683T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE525350T1 (de) | 2011-10-15 |
| KR20100092441A (ko) | 2010-08-20 |
| AU2008312638B2 (en) | 2013-05-16 |
| CA2702482A1 (en) | 2009-04-23 |
| ZA201001946B (en) | 2010-10-27 |
| CO6190616A2 (es) | 2010-08-19 |
| RU2477719C2 (ru) | 2013-03-20 |
| HRP20110953T1 (hr) | 2012-01-31 |
| PL2212282T3 (pl) | 2012-02-29 |
| PT2212282E (pt) | 2012-01-09 |
| IL205003A0 (en) | 2010-11-30 |
| MY149650A (en) | 2013-09-30 |
| WO2009052065A1 (en) | 2009-04-23 |
| MA31855B1 (fr) | 2010-11-01 |
| HK1146054A1 (en) | 2011-05-13 |
| RU2010119560A (ru) | 2011-11-27 |
| AU2008312638A1 (en) | 2009-04-23 |
| JP2011500696A (ja) | 2011-01-06 |
| MX2010004094A (es) | 2010-04-30 |
| CN101903339A (zh) | 2010-12-01 |
| DK2212282T3 (da) | 2012-01-23 |
| ES2374116T3 (es) | 2012-02-13 |
| US20100173897A1 (en) | 2010-07-08 |
| JP5255644B2 (ja) | 2013-08-07 |
| NZ584688A (en) | 2011-12-22 |
| CN101903339B (zh) | 2012-06-27 |
| EP2212282B1 (en) | 2011-09-21 |
| EP2212282A1 (en) | 2010-08-04 |
| CA2702482C (en) | 2012-11-27 |
| US8618159B2 (en) | 2013-12-31 |
| SI2212282T1 (sl) | 2012-01-31 |
| BRPI0818626A2 (pt) | 2015-09-29 |
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