CY1112317T1 - Καινοφανης κρυσταλλικη μορφη ενος παραγωγου της πυριδαζινο [4,5-β] ινδολης - Google Patents

Καινοφανης κρυσταλλικη μορφη ενος παραγωγου της πυριδαζινο [4,5-β] ινδολης

Info

Publication number
CY1112317T1
CY1112317T1 CY20121100092T CY121100092T CY1112317T1 CY 1112317 T1 CY1112317 T1 CY 1112317T1 CY 20121100092 T CY20121100092 T CY 20121100092T CY 121100092 T CY121100092 T CY 121100092T CY 1112317 T1 CY1112317 T1 CY 1112317T1
Authority
CY
Cyprus
Prior art keywords
pyridasin
indolis
producer
crystal form
rapid crystal
Prior art date
Application number
CY20121100092T
Other languages
English (en)
Inventor
William L Rocco
John D Higgins
Original Assignee
Sanofi-Aventis U.S. Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1112317(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi-Aventis U.S. Llc filed Critical Sanofi-Aventis U.S. Llc
Publication of CY1112317T1 publication Critical patent/CY1112317T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Αποκαλύπτονται μία καινοφανής κρυσταλλική μορφή του 7-χλωρο -Ν,Ν,5-τριμεθυλ -4-οξο -3-φαινυλ -3,5-διυδρο -4Η-πυριδαζινο [4,5-]ινδολ -1-ακεταμιδίου, διεργασίες παρασκευής της εν λόγω κρυσταλλικής μορφής του 7-χλωρο -Ν,Ν,5-τριμεθυλ -4-οξο -3-φαινυλ -3,5-διυδρο -4Η-πυριδαζινο [4,5-ο]ινδολ -1-ακεταμιδίου, συνθέσεις περιλαμβάνουσες την εν λόγω μορφή σε πρόσμειξη με ένα ή περισσότερα φαρμακευτικώς αποδεκτά έκδοχα, και χρήσεις για τις ίδιες.
CY20121100092T 2005-08-29 2012-01-26 Καινοφανης κρυσταλλικη μορφη ενος παραγωγου της πυριδαζινο [4,5-β] ινδολης CY1112317T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71215305P 2005-08-29 2005-08-29
EP06813757A EP1924585B1 (en) 2005-08-29 2006-08-24 Novel crystalline form of a pyridazino [4 , 5-b] indole derivative

Publications (1)

Publication Number Publication Date
CY1112317T1 true CY1112317T1 (el) 2015-12-09

Family

ID=37546937

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100092T CY1112317T1 (el) 2005-08-29 2012-01-26 Καινοφανης κρυσταλλικη μορφη ενος παραγωγου της πυριδαζινο [4,5-β] ινδολης

Country Status (32)

Country Link
US (1) US7683062B2 (el)
EP (1) EP1924585B1 (el)
JP (1) JP5063600B2 (el)
KR (2) KR20130087059A (el)
CN (1) CN101253176B (el)
AR (1) AR057099A1 (el)
AT (1) ATE531717T1 (el)
AU (1) AU2006285142B2 (el)
BR (1) BRPI0615259A2 (el)
CA (1) CA2619284C (el)
CR (1) CR9723A (el)
CY (1) CY1112317T1 (el)
DK (1) DK1924585T3 (el)
EA (1) EA014164B1 (el)
EC (1) ECSP088209A (el)
ES (1) ES2375841T3 (el)
HK (1) HK1123794A1 (el)
HR (1) HRP20120073T1 (el)
IL (1) IL189276A (el)
MA (1) MA30000B1 (el)
NO (1) NO20081365L (el)
NZ (1) NZ566087A (el)
PL (1) PL1924585T3 (el)
PT (1) PT1924585E (el)
RS (1) RS52318B (el)
SI (1) SI1924585T1 (el)
TN (1) TNSN08059A1 (el)
TW (1) TW200813060A (el)
UA (1) UA91716C2 (el)
UY (1) UY29771A1 (el)
WO (1) WO2007027525A1 (el)
ZA (1) ZA200801890B (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007536210A (ja) * 2003-11-17 2007-12-13 メルック・エプロバ・アクチエンゲゼルシヤフト （６ｒ）−ｌ−エリスロ−テトラヒドロビオプテリンジヒドロクロライドの結晶形
CN1960992B (zh) * 2004-06-02 2011-10-19 桑多斯股份公司 晶体形式的美罗培南中间体
US8188138B2 (en) * 2005-09-21 2012-05-29 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
EP1951700A2 (en) * 2005-10-31 2008-08-06 Janssen Pharmaceutica N.V. Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
PL2044020T3 (pl) * 2006-06-16 2011-09-30 H Lundbeck As Krystaliczne postaci 4-[2-(4-metylofenylosulfanylo)-fenylo]piperydyny z równoczesnym hamowaniem wychwytu zwrotnego serotoniny i norepinefryny do leczenia bólu neuropatycznego
KR20150028857A (ko) * 2006-10-27 2015-03-16 시그날 파마소티칼 엘엘씨 4-[9-(테트라하이드로-퓨란-3-일)-8-(2,4,6-트리플루오로-페닐아미노)-9ｈ-퓨린-2-일아미노]-사이클로헥산-1-올을포함하는 고체 형태들, 이들의 조성물들 및 이들의 용도
EP2085397A1 (en) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
RU2011110241A (ru) * 2008-08-18 2012-09-27 САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи (US) СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФА 7-ХЛОР-N,N,5-ТРИМЕТИЛ-4-ОКСО-3-ФЕНИЛ-3,5-ДИГИДРО-4Н-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА
CN107445919A (zh) 2010-03-12 2017-12-08 奥默罗斯公司 Pde10抑制剂以及相关组合物和方法
SG188361A1 (en) * 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
WO2013044816A1 (en) * 2011-09-30 2013-04-04 Sunshine Lake Pharma Co., Ltd. Crystalline forms of azilsartan and preparation and uses thereof
NZ630803A (en) 2014-04-28 2016-03-31 Omeros Corp Optically active pde10 inhibitor
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
BR112017022936A2 (pt) 2015-04-24 2018-07-17 Omeros Corp inibidores da pde10 e composições e métodos relacionados
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態
CN111303230B (zh) * 2020-03-09 2021-07-13 中国食品药品检定研究院 一种黄体酮共晶物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2829939B3 (fr) 2001-09-21 2003-11-28 Sanofi Synthelabo Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide
US20050220881A1 (en) 2003-10-10 2005-10-06 Bvm Holding Co. Pharmaceutical composition

Also Published As

Publication number Publication date
CN101253176B (zh) 2012-04-18
DK1924585T3 (da) 2012-02-27
PT1924585E (pt) 2012-01-19
NO20081365L (no) 2008-04-03
EP1924585A1 (en) 2008-05-28
AU2006285142A1 (en) 2007-03-08
CR9723A (es) 2008-06-18
EA014164B1 (ru) 2010-10-29
US20080139569A1 (en) 2008-06-12
JP5063600B2 (ja) 2012-10-31
AU2006285142B2 (en) 2012-06-14
KR20080050577A (ko) 2008-06-09
SI1924585T1 (sl) 2012-09-28
HK1123794A1 (en) 2009-06-26
ATE531717T1 (de) 2011-11-15
RS52318B (en) 2012-12-31
IL189276A0 (en) 2008-08-07
HRP20120073T1 (hr) 2012-07-31
ZA200801890B (en) 2009-11-25
ECSP088209A (es) 2008-06-30
TNSN08059A1 (en) 2009-07-14
CA2619284A1 (en) 2007-03-08
MA30000B1 (fr) 2008-12-01
UY29771A1 (es) 2007-03-30
BRPI0615259A2 (pt) 2011-05-17
IL189276A (en) 2012-07-31
US7683062B2 (en) 2010-03-23
EP1924585B1 (en) 2011-11-02
EA200800716A1 (ru) 2008-08-29
UA91716C2 (ru) 2010-08-25
CN101253176A (zh) 2008-08-27
WO2007027525A1 (en) 2007-03-08
CA2619284C (en) 2014-04-29
TW200813060A (en) 2008-03-16
AR057099A1 (es) 2007-11-14
NZ566087A (en) 2011-03-31
ES2375841T3 (es) 2012-03-06
PL1924585T3 (pl) 2012-08-31
JP2009506116A (ja) 2009-02-12
KR20130087059A (ko) 2013-08-05

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