CY1111569T1 - Μονολυσινικα αλατα αζολικων ενωσεων - Google Patents
Μονολυσινικα αλατα αζολικων ενωσεωνInfo
- Publication number
- CY1111569T1 CY1111569T1 CY20111100582T CY111100582T CY1111569T1 CY 1111569 T1 CY1111569 T1 CY 1111569T1 CY 20111100582 T CY20111100582 T CY 20111100582T CY 111100582 T CY111100582 T CY 111100582T CY 1111569 T1 CY1111569 T1 CY 1111569T1
- Authority
- CY
- Cyprus
- Prior art keywords
- salts
- formula
- monolysin
- new water
- triazole antifungal
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 2
- 229940121375 antifungal agent Drugs 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003852 triazoles Chemical class 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003851 azoles Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Παρέχονται μονολυσινικά άλατα τριαζολικών ενώσεων με δευτεροταγή ή τριτοταγή υδροξυομάδα. Ειδικότερα, παρέχονται οι νέες υδατοδιαλυτές τριαζολικές αντιμυκητικές ενώσεις-μονολυσινικά άλατα, ή επιδιαλυτωμένα συμπλέγματα αυτών, με το γενικό τύπο I: όπου η Α στον τύπο I αντιπροσωπεύει το μη υδροξυλικό τμήμα τριαζολικής αντιμυκητικής ένωσης του τύπου που περιέχει δευτεροταγή ή τριτοταγή υδροξυλομάδα. Οι R και R1 στον τύπο I μπορούν έκαστη να είναι άτομο υδρογόνου ή ομάδα αλκυλίου με ένα έως έξι άτομα άνθρακα. Οι νέες υδατοδιαλυτές αζολικές ενώσεις είναι χρήσιμες για την αγωγή μυκητικών μολύνσεων και μπορούν να χορηγηθούν από το στόμα, τοπικά και παρεντερικά.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67693205P | 2005-05-03 | 2005-05-03 | |
| EP06746245A EP1877403B1 (en) | 2005-05-03 | 2006-05-01 | Mono-lysine salts of azole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111569T1 true CY1111569T1 (el) | 2015-10-07 |
Family
ID=36910951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100582T CY1111569T1 (el) | 2005-05-03 | 2011-06-17 | Μονολυσινικα αλατα αζολικων ενωσεων |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US20060264406A1 (el) |
| EP (1) | EP1877403B1 (el) |
| JP (1) | JP4015691B1 (el) |
| KR (1) | KR100887044B1 (el) |
| CN (1) | CN101213193B (el) |
| AR (1) | AR053862A1 (el) |
| AT (1) | ATE503753T1 (el) |
| AU (1) | AU2006241694B2 (el) |
| BR (1) | BRPI0610423B8 (el) |
| CA (1) | CA2606185C (el) |
| CY (1) | CY1111569T1 (el) |
| DE (1) | DE602006020998D1 (el) |
| DK (1) | DK1877403T3 (el) |
| EC (1) | ECSP077812A (el) |
| ES (1) | ES2361768T3 (el) |
| HK (1) | HK1117502A1 (el) |
| HR (1) | HRP20110467T1 (el) |
| IL (1) | IL187059A (el) |
| JO (1) | JO2691B1 (el) |
| MX (1) | MX2007013605A (el) |
| MY (1) | MY138095A (el) |
| NO (1) | NO20075541L (el) |
| NZ (1) | NZ563092A (el) |
| PE (1) | PE20071423A1 (el) |
| PL (1) | PL1877403T3 (el) |
| PT (1) | PT1877403E (el) |
| RS (1) | RS51779B (el) |
| RU (1) | RU2399625C2 (el) |
| SA (1) | SA06270126B1 (el) |
| SI (1) | SI1877403T1 (el) |
| TW (1) | TWI363630B (el) |
| UY (1) | UY29507A1 (el) |
| WO (1) | WO2006118351A1 (el) |
| ZA (1) | ZA200709127B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2432360T3 (es) * | 2005-12-20 | 2013-12-03 | Eisai R&D Management Co., Ltd. | Procedimiento para la producción de profármaco de azol soluble en agua |
| CN101389333A (zh) | 2006-02-22 | 2009-03-18 | 卫材R&D管理有限公司 | 稳定化药物组合物 |
| CN105287403A (zh) * | 2014-08-02 | 2016-02-03 | 陕西合成药业股份有限公司 | 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途 |
| CN106432338A (zh) * | 2015-08-08 | 2017-02-22 | 陕西合成药业股份有限公司 | 泊沙康唑衍生物、合成和在长效制剂中的用途 |
| WO2019106571A1 (en) | 2017-11-28 | 2019-06-06 | Roivant Sciences Gmbh | Dosing regimens for the treatment of fungal infections |
| CN110938093B (zh) * | 2018-09-21 | 2022-08-19 | 华创合成制药股份有限公司 | 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE186540T1 (de) * | 1994-01-24 | 1999-11-15 | Janssen Pharmaceutica Nv | Wasserlösliche azol-antifungus |
| NZ270418A (en) * | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| US5883097A (en) * | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| US6265584B1 (en) * | 1998-05-22 | 2001-07-24 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| WO2000030655A1 (en) * | 1998-11-20 | 2000-06-02 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6235728B1 (en) * | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
| US6362172B2 (en) * | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
-
2006
- 2006-04-17 JO JO2006103A patent/JO2691B1/en active
- 2006-04-28 UY UY29507A patent/UY29507A1/es active IP Right Grant
- 2006-04-28 MY MYPI20061985A patent/MY138095A/en unknown
- 2006-05-01 RS RS20110275A patent/RS51779B/en unknown
- 2006-05-01 JP JP2007509811A patent/JP4015691B1/ja active Active
- 2006-05-01 EP EP06746245A patent/EP1877403B1/en active Active
- 2006-05-01 PL PL06746245T patent/PL1877403T3/pl unknown
- 2006-05-01 DK DK06746245.7T patent/DK1877403T3/da active
- 2006-05-01 BR BRPI0610423A patent/BRPI0610423B8/pt active IP Right Grant
- 2006-05-01 AT AT06746245T patent/ATE503753T1/de active
- 2006-05-01 CA CA2606185A patent/CA2606185C/en active Active
- 2006-05-01 MX MX2007013605A patent/MX2007013605A/es active IP Right Grant
- 2006-05-01 CN CN2006800150290A patent/CN101213193B/zh not_active Expired - Fee Related
- 2006-05-01 RU RU2007140788/04A patent/RU2399625C2/ru active
- 2006-05-01 DE DE602006020998T patent/DE602006020998D1/de active Active
- 2006-05-01 WO PCT/JP2006/309435 patent/WO2006118351A1/en active Application Filing
- 2006-05-01 ES ES06746245T patent/ES2361768T3/es active Active
- 2006-05-01 PT PT06746245T patent/PT1877403E/pt unknown
- 2006-05-01 AU AU2006241694A patent/AU2006241694B2/en not_active Ceased
- 2006-05-01 NZ NZ563092A patent/NZ563092A/en not_active IP Right Cessation
- 2006-05-01 KR KR1020077001773A patent/KR100887044B1/ko active IP Right Grant
- 2006-05-01 SI SI200630984T patent/SI1877403T1/sl unknown
- 2006-05-02 PE PE2006000458A patent/PE20071423A1/es active IP Right Grant
- 2006-05-02 AR ARP060101759A patent/AR053862A1/es not_active Application Discontinuation
- 2006-05-03 US US11/416,322 patent/US20060264406A1/en not_active Abandoned
- 2006-05-03 TW TW095115682A patent/TWI363630B/zh not_active IP Right Cessation
- 2006-05-03 SA SA06270126A patent/SA06270126B1/ar unknown
-
2007
- 2007-10-16 EC EC2007007812A patent/ECSP077812A/es unknown
- 2007-10-23 ZA ZA200709127A patent/ZA200709127B/en unknown
- 2007-10-31 IL IL187059A patent/IL187059A/en active IP Right Grant
- 2007-11-02 NO NO20075541A patent/NO20075541L/no not_active Application Discontinuation
-
2008
- 2008-07-14 HK HK08107745.5A patent/HK1117502A1/xx unknown
-
2011
- 2011-06-17 CY CY20111100582T patent/CY1111569T1/el unknown
- 2011-06-21 HR HR20110467T patent/HRP20110467T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1111569T1 (el) | Μονολυσινικα αλατα αζολικων ενωσεων | |
| ES2528797T3 (es) | Compuestos de aza-benzotiofenilo y métodos de uso | |
| BR0107618A (pt) | Pró-medicamentos solúveis em água de compostos de azol | |
| MA31580B1 (fr) | Derives de bicyclolactames substitués | |
| MX2013002558A (es) | Derivado de imidazol de heteroanillo fusionado que tiene efecto de activacion de proteina cinasa activada por monofosfato de adenosina (amk). | |
| NO20054856D0 (no) | 4-anilo-kinazolinderivater som antiproliferative midler | |
| UY29479A1 (es) | Inhibidores de adn-pk | |
| MX2020010181A (es) | Compuestos de piperidina como inhibidores covalentes de menina. | |
| PA8660001A1 (es) | Amino-imidazolonas para la inhibicion de b-secretasa | |
| TW200730496A (en) | Oxime ester photoinitiators | |
| EP1338595A3 (en) | Xanthine derivatives as DPP-IV inhibitors | |
| TW200504061A (en) | Pyrazolopyridine derivatives | |
| NO20044995L (no) | Heterosykliske forbindelser | |
| AU2003222106A1 (en) | Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same | |
| WO2009041514A1 (ja) | 染毛用染料及び染毛用組成物 | |
| GEP20125523B (en) | Metabolites of (thio) carbamoyl-cyclohexane derivatives | |
| TW200706694A (en) | Water-soluble preflux and use thereof | |
| WO2009047298A3 (en) | Dimers of harmol or of its derivatives and uses thereof | |
| ATE526381T1 (de) | Organische elektrolumineszenzvorrichtung sowie platinverbindung | |
| EA200100422A1 (ru) | Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью | |
| DE60237637D1 (de) | Thiadiazolinderivate zur Krebsbehandlung | |
| EP1671957A4 (en) | THIADIAZOLINDERIVATE | |
| NO20071100L (no) | 5-jodtetrazoler | |
| WO2009016954A1 (ja) | 水性金属加工油剤 | |
| TW200615274A (en) | Chemical compounds |