CY1112471T1 - Αναμικτοι orl1/μ-αγωνιστες για τη θεραπεια πονου - Google Patents

Αναμικτοι orl1/μ-αγωνιστες για τη θεραπεια πονου

Info

Publication number
CY1112471T1
CY1112471T1 CY20121100252T CY121100252T CY1112471T1 CY 1112471 T1 CY1112471 T1 CY 1112471T1 CY 20121100252 T CY20121100252 T CY 20121100252T CY 121100252 T CY121100252 T CY 121100252T CY 1112471 T1 CY1112471 T1 CY 1112471T1
Authority
CY
Cyprus
Prior art keywords
orl1
receptor
agonist
pain
agonists
Prior art date
Application number
CY20121100252T
Other languages
English (en)
Inventor
Klaus Dr Linz
Babette-Yvonne Dr Kögel
Wolfgang Dr SCHRÖDER
Thomas Dr Christoph
Vry Jean Dr De
Elmar Friderichs
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1112471T1 publication Critical patent/CY1112471T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αφορά τη χρησιμοποίηση ενώσεων, οι οποίες παρουσιάζουν μία χημική συγγένεια προς τον υποδοχέα μ-οπιοειδών από τουλάχιστον 100 nΜ(ανθρώπινη τιμή Κi) και μία χημική συγγένεια προς τον ORL1-υποδοχέα, όπου η αναλογία μεταξύ χημικών συγγενειών ORL1/μ, προσδιορισμένη σαν 1/[Κi(ORL1)/Κi(μ)], βρίσκεται από 0,1 έως 30, για την παρασκευή ενός φαρμάκου για τη θεραπεία πόνου.
CY20121100252T 2006-09-29 2012-03-12 Αναμικτοι orl1/μ-αγωνιστες για τη θεραπεια πονου CY1112471T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006046745A DE102006046745A1 (de) 2006-09-29 2006-09-29 Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP10003202A EP2206498B9 (de) 2006-09-29 2007-09-26 Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Publications (1)

Publication Number Publication Date
CY1112471T1 true CY1112471T1 (el) 2015-12-09

Family

ID=38982475

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20101100993T CY1110879T1 (el) 2006-09-29 2010-11-03 ΧΑΡΑΚΤΗΡΙΣΜΟΣ: ΑΝΑΜΙΚΤΟΙ ORL1/μ-ΑΓΩΝΙΣΤΕΣ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΠΟΝΟΥ
CY20121100252T CY1112471T1 (el) 2006-09-29 2012-03-12 Αναμικτοι orl1/μ-αγωνιστες για τη θεραπεια πονου

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20101100993T CY1110879T1 (el) 2006-09-29 2010-11-03 ΧΑΡΑΚΤΗΡΙΣΜΟΣ: ΑΝΑΜΙΚΤΟΙ ORL1/μ-ΑΓΩΝΙΣΤΕΣ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΠΟΝΟΥ

Country Status (13)

Country Link
US (3) US20080125475A1 (el)
EP (2) EP2206498B9 (el)
JP (2) JP5203373B2 (el)
AT (2) ATE478667T1 (el)
CA (1) CA2664702C (el)
CY (2) CY1110879T1 (el)
DE (2) DE102006046745A1 (el)
DK (2) DK2081571T3 (el)
ES (2) ES2377482T3 (el)
PL (2) PL2206498T3 (el)
PT (2) PT2206498E (el)
SI (2) SI2206498T1 (el)
WO (1) WO2008040481A1 (el)

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EP2476680B1 (en) 2008-01-11 2014-08-27 Albany Molecular Research, Inc. (1-Azinone)-Substituted Pyridoindoles
WO2009118169A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH Spiro(5.5)undecan derivate
ES2694103T3 (es) 2008-03-27 2018-12-18 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
US8357705B2 (en) 2008-03-27 2013-01-22 Gruenenthal Gmbh Substituted cyclohexyldiamines
AR073841A1 (es) 2008-03-27 2010-12-09 Gruenenthal Chemie Hidroximetilciclohexilaminas, medicamentos y uso de los mismos para la fabricacion de medicamentos.
BRPI0910607A2 (pt) 2008-03-27 2015-09-22 Gruenenthal Gmbh derivados do ciclohexano espirocíclicos substituídos
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US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
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US9308196B2 (en) * 2012-05-18 2016-04-12 Gruenenthal Gmbh Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
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US9345689B2 (en) * 2012-05-18 2016-05-24 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant
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HUE040039T2 (hu) 2014-02-27 2019-02-28 Gruenenthal Gmbh Az 5-fluor-triptofol elõállítására szolgáló eljárás
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Also Published As

Publication number Publication date
EP2206498A1 (de) 2010-07-14
SI2206498T1 (sl) 2012-03-30
ES2351528T3 (es) 2011-02-07
EP2081571A1 (de) 2009-07-29
JP5698282B2 (ja) 2015-04-08
EP2206498B9 (de) 2012-04-18
SI2081571T1 (sl) 2010-12-31
CY1110879T1 (el) 2015-06-10
DK2081571T3 (da) 2010-11-08
JP2013116907A (ja) 2013-06-13
ATE478667T1 (de) 2010-09-15
US20110015220A1 (en) 2011-01-20
JP5203373B2 (ja) 2013-06-05
PT2206498E (pt) 2012-02-15
PT2081571E (pt) 2010-11-29
ATE542532T1 (de) 2012-02-15
PL2206498T3 (pl) 2012-04-30
DE102006046745A1 (de) 2008-04-03
EP2081571B1 (de) 2010-08-25
ES2377482T3 (es) 2012-03-28
DK2206498T3 (da) 2012-03-19
EP2206498B1 (de) 2012-01-25
DE502007004875D1 (de) 2010-10-07
US20080125475A1 (en) 2008-05-29
JP2010504926A (ja) 2010-02-18
PL2081571T3 (pl) 2011-02-28
CA2664702A1 (en) 2008-04-10
WO2008040481A1 (de) 2008-04-10
CA2664702C (en) 2016-08-09
US20150342929A1 (en) 2015-12-03

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