CN101903339B - 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 - Google Patents
取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 Download PDFInfo
- Publication number
- CN101903339B CN101903339B CN2008801211996A CN200880121199A CN101903339B CN 101903339 B CN101903339 B CN 101903339B CN 2008801211996 A CN2008801211996 A CN 2008801211996A CN 200880121199 A CN200880121199 A CN 200880121199A CN 101903339 B CN101903339 B CN 101903339B
- Authority
- CN
- China
- Prior art keywords
- methyl
- phenyl
- bipyrrolidine
- carboxylic acid
- acid amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MWACHFODPQVXHF-CYBMUJFWSA-N CC(C)(C)OC(N(CC1)C[C@@H]1OS(c1ccc(C)cc1)(=O)=O)=O Chemical compound CC(C)(C)OC(N(CC1)C[C@@H]1OS(c1ccc(C)cc1)(=O)=O)=O MWACHFODPQVXHF-CYBMUJFWSA-N 0.000 description 1
- FYGOODXSNRCBFF-UHFFFAOYSA-N CC(C)[n]1nnc2cc(C(Nc(cc3)c(C)cc3N(CC3)CC3N3C(C)CCC3)=O)ccc12 Chemical compound CC(C)[n]1nnc2cc(C(Nc(cc3)c(C)cc3N(CC3)CC3N3C(C)CCC3)=O)ccc12 FYGOODXSNRCBFF-UHFFFAOYSA-N 0.000 description 1
- HLXWQWSECJUMCI-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(C(CCC1)N1C(C)=O)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(C(CCC1)N1C(C)=O)=O HLXWQWSECJUMCI-UHFFFAOYSA-N 0.000 description 1
- HQZMWPHWEDSLFJ-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(c1cnccc1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(c1cnccc1)=O HQZMWPHWEDSLFJ-UHFFFAOYSA-N 0.000 description 1
- VGQZQHMXFIUPLV-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1NC(c(cc1)cc(N2)c1NC2=O)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1NC(c(cc1)cc(N2)c1NC2=O)=O VGQZQHMXFIUPLV-UHFFFAOYSA-N 0.000 description 1
- IYKCUCPLQOHLBC-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1NC(c1ccc2nc(-c3ncccc3)[nH]c2c1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1NC(c1ccc2nc(-c3ncccc3)[nH]c2c1)=O IYKCUCPLQOHLBC-UHFFFAOYSA-N 0.000 description 1
- GAHOQBHYBQXWSW-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c(cc1)ccc1OC)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c(cc1)ccc1OC)=O GAHOQBHYBQXWSW-UHFFFAOYSA-N 0.000 description 1
- MIXABWQHZDQHOX-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O MIXABWQHZDQHOX-UHFFFAOYSA-N 0.000 description 1
- YWIRUJOFDLUXEH-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1C)ccc1NC(c(cc1)ccc1N(C)C=O)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1C)ccc1NC(c(cc1)ccc1N(C)C=O)=O YWIRUJOFDLUXEH-UHFFFAOYSA-N 0.000 description 1
- LAUIXSJMNZRLFP-KIYNQFGBSA-N CC(CCC1)N1[C@@H](CC1)CN1C(OC(C)(C)C)=O Chemical compound CC(CCC1)N1[C@@H](CC1)CN1C(OC(C)(C)C)=O LAUIXSJMNZRLFP-KIYNQFGBSA-N 0.000 description 1
- HHAUFTJSDMPHKG-ZFWWWQNUSA-N C[C@@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1[N+]([O-])=O Chemical compound C[C@@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1[N+]([O-])=O HHAUFTJSDMPHKG-ZFWWWQNUSA-N 0.000 description 1
- 0 Cc(c(*)c(cc1)N(CC2)CC2N2C(*)CCC2)c1N(*)C(*)=O Chemical compound Cc(c(*)c(cc1)N(CC2)CC2N2C(*)CCC2)c1N(*)C(*)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060107P | 2007-10-17 | 2007-10-17 | |
| US60/980,601 | 2007-10-17 | ||
| PCT/US2008/079760 WO2009052065A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101903339A CN101903339A (zh) | 2010-12-01 |
| CN101903339B true CN101903339B (zh) | 2012-06-27 |
Family
ID=40243633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801211996A Expired - Fee Related CN101903339B (zh) | 2007-10-17 | 2008-10-14 | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8618159B2 (enExample) |
| EP (1) | EP2212282B1 (enExample) |
| JP (1) | JP5255644B2 (enExample) |
| KR (1) | KR20100092441A (enExample) |
| CN (1) | CN101903339B (enExample) |
| AT (1) | ATE525350T1 (enExample) |
| AU (1) | AU2008312638B2 (enExample) |
| BR (1) | BRPI0818626A2 (enExample) |
| CA (1) | CA2702482C (enExample) |
| CO (1) | CO6190616A2 (enExample) |
| CY (1) | CY1112683T1 (enExample) |
| DK (1) | DK2212282T3 (enExample) |
| ES (1) | ES2374116T3 (enExample) |
| HR (1) | HRP20110953T1 (enExample) |
| IL (1) | IL205003A0 (enExample) |
| MA (1) | MA31855B1 (enExample) |
| MX (1) | MX2010004094A (enExample) |
| MY (1) | MY149650A (enExample) |
| NZ (1) | NZ584688A (enExample) |
| PL (1) | PL2212282T3 (enExample) |
| PT (1) | PT2212282E (enExample) |
| RU (1) | RU2477719C2 (enExample) |
| SI (1) | SI2212282T1 (enExample) |
| WO (1) | WO2009052065A1 (enExample) |
| ZA (1) | ZA201001946B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS52235B (sr) | 2007-10-17 | 2012-10-31 | Sanofi | Supstituisani n-fenil-bipirolidin karboksamidi i njihova terapeutska upotreba |
| ES2378011T3 (es) | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
| RU2477721C2 (ru) * | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| AR074466A1 (es) * | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| JP5833105B2 (ja) | 2010-05-11 | 2015-12-16 | サノフイ | 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
| AR081382A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
| TW201206901A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| TW201206444A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| WO2011143163A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| JP5766278B2 (ja) * | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| WO2012162291A1 (en) * | 2011-05-24 | 2012-11-29 | The Wistar Institute | Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1 |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004037257A1 (en) * | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7951826B2 (en) | 2005-03-17 | 2011-05-31 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
| AU2006232871B9 (en) * | 2005-04-01 | 2011-11-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| JP5193033B2 (ja) * | 2005-07-01 | 2013-05-08 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
| WO2007048595A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| RS52235B (sr) | 2007-10-17 | 2012-10-31 | Sanofi | Supstituisani n-fenil-bipirolidin karboksamidi i njihova terapeutska upotreba |
| RU2477721C2 (ru) * | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
| ES2378011T3 (es) * | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
-
2008
- 2008-10-14 HR HR20110953T patent/HRP20110953T1/hr unknown
- 2008-10-14 MY MYPI2010001276A patent/MY149650A/en unknown
- 2008-10-14 ES ES08839473T patent/ES2374116T3/es active Active
- 2008-10-14 SI SI200830482T patent/SI2212282T1/sl unknown
- 2008-10-14 RU RU2010119560/04A patent/RU2477719C2/ru not_active IP Right Cessation
- 2008-10-14 MX MX2010004094A patent/MX2010004094A/es active IP Right Grant
- 2008-10-14 PL PL08839473T patent/PL2212282T3/pl unknown
- 2008-10-14 AU AU2008312638A patent/AU2008312638B2/en not_active Ceased
- 2008-10-14 AT AT08839473T patent/ATE525350T1/de active
- 2008-10-14 CA CA2702482A patent/CA2702482C/en not_active Expired - Fee Related
- 2008-10-14 NZ NZ584688A patent/NZ584688A/en not_active IP Right Cessation
- 2008-10-14 KR KR1020107010545A patent/KR20100092441A/ko not_active Ceased
- 2008-10-14 JP JP2010530052A patent/JP5255644B2/ja not_active Expired - Fee Related
- 2008-10-14 CN CN2008801211996A patent/CN101903339B/zh not_active Expired - Fee Related
- 2008-10-14 EP EP08839473A patent/EP2212282B1/en active Active
- 2008-10-14 BR BRPI0818626A patent/BRPI0818626A2/pt not_active IP Right Cessation
- 2008-10-14 PT PT08839473T patent/PT2212282E/pt unknown
- 2008-10-14 WO PCT/US2008/079760 patent/WO2009052065A1/en not_active Ceased
- 2008-10-14 DK DK08839473.9T patent/DK2212282T3/da active
-
2010
- 2010-03-15 US US12/724,035 patent/US8618159B2/en active Active
- 2010-03-18 ZA ZA201001946A patent/ZA201001946B/xx unknown
- 2010-04-11 IL IL205003A patent/IL205003A0/en unknown
- 2010-04-16 CO CO10044768A patent/CO6190616A2/es not_active Application Discontinuation
- 2010-05-17 MA MA32846A patent/MA31855B1/fr unknown
-
2011
- 2011-12-21 CY CY20111101272T patent/CY1112683T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004037257A1 (en) * | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| SI2212282T1 (sl) | 2012-01-31 |
| NZ584688A (en) | 2011-12-22 |
| US8618159B2 (en) | 2013-12-31 |
| EP2212282B1 (en) | 2011-09-21 |
| PL2212282T3 (pl) | 2012-02-29 |
| BRPI0818626A2 (pt) | 2015-09-29 |
| CY1112683T1 (el) | 2016-02-10 |
| CO6190616A2 (es) | 2010-08-19 |
| HK1146054A1 (en) | 2011-05-13 |
| ES2374116T3 (es) | 2012-02-13 |
| ZA201001946B (en) | 2010-10-27 |
| DK2212282T3 (da) | 2012-01-23 |
| CN101903339A (zh) | 2010-12-01 |
| MA31855B1 (fr) | 2010-11-01 |
| EP2212282A1 (en) | 2010-08-04 |
| PT2212282E (pt) | 2012-01-09 |
| CA2702482A1 (en) | 2009-04-23 |
| ATE525350T1 (de) | 2011-10-15 |
| AU2008312638B2 (en) | 2013-05-16 |
| HRP20110953T1 (hr) | 2012-01-31 |
| IL205003A0 (en) | 2010-11-30 |
| JP5255644B2 (ja) | 2013-08-07 |
| MY149650A (en) | 2013-09-30 |
| RU2477719C2 (ru) | 2013-03-20 |
| KR20100092441A (ko) | 2010-08-20 |
| JP2011500696A (ja) | 2011-01-06 |
| RU2010119560A (ru) | 2011-11-27 |
| MX2010004094A (es) | 2010-04-30 |
| US20100173897A1 (en) | 2010-07-08 |
| WO2009052065A1 (en) | 2009-04-23 |
| CA2702482C (en) | 2012-11-27 |
| AU2008312638A1 (en) | 2009-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101903339B (zh) | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 | |
| CN101903340B (zh) | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 | |
| CN101903341B (zh) | 取代的n-苯基-联吡咯烷脲及其治疗用途 | |
| CN101903342B (zh) | 取代的n-苯基-吡咯烷基甲基吡咯烷酰胺及其作为组胺h3受体调节剂的治疗用途 | |
| EP2569280B1 (en) | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof | |
| JP2013526528A (ja) | 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 | |
| EP2569294B1 (en) | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof | |
| HK1146054B (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| HK1146053B (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| HK1146055B (en) | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators | |
| HK1146056B (en) | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1146054 Country of ref document: HK |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1146054 Country of ref document: HK |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120627 Termination date: 20141014 |
|
| EXPY | Termination of patent right or utility model |