EA200800716A1 - Новая кристаллическая форма производного пиридазино[4,5-в]индола - Google Patents

Новая кристаллическая форма производного пиридазино[4,5-в]индола

Info

Publication number
EA200800716A1
EA200800716A1 EA200800716A EA200800716A EA200800716A1 EA 200800716 A1 EA200800716 A1 EA 200800716A1 EA 200800716 A EA200800716 A EA 200800716A EA 200800716 A EA200800716 A EA 200800716A EA 200800716 A1 EA200800716 A1 EA 200800716A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridazino
indol
derivative
crystal form
new crystal
Prior art date
Application number
EA200800716A
Other languages
English (en)
Other versions
EA014164B1 (ru
Inventor
Уилльям Л. Рокко
Джон Д. Хиггинс
Original Assignee
САНОФИ-АВЕНТИС Ю. Эс. ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800716(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by САНОФИ-АВЕНТИС Ю. Эс. ЭлЭлСи filed Critical САНОФИ-АВЕНТИС Ю. Эс. ЭлЭлСи
Publication of EA200800716A1 publication Critical patent/EA200800716A1/ru
Publication of EA014164B1 publication Critical patent/EA014164B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Раскрывается новая кристаллическая форма 7-хлор-N,N,5-триметил-4-оксо-3-фенил-3,5-дигидро-4Н-пиридазино[4,5-b]индол-1-ацетамида; способ получения указанной кристаллической формы 7-хлор-N,N,5-триметил-4-оксо-3-фенил-3,5-дигидро-4Н-пиридазино[4,5-b]индол-1-ацетамида; композиции, содержащие указанную форму в смеси с одним или несколькими фармацевтически приемлемыми наполнителями, и применения указанной формы.
EA200800716A 2005-08-29 2006-08-24 Новая кристаллическая форма производного пиридазино[4,5-в]индола EA014164B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71215305P 2005-08-29 2005-08-29
PCT/US2006/033254 WO2007027525A1 (en) 2005-08-29 2006-08-24 Novel crystalline form of a pyridazino [4 , 5-b] indole derivative

Publications (2)

Publication Number Publication Date
EA200800716A1 true EA200800716A1 (ru) 2008-08-29
EA014164B1 EA014164B1 (ru) 2010-10-29

Family

ID=37546937

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800716A EA014164B1 (ru) 2005-08-29 2006-08-24 Новая кристаллическая форма производного пиридазино[4,5-в]индола

Country Status (32)

Country Link
US (1) US7683062B2 (ru)
EP (1) EP1924585B1 (ru)
JP (1) JP5063600B2 (ru)
KR (2) KR20080050577A (ru)
CN (1) CN101253176B (ru)
AR (1) AR057099A1 (ru)
AT (1) ATE531717T1 (ru)
AU (1) AU2006285142B2 (ru)
BR (1) BRPI0615259A2 (ru)
CA (1) CA2619284C (ru)
CR (1) CR9723A (ru)
CY (1) CY1112317T1 (ru)
DK (1) DK1924585T3 (ru)
EA (1) EA014164B1 (ru)
EC (1) ECSP088209A (ru)
ES (1) ES2375841T3 (ru)
HK (1) HK1123794A1 (ru)
HR (1) HRP20120073T1 (ru)
IL (1) IL189276A (ru)
MA (1) MA30000B1 (ru)
NO (1) NO20081365L (ru)
NZ (1) NZ566087A (ru)
PL (1) PL1924585T3 (ru)
PT (1) PT1924585E (ru)
RS (1) RS52318B (ru)
SI (1) SI1924585T1 (ru)
TN (1) TNSN08059A1 (ru)
TW (1) TW200813060A (ru)
UA (1) UA91716C2 (ru)
UY (1) UY29771A1 (ru)
WO (1) WO2007027525A1 (ru)
ZA (1) ZA200801890B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1687308B1 (en) * 2003-11-17 2019-06-12 Merck & Cie Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
CN101287706A (zh) * 2005-09-21 2008-10-15 尼科梅德有限责任公司 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐
BRPI0617947A2 (pt) * 2005-10-31 2011-08-09 Janssen Pharmaceutica Nv processos para a preparação de derivados de piperazinil e diazapanil benzamida
PL2044020T3 (pl) * 2006-06-16 2011-09-30 H Lundbeck As Krystaliczne postaci 4-[2-(4-metylofenylosulfanylo)-fenylo]piperydyny z równoczesnym hamowaniem wychwytu zwrotnego serotoniny i norepinefryny do leczenia bólu neuropatycznego
KR20150028857A (ko) * 2006-10-27 2015-03-16 시그날 파마소티칼 엘엘씨 4-[9-(테트라하이드로-퓨란-3-일)-8-(2,4,6-트리플루오로-페닐아미노)-9ｈ-퓨린-2-일아미노]-사이클로헥산-1-올을포함하는 고체 형태들, 이들의 조성물들 및 이들의 용도
EP2085397A1 (en) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
EP2364315A1 (en) * 2008-08-18 2011-09-14 Sanofi-Aventis U.S. LLC Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide
CN102869355B (zh) 2010-03-12 2015-07-08 奥默罗斯公司 Pde10抑制剂以及相关组合物和方法
US9365521B2 (en) * 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
US9174973B2 (en) * 2011-09-30 2015-11-03 Sunshine Lake Pharma Co., Ltd. Crystalline forms of azilsartan and preparation and uses thereof
NZ630803A (en) * 2014-04-28 2016-03-31 Omeros Corp Optically active pde10 inhibitor
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
JP2018513153A (ja) 2015-04-24 2018-05-24 オメロス コーポレーション Ｐｄｅ１０インヒビターならびに関連する組成物および方法
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態
CN111303230B (zh) * 2020-03-09 2021-07-13 中国食品药品检定研究院 一种黄体酮共晶物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2829939B3 (fr) 2001-09-21 2003-11-28 Sanofi Synthelabo Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide
US20050220881A1 (en) 2003-10-10 2005-10-06 Bvm Holding Co. Pharmaceutical composition

Also Published As

Publication number Publication date
US20080139569A1 (en) 2008-06-12
CA2619284C (en) 2014-04-29
UY29771A1 (es) 2007-03-30
ES2375841T3 (es) 2012-03-06
RS52318B (en) 2012-12-31
EA014164B1 (ru) 2010-10-29
US7683062B2 (en) 2010-03-23
IL189276A0 (en) 2008-08-07
ATE531717T1 (de) 2011-11-15
PL1924585T3 (pl) 2012-08-31
UA91716C2 (ru) 2010-08-25
KR20080050577A (ko) 2008-06-09
SI1924585T1 (sl) 2012-09-28
NZ566087A (en) 2011-03-31
JP5063600B2 (ja) 2012-10-31
MA30000B1 (fr) 2008-12-01
CN101253176B (zh) 2012-04-18
CA2619284A1 (en) 2007-03-08
ECSP088209A (es) 2008-06-30
PT1924585E (pt) 2012-01-19
IL189276A (en) 2012-07-31
NO20081365L (no) 2008-04-03
HRP20120073T1 (hr) 2012-07-31
TNSN08059A1 (en) 2009-07-14
JP2009506116A (ja) 2009-02-12
TW200813060A (en) 2008-03-16
AR057099A1 (es) 2007-11-14
WO2007027525A1 (en) 2007-03-08
DK1924585T3 (da) 2012-02-27
EP1924585B1 (en) 2011-11-02
EP1924585A1 (en) 2008-05-28
HK1123794A1 (en) 2009-06-26
ZA200801890B (en) 2009-11-25
AU2006285142B2 (en) 2012-06-14
CR9723A (es) 2008-06-18
CN101253176A (zh) 2008-08-27
CY1112317T1 (el) 2015-12-09
KR20130087059A (ko) 2013-08-05
AU2006285142A1 (en) 2007-03-08
BRPI0615259A2 (pt) 2011-05-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU